LOCUS       NM_015982               1654 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens Y-box binding protein 2 (YBX2), mRNA.
ACCESSION   NM_015982
VERSION     NM_015982.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1654)
  AUTHORS   Cai,Y., Li,N. and Li,H.
  TITLE     YBX2 modulates mRNA stability via interaction with YTHDF2 in
            endometrial cancer cells
  JOURNAL   Exp Cell Res 427 (1), 113586 (2023)
   PUBMED   37030331
  REMARK    GeneRIF: YBX2 modulates mRNA stability via interaction with YTHDF2
            in endometrial cancer cells.
REFERENCE   2  (bases 1 to 1654)
  AUTHORS   Zhang,L. and Hu,G.
  TITLE     NSD2 activates the E2F transcription factor 1/Y-box binding protein
            2 axis to promote the malignant development of oral squamous cell
            carcinoma
  JOURNAL   Arch Oral Biol 138, 105412 (2022)
   PUBMED   35364436
  REMARK    GeneRIF: NSD2 activates the E2F transcription factor 1/Y-box
            binding protein 2 axis to promote the malignant development of oral
            squamous cell carcinoma.
REFERENCE   3  (bases 1 to 1654)
  AUTHORS   Guo,L., Lin,Q., Zhao,X. and Xu,J.
  TITLE     Circular CDC like kinase 1 suppresses cell apoptosis through
            miR-18b-5p/Y-box protein 2 axis in oral squamous cell carcinoma
  JOURNAL   Bioengineered 13 (2), 4226-4234 (2022)
   PUBMED   35156507
  REMARK    GeneRIF: Circular CDC like kinase 1 suppresses cell apoptosis
            through miR-18b-5p/Y-box protein 2 axis in oral squamous cell
            carcinoma.
REFERENCE   4  (bases 1 to 1654)
  AUTHORS   Suzuki,I., Yoshida,S., Tabu,K., Kusunoki,S., Matsumura,Y.,
            Izumi,H., Asanoma,K., Yagi,H., Onoyama,I., Sonoda,K., Kohno,K.,
            Taga,T., Itakura,A., Takeda,S. and Kato,K.
  TITLE     YBX2 and cancer testis antigen 45 contribute to stemness,
            chemoresistance and a high degree of malignancy in human
            endometrial cancer
  JOURNAL   Sci Rep 11 (1), 4220 (2021)
   PUBMED   33602962
  REMARK    GeneRIF: YBX2 and cancer testis antigen 45 contribute to stemness,
            chemoresistance and a high degree of malignancy in human
            endometrial cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1654)
  AUTHORS   Niu,X., Yang,B., Liu,F. and Fang,Q.
  TITLE     LncRNA HOXA11-AS promotes OSCC progression by sponging miR-98-5p to
            upregulate YBX2 expression
  JOURNAL   Biomed Pharmacother 121, 109623 (2020)
   PUBMED   31731187
  REMARK    GeneRIF: LncRNA HOXA11-AS promotes OSCC progression by sponging
            miR-98-5p to upregulate YBX2 expression.
REFERENCE   6  (bases 1 to 1654)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 1654)
  AUTHORS   Kohno,Y., Matsuki,Y., Tanimoto,A., Izumi,H., Uchiumi,T., Kohno,K.,
            Shimajiri,S. and Sasaguri,Y.
  TITLE     Expression of Y-box-binding protein dbpC/contrin, a potentially new
            cancer/testis antigen
  JOURNAL   Br J Cancer 94 (5), 710-716 (2006)
   PUBMED   16479255
  REMARK    GeneRIF: provides first evidence showing dbpC highly expressed in
            human testicular seminoma and ovarian dysgerminomas, and in
            carcinomas in other tissues and that its expression in normal
            tissues is nearly restricted to germ cells and placental
            trophoblasts
REFERENCE   8  (bases 1 to 1654)
  AUTHORS   Yoshida,T., Izumi,H., Uchiumi,T., Sasaguri,Y., Tanimoto,A.,
            Matsumoto,T., Naito,S. and Kohno,K.
  TITLE     Expression and cellular localization of dbpC/Contrin in germ cell
            tumor cell lines
  JOURNAL   Biochim Biophys Acta 1759 (1-2), 80-88 (2006)
   PUBMED   16624424
  REMARK    GeneRIF: transcriptional regulation of Contrin was investigated,
            and the promoter region between -272 and -253 relative to the
            transcription start site was shown to be critical for the
            manifestation of cell-type specific transcription
REFERENCE   9  (bases 1 to 1654)
  AUTHORS   Tekur,S., Pawlak,A., Guellaen,G. and Hecht,N.B.
  TITLE     Contrin, the human homologue of a germ-cell Y-box-binding protein:
            cloning, expression, and chromosomal localization
  JOURNAL   J Androl 20 (1), 135-144 (1999)
   PUBMED   10100484
REFERENCE   10 (bases 1 to 1654)
  AUTHORS   Gu,W., Tekur,S., Reinbold,R., Eppig,J.J., Choi,Y.C., Zheng,J.Z.,
            Murray,M.T. and Hecht,N.B.
  TITLE     Mammalian male and female germ cells express a germ cell-specific
            Y-Box protein, MSY2
  JOURNAL   Biol Reprod 59 (5), 1266-1274 (1998)
   PUBMED   9780336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC003688.1, DB065912.1, BC033800.1 and AI805280.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015982.3.
            
            Summary: This gene encodes a nucleic acid binding protein which is
            highly expressed in germ cells. The encoded protein binds to a
            Y-box element in the promoters of certain genes but also binds to
            mRNA transcribed from these genes. Pseudogenes for this gene are
            located on chromosome 10 and 15. [provided by RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF096834.1, BC047760.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000007699.10/ ENSP00000007699.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC003688.1         96954-97035         c
            83-119              DB065912.1         1-37
            120-1653            BC033800.1         1-1534
            1654-1654           AI805280.1         35-35               c
FEATURES             Location/Qualifiers
     source          1..1654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1654
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /note="Y-box binding protein 2"
                     /db_xref="GeneID:51087"
                     /db_xref="HGNC:HGNC:17948"
                     /db_xref="MIM:611447"
     exon            1..410
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1234
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /note="germ cell specific Y-box binding protein;
                     DNA-binding protein C; epididymis secretory sperm binding
                     protein; alternative protein YBX2"
                     /codon_start=1
                     /product="Y-box-binding protein 2"
                     /protein_id="NP_057066.2"
                     /db_xref="CCDS:CCDS11098.1"
                     /db_xref="GeneID:51087"
                     /db_xref="HGNC:HGNC:17948"
                     /db_xref="MIM:611447"
                     /translation="MSEVEAAAGATAVPAATVPATAAGVVAVVVPVPAGEPQKGGGAG
                     GGGGAASGPAAGTPSAPGSRTPGNPATAVSGTPAPPARSQADKPVLAIQVLGTVKWFN
                     VRNGYGFINRNDTKEDVFVHQTAIKRNNPRKFLRSVGDGETVEFDVVEGEKGAEATNV
                     TGPGGVPVKGSRYAPNRRKSRRFIPRPPSVAPPPMVAEIPSAGTGPGSKGERAEDSGQ
                     RPRRWCPPPFFYRRRFVRGPRPPNQQQPIEGTDRVEPKETAPLEGHQQQGDERVPPPR
                     FRPRYRRPFRPRPRQQPTTEGGDGETKPSQGPADGSRPEPQRPRNRPYFQRRRQQAPG
                     PQQAPGPRQPAAPETSAPVNSGDPTTTILE"
     exon            411..474
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..508
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..598
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..883
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..987
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1183
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1273
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1654
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1636..1641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /note="hexamer: AGTAAA"
     polyA_site      1654
                     /gene="YBX2"
                     /gene_synonym="CONTRIN; CSDA3; DBPC; MSY2"
                     /note="major polyA site"
ORIGIN      
        1 gccattggcc tcggctccgg gcccgctgcc ggcgtgtggg cgaggctcgg ggcgcgagga
       61 ccgagcaggg cggtgggttc gcgagccggg gggaggggcc ggggcggtgg cggctgtggc
      121 cggtactgga cccggcggga tgagcgaggt ggaggcggca gcgggggcta cagcggtccc
      181 cgcggcgacg gtgcccgcga cggcggcagg ggtggtagcg gtggtggtac cggtgcccgc
      241 aggggagccg cagaaaggcg gcggggcggg cggcgggggc ggagccgcct cgggccccgc
      301 tgctgggacc ccctcggcgc cgggctcccg cacccctggc aatccggcga cggcggtctc
      361 gggaaccccc gcccccccgg cccggagtca ggcggacaag ccggtgctgg caatccaagt
      421 cctgggcact gtcaaatggt tcaacgtccg gaatggttac ggattcatca acaggaatga
      481 caccaaggaa gatgtctttg ttcaccagac agctattaaa agaaacaacc ccaggaagtt
      541 tctgcgcagc gttggagatg gggagactgt ggaatttgat gtcgtggaag gagagaaggg
      601 cgcagaagcc actaatgtaa ctgggcctgg gggagtaccc gtgaagggca gccgttatgc
      661 ccccaaccga cgtaagtccc gccgattcat cccccggcct ccctcagttg ccccaccacc
      721 catggtggca gagatcccct cggcggggac aggacctggc agtaaagggg agcgggctga
      781 agactctggg caacggcccc gacgatggtg ccccccaccc ttcttctacc gacggcggtt
      841 tgtgcgaggc ccccggcctc ccaaccagca gcagcctata gagggcactg acagggtaga
      901 acccaaagag acagccccat tggaggggca ccaacagcag ggagatgagc gagtcccccc
      961 gcccagattc cggcccaggt accgaaggcc tttccgcccc aggccacgcc agcagcctac
     1021 cacagaaggt ggggatggtg agaccaagcc cagccaaggt cccgctgatg gttcccggcc
     1081 tgagccccag cgcccacgaa accgccccta cttccagcgg agacggcagc aggcccctgg
     1141 cccccagcag gcccctggcc cccggcagcc cgcagcccct gagacctcag cccctgtcaa
     1201 cagtggggac cccaccacca ccatcctgga gtgattccaa ctcaactcag aggacaccca
     1261 gagctgccat ctggtatctg ccagtttttc caaatgacct gtaccctacc cagtaccctg
     1321 ctcccccttt cccataattc atgacatcaa aacaccagct tttcaccttt tccttgagac
     1381 tcaggaggac caaagcagca gccttttgct ttttcttttt tcttccctcc ccttatcaag
     1441 ggttgaagga agggagccat ccttactgtt cagagacagc aactccctcc cgtaactcag
     1501 gctgagaagg aaccagccag ctcttacctc ctcctggttg cttttcttgc ccccacccca
     1561 agtttatttt tgttttcccc cggcccccta cctctgaagc cattttatga tctgtcatgt
     1621 gccacctgag cctccagtaa aaacaaaaac aggc
//
