LOCUS       NM_001130145            5401 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens Yes1 associated transcriptional regulator (YAP1),
            transcript variant 1, mRNA.
ACCESSION   NM_001130145
VERSION     NM_001130145.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5401)
  AUTHORS   Tang,W., Yang,Y., Fu,Z., Xu,W., Ou,W., Liu,F., Du,P. and Liu,C.Y.
  TITLE     The RNA helicase DDX21 activates YAP to promote tumorigenesis and
            is transcriptionally upregulated by beta-catenin in colorectal
            cancer
  JOURNAL   Oncogene 43 (44), 3227-3239 (2024)
   PUBMED   39285230
  REMARK    GeneRIF: The RNA helicase DDX21 activates YAP to promote
            tumorigenesis and is transcriptionally upregulated by beta-catenin
            in colorectal cancer.
REFERENCE   2  (bases 1 to 5401)
  AUTHORS   He,C., Lv,X., Liu,J., Ruan,J., Chen,P., Huang,C., Angeletti,P.C.,
            Hua,G., Moness,M.L., Shi,D., Dhar,A., Yang,S., Murphy,S.,
            Montoute,I., Chen,X., Islam,K.N., George,S., Ince,T.A., Drapkin,R.,
            Guda,C., Davis,J.S. and Wang,C.
  TITLE     HPV-YAP1 oncogenic alliance drives malignant transformation of
            fallopian tube epithelial cells
  JOURNAL   EMBO Rep 25 (10), 4542-4569 (2024)
   PUBMED   39271776
  REMARK    GeneRIF: HPV-YAP1 oncogenic alliance drives malignant
            transformation of fallopian tube epithelial cells.
REFERENCE   3  (bases 1 to 5401)
  AUTHORS   Chen,X., Li,D., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A.,
            Ding,S., Xu,R., Liu,Z., Long,X., Zhang,J., Yang,Z., Qi,Y. and Wu,H.
  TITLE     SENP3 mediates the deSUMOylation and degradation of YAP1 to
            regulate the progression of triple-negative breast cancer
  JOURNAL   J Biol Chem 300 (10), 107764 (2024)
   PUBMED   39270822
  REMARK    GeneRIF: SENP3 mediates the deSUMOylation and degradation of YAP1
            to regulate the progression of triple-negative breast cancer.
REFERENCE   4  (bases 1 to 5401)
  AUTHORS   Meyer,N.P., Singh,T., Kutys,M.L., Nystul,T.G. and Barber,D.L.
  TITLE     Arp2/3 complex activity enables nuclear YAP for naive pluripotency
            of human embryonic stem cells
  JOURNAL   Elife 13, e89725 (2024)
   PUBMED   39319536
  REMARK    GeneRIF: Arp2/3 complex activity enables nuclear YAP for naive
            pluripotency of human embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5401)
  AUTHORS   Jimbo,N., Ohbayashi,C., Fujii,T., Takeda,M., Mitsui,S., Tanaka,Y.,
            Itoh,T. and Maniwa,Y.
  TITLE     The expression of YAP1 and other transcription factors contributes
            to lineage plasticity in combined small cell lung carcinoma
  JOURNAL   J Pathol Clin Res 10 (5), e70001 (2024)
   PUBMED   39283755
  REMARK    GeneRIF: The expression of YAP1 and other transcription factors
            contributes to lineage plasticity in combined small cell lung
            carcinoma.
REFERENCE   6  (bases 1 to 5401)
  AUTHORS   Gaffney,C.J., Oka,T., Mazack,V., Hilman,D., Gat,U., Muramatsu,T.,
            Inazawa,J., Golden,A., Carey,D.J., Farooq,A., Tromp,G. and Sudol,M.
  TITLE     Identification, basic characterization and evolutionary analysis of
            differentially spliced mRNA isoforms of human YAP1 gene
  JOURNAL   Gene 509 (2), 215-222 (2012)
   PUBMED   22939869
REFERENCE   7  (bases 1 to 5401)
  AUTHORS   Gavva,N.R., Gavva,R., Ermekova,K., Sudol,M. and Shen,C.J.
  TITLE     Interaction of WW domains with hematopoietic transcription factor
            p45/NF-E2 and RNA polymerase II
  JOURNAL   J Biol Chem 272 (39), 24105-24108 (1997)
   PUBMED   9305852
REFERENCE   8  (bases 1 to 5401)
  AUTHORS   Chen,H.I., Einbond,A., Kwak,S.J., Linn,H., Koepf,E., Peterson,S.,
            Kelly,J.W. and Sudol,M.
  TITLE     Characterization of the WW domain of human yes-associated protein
            and its polyproline-containing ligands
  JOURNAL   J Biol Chem 272 (27), 17070-17077 (1997)
   PUBMED   9202023
REFERENCE   9  (bases 1 to 5401)
  AUTHORS   Chen,H.I. and Sudol,M.
  TITLE     The WW domain of Yes-associated protein binds a proline-rich ligand
            that differs from the consensus established for Src homology
            3-binding modules
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7819-7823 (1995)
   PUBMED   7644498
REFERENCE   10 (bases 1 to 5401)
  AUTHORS   Sudol,M., Bork,P., Einbond,A., Kastury,K., Druck,T., Negrini,M.,
            Huebner,K. and Lehman,D.
  TITLE     Characterization of the mammalian YAP (Yes-associated protein) gene
            and its role in defining a novel protein module, the WW domain
  JOURNAL   J Biol Chem 270 (24), 14733-14741 (1995)
   PUBMED   7782338
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001527.5, BC038235.1,
            AP000942.6, AL832620.2 and AI128142.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001130145.2.
            
            Summary: This gene encodes a downstream nuclear effector of the
            Hippo signaling pathway which is involved in development, growth,
            repair, and homeostasis. This gene is known to play a role in the
            development and progression of multiple cancers as a
            transcriptional regulator of this signaling pathway and may
            function as a potential target for cancer treatment. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 9. The
            encoded protein (isoform 1) represents the YAP1-2gamma isoform
            described in Figure 3 of PMID: 22939869. It is shorter, compared to
            isoform 9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.100687.1, BC038235.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282441.10/ ENSP00000282441.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AP001527.5         88776-88884
            110-2433            BC038235.1         1-2324
            2434-3860           AP000942.6         5801-7227
            3861-5395           AL832620.2         3141-4675
            5396-5400           AI128142.1         11-15               c
            5401-5401           AP000942.6         8768-8768
FEATURES             Location/Qualifiers
     source          1..5401
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.1"
     gene            1..5401
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /note="Yes1 associated transcriptional regulator"
                     /db_xref="GeneID:10413"
                     /db_xref="HGNC:HGNC:16262"
                     /db_xref="MIM:606608"
     exon            1..723
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..1917
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /note="isoform 1 is encoded by transcript variant 1; 65
                     kDa Yes-associated protein; yorkie homolog; yes-associated
                     protein 2; protein yorkie homolog; yes-associated protein
                     YAP65 homolog; transcriptional coactivator YAP1; Yes
                     associated protein 1"
                     /codon_start=1
                     /product="transcriptional coactivator YAP1 isoform 1"
                     /protein_id="NP_001123617.1"
                     /db_xref="CCDS:CCDS44716.1"
                     /db_xref="GeneID:10413"
                     /db_xref="HGNC:HGNC:16262"
                     /db_xref="MIM:606608"
                     /translation="MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAA
                     PQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPK
                     SHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHL
                     RQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSP
                     PVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQS
                     APVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNIN
                     PSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYH
                     SRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPG
                     TNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL"
     exon            724..974
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1090
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1204
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1386
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1434
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1565
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1678
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..5401
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2580..2585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /note="hexamer: AATATA"
     polyA_site      2600
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /note="major polyA site"
     regulatory      4691..4696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /note="hexamer: AATAAA"
     polyA_site      4720
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /note="major polyA site"
     regulatory      5239..5244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /note="hexamer: AATATA"
     polyA_site      5259
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
     regulatory      5377..5382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
                     /note="hexamer: AATATA"
     polyA_site      5401
                     /gene="YAP1"
                     /gene_synonym="COB1; YAP; YAP-1; YAP2; YAP65; YKI"
ORIGIN      
        1 ctcagtcggg cgcagccgcc gccagggaaa agaaagggag gaaggaagga acaagaaaag
       61 gaaataaaga gaaaggggag gcggggaaag gcaacgagct gtccggcctc cgtcaaggga
      121 gttggaggga aaaagttctc aggcgccgca ggtccgagtg cctcgcagcc cctcccgagg
      181 cgcagccgcc agaccagtgg agccggggcg cagggcgggg gcggaggcgc cggggcgggg
      241 gatgcggggc cgcggcgcag ccccccggcc ctgagagcga ggacagcgcc gcccggcccg
      301 cagccgtcgc cgcttctcca cctcggcccg tggagccggg gcgtccgggc gtagccctcg
      361 ctcgcctggg tcagggggtg cgcgtcgggg gaggcagaag ccatggatcc cgggcagcag
      421 ccgccgcctc aaccggcccc ccagggccaa gggcagccgc cttcgcagcc cccgcagggg
      481 cagggcccgc cgtccggacc cgggcaaccg gcacccgcgg cgacccaggc ggcgccgcag
      541 gcaccccccg ccgggcatca gatcgtgcac gtccgcgggg actcggagac cgacctggag
      601 gcgctcttca acgccgtcat gaaccccaag acggccaacg tgccccagac cgtgcccatg
      661 aggctccgga agctgcccga ctccttcttc aagccgccgg agcccaaatc ccactcccga
      721 caggccagta ctgatgcagg cactgcagga gccctgactc cacagcatgt tcgagctcat
      781 tcctctccag cttctctgca gttgggagct gtttctcctg ggacactgac ccccactgga
      841 gtagtctctg gcccagcagc tacacccaca gctcagcatc ttcgacagtc ttcttttgag
      901 atacctgatg atgtacctct gccagcaggt tgggagatgg caaagacatc ttctggtcag
      961 agatacttct taaatcacat cgatcagaca acaacatggc aggaccccag gaaggccatg
     1021 ctgtcccaga tgaacgtcac agcccccacc agtccaccag tgcagcagaa tatgatgaac
     1081 tcggcttcag gtcctcttcc tgatggatgg gaacaagcca tgactcagga tggagaaatt
     1141 tactatataa accataagaa caagaccacc tcttggctag acccaaggct tgaccctcgt
     1201 tttgccatga accagagaat cagtcagagt gctccagtga aacagccacc acccctggct
     1261 ccccagagcc cacagggagg cgtcatgggt ggcagcaact ccaaccagca gcaacagatg
     1321 cgactgcagc aactgcagat ggagaaggag aggctgcggc tgaaacagca agaactgctt
     1381 cggcaggcaa tgcggaatat caatcccagc acagcaaatt ctccaaaatg tcaggagtta
     1441 gccctgcgta gccagttacc aacactggag caggatggtg ggactcaaaa tccagtgtct
     1501 tctcccggga tgtctcagga attgagaaca atgacgacca atagctcaga tcctttcctt
     1561 aacagtggca cctatcactc tcgagatgag agtacagaca gtggactaag catgagcagc
     1621 tacagtgtcc ctcgaacccc agatgacttc ctgaacagtg tggatgagat ggatacaggt
     1681 gatactatca accaaagcac cctgccctca cagcagaacc gtttcccaga ctaccttgaa
     1741 gccattcctg ggacaaatgt ggaccttgga acactggaag gagatggaat gaacatagaa
     1801 ggagaggagc tgatgccaag tctgcaggaa gctttgagtt ctgacatcct taatgacatg
     1861 gagtctgttt tggctgccac caagctagat aaagaaagct ttcttacatg gttatagagc
     1921 cctcaggcag actgaattct aaatctgtga aggatctaag gagacacatg caccggaaat
     1981 ttccataagc cagttgcagt tttcaggcta atacagaaaa agatgaacaa acgtccagca
     2041 agatacttta atcctctatt ttgctcttcc ttgtccattg ctgctgttaa tgtattgctg
     2101 acctctttca cagttggctc taaagaatca aaagaaaaaa actttttatt tcttttgcta
     2161 ttaaaactac tgttcatttt gggggctggg ggaagtgagc ctgtttggat gatggatgcc
     2221 attccttttg cccagttaaa tgttcaccaa tcattttaac taaatactca gacttagaag
     2281 tcagatgctt catgtcacag catttagttt gttcaacagt tgtttcttca gcttcctttg
     2341 tccagtggaa aaacatgatt tactggtctg acaagccaaa aatgttatat ctgatattaa
     2401 atacttaatg ctgatttgaa gagatagctg aaaccaaggc tgaagactgt tttactttca
     2461 gtattttctt ttcctcctag tgctatcatt agtcacataa tgaccttgat tttattttag
     2521 gagcttataa ggcatgagac aatttccata taaatatatt aattattgcc acatactcta
     2581 atatagattt tggtggataa ttttgtgggt gtgcattttg ttctgttttg ttgggttttt
     2641 tgtttttttt gtttttggca gggtcggtgg gggggttggt tggttggttg gttttgtcgg
     2701 aacctaggca aatgaccata ttagtgaatc tgttaatagt tgtagcttgg gatggttatt
     2761 gtagttgttt tggtaaaatc ttcatttcct ggtttttttt accaccttat ttaaatctcg
     2821 attatctgct ctctctttta tatacataca cacacccaaa cataacattt ataatagtgt
     2881 ggtagtggaa tgtatccttt tttaggtttc cctgctttcc agttaatttt taaaatggta
     2941 gcgctttgta tgcatttaga atacatgact agtagtttat atttcactgg tagtttaaat
     3001 ctggttgggg cagtctgcag atgtttgaag tagtttagtg ttctagaaag agctattact
     3061 gtggatagtg cctaggggag tgctccacgc cctctgggca tacggtagat attatctgat
     3121 gaattggaaa ggagcaaacc agaaatggct ttattttctc ccttggacta atttttaagt
     3181 ctcgattgga attcagtgag taggttcata atgtgcatga cagaaataag ctttatagtg
     3241 gtttaccttc atttagcttt ggaagttttc tttgccttag ttttggaagt aaattctagt
     3301 ttgtagttct catttgtaat gaacacatta acgactagat taaaatattg ccttcaagat
     3361 tgttcttact tacaagactt gctcctactt ctatgctgaa aattgaccct ggatagaata
     3421 ctataaggtt ttgagttagc tggaaaagtg atcagattaa taaatgtata ttggtagttg
     3481 aatttagcaa agaaatagag ataatcatga ttataccttt atttttacag gaagagatga
     3541 tgtaactaga gtatgtgtct acaggagtaa taatggtttc caaagagtat tttttaaagg
     3601 aacaaaacga gcatgaatta actcttcaat ataagctatg aagtaatagt tggttgtgaa
     3661 ttaaagtggc accagctagc acctctgtgt tttaagggtc tttcaatgtt tctagaataa
     3721 gcccttattt tcaagggttc ataacaggca taaaatctct tctcctggca aaagctgcta
     3781 tgaaaagcct cagcttggga agatagattt ttttcccccc aattacaaaa tctaagtatt
     3841 ttggcccttc aatttggagg agggcaaaag ttggaagtaa gaagttttat tttaagtact
     3901 ttcagtgctc aaaaaaatgc aatcactgtg ttgtatataa tagttcatag gttgatcact
     3961 cataataatt gactctaagg cttttattaa gaaaacagca gaaagattaa atcttgaatt
     4021 aagtctgggg ggaaatggcc actgcagatg gagttttaga gtagtaatga aattctacct
     4081 agaatgcaaa attgggtata tgaattacat agcatgttgt tgggattttt tttaatgtgc
     4141 agaagatcaa agctacttgg aaggagtgcc tataatttgc cagtagccac agattaagat
     4201 tatatcttat atatcagcag attagcttta gcttaggggg agggtgggaa agtttggggg
     4261 gggggttgtg aagatttagg gggaccttga tagagaactt tataaacttc tttctcttta
     4321 ataaagactt gtcttacacc gtgctgccat taaaggcagc tgttctagag tttcagtcac
     4381 ctaagtacac ccacaaaaca atatgaatat ggagatcttc ctttacccct caactttaat
     4441 ttgcccagtt atacctcagt gttgtagcag tactgtgata cctggcacag tgctttgatc
     4501 ttacgatgcc ctctgtactg acctgaagga gacctaagag tcctttccct ttttgagttt
     4561 gaatcatagc cttgatgtgg tctcttgttt tatgtccttg ttcctaatgt aaaagtgctt
     4621 aactgcttct tggttgtatt gggtagcatt gggataagat tttaactggg tattcttgaa
     4681 ttgcttttac aataaaccaa ttttataatc tttaaattta tcaacttttt acatttgtgt
     4741 tattttcagt cagggcttct tagatctact tatggttgat ggagcacatt gatttggagt
     4801 ttcagatctt ccaaagcact atttgttgta ataacttttc taaatgtagt gcctttaaag
     4861 gaaaaatgaa cacagggaag tgactttgct acaaataatg ttgctgtgtt aagtattcat
     4921 attaaataca tgccttctat atggaacatg gcagaaagac tgaaaaataa cagtaattaa
     4981 ttgtgtaatt cagaattcat accaatcagt gttgaaactc aaacattgca aaagtgggtg
     5041 gcaatattca gtgcttaaca cttttctagc gttggtacat ctgagaaatg agtgctcagg
     5101 tggattttat cctcgcaagc atgttgttat aagaattgtg ggtgtgccta tcataacaat
     5161 tgttttctgt atcttgaaaa agtattctcc acattttaaa tgttttatat tagagaattc
     5221 tttaatgcac acttgtcaaa tatatatata tagtaccaat gttacctttt tattttttgt
     5281 tttagatgta agagcatgct catatgttag gtacttacat aaattgttac attatttttt
     5341 cttatgtaat acctttttgt ttgtttatgt ggttcaaata tattctttcc ttaaactctt
     5401 c
//
