LOCUS       NM_005748               4096 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens YY1 associated factor 2 (YAF2), transcript variant 2,
            mRNA.
ACCESSION   NM_005748
VERSION     NM_005748.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4096)
  AUTHORS   Shen,H., Song,H., Wang,S., Su,D. and Sun,Q.
  TITLE     NEAT1 enhances MPP+ -induced pyroptosis in a cell model of
            Parkinson's disease via targeting miR-5047/YAF2 signaling
  JOURNAL   Immun Inflamm Dis 11 (6), e817 (2023)
   PUBMED   37382256
  REMARK    GeneRIF: NEAT1 enhances MPP[+] -induced pyroptosis in a cell model
            of Parkinson's disease via targeting miR-5047/YAF2 signaling.
REFERENCE   2  (bases 1 to 4096)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4096)
  AUTHORS   Zhang,S., Zhang,X., Guan,X., Ma,X., Chen,H., Huang,B. and Chen,D.
  TITLE     YAF2 exerts anti-apoptotic effect in human tumor cells in a FANK1-
            and phosphorylation-dependent manner
  JOURNAL   Biochem Biophys Res Commun 554, 99-106 (2021)
   PUBMED   33784512
  REMARK    GeneRIF: YAF2 exerts anti-apoptotic effect in human tumor cells in
            a FANK1- and phosphorylation-dependent manner.
REFERENCE   4  (bases 1 to 4096)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4096)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4096)
  AUTHORS   Madge,B., Geisen,C., Moroy,T. and Schwab,M.
  TITLE     Yaf2 inhibits Myc biological function
  JOURNAL   Cancer Lett 193 (2), 171-176 (2003)
   PUBMED   12706874
REFERENCE   7  (bases 1 to 4096)
  AUTHORS   Sawa,C., Yoshikawa,T., Matsuda-Suzuki,F., Delehouzee,S., Goto,M.,
            Watanabe,H., Sawada,J., Kataoka,K. and Handa,H.
  TITLE     YEAF1/RYBP and YAF-2 are functionally distinct members of a
            cofactor family for the YY1 and E4TF1/hGABP transcription factors
  JOURNAL   J Biol Chem 277 (25), 22484-22490 (2002)
   PUBMED   11953439
  REMARK    GeneRIF: YEAF1/RYBP and YAF-2 are functionally distinct members of
            a cofactor family for the YY1 and E4TF1/hGABP transcription
            factors.
REFERENCE   8  (bases 1 to 4096)
  AUTHORS   Ogawa,H., Ishiguro,K., Gaubatz,S., Livingston,D.M. and Nakatani,Y.
  TITLE     A complex with chromatin modifiers that occupies E2F- and
            Myc-responsive genes in G0 cells
  JOURNAL   Science 296 (5570), 1132-1136 (2002)
   PUBMED   12004135
REFERENCE   9  (bases 1 to 4096)
  AUTHORS   Bannasch,D., Madge,B. and Schwab,M.
  TITLE     Functional interaction of Yaf2 with the central region of MycN
  JOURNAL   Oncogene 20 (41), 5913-5919 (2001)
   PUBMED   11593398
REFERENCE   10 (bases 1 to 4096)
  AUTHORS   Kalenik,J.L., Chen,D., Bradley,M.E., Chen,S.J. and Lee,T.C.
  TITLE     Yeast two-hybrid cloning of a novel zinc finger protein that
            interacts with the multifunctional transcription factor YY1
  JOURNAL   Nucleic Acids Res 25 (4), 843-849 (1997)
   PUBMED   9016636
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA011078.1, AC020629.6 and
            AA789222.1.
            
            On Feb 27, 2020 this sequence version replaced NM_005748.5.
            
            Summary: This gene encodes a zinc finger containing protein that
            functions in the regulation of transcription. This protein was
            identified as an interacting partner of transcriptional repressor
            protein Yy1, and also interacts with other transcriptional
            regulators, including Myc and Polycomb. This protein can promote
            proteolysis of Yy1. Multiple alternatively spliced transcript
            variants have been found. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (2) lacks an in-frame exon
            compared to variant 1. The resulting isoform (2) is shorter than
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.1620568.1,
                                           SRR11853561.6579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000534854.7/ ENSP00000439256.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               DA011078.1         102-566
            466-3697            AC020629.6         3614-6845           c
            3698-4096           AA789222.1         10-408              c
FEATURES             Location/Qualifiers
     source          1..4096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..4096
                     /gene="YAF2"
                     /note="YY1 associated factor 2"
                     /db_xref="GeneID:10138"
                     /db_xref="HGNC:HGNC:17363"
                     /db_xref="MIM:607534"
     exon            1..94
                     /gene="YAF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..611
                     /gene="YAF2"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="YY1-associated factor 2 isoform 2"
                     /protein_id="NP_005739.2"
                     /db_xref="CCDS:CCDS31775.1"
                     /db_xref="GeneID:10138"
                     /db_xref="HGNC:HGNC:17363"
                     /db_xref="MIM:607534"
                     /translation="MGDKKSPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDV
                     RKGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDKVEKEKSEKETTSKKNSHKKTR
                     PRLKNVDRSSAQHLEVTVGDLTVIITDFKEKTKSPPASSAASADQHSQSGSSSDNTER
                     GMSRSSSPRGEASSLNGESH"
     exon            95..220
                     /gene="YAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            221..373
                     /gene="YAF2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..4096
                     /gene="YAF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1135..1140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YAF2"
                     /note="hexamer: AATAAA"
     polyA_site      1158
                     /gene="YAF2"
                     /note="major polyA site"
     regulatory      2145..2150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YAF2"
                     /note="hexamer: ATTAAA"
     polyA_site      2166
                     /gene="YAF2"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YAF2"
                     /note="hexamer: AATAAA"
     polyA_site      4096
                     /gene="YAF2"
                     /note="major polyA site"
ORIGIN      
        1 attatcctcc ttattgacaa acagagcggt cgcggcggcg actctcggcg tgcggtgata
       61 gccaagccat gggagacaag aagagcccca ccaggccgaa gcggcagccg aagccgtcct
      121 cggatgaggg ttactgggac tgtagcgtct gcaccttccg gaacagcgcc gaggccttca
      181 agtgcatgat gtgcgatgtg cggaagggca cctccacccg gaaacctcga cctgtctccc
      241 agttggttgc acagcaggtt actcagcagt ttgtgcctcc tacacagtca aagaaagaga
      301 aaaaagataa agtagaaaaa gaaaaaagtg aaaaggaaac aactagcaaa aagaatagcc
      361 ataagaaaac caggccaaga ttgaaaaatg tggatcggag tagtgctcag catttggaag
      421 ttactgttgg agatctgaca gtcattatta cagactttaa ggagaaaaca aagtcaccgc
      481 ctgcatctag tgctgcttct gcagatcaac acagtcaaag cggctctagc tctgataaca
      541 cagagagagg aatgtccagg tcatcttcac ccagaggaga agcctcatca ttgaatggag
      601 aatctcatta aagtttattt tctccaattt cttagtcact tctgtcctac catgcaaata
      661 cacagattat gccaagaggt accacatttt catgacagat acattcatgc acaatccata
      721 atttgagttt tacataaaat agaaatttgt tagaatttgt tagattttat tgcaatgatg
      781 cctaccaaac atttccagac ttaacatttt ggtctctgca gttaagtgcc atgaaaatgt
      841 ggttgaatta ttcattatgc agtgttattg gtaagtgtat tttcactttt agtttagtga
      901 attctaacac ataattcttg aattctctac tattggcatg taacgaattt aaatttttta
      961 taacatagtg caagctgcct aaatatgtat tatttgagaa ttgtgaaaca gatagttata
     1021 tgtatacaag tcaaagaaca acttaactat tgctgcaaca ggtttttctt aatggttatc
     1081 ctcttaaata cacctgctgg tacttggtgt ggttaaatag gaaaattgtt attaaataaa
     1141 gaatttgtat gaacctttgc caatgttttt gacacgtttt actaattatt gttcctgaat
     1201 tatgtttctg gttttatcta ttttttgagg tttttttgtt tgcttatttt tcaaaacatt
     1261 catttattgt aatgtttact agcggactag taaacaataa aacattgatt atttagcttt
     1321 ataattcagg tttagtgcta ttgtcattga acactggtat tttctgtatc atataaaaca
     1381 ttaaaattca aataattata agcatttggc aaaaacaaga gaaaagaaac ttgccatatt
     1441 ttacaagctg caattttaga aaagctttaa cttaatgata gttttatcat tgttttcttg
     1501 tcccaaactt atccagggcc atagaagtat gaatctaatt aaaacagaaa tgggaattat
     1561 tgcacagaaa tgggaaataa ctaattttaa atcagtcaaa ttggcttctt attaaataca
     1621 ataattctta tgaaaatcat agtaccctat tttcagacac agctgccagt ttacacattt
     1681 ctcagtatcc tgaaaggaaa aaagtatagc cccacttata ctatgtaaaa ttaccaataa
     1741 aatattttta tgactacaga ttttgcattt ttgtttacaa ctatttaaag agttttatgt
     1801 tgtatttaga atttcaacct agaaaccaca cagtacttaa attctcctgg ggtctcctgc
     1861 tttctcttaa ccatttgctt aatatatatc tacctaaagg agacttctga attgtaaatg
     1921 aacttaaaaa tagaatgtgg atgcaaaata tcacataaga catcatgata acatttgaag
     1981 aaaaaataaa actgtagacc ctaacagttg tgatatttgg tggtttcatg tggtaatgta
     2041 attttctgtt taattacagt actttttaca ggcacagtgg tactgtcttt tttgtaagat
     2101 gctagttgtg aaatacaatt aattgcatac agtaaaagtc tgtgattaaa acatttatat
     2161 acctcattct ttagtgttgt taaatgaaaa attaaaattt gtgtttatta taagatactt
     2221 tcaatggaat accagctaac cagatatgtt cctttaaaac atgaattttt ttgtcttatt
     2281 ctgtttttaa catgtttcaa atgttttata catttttgga gatagtaaaa atttaaaaat
     2341 gtaataggga aaatatttaa tttttaagtc aaaaactatg ctttaaagga attacatctt
     2401 atgatcaaat aactttcagg atgtatttta aatgagctgc aagagagaaa aatctgacag
     2461 gagatgggat tttacctgaa tggagcatac tcatatttct acataggtgg gaagatactc
     2521 atctttctac atagacggga acacggtgta gcatggagat taagcgtgct aactgacacc
     2581 tcatgtttga atcctgttgt agaatggaaa tgagcttaaa ttacccaagc ttactttcca
     2641 tctataaaac agggctaata atggtaatca catctaattt atagggtttt tgggaggatt
     2701 aagtcaatcc gtgtaaaatt cttaattatc tgacacatac tggtcactca gtaaatgtga
     2761 gcttttacca ttgttatagg taaaatccca ttacaaaaat acaaaaatat tttttgtaac
     2821 agttattttc ctgccctctt ggatgaccta aagtaatagt gttttataga tttcactaaa
     2881 ttttcagtgt aatatcagat gttttctctg gatgcagaaa gaccatcttt ccataattaa
     2941 agaacctggt gggtgtgcac tatgagattg gagaaatgaa ttaagttgac ttgaaattat
     3001 tttactttta ttaatcacag gtatctcaac ctgcctttgt ttcaccctac ttcaagtaca
     3061 cttccacacc aggaaaacag acccaaattc cataaacaga actgacgtta aaatatgcga
     3121 aagattcaga acctaggttt agggtacatg tttttctctg tttcatgaac ttacagtgtg
     3181 gtttgagcac tgggttcttt tagccaaatt ccatacaaaa agaatttgga tgttttccag
     3241 catttattac cttactttgc tataagtaag agtgaagata ggccgggtgt gatggctcat
     3301 gccagtaatc ccagcacttt gggctgaagc aggcagatat tttgagccca ggaccagcct
     3361 gggcaacatg gtgaaagctc atctctatga aaaaatttga atatacatat atatatatat
     3421 gtatatttaa aaagtgaata taatttgagg cacagaagaa tattcttaaa accttttgta
     3481 ttatacaata gaaataaagg ttttattttt attaaatgct ttcctaaaat gatagtggat
     3541 aatagacaaa gtgaaaacat ttaaaaagga agagaaactt cagcctttct aagttgatag
     3601 catgtttatt aacttttaga taaagatcct tatagactga aagaatgtag cctctgcatt
     3661 aatggtaaat ggtctagaag ttttcgtttc cactgaggct tccgccactc gcttttttaa
     3721 acttcctgct atggtttgga tatggtttgt cctcaccaaa actcatgctg aggcctgagt
     3781 ccccagtttg attgtgttgg taggtggtgc ctttaagagg tgattaggtc attgagatgg
     3841 attaaaggct ttctcatgag gctcagttag ttctggaatg gattcgctct tgcaggaatg
     3901 gatgaattct cacaagagtg ggttgttatg aagtgaggat gcttcttgtg ttctgttctc
     3961 tttgccctcc tcagttcacc atctgctttc caccatgagt tgaagcagca tgaggccctc
     4021 atcagatggg ctccctgatc ttggactcct cagcctttgg actcataagc caaaataaat
     4081 ctgttttctt tataaa
//
