LOCUS       NM_020192                871 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens YAE1 maturation factor of ABCE1 (YAE1), transcript
            variant 1, mRNA.
ACCESSION   NM_020192
VERSION     NM_020192.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 871)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 871)
  AUTHORS   Paul,V.D., Muhlenhoff,U., Stumpfig,M., Seebacher,J., Kugler,K.G.,
            Renicke,C., Taxis,C., Gavin,A.C., Pierik,A.J. and Lill,R.
  TITLE     The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the
            ABC protein Rli1 for iron-sulfur cluster insertion
  JOURNAL   Elife 4, e08231 (2015)
   PUBMED   26182403
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 871)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   4  (bases 1 to 871)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM767075.1 and AF226046.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020192.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.178280.1,
                                           SRR1803611.13696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223273.7/ ENSP00000223273.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BM767075.1         29-34
            7-871               AF226046.1         1-865
FEATURES             Location/Qualifiers
     source          1..871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..871
                     /gene="YAE1"
                     /gene_synonym="C7orf36; CIAB2; GK003; YAE1D1"
                     /note="YAE1 maturation factor of ABCE1"
                     /db_xref="GeneID:57002"
                     /db_xref="HGNC:HGNC:24857"
     exon            1..144
                     /gene="YAE1"
                     /gene_synonym="C7orf36; CIAB2; GK003; YAE1D1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..696
                     /gene="YAE1"
                     /gene_synonym="C7orf36; CIAB2; GK003; YAE1D1"
                     /note="isoform 1 is encoded by transcript variant 1; yae1
                     domain-containing protein 1; Yae1 domain containing 1;
                     protein YAE1 homolog; YAE1, ABCE1 maturation factor"
                     /codon_start=1
                     /product="protein YAE1 homolog isoform 1"
                     /protein_id="NP_064577.1"
                     /db_xref="CCDS:CCDS5459.1"
                     /db_xref="GeneID:57002"
                     /db_xref="HGNC:HGNC:24857"
                     /translation="MSWVQAASLIQGPGDKGDVFDEEADESLLAQREWQSNMQRRVKE
                     GYRDGIDAGKAVTLQQGFNQGYKKGAEVILNYGRLRGTLSALLSWCHLHNNNSTLINK
                     INNLLDAVGQCEEYVLKHLKSITPPSHVVDLLDSIEDMDLCHVVPAEKKIDEAKDERL
                     CENNAEFNKNCSKSHSGIDCSYVECCRTQEHAHSENPSPTWILEQTASLVKQLGLSVD
                     VLQHLKQL"
     exon            145..266
                     /gene="YAE1"
                     /gene_synonym="C7orf36; CIAB2; GK003; YAE1D1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..871
                     /gene="YAE1"
                     /gene_synonym="C7orf36; CIAB2; GK003; YAE1D1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      850..855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="YAE1"
                     /gene_synonym="C7orf36; CIAB2; GK003; YAE1D1"
                     /note="hexamer: ATTAAA"
     polyA_site      871
                     /gene="YAE1"
                     /gene_synonym="C7orf36; CIAB2; GK003; YAE1D1"
                     /note="major polyA site"
ORIGIN      
        1 gtaattgcct cggtgatgtc gtgggttcaa gcagcctcct tgatccaggg ccctggagac
       61 aaaggggacg tgtttgacga agaagcagac gagtcgctcc tggcgcagcg ggaatggcag
      121 agtaacatgc aaagacgagt caaagaaggt tatagagatg gaatagatgc tggcaaagca
      181 gttactcttc aacagggctt caatcaaggt tataagaaag gtgcagaagt cattttaaac
      241 tatggacgac tccgaggaac attgagtgct ttgctctcct ggtgtcacct tcataataat
      301 aattcaactt tgatcaataa aataaacaat cttctggatg cagttggcca gtgtgaagag
      361 tatgtgctca aacatctgaa atcaatcact ccaccgtccc atgttgtaga tttattggac
      421 tccattgagg atatggacct ttgtcatgta gttccagctg agaaaaagat tgatgaagct
      481 aaagatgaaa gactctgtga aaataatgct gagtttaaca aaaactgtag caagagccat
      541 agtgggatag attgttcata tgtagaatgt tgtagaacac aggagcatgc acattcagaa
      601 aacccaagcc ccacatggat tttggaacag acagccagtt tagttaaaca gctgggccta
      661 tcagtagatg tattacaaca cctcaaacaa ctataaaatt accttccctt ttctaatgaa
      721 aataatgttc agaacatttg gtttcctaac aatcgaaatt tgtactggtt tctgcatcaa
      781 acacctcaac tgtagggtta ccctttatgg aagtttgaaa ttaacactat tgtcttcaaa
      841 attaacacta ttaaatgtaa tataagcctt t
//
