LOCUS       NM_022166               9970 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens xylosyltransferase 1 (XYLT1), mRNA.
ACCESSION   NM_022166 XM_936476
VERSION     NM_022166.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9970)
  AUTHORS   Bao,L., Chu,Y. and Kang,H.
  TITLE     SNAI1-activated long non-coding RNA LINC01711 promotes hepatic
            fibrosis cell proliferation and migration by regulating XYLT1
  JOURNAL   Genomics 115 (3), 110597 (2023)
   PUBMED   36871637
  REMARK    GeneRIF: SNAI1-activated long non-coding RNA LINC01711 promotes
            hepatic fibrosis cell proliferation and migration by regulating
            XYLT1.
REFERENCE   2  (bases 1 to 9970)
  AUTHORS   Fischer,B., Kuhn,J., Ly,T.D., Schmidt,V., Kleine,A., Hendig,D.,
            Knabbe,C. and Faust,I.
  TITLE     Development of a xylosyltransferase-I-selective UPLC MS/MS activity
            assay using a specific acceptor peptide
  JOURNAL   Biochimie 184, 88-94 (2021)
   PUBMED   33609631
  REMARK    GeneRIF: Development of a xylosyltransferase-I-selective UPLC MS/MS
            activity assay using a specific acceptor peptide.
REFERENCE   3  (bases 1 to 9970)
  AUTHORS   Ly,T.D., Kleine,A., Plumers,R., Fischer,B., Schmidt,V., Hendig,D.,
            Distler,J.H.W., Kuhn,J., Knabbe,C. and Faust,I.
  TITLE     Cytokine-mediated induction of human xylosyltransferase-I in
            systemic sclerosis skin fibroblasts
  JOURNAL   Biochem Biophys Res Commun 549, 34-39 (2021)
   PUBMED   33662666
  REMARK    GeneRIF: Cytokine-mediated induction of human xylosyltransferase-I
            in systemic sclerosis skin fibroblasts.
REFERENCE   4  (bases 1 to 9970)
  AUTHORS   Zhou,Y., Little,P.J., Cao,Y., Ta,H.T. and Kamato,D.
  TITLE     Lysophosphatidic acid receptor 5 transactivation of TGFBR1
            stimulates the mRNA expression of proteoglycan synthesizing genes
            XYLT1 and CHST3
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1867 (12), 118848 (2020)
   PUBMED   32920014
  REMARK    GeneRIF: Lysophosphatidic acid receptor 5 transactivation of TGFBR1
            stimulates the mRNA expression of proteoglycan synthesizing genes
            XYLT1 and CHST3.
REFERENCE   5  (bases 1 to 9970)
  AUTHORS   Schon,S., Schulz,V., Prante,C., Hendig,D., Szliska,C., Kuhn,J.,
            Kleesiek,K. and Gotting,C.
  TITLE     Polymorphisms in the xylosyltransferase genes cause higher serum
            XT-I activity in patients with pseudoxanthoma elasticum (PXE) and
            are involved in a severe disease course
  JOURNAL   J Med Genet 43 (9), 745-749 (2006)
   PUBMED   16571645
  REMARK    GeneRIF: Variations in the XYLT-II gene are genetic co-factors in
            the severity of PXE.
REFERENCE   6  (bases 1 to 9970)
  AUTHORS   Gotting,C., Muller,S., Schottler,M., Schon,S., Prante,C.,
            Brinkmann,T., Kuhn,J. and Kleesiek,K.
  TITLE     Analysis of the DXD motifs in human xylosyltransferase I required
            for enzyme activity
  JOURNAL   J Biol Chem 279 (41), 42566-42573 (2004)
   PUBMED   15294915
  REMARK    GeneRIF: DXD motifs in human xylosyltransferase I are required for
            enzyme activity
REFERENCE   7  (bases 1 to 9970)
  AUTHORS   Gotting,C., Kuhn,J., Brinkmann,T. and Kleesiek,K.
  TITLE     Xylosyltransferase activity in seminal plasma of infertile men
  JOURNAL   Clin Chim Acta 317 (1-2), 199-202 (2002)
   PUBMED   11814476
REFERENCE   8  (bases 1 to 9970)
  AUTHORS   Kuhn,J., Gotting,C., Schnolzer,M., Kempf,T., Brinkmann,T. and
            Kleesiek,K.
  TITLE     First isolation of human UDP-D-xylose: proteoglycan core protein
            beta-D-xylosyltransferase secreted from cultured JAR
            choriocarcinoma cells
  JOURNAL   J Biol Chem 276 (7), 4940-4947 (2001)
   PUBMED   11087729
REFERENCE   9  (bases 1 to 9970)
  AUTHORS   Gotting,C., Kuhn,J., Zahn,R., Brinkmann,T. and Kleesiek,K.
  TITLE     Molecular cloning and expression of human UDP-d-Xylose:proteoglycan
            core protein beta-d-xylosyltransferase and its first isoform XT-II
  JOURNAL   J Mol Biol 304 (4), 517-528 (2000)
   PUBMED   11099377
REFERENCE   10 (bases 1 to 9970)
  AUTHORS   Gotting,C., Sollberg,S., Kuhn,J., Weilke,C., Huerkamp,C.,
            Brinkmann,T., Krieg,T. and Kleesiek,K.
  TITLE     Serum xylosyltransferase: a new biochemical marker of the sclerotic
            process in systemic sclerosis
  JOURNAL   J Invest Dermatol 112 (6), 919-924 (1999)
   PUBMED   10383739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009152.8, AI524006.1,
            AJ539163.1, AC099494.3 and AC109446.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_022166.3.
            
            Summary: This locus encodes a xylosyltransferase enzyme. The
            encoded protein catalyzes transfer of UDP-xylose to serine residues
            of an acceptor protein substrate. This transfer reaction is
            necessary for biosynthesis of glycosaminoglycan chains. Mutations
            in this gene have been associated with increased severity of
            pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ539163.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261381.7/ ENSP00000261381.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC009152.8         163093-163171       c
            80-205              AI524006.1         1-126
            206-652             AJ539163.1         127-573
            653-1077            AC099494.3         56946-57370
            1078-2152           AJ539163.1         999-2073
            2153-2191           AC109446.2         39133-39171
            2192-3013           AJ539163.1         2113-2934
            3014-9415           AC109446.2         64919-71320
            9416-9970           AC109446.2         71321-71875
FEATURES             Location/Qualifiers
     source          1..9970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..9970
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /note="xylosyltransferase 1"
                     /db_xref="GeneID:64131"
                     /db_xref="HGNC:HGNC:15516"
                     /db_xref="MIM:608124"
     exon            1..527
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..3044
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /EC_number="2.4.2.26"
                     /note="beta-D-xylosyltransferase 1; xylosyltransferase
                     iota; peptide O-xylosyltransferase 1; xylosyltransferase
                     I"
                     /codon_start=1
                     /product="xylosyltransferase 1"
                     /protein_id="NP_071449.1"
                     /db_xref="CCDS:CCDS10569.1"
                     /db_xref="GeneID:64131"
                     /db_xref="HGNC:HGNC:15516"
                     /db_xref="MIM:608124"
                     /translation="MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGE
                     RRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGGRGPQARARGGGP
                     GEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDF
                     ENVDNSNFAPRTQKQKHQPELAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLP
                     PGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSRAKSKHC
                     RQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVV
                     HGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIW
                     GGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKS
                     HGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTF
                     STDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYK
                     HIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGT
                     PGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGH
                     PASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPPSDFGRLQFS
                     EVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDIL
                     IESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEAL
                     KLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMW
                     TAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR"
     exon            528..566
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            567..1077
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1250
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1453
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1534
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1751
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1928
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2191
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2387
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2721
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..9970
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9390..9395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /note="hexamer: ATTAAA"
     polyA_site      9415
                     /gene="XYLT1"
                     /gene_synonym="DBQD2; PXYLT1; XT-I; XT1; XTI; xylT-I;
                     XYLTI"
                     /note="major polyA site"
ORIGIN      
        1 accctcccct ccagcgggga caggggtgtg gggagggggg cggcggcggc ggcccgagcg
       61 ggagcccgag cggcagccgg cggccgcggg agctgcgggg agcgcggggg cggcccggag
      121 cgtgccgggg tccccgcgcc tcgctcgccg gccgcgctcc gaagatggtg gcggcgccgt
      181 gcgcccggag gctggcccgg cgctcgcact cggcgctgct cgcggcgctc acggtgctgc
      241 tgctgcagac gctggtcgtg tggaatttca gcagcctcga ctccggggcc ggggagcgcc
      301 gcgggggcgc agcggtcggc ggcggggagc agccgccccc ggccccggcc ccgcgccggg
      361 agcgccggga cctgcccgcc gagccggctg cagcccgagg aggaggagga ggcggcggcg
      421 gaggaggagg aggacggggg ccccaggcgc gggcgcgggg aggcggcccc ggagaaccgc
      481 ggggacagca gccggccagc cggggggcac tgcccgcccg ggctctggat ccacacccaa
      541 gtccgctcat caccctggag actcaggatg gctacttttc tcatcggccg aaagagaaag
      601 tgcgaacaga cagcaacaac gagaactctg tccccaaaga ctttgagaat gtcgacaaca
      661 gcaacttcgc acccaggact caaaagcaga agcaccagcc tgagttggcg aagaagccac
      721 cgagtagaca gaaggagctt ttgaaaagga agctggaaca gcaggagaaa ggaaaaggac
      781 atacattccc tgggaaaggc cccggtgagg tgctgcctcc cggggacaga gccgcagcca
      841 acagcagcca cgggaaggat gtgtccagac cgcctcatgc caggaaaact gggggcagct
      901 cccccgagac caagtatgac cagcccccta agtgtgacat ctcaggcaag gaggccatct
      961 ctgccctgtc ccgtgctaag tccaagcact gccgccagga gattggggag acttactgcc
     1021 gccacaagtt agggctgctg atgcctgaga aggtgactcg gttctgcccc ctcgagggta
     1081 aagccaacaa gaacgtgcag tgggacgagg actccgtgga gtacatgcca gccaacccgg
     1141 tcagaatcgc ctttgtcctg gtggtccacg gccgtgcctc tcggcagttg cagcgcatgt
     1201 tcaaggccat ctaccacaaa gaccacttct actacatcca cgtggacaag cgctctaatt
     1261 acctgcatcg gcaagtgctc caggtctcca ggcagtacag caatgtccgc gtcaccccct
     1321 ggagaatggc caccatctgg ggaggagcca gcctcctgtc cacctacctg cagagcatgc
     1381 gggacctcct ggagatgacc gactggccct gggacttctt catcaacctg agtgcggccg
     1441 actaccccat caggacaaat gaccagttgg tggcgtttct ctcccgatac cgagatatga
     1501 atttcttgaa gtcacacggc cgggacaatg caaggttcat tcggaagcag ggcctggatc
     1561 ggctcttcct ggagtgcgac gctcacatgt ggcgcctggg agatcggcgg atcccagagg
     1621 gcattgccgt ggatggcggt tcggactggt tcctgctgaa ccggaggttt gtagaatatg
     1681 tgaccttctc cacagacgat ctggtgacca agatgaaaca gttctactcc tacaccctgc
     1741 ttcctgctga gtccttcttc catacggtcc tggagaacag cccccactgc gacaccatgg
     1801 tggacaacaa cctgcgcatc accaactgga atcgcaagct gggctgcaag tgccagtaca
     1861 agcacatcgt ggactggtgc ggctgctccc ccaatgactt caagccgcag gacttccacc
     1921 gcttccagca gacagcccgg cctaccttct ttgcccgcaa gtttgaagcc gtggtgaatc
     1981 aggaaatcat tgggcagctg gactattacc tgtacgggaa ctaccctgca ggtaccccgg
     2041 gcctgcgctc ctactgggag aatgtctacg atgagcctga cggcatccac agcctgagcg
     2101 acgtgacact caccttgtac cactcctttg cccgcctggg tcttcgacgg gccgagacgt
     2161 ccctgcacac ggatggggag aacagctgcc gatactaccc aatgggccac ccagcatctg
     2221 tgcacctcta cttccttgct gaccgcttcc agggctttct gatcaagcat catgctacca
     2281 atctggctgt gagcaaacta gagactctgg agacctgggt gatgccgaaa aaagtcttca
     2341 agatcgcaag cccacccagt gactttggga ggcttcagtt ttccgaggtc ggcactgact
     2401 gggatgccaa ggagaggcta ttccgcaact ttgggggtct tctggggccc atggatgagc
     2461 cggtgggtat gcagaagtgg gggaagggac ctaatgtgac cgtgaccgtc atttgggtgg
     2521 atcccgtcaa tgtcatcgca gccacctacg acatcctcat tgagtccact gccgaattca
     2581 cacactacaa gccccctttg aacttgcccc tgaggcctgg ggtctggaca gtgaaaattc
     2641 tccaccactg ggtgccagtt gcagagacca aattcctcgt tgcgcctctg accttctcga
     2701 acaggcagcc catcaaacct gaggaggcac tgaagctgca caatgggccc ctccgcaatg
     2761 cctacatgga gcagagcttc cagagcctaa accccgtcct cagcctgccc atcaaccccg
     2821 cccaggtgga acaggcacgg aggaacgcag cctccacggg cacagcgctg gagggatggc
     2881 tggactcgtt ggtgggcggg atgtggactg ccatggacat ctgtgccacg ggccccacag
     2941 cctgcccggt catgcagacc tgcagccaga cggcctggag ctccttcagc cctgacccca
     3001 agtcggagct gggggcagtc aaacctgatg gccggctcag gtagcactgg gcacgaggag
     3061 tgggccacag caggatctca acgggaaagc agccagaggg gttgtggggc ctgaaccccg
     3121 gcctcccacc ctgggggagg ccctctgtga atgggtctct cctggccata gaatgatgga
     3181 aagggaaggt cagcaggtca aagcaggatc agccaacaac ctgcctttgg caagctgcgg
     3241 gtgggatggc tcagtccctg cactgtgact gtctcacctc ttctggttga tcctcaagtc
     3301 ctacaggttc cttgtcttcc ccttccagtg acccacccct gaccccagac gtgtgatttt
     3361 cagacttttc tttcgagcag cagaacttcg tttacggagc acagtcataa gtggaggttc
     3421 agggtgctga cgaaatccaa gctgctctgg ttgaagctga caagtgcgag gttccctccc
     3481 aaagctcagc cctctgggcg gtccccttgc ccagggtatc tcctacggta cctcttcaga
     3541 acccaagggc tctgcaaatg ccagtttgac aagcactgcc cagaccaacc atgggttcaa
     3601 actccagccc tgccctttgg ttcatttttc tgcttctctt ggctggggga ctctggtgcc
     3661 agccttgaaa gtcatggtcg tgggcccttt cccatggagg ctgcagcctt aggagagctc
     3721 tgagcctctc agcagccctc cttgggttga actattctcc ttagtaacta ggtaagtggg
     3781 aaagcctttt gatgtggcat ggccaaggtc cagccacaag tgcaactgcc acctgtccag
     3841 gggtctgggc ctccttccct caaggctgcc acacaaagta gcagaaatag gatgatgttt
     3901 gtgagcacca gactcaagac catgaccttc tttgatcctt gaaaatggga actttgacag
     3961 ccatgaccat gaaactcaca aggcaacgcg atgaaactca caaagcaatg cttggagcaa
     4021 aactcctgag ctagacagca cagcagcacc catcccctgc cagagccctt ccgttctgag
     4081 gtcagacaca caaaaccttc gtcaattgca caccggtgct gttgggagtg accaaaccac
     4141 atgaaccaga cttttcccgt ccaggaaata gcatttcaga tttggttttt aatttcatgc
     4201 ccttcggcca caggctcaac gggacatgca acataaaaat gggaaggtta tttaaacaac
     4261 aaaaaacagt atgatttaag tgttgagtta ccagaaaccc aaaaggtttc cttgccacga
     4321 gccccctgga gtgtcatccc tgttcaccag gagagctctt cgcaggaggc ctcccttgct
     4381 cctgtaatcc cacctcccct gaatgatggg attcccttgg aaaaaggtct cacccctggt
     4441 agccatctgc ccttcccatg gagagccagt cctgacactt ctctccagcg tgggtttgaa
     4501 ggggctgccc ttcgctttgt gtgacttgtc ctaatcctag ccagatgtgt tgccccatcc
     4561 caagcctcgc aaggcagggt gtcctgttgg caatggagga cgtagagaag ggacacttta
     4621 gatatttatt atttacatgt tttagtcgat gactaattag taggtgctgt ttttgcagct
     4681 tgtcaattat gttaccttac taactgaagc tgcctttatt cacaaaaggc cccttttccc
     4741 atcttttccc accccctggt gtctctctct ctctcggttt ctctttctct gcgtctaccc
     4801 cccatcctcc tcatcctcag agtaaagcag gggcatcgaa caccacgcaa agaaagctcc
     4861 aacccgcatc ttccactggc tttgagtggg gtgccttggg gaccgttgga gccttgtttt
     4921 tttccttatg cagagtgtca gcctcactct ccctcggatt ccaagagtat tggaattcct
     4981 gagcctccca tcctccccct actcaccccc cgtcacaggc acaaggaggt gacaggcaga
     5041 aaacgtggag ggtgagtggg gaatgtgcta gctgcagaga gtttgtgggg aatgtgctag
     5101 ctgcagagag tttgggccat tcctgcttgc tccgtggttg ccttcccatg gcccatctaa
     5161 ttatgggcat tcatgcgacc ttaacagagg gaaacaggct cctttgagag agatccatct
     5221 taggaggagg gtcgtcagat ccaggcagca gagtccggga gatagccatt ctcaacagcg
     5281 attccaggga tctcagggta cttttctcag aaagccccta tgatctcttt tacagactct
     5341 atggtggcca cgcgctgggt gccacatcct ctttctgccc ccggcctctg cctctggcca
     5401 gggtttccct ggggctgccg aagccacttt gggagcttcc ctttcaccct ccttgctggg
     5461 ccaccagtgc tttgtgttcg cagcgttatt tgcagtggct ttggggactc agcagtggca
     5521 agtccctgtg cataatgtga acctgcagac ttcaagatgg ggcccctcct gcacccacta
     5581 acatgtctgc ctttttttgt ttttatcctg gaacaagtgg agaaatggca gagctggctg
     5641 actctgggga cccttccctt tttcccatgg cttcatttct tcctcaccac aactaattcg
     5701 gggagctgag aagtcacaca gggtattcct ctcccttctc tgatgttatt aattaataga
     5761 ccagagaata aggttgcaga tattacattt gttgtgtttt tgtgttttgt tttttttttt
     5821 aaggaaaatc ccaaacaaag cccagcatga tttgagaaaa gaggatgttt tcccagggaa
     5881 aataattttt ttaacctgcc tgagaatgat ttatttattt gttggaggcc attggtcaga
     5941 cagcctggag cttgggctgt ggaagatttc aaaagcatag ggctgtggtc tctggaaacc
     6001 tattacagcc tgcagctgtg agctgagcca gtgacgaggt ccctggaaac tcaggaaggc
     6061 tgacaggtgg gccttggggt attggtttgt ggagaaggaa gcattcttta ggctgcggca
     6121 ctccttatag tttcccaccc accgagtgac attcaggcag aaattgagct caggagacag
     6181 ccagccttcc cacatcccac ttcacttccc ggtccacacg taaagcagtg tgtctccaag
     6241 gaggcagtga gcaattccca aggtccccgt gttgtgagaa gcgcgctgct ttctcccttt
     6301 gcaggggaaa aaaaaggctt tcctggtgag atcatgagtc cttccggctt catttctcat
     6361 tgtgggttta acttctaaaa cgcaaatgga gtttagagag gatgagcaga accacaggac
     6421 ctgcccccat ctctcactca ctgcaattgc ttctactctg ggcacaagta gggtgtctga
     6481 agaccatgtt tccctctggt tctctagttt gcagataaca cagaagacac tggctagaac
     6541 cttaagcttt ctgccaaaaa gatgcagaga gcagggcagt agctactggc agtggggtgt
     6601 gaataaagag tcctttcaca accaagttca ctgaggattt ggagcaccag cttcccagca
     6661 gtatcgaggg gtggagaggt gtacattcag gtggaggggt acatctaggg gtggagaggt
     6721 gtacattcta gaaacagctg ttaacacact ccactttaaa gacagcaagc tagacctgca
     6781 ggatcaaagc cacacactgt ggtaggggtt acaaatgttt atggggccca gaatactagc
     6841 atagatgcgt gaaatggttg gtgtgaggca aaagggcatg gtgggggcaa ggatggggac
     6901 tgtggtctta ctggcatgca cgtgacctac ccagaatgag cagctgctac tcagccccaa
     6961 cctgtcattg tttgtaaaaa tgtaagcaca gtgtagtgga atcttccaat ttggaaggga
     7021 agccggaaat ccagatttaa tggaaaaaat ctgatttttc aacgtcgggt tgtttgtttg
     7081 tttgtttttg ttttttttaa cagatagtgg gcaaagaaaa attccactgt tccacgtgta
     7141 cactgccagc aacctctgct ctctggagag gtggtttaaa gtgagattat gcattgccct
     7201 ggtagaagag gaaaaaagcc agcatcaggt cagggcaaaa ataacagccc atgttgaact
     7261 cggaatgggg acctcttgct aagtcattcc actcctcaag agaccattcc acagaggggg
     7321 gatggatcat tcagctctcc tggtcccaag attgtgctga agggaagaag gaatagaatc
     7381 tggagatctg gactgctgcc ccttagatat gcagaggtcc acatctgcct ggggctacag
     7441 cttgtgggac tccatcaaac caggccgaaa tggcaaagac agtctaggag gaggaggagg
     7501 tagggtgtga aacagccagg ctctctccaa atcccaagtg ttgacacagc catcttgtcc
     7561 catccctgga agcctctttg gaaaccacat agagctgtgc tggctcacgg gatgtcctgt
     7621 ttgcttctgc ctcagttacc ttactttgcc catgggtcta ccacaggcgc tacctcattg
     7681 tgtctgctga gaagtttacc tgggaggggg gaacaaagtt gtccaaatct gcttgagctg
     7741 aatgtatgat ctatgcaaat tctctctctc ctctctctct tcctctctgg ctctcttaga
     7801 agtttttttg ttttgttttg ttttgttttg tgtttacctt gcaaacaaga tactgtatag
     7861 gaccctctta agatggagga gggctttctt gcgccacctg tgtctacccc tcacgttgtc
     7921 tttggctctg gtcttaccag gcgtatgcag ggagaaagtg acctctcttc cctctccact
     7981 tggctgggaa tattccaact gcctctgcct acagatacca ccagaaagcg ggttctgcac
     8041 cttgtcatcc ccctccctaa cgtcatctac tccatccctc atgttcctcc aacttgcttc
     8101 tcccatccct ccttcaaaaa caaaacaaaa caaaacaaaa gccttaggtt tctccttttt
     8161 gaaatgtggc cttaacatta tttttgggaa gctgaccatc catcctttcc ctcccatctc
     8221 caccaacatc agagaagaca gcatcgtgaa gcttctgtgg cagcctccta aggaaggggc
     8281 tgccaatctg tagttggcag atgctatagg aattgcttac aaatgtcgtc tttaagaaaa
     8341 atgttcttat atttttccta tgggcaaaat gaaggcttgg gtgctcatct aaagctcagc
     8401 caactcctga agcactctct cagagcatac tgctgctgta atgggctggc ttaattatcg
     8461 gcagagtgct tgaaaaggct ttgcagacct cccctgcccc caagactggg tgactttata
     8521 tgtacttcat tcaagggtaa atcaggagac gttctccatt tatctcttcg tccttcctgc
     8581 ctggaaagtg atagcactaa atattcccag cagatgggta gtgttctcaa aggaatcacc
     8641 ctttccctac cttcagactc tattctttac ccttccattg ctccagtgct gatggaggcc
     8701 aaagacaacc ccagggtttt cataggaaat tcactggaat tgtgcgcaat tgtctttgta
     8761 gtccttttgc cttttttttt tttaaatatt atgttgtcaa tagcatttgt ttgggtattt
     8821 gttttagagg cctcactcta agttattacc gtccccttca ttgttttcaa agacatgtgg
     8881 tgatatagtt tttaaaaata actattttgt tatagatcat aatatgcata aaactgtaca
     8941 gaaatatttt gtaatgtgtt gattttaaaa aaaatctgta aataaagttt taaaaaaaga
     9001 attcaaatgg cacacgctga aatatgtaga tattttgcta tttatttaaa ggagtatttt
     9061 aagagatatt gaactatctg aaattgacca gtaatcaaag ttccaatcat ctgaatgctt
     9121 ttccttgagg tagaatgtga gtctcagaaa tgactgcatt acctgccctt ttttgcacct
     9181 tttctgtctt tttattttgc agaacaacaa caacaacaaa attgtgcctt agctgtattt
     9241 ttttgtctag gggagtttgt ttctgtctga caaagcaaca ttttttgcag aaaacagtgg
     9301 atgtattaaa tactgtatca taccaaaaac actgcaggtg tatatagatg ctttctgtca
     9361 tactgtgttt tcagatgcag aattttaaaa ttaaaaaaac actgccttta tggaacagtg
     9421 actatatgtg gcttcttttc agcaacattg tgcatcttta cacaatctca tattctcttc
     9481 tgtcatctgc atggtgaaga taggatgact atataattta tcatccaaac tgggatactt
     9541 ttgagagtta aaggaagcac cacgtggatg ggatgctgag actgcaggca taaatggcct
     9601 atcctgggaa aacctgggtg tgtggacaca tttccctcat aaaaactgct gtcatcttct
     9661 aactggatta tagcaacaac ctcctataag tacctcctgg ttgaggcaga agtatatgat
     9721 ttttaaaccc gtactgagta gagaataaca agaagggact gccatggaaa gttgcagttt
     9781 cctataccca actggttggt tggttggcaa acgtgttttc ctttcctctt taccacagag
     9841 actacatttc ccagactgcc ttgctcttag ctgtgaccat gtgaccaggc caatggaaca
     9901 gctagactgc atcttccaga ctgccttgct cttagccatg gccatgtgac tgactcaggc
     9961 caatggaatg
//
