LOCUS       NM_152531               2714 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens xyloside xylosyltransferase 1 (XXYLT1), transcript
            variant 1, mRNA.
ACCESSION   NM_152531
VERSION     NM_152531.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2714)
  AUTHORS   Zeng,H., Wang,Y., Wang,Y. and Zhang,Y.
  TITLE     XXYLT1 methylation contributes to the occurrence of lung
            adenocarcinoma: Methylation and lung adenocarcinoma
  JOURNAL   Medicine (Baltimore) 100 (1), e24150 (2021)
   PUBMED   33429795
  REMARK    GeneRIF: XXYLT1 methylation contributes to the occurrence of lung
            adenocarcinoma: Methylation and lung adenocarcinoma.
REFERENCE   2  (bases 1 to 2714)
  AUTHORS   Pandey,A., Li-Kroeger,D., Sethi,M.K., Lee,T.V., Buettner,F.F.,
            Bakker,H. and Jafar-Nejad,H.
  TITLE     Sensitized genetic backgrounds reveal differential roles for EGF
            repeat xylosyltransferases in Drosophila Notch signaling
  JOURNAL   Glycobiology 28 (11), 849-859 (2018)
   PUBMED   30169771
REFERENCE   3  (bases 1 to 2714)
  AUTHORS   Yang,L., Wang,Y., Fang,M., Deng,D. and Zhang,Y.
  TITLE     C3orf21 ablation promotes the proliferation of lung adenocarcinoma,
            and its mutation at the rs2131877 locus may serve as a
            susceptibility marker
  JOURNAL   Oncotarget 8 (20), 33422-33431 (2017)
   PUBMED   28422717
  REMARK    GeneRIF: our study concluded that C30rf21 rs 2131877 T/C+C/C
            genotype patients may experience increased nicotine addiction and
            that C30rf21 can likely serve as a susceptibility marker for lung
            adenocarcinoma with a higher degree of malignancy.
REFERENCE   4  (bases 1 to 2714)
  AUTHORS   Sethi,M.K., Buettner,F.F., Ashikov,A., Krylov,V.B., Takeuchi,H.,
            Nifantiev,N.E., Haltiwanger,R.S., Gerardy-Schahn,R. and Bakker,H.
  TITLE     Molecular cloning of a xylosyltransferase that transfers the second
            xylose to O-glucosylated epidermal growth factor repeats of notch
  JOURNAL   J Biol Chem 287 (4), 2739-2748 (2012)
   PUBMED   22117070
REFERENCE   5  (bases 1 to 2714)
  AUTHORS   Yoon,K.A., Park,J.H., Han,J., Park,S., Lee,G.K., Han,J.Y., Zo,J.I.,
            Kim,J., Lee,J.E., Takahashi,A., Kubo,M., Nakamura,Y. and Lee,J.S.
  TITLE     A genome-wide association study reveals susceptibility variants for
            non-small cell lung cancer in the Korean population
  JOURNAL   Hum Mol Genet 19 (24), 4948-4954 (2010)
   PUBMED   20876614
REFERENCE   6  (bases 1 to 2714)
  AUTHORS   Minamida,S., Aoki,K., Natsuka,S., Omichi,K., Fukase,K., Kusumoto,S.
            and Hase,S.
  TITLE     Detection of UDP-D-xylose: alpha-D-xyloside alpha
            1-->3xylosyltransferase activity in human hepatoma cell line HepG2
  JOURNAL   J Biochem 120 (5), 1002-1006 (1996)
   PUBMED   8982869
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA575404.1, BC039067.1, AC106705.7 and AK075551.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152531.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039067.1, SRR1803614.86990.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310380.11/ ENSP00000309640.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA575404.1         8-18
            12-1292             BC039067.1         1-1281
            1293-1730           AC106705.7         15658-16095         c
            1731-2063           BC039067.1         1720-2052
            2064-2397           AK075551.1         2039-2372
            2398-2413           BC039067.1         2390-2405
            2414-2563           BC039067.1         2407-2556
            2564-2564           AC106705.7         14824-14824         c
            2565-2651           BC039067.1         2558-2644
            2652-2694           BC039067.1         2649-2691
            2695-2695           AC106705.7         14693-14693         c
            2696-2714           BC039067.1         2693-2711
FEATURES             Location/Qualifiers
     source          1..2714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..2714
                     /gene="XXYLT1"
                     /gene_synonym="C3orf21"
                     /note="xyloside xylosyltransferase 1"
                     /db_xref="GeneID:152002"
                     /db_xref="HGNC:HGNC:26639"
                     /db_xref="MIM:614552"
     exon            1..605
                     /gene="XXYLT1"
                     /gene_synonym="C3orf21"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1283
                     /gene="XXYLT1"
                     /gene_synonym="C3orf21"
                     /EC_number="2.4.2.62"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase"
                     /codon_start=1
                     /product="xyloside xylosyltransferase 1 isoform 1"
                     /protein_id="NP_689744.3"
                     /db_xref="CCDS:CCDS43188.1"
                     /db_xref="GeneID:152002"
                     /db_xref="HGNC:HGNC:26639"
                     /db_xref="MIM:614552"
                     /translation="MGLLRGGLPCARAMARLGAVRSHYCALLLAAALAVCAFYYLGSG
                     RETFSSATKRLKEARAGAPAAPSPPALELARGSVAPAPGAKAKSLEGGGAGPVDYHLL
                     MMFTKAEHNAALQAKARVALRSLLRLAKFEAHEVLNLHFVSEEASREVAKGLLRELLP
                     PAAGFKCKVIFHDVAVLTDKLFPIVEAMQKHFSAGLGTYYSDSIFFLSVAMHQIMPKE
                     ILQIIQLDLDLKFKTNIRELFEEFDSFLPGAIIGIAREMQPVYRHTFWQFRHENPQTR
                     VGGPPPEGLPGFNSGVMLLNLEAMRQSPLYSRLLEPAQVQQLADKYHFRGHLGDQDFF
                     TMIGMEHPKLFHVLDCTWNRQLCTWWRDHGYSDVFEAYFRCEGHVKIYHGNCNTPIPE
                     D"
     exon            606..753
                     /gene="XXYLT1"
                     /gene_synonym="C3orf21"
                     /inference="alignment:Splign:2.1.0"
     exon            754..886
                     /gene="XXYLT1"
                     /gene_synonym="C3orf21"
                     /inference="alignment:Splign:2.1.0"
     exon            887..2714
                     /gene="XXYLT1"
                     /gene_synonym="C3orf21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XXYLT1"
                     /gene_synonym="C3orf21"
                     /note="hexamer: AATAAA"
     polyA_site      2714
                     /gene="XXYLT1"
                     /gene_synonym="C3orf21"
                     /note="major polyA site"
ORIGIN      
        1 atggccgccg cctggcgccg gggctaagtg gccgccggcg tccgggtacc cgagggctct
       61 cccgcgttgc tggcaccgct ggcgccgcgg tctcgtagcg catgggcctc ctccgaggcg
      121 ggctcccatg cgctcgggcc atggcgcgcc tgggcgctgt gcgctcccac tactgcgccc
      181 tgctgctggc cgcggcgctg gccgtctgcg ccttctacta cctcggctca ggccgggaga
      241 ccttctccag cgccaccaag aggctgaagg aggcccgcgc cggggctccc gccgcgccct
      301 cgccgcccgc gctggagcta gcgcggggct ccgtggcgcc agcccccggc gcgaaggcca
      361 agagcttgga gggcggcggt gccgggccgg tggactacca cctgctgatg atgttcacca
      421 aggcggagca caatgccgcg ctgcaggcca aggcccgcgt cgcgctgcgc tcactgctgc
      481 gcctcgccaa gttcgaggcg cacgaggtgc ttaaccttca cttcgtgagc gaggaggcca
      541 gccgcgaggt ggccaagggc ctgctgcggg agctcctgcc gcccgccgct ggcttcaagt
      601 gcaaggtcat cttccacgat gttgctgtgc tgacggataa gctcttcccc atcgtggagg
      661 ccatgcagaa gcacttcagt gctggcttgg gaacctacta cagtgactcc atcttcttcc
      721 tctcggtcgc catgcatcag atcatgccca aagagatcct gcagatcatt cagctggacc
      781 tagacctgaa gtttaagacc aacatccggg agttgtttga ggaatttgac agtttcctgc
      841 caggcgccat catcggcata gcccgggaga tgcagccagt ttacaggcac acattctggc
      901 agttccgcca tgagaacccc cagacccggg ttgggggccc gccccccgag gggctgccgg
      961 gcttcaacag cggggtgatg ttgctgaacc tggaggccat gcgccagtcc ccgctctaca
     1021 gccgcctgct ggagccggcg caggtgcagc agctggccga caagtaccac ttccgcggcc
     1081 acctcgggga ccaggacttc ttcaccatga tcggcatgga gcaccccaag ctcttccatg
     1141 tgctggactg tacctggaac cggcagctgt gcacctggtg gagggaccat ggctacagtg
     1201 acgtcttcga ggcctatttc aggtgtgagg gccacgtcaa gatctaccac gggaactgca
     1261 acactcccat cccggaggac taggcgctcc ccgtgccttg cccccggggc ctccagatct
     1321 gggggaagga cagggttcct tgggacagac ccaagggcag tgtctgaccc gctagagaga
     1381 caccgcaggg aagtcctgtg attaaggtgc tgagacctcc tgccgggcag gtcactgtgc
     1441 tgaggccacc cgccaaggac tggcctgtgc actgctggtg cttgggacct tattcctcca
     1501 gggagcaggc gacacaaagg acacgcatgt ccagtgggct gggaagcaag cacttgaaga
     1561 gaaggaaggg gagaaagggt cccccttgct gtctgcctct gaggaatgga aatcctttag
     1621 acccggcctt ttttggacca atataaattt aatttaaatt gacagccttc catttttcga
     1681 gaaagtacaa acagaactgc tttagcaccc atcgagcccc aaacgggtaa ggtaagccaa
     1741 ggttttaatg accagcccag tatctaagct tccaaacgaa tgccagccca tcacatactc
     1801 accctgggag gctgctgcac gcgcattctc ctgatgctca cgtcacttgg tgtaggtttc
     1861 aggatcgcct ctttgaggaa ggacttcagg accaactggg gcctgcataa gaaaacttat
     1921 ctcattatta gagtactcac agcttgtatc tcccagctac atcctagaac cccattgtcc
     1981 tttattccac caaaccagct ccaggtgacc agactctact cagaaagcaa attcgtcatc
     2041 aaagaacaga gactggccac cacaaggaca tgcaggagaa ctgtcgggac caggaagact
     2101 cattccaaaa agcccaggcc gggcacagtc gtcaagcctg taatcccaac actttgggag
     2161 accgaggtgg gggtatcgat tgagcctcgg aggtcgagat cagcctggga aacacaggga
     2221 ggcccccatc gctacaaaat attttaaaaa ttagccaggt gtggtggctt gtgcttgttg
     2281 tcccggctac ttgggaggct gaagtgggag ggtggcttga gtccaggagt tcactgcact
     2341 gagctgtgat cacaccactg cactccagcc tggacgacag agtgagacgt ccatctcaaa
     2401 aaaaaaaaaa aaaccaaaaa ggaacccagc aattcccaag tgtgaccatg tgggcttgga
     2461 agacatgtca ctcatgggct agtaagcatt ctagtttctt tgtttaaaaa atccccttat
     2521 cataccacgt tagaccgtag accttagcag aaattaaagc gtcatttctt ttgatggggc
     2581 ctcctgtacg taggctgcag acgtgaaagc cccaggggtc catttgtatc aattttcatc
     2641 ttgttttgtt ttgatttcat ttacgttttt ctttttccca tgagtgagga tagccaataa
     2701 atcatctttg agaa
//
