LOCUS       NM_001378167            4353 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens X-ray radiation resistance associated 1 (XRRA1),
            transcript variant 14, mRNA.
ACCESSION   NM_001378167
VERSION     NM_001378167.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4353)
  AUTHORS   Chang,X., March,M., Mentch,F., Qu,H., Liu,Y., Glessner,J.,
            Sleiman,P. and Hakonarson,H.
  TITLE     Genetic architecture of asthma in African American patients
  JOURNAL   J Allergy Clin Immunol 151 (4), 1132-1136 (2023)
   PUBMED   36089080
  REMARK    GeneRIF: Genetic architecture of asthma in African American
            patients.
REFERENCE   2  (bases 1 to 4353)
  AUTHORS   Wang,W., Guo,M., Xia,X., Zhang,C., Zeng,Y. and Wu,S.
  TITLE     XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer
  JOURNAL   Biomed Res Int 2017, 5718968 (2017)
   PUBMED   29082250
  REMARK    GeneRIF: our results identify a novel link between XRRA1 and the
            ATM/CHK1/2 pathway and suggest that XRRA1 is involved in a DNA
            damage response that drives radio- and chemoresistance by
            regulating the ATM/CHK1/2 pathway.
            Erratum:[Biomed Res Int. 2021 Feb 19;2021:3030267. doi:
            10.1155/2021/3030267.. PMID: 33728327]
REFERENCE   3  (bases 1 to 4353)
  AUTHORS   Mori,T., Watanuki,T. and Kashiwagura,T.
  TITLE     Diesel exhaust particles disturb gene expression in mouse testis
  JOURNAL   Environ Toxicol 22 (1), 58-63 (2007)
   PUBMED   17295261
REFERENCE   4  (bases 1 to 4353)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   5  (bases 1 to 4353)
  AUTHORS   Mesak,F.M., Osada,N., Hashimoto,K., Liu,Q.Y. and Ng,C.E.
  TITLE     Molecular cloning, genomic characterization and over-expression of
            a novel gene, XRRA1, identified from human colorectal cancer cell
            HCT116Clone2_XRR and macaque testis
  JOURNAL   BMC Genomics 4 (1), 32 (2003)
   PUBMED   12908878
  REMARK    GeneRIF: Molecular cloning and gene expression patterns of XRRA1.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001992.4 and AP000560.4.
            
            Transcript Variant: This variant (14), as well as variants 12 and
            13, encodes isoform 11.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.763645.1,
                                           SRR14038197.1050376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AP001992.4         97239-97402         c
            165-349             AP001992.4         85195-85379         c
            350-483             AP001992.4         69525-69658         c
            484-612             AP001992.4         55456-55584         c
            613-830             AP001992.4         54550-54767         c
            831-924             AP000560.4         103520-103613       c
            925-1040            AP000560.4         102619-102734       c
            1041-1388           AP000560.4         99646-99993         c
            1389-1587           AP000560.4         96604-96802         c
            1588-1703           AP000560.4         95699-95814         c
            1704-1809           AP000560.4         95385-95490         c
            1810-4353           AP000560.4         92441-94984         c
FEATURES             Location/Qualifiers
     source          1..4353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..4353
                     /gene="XRRA1"
                     /note="X-ray radiation resistance associated 1"
                     /db_xref="GeneID:143570"
                     /db_xref="HGNC:HGNC:18868"
                     /db_xref="MIM:609788"
     exon            1..164
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            165..349
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..483
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..612
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..830
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             816..2063
                     /gene="XRRA1"
                     /note="isoform 11 is encoded by transcript variant 14;
                     X-ray radiation resistance-associated protein 1"
                     /codon_start=1
                     /product="X-ray radiation resistance-associated protein 1
                     isoform 11"
                     /protein_id="NP_001365096.1"
                     /db_xref="GeneID:143570"
                     /db_xref="HGNC:HGNC:18868"
                     /db_xref="MIM:609788"
                     /translation="MLTGQIAKEDAVLPVALFPSLCEFVFHNNPLVAHTRGVPPLLKS
                     FLQERLGIHLIRRKIVKPKHHVLMSRKESWKVKSEIPKVPKQPLVLHHPRMTTTKSPS
                     KDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEET
                     LSHLSDTTVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTA
                     PREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPKGIQKNAQALQQMLKHPLLC
                     HSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAV
                     LHQWTERRLVNHKQYLEAKRLLKEFQARYRQLVSGSLRTVFGTTPLPMACPALSESQP
                     KFGHFLEFMDEFCQEPTASDSQG"
     exon            831..924
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1040
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1388
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1587
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1703
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1809
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..4353
                     /gene="XRRA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XRRA1"
                     /note="hexamer: AATAAA"
     polyA_site      2295
                     /gene="XRRA1"
                     /note="major polyA site"
     regulatory      4313..4318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XRRA1"
                     /note="hexamer: AATAAA"
     polyA_site      4353
                     /gene="XRRA1"
ORIGIN      
        1 actgtctgcc gtcgcgtcgc agttactaag gcgtggggaa gatagcggca ggcaccgcag
       61 tggagcggct ccgagatccc cggggggctc gcaggcgcgc atccctcctg actgggacgt
      121 cgcctccgca gacccctcgg aggctgaagc gacgccggag gcaggccaag gacactggtt
      181 agtggttcag aaaggtaacc tcaagaagaa gcccaagggt ttggttggag cacaagctga
      241 acgtcgggaa agcctgaagg cgacttcttt tgagttcaag gggaagaaag agtctcggcg
      301 ggaaaatcag gtggaccttc ctggacatat cctggaccag gcttttctgt tcttggacct
      361 ttccttcaac agcctgactg tggaggccat ctgtgatttg gggattctgc cacacctccg
      421 tgtcctgctc ctcacaggca atggccttac ctccctgccg cccaatttgg ccgtcgcaga
      481 acaggaggca tctgtaacat cgctgacaag caagaggtac atcctgaggt tcccagcgct
      541 ggagacactg atgctggatg acaacagact ctccaacccc agttgctttg ccagcctggc
      601 tgggctcagg agactgaaga agttaagctt ggatgaaaac aggattatca ggatcccata
      661 cctacagcaa gttcagctct atgacgagtc agtagactgg aatggaggca ggggaagtcc
      721 ccataaagag ccccaattca tgctgcagtc caagccaagg atgcttgagg actcagatga
      781 gcaactggat tatactgtac tgcccatgaa aaaggatgtt gaccggacag atcgcaaaag
      841 aggatgctgt cctaccagta gctctcttcc catctctctg cgagttcgtc tttcataaca
      901 accctctggt ggcccataca cgaggggtcc ctccactgct gaagagcttc ctccaggagc
      961 gactgggaat ccacttaatt cgaaggaaga tagtaaagcc taagcatcat gttttgatgt
     1021 ctcggaagga atcatggaag gtgaaaagcg aaatcccaaa ggtgccgaag cagcctctgg
     1081 tgctccatca cccgcgcatg acgacaacca agtctccctc aaaggatatg ctagagccag
     1141 aggcagagct ggctgaagat ctgcccacta ccaaaagcac ttctgtggag tcagagatgc
     1201 ccactgagaa cctggaaggc cattccccgt cttgccggac cttcgtgcca ctgcctccca
     1261 tctgctccaa ctccactgtg catagtgaag agaccctgtc ccacctgagt gacacaactg
     1321 tccgcctcag cccagagcgc ccatcagatg aggactccaa gagcacagag tccatcttcc
     1381 tgacccaggt gagtgaactg ccttcctccg tcatccataa ggatgattta gagttaaagg
     1441 agaaagacca aaagaaacca ccaacggcac ccagagaggt gaaagggact cggaggaaac
     1501 tcccaactgc cttccttccc agcaagtacc acggctatga agaactgctg acagccaagc
     1561 ctgatccagc cttcattgag ccaaagggaa tccagaagaa tgcacaagcc ctgcaacaaa
     1621 tgctgaagca cccactcctg tgccactcct ccaagcccaa gctggacact cttcagaaac
     1681 cctatgttca caaagagaaa cgggcccaga gaatcccgat tccaccccca aagaagacta
     1741 gagcccaact tctggatgac atcttcattc gcttgcggga tccccggaac attacagagg
     1801 ctccactagg tgctgtcctg caccagtgga cagaacggcg gctggtgaac cacaagcagt
     1861 acctggaggc caagaggctg ttgaaggagt tccaggcacg ttaccggcag ctggtgagtg
     1921 gctctctgcg cacagtgttc gggactaccc cgctccccat ggcctgccca gcgctgagtg
     1981 agagccagcc caagttcggc cacttcctcg agttcatgga tgagttctgc caggagccca
     2041 cagccagtga ctcacaaggc tagagctgtg catgggggct gtgtgcacca cccggcctgt
     2101 gccccagctc tccccgaggg ctctgtgccc tggaccgcac ctcaaggttg accagccggc
     2161 cacaggcctc agagctcagc tgggccccac ttgctggcca caaggtggca tccccttgtc
     2221 aggatctccc ctccttggcc caggcatgac ctggtgcctg gcccagcggc aataaagagt
     2281 gggtgcacag ggcaatagac tgggtgccac atgcattctt tcttggaacc caggccacag
     2341 cagcattgtc acacttccct ctaaaaatgg ttttccagtt cagatgcaac agggatacat
     2401 ttgttctctg ttgtatgaga aactgacacc aaggggatct taacaaattc ctgaacaatg
     2461 gctccaaaaa agggtatttt taaaaaccag atcttgtgag tacagcccta atgtgcaggg
     2521 acagtgtcat cctgtatatt cgttctttac tcagactctt tcttggttcc ttcattagga
     2581 gcatgaatgg ttgaatgtga acatgacagt aaattggagc aaactgtaaa ctggacataa
     2641 cttatgccaa aagacgtagt tgtacaccat ggaaacccca tccctgctcc taatctctac
     2701 tgccattctg aatgccaaag caagacatcc aacatggggc atctcccaga gcacatacag
     2761 caccaaaaat ccacacacag cctaagctta acccatgttt ttgtctgaga ttgttcacca
     2821 gagacaagac tctgactata aacagaacat ccactttcat gagtttcctt tactgtattc
     2881 tcaacttggg ccttgcttca agcaggcaaa catacattga agaatgcact ttggtactgt
     2941 ttaaataaca acacatcagc ccacttgatt ccatgccatg tccttgctga cagaaacatc
     3001 cccaacaggg catgccctgg tccaagtcct ctgtctttgt caaaatgctc ttctgatgag
     3061 ttggagagga ggcagccagc agtggcagtc cacaaggatc caggtacctt ctccaatcct
     3121 aaagcagaca gcaggttgaa taaaaccaat acacaaccta ttttctaggc aggaggggaa
     3181 aaggccctta ggacaataat atttgtacaa agagttgaga gtaaacaaac agtgtatcag
     3241 gttcaaaaaa aaaaaaacta ttcgttggca tttaaatttt tttcccttgc atagtatcta
     3301 ttctctcact aggactttta agtgctctgc tggaggctca gcgttggtaa taccatgttt
     3361 gatgcaaact tgaacccaat gctctcattg gtggcacagc tttggagggt ggtggcccca
     3421 agaaggggca atctgcctgc tgctatatta atctggaacc agggccaaca gctactcttg
     3481 aactatggta tttgaagagc gagttcattg cctgttttac cttaaatgac aggaaaggaa
     3541 gatgaacaaa ccttgctttg ccttggcttc aaactagttc ttgatttaag acaccagaaa
     3601 gggagagagg gagtctgctt agagtttgag gttgcctctc acaagatgac agttaaaagt
     3661 tgccacctta cttaaaaggc attaaggagg catttactca caaaggagag agagtaaatt
     3721 tttttcttaa gaggaaaaaa atactgataa tacatagaac aatctgcaca tccagtcttg
     3781 gcactttttc caatttgact gatctctaaa ctggtgaccc ttgcatatat cttagtctct
     3841 tttctacaat cttcttcaga aagctacagc agctaacaat catgtataaa gatgcatttc
     3901 ctagatcatc ttcagaagaa aatctcttca gcactttccc tagaatctgt ctcctgacca
     3961 ccccgcccca gacctgcttt ctcttttgag aattcataac caggtatgtt tagataccag
     4021 ttcaaaagac cactctatgg gttgatgagg aaaaggctgc ctgaggacaa tttaagacca
     4081 taatgagttt ccaattttta aagaaaattt ggctagctgg cttttaattc ttaattaaaa
     4141 tcattaaatt taattaaaat tattccaatc aaaatatatc actttccaag attccacatt
     4201 catattactt acttatacta tggagacttt ctctacctga gcatgtattc aggggctata
     4261 ggtacattta actctaacta actgaaaaaa atcaggaaga aaaaactatt aaaataaaat
     4321 aacctcctaa atcatttggg ggtatcccca tca
//
