LOCUS       NM_005432               2567 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens X-ray repair cross complementing 3 (XRCC3), transcript
            variant 2, mRNA.
ACCESSION   NM_005432
VERSION     NM_005432.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2567)
  AUTHORS   Datkhile,K.D., Gudur,R.A., Bhosale,S.J., Durgawale,P.P.,
            Jagdale,N.J., More,A.L., Gudur,A.K. and Patil,S.R.
  TITLE     Impact of Interaction between Single Nucleotide Polymorphism of
            XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk
            of Breast Cancer: A Hospital Based Case-Control Study
  JOURNAL   Asian Pac J Cancer Prev 24 (9), 3065-3075 (2023)
   PUBMED   37774058
  REMARK    GeneRIF: Impact of Interaction between Single Nucleotide
            Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene
            Increases Risk of Breast Cancer: A Hospital Based Case-Control
            Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2567)
  AUTHORS   Gupta,P., Sambyal,V., Guleria,K., Uppal,M.S. and Sudan,M.
  TITLE     Association of RAD51, XRCC1, XRCC2, and XRCC3 Polymorphisms with
            Risk of Breast Cancer
  JOURNAL   Genet Test Mol Biomarkers 27 (7), 205-214 (2023)
   PUBMED   37522793
  REMARK    GeneRIF: Association of RAD51, XRCC1, XRCC2, and XRCC3
            Polymorphisms with Risk of Breast Cancer.
REFERENCE   3  (bases 1 to 2567)
  AUTHORS   Liang,Q., Huang,G., Zhong,P., Deng,D., Yang,L. and Yu,X.
  TITLE     Systematic evaluation of the association between a missense variant
            in XRCC3 gene splicing site and the pathogenesis of ovarian cancer
  JOURNAL   Biosci Rep 43 (6) (2023)
   PUBMED   37212185
  REMARK    GeneRIF: Systematic evaluation of the association between a
            missense variant in XRCC3 gene splicing site and the pathogenesis
            of ovarian cancer.
REFERENCE   4  (bases 1 to 2567)
  AUTHORS   Nigam,K., Gupta,S., Singh,N., Yadav,S.K. and Sanyal,S.
  TITLE     XRCC3 and NBS1 gene polymorphisms modulate the risk of pre-oral
            cancer and oral cancer in the North Indian population
  JOURNAL   J Cancer Res Ther 19 (2), 304-311 (2023)
   PUBMED   37006067
  REMARK    GeneRIF: XRCC3 and NBS1 gene polymorphisms modulate the risk of
            pre-oral cancer and oral cancer in the North Indian population.
REFERENCE   5  (bases 1 to 2567)
  AUTHORS   Tan,S.C., Low,T.Y., Hussain,H.M.J., Sharzehan,M.A.K., Sito,H.,
            Kord-Varkaneh,H. and Islam,M.A.
  TITLE     Association between XRCC3 p.Thr241Met polymorphism and risk of
            glioma: A systematic review and meta-analysis
  JOURNAL   PLoS One 17 (10), e0276313 (2022)
   PUBMED   36264998
  REMARK    GeneRIF: Association between XRCC3 p.Thr241Met polymorphism and
            risk of glioma: A systematic review and meta-analysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2567)
  AUTHORS   Liu,N., Lamerdin,J.E., Tebbs,R.S., Schild,D., Tucker,J.D.,
            Shen,M.R., Brookman,K.W., Siciliano,M.J., Walter,C.A., Fan,W.,
            Narayana,L.S., Zhou,Z.Q., Adamson,A.W., Sorensen,K.J., Chen,D.J.,
            Jones,N.J. and Thompson,L.H.
  TITLE     XRCC2 and XRCC3, new human Rad51-family members, promote chromosome
            stability and protect against DNA cross-links and other damages
  JOURNAL   Mol Cell 1 (6), 783-793 (1998)
   PUBMED   9660962
REFERENCE   7  (bases 1 to 2567)
  AUTHORS   Dosanjh,M.K., Collins,D.W., Fan,W., Lennon,G.G., Albala,J.S.,
            Shen,Z. and Schild,D.
  TITLE     Isolation and characterization of RAD51C, a new human member of the
            RAD51 family of related genes
  JOURNAL   Nucleic Acids Res 26 (5), 1179-1184 (1998)
   PUBMED   9469824
REFERENCE   8  (bases 1 to 2567)
  AUTHORS   Price,E.A., Bourne,S.L., Radbourne,R., Lawton,P.A., Lamerdin,J.,
            Thompson,L.H. and Arrand,J.E.
  TITLE     Rare microsatellite polymorphisms in the DNA repair genes XRCC1,
            XRCC3 and XRCC5 associated with cancer in patients of varying
            radiosensitivity
  JOURNAL   Somat Cell Mol Genet 23 (4), 237-247 (1997)
   PUBMED   9542526
REFERENCE   9  (bases 1 to 2567)
  AUTHORS   Tebbs,R.S., Zhao,Y., Tucker,J.D., Scheerer,J.B., Siciliano,M.J.,
            Hwang,M., Liu,N., Legerski,R.J. and Thompson,L.H.
  TITLE     Correction of chromosomal instability and sensitivity to diverse
            mutagens by a cloned cDNA of the XRCC3 DNA repair gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6354-6358 (1995)
   PUBMED   7603995
REFERENCE   10 (bases 1 to 2567)
  AUTHORS   Kopecny,J.
  TITLE     [Rational approaches to the treatment of urinary incontinence
            (author's transl)]
  JOURNAL   Cesk Gynekol 41 (6), 408-409 (1976)
   PUBMED   975276
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB041321.1, AK023646.1,
            BX161398.1 and BC002949.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005432.3.
            
            Summary: This gene encodes a member of the RecA/Rad51-related
            protein family that participates in homologous recombination to
            maintain chromosome stability and repair DNA damage. This gene
            functionally complements Chinese hamster irs1SF, a repair-deficient
            mutant that exhibits hypersensitivity to a number of different
            DNA-damaging agents and is chromosomally unstable. A rare
            microsatellite polymorphism in this gene is associated with cancer
            in patients of varying radiosensitivity. Alternatively spliced
            transcript variants encoding the same protein have been identified.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks a segment in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001036.1, AK023646.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000555055.6/ ENSP00000452598.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DB041321.1         53-80
            29-85               AK023646.1         37-93
            86-2536             BX161398.1         33-2483
            2537-2567           BC002949.1         1319-1349
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..2567
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /note="X-ray repair cross complementing 3"
                     /db_xref="GeneID:7517"
                     /db_xref="HGNC:HGNC:12830"
                     /db_xref="MIM:600675"
     exon            1..28
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     exon            29..85
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     exon            86..187
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     exon            188..400
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1386
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /note="X-ray repair cross-complementing protein 3; X-ray
                     repair complementing defective repair in Chinese hamster
                     cells 3"
                     /codon_start=1
                     /product="DNA repair protein XRCC3"
                     /protein_id="NP_005423.1"
                     /db_xref="CCDS:CCDS9984.1"
                     /db_xref="GeneID:7517"
                     /db_xref="HGNC:HGNC:12830"
                     /db_xref="MIM:600675"
                     /translation="MDLDLLDLNPRIIAAIKKAKLKSVKEVLHFSGPDLKRLTNLSSP
                     EVWHLLRTASLHLRGSSILTALQLHQQKERFPTQHQRLSLGCPVLDALLRGGLPLDGI
                     TELAGRSSAGKTQLALQLCLAVQFPRQHGGLEAGAVYICTEDAFPHKRLQQLMAQQPR
                     LRTDVPGELLQKLRFGSQIFIEHVADVDTLLECVNKKVPVLLSRGMARLVVIDSVAAP
                     FRCEFDSQASAPRARHLQSLGATLRELSSAFQSPVLCINQVTEAMEEQGAAHGPLGFW
                     DERVSPALGITWANQLLVRLLADRLREEEAALGCPARTLRVLSAPHLPPSSCSYTISA
                     EGVRGTPGTQSH"
     exon            401..538
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     exon            539..751
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     exon            752..906
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1119
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1166
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..2567
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2547..2552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /note="hexamer: AATAAA"
     polyA_site      2567
                     /gene="XRCC3"
                     /gene_synonym="CMM6"
                     /note="major polyA site"
ORIGIN      
        1 gggaagagga gtgcggaacc cgcgggagga tgtgcacaga gggcccagga ggagcctcag
       61 gagccggact gccgttggcc aaccgagtcc ccagggagac acttaaggga aattaaactg
      121 cagagtgcaa gagatgcctc agtcaagtca gccaaaaaca cgcgggtcat ccccaagccc
      181 cagagagtga cagagccccg atgacacgga cacctcggct gctgtcactt ccctggttcg
      241 ggcctcccac aggctttgaa ttgaaggcga gtgcctcaga atttgcatcc attgttctgt
      301 ctttcctggg aagttattca tcctggtggc cagcccaccg acaaaatgga tttggatcta
      361 ctggacctga atcccagaat tattgctgca attaagaaag ccaaactgaa atcggtaaag
      421 gaggttttac acttttctgg accagacttg aagagactga ccaacctctc cagccccgag
      481 gtctggcact tgctgagaac ggcctcctta cacttgcggg gaagcagcat ccttacagca
      541 ctgcagctgc accagcagaa ggagcggttc cccacgcagc accagcgcct gagcctgggc
      601 tgcccggtgc tggacgcgct gctccgcggt ggcctgcccc tggacggcat cactgagctg
      661 gccggacgca gctcggcagg gaagacccag ctggcgctgc agctctgcct ggctgtgcag
      721 ttcccgcggc agcacggagg cctggaggct ggagccgtct acatctgcac ggaagacgcc
      781 ttcccgcaca agcgcctgca gcagctcatg gcccagcagc cgcggctgcg cactgacgtt
      841 ccaggagagc tgcttcagaa gctccgattt ggcagccaga tcttcatcga gcacgtggcc
      901 gatgtggaca ccttgttgga gtgtgtgaat aagaaggtcc ccgtactgct gtctcggggc
      961 atggctcgcc tggtggtcat cgactcggtg gcagccccat tccgctgtga atttgacagc
     1021 caggcctccg cccccagggc caggcatctg cagtccctgg gggccacgct gcgtgagctg
     1081 agcagtgcct tccagagccc tgtgctgtgc atcaaccagg tgacagaggc catggaggag
     1141 cagggcgcag cacacgggcc gctggggttc tgggacgaac gtgtttcccc agcccttggc
     1201 ataacctggg ctaaccagct cctggtgaga ctgctggctg accggctccg cgaggaagag
     1261 gctgccctcg gctgcccagc ccggaccctg cgggtgctct ctgcccccca cctgcccccc
     1321 tcctcctgtt cctacacgat cagtgccgaa ggggtgcgag ggacacctgg gacccagtcc
     1381 cactgacacg gtggcggctg cacaacagcc ctgcctgaga agccccgaca cacggggctc
     1441 gggcctttaa aacgcgtctg cctgggccgt ggcacagctg ggagcctggt tcagacacag
     1501 ctcttccagg gcagcggctc cactttctca tccgaagatg gtggccacag actgaccccc
     1561 atctgagctg gggggatgtt ctgcctctcc ctgggtctgg ggacaggccc gcttgctggg
     1621 tacctggtcc ccactgctga gctggccctt ggggagaggt gattctcagg gctggagcct
     1681 ggggtgtcct acagtgactc cctgggagcc gcctgcttct tctctccaca tggaagccca
     1741 actggggttg cgtctgaggc ctgccccctg ggctggggcc tcagaccccc tcagccttgg
     1801 gaccgtgccc acgagggtct cccctcctgc acacagggca gtccttactc ccccaccact
     1861 caggccacag tggggctgca ggcaggcggc tcctcctcac ccacctctgg gtccttggct
     1921 cccgggggcc ccacctcggc acacactgtg ccccacaaaa cttcagtgtg gtacaaggtg
     1981 gagaaagcat atcccaccaa cctccagtgt cagggtccag gagagcctgg gggtgggggg
     2041 actgccttgt ctctagtagt gtggcctgtg ccagcaccac agccggtcag aggagcgcag
     2101 gcagcgcagg gctggcacgt gacaggctcg tcagccacct gggaacacag ttctgggcaa
     2161 agaggatccg aggttgagag gaaggagggt cccggtgtat cctggccctg ggggtctggg
     2221 cgtccagctc agccctggcc tggctgggtg gtattctggt agggatatgg caggactcct
     2281 ggcagggcca cctgcaggac cctgtcctgc agtcccacac tgtgcagacc cagtcccaca
     2341 ctgtggccag gccttacatc tggctggaaa gcagagcctc ctgggaacac atctggctgc
     2401 acaggctgaa atatccaccc agcaggcaga gtggcgtggc ctccccatgg gcacagtggt
     2461 gacccccttg attcccaccg tacaaccccc tccacccccc actcagtgcc tccacatgct
     2521 gcctggcaca gaccaggcct ttgacaaata aatgttcaat ggatgca
//
