LOCUS       NM_005431               4771 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens X-ray repair cross complementing 2 (XRCC2), mRNA.
ACCESSION   NM_005431
VERSION     NM_005431.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4771)
  AUTHORS   Dastgheib,S.A., Sayad,S., Azizi,S., Hajizadeh,N., Asadian,F.,
            Karimi-Zarchi,M., Barahman,M., Shiri,A., Manzourolhojeh,M.,
            Aghili,K. and Neamatzadeh,H.
  TITLE     Association between XRCC2 Arg188His Polymorphism and Breast Cancer
            Susceptibility: A Systematic Review and Meta-Analysis
  JOURNAL   Asian Pac J Cancer Prev 25 (1), 43-55 (2024)
   PUBMED   38285766
  REMARK    GeneRIF: Association between XRCC2 Arg188His Polymorphism and
            Breast Cancer Susceptibility: A Systematic Review and
            Meta-Analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4771)
  AUTHORS   Datkhile,K.D., Gudur,R.A., Bhosale,S.J., Durgawale,P.P.,
            Jagdale,N.J., More,A.L., Gudur,A.K. and Patil,S.R.
  TITLE     Impact of Interaction between Single Nucleotide Polymorphism of
            XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk
            of Breast Cancer: A Hospital Based Case-Control Study
  JOURNAL   Asian Pac J Cancer Prev 24 (9), 3065-3075 (2023)
   PUBMED   37774058
  REMARK    GeneRIF: Impact of Interaction between Single Nucleotide
            Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene
            Increases Risk of Breast Cancer: A Hospital Based Case-Control
            Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4771)
  AUTHORS   Gupta,P., Sambyal,V., Guleria,K., Uppal,M.S. and Sudan,M.
  TITLE     Association of RAD51, XRCC1, XRCC2, and XRCC3 Polymorphisms with
            Risk of Breast Cancer
  JOURNAL   Genet Test Mol Biomarkers 27 (7), 205-214 (2023)
   PUBMED   37522793
  REMARK    GeneRIF: Association of RAD51, XRCC1, XRCC2, and XRCC3
            Polymorphisms with Risk of Breast Cancer.
REFERENCE   4  (bases 1 to 4771)
  AUTHORS   Rawal,Y., Jia,L., Meir,A., Zhou,S., Kaur,H., Ruben,E.A., Kwon,Y.,
            Bernstein,K.A., Jasin,M., Taylor,A.B., Burma,S., Hromas,R.,
            Mazin,A.V., Zhao,W., Zhou,D., Wasmuth,E.V., Greene,E.C., Sung,P.
            and Olsen,S.K.
  TITLE     Structural insights into BCDX2 complex function in homologous
            recombination
  JOURNAL   Nature 619 (7970), 640-649 (2023)
   PUBMED   37344589
  REMARK    GeneRIF: Structural insights into BCDX2 complex function in
            homologous recombination.
REFERENCE   5  (bases 1 to 4771)
  AUTHORS   Greenhough,L.A., Liang,C.C., Belan,O., Kunzelmann,S., Maslen,S.,
            Rodrigo-Brenni,M.C., Anand,R., Skehel,M., Boulton,S.J. and
            West,S.C.
  TITLE     Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour
            suppressor
  JOURNAL   Nature 619 (7970), 650-657 (2023)
   PUBMED   37344587
  REMARK    GeneRIF: Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2
            tumour suppressor.
REFERENCE   6  (bases 1 to 4771)
  AUTHORS   Cartwright,R., Tambini,C.E., Simpson,P.J. and Thacker,J.
  TITLE     The XRCC2 DNA repair gene from human and mouse encodes a novel
            member of the recA/RAD51 family
  JOURNAL   Nucleic Acids Res 26 (13), 3084-3089 (1998)
   PUBMED   9628903
REFERENCE   7  (bases 1 to 4771)
  AUTHORS   Tambini,C.E., George,A.M., Rommens,J.M., Tsui,L.C., Scherer,S.W.
            and Thacker,J.
  TITLE     The XRCC2 DNA repair gene: identification of a positional candidate
  JOURNAL   Genomics 41 (1), 84-92 (1997)
   PUBMED   9126486
REFERENCE   8  (bases 1 to 4771)
  AUTHORS   Jones,N.J., Zhao,Y., Siciliano,M.J. and Thompson,L.H.
  TITLE     Assignment of the XRCC2 human DNA repair gene to chromosome 7q36 by
            complementation analysis
  JOURNAL   Genomics 26 (3), 619-622 (1995)
   PUBMED   7607692
REFERENCE   9  (bases 1 to 4771)
  AUTHORS   Thacker,J., Tambini,C.E., Simpson,P.J., Tsui,L.C. and Scherer,S.W.
  TITLE     Localization to chromosome 7q36.1 of the human XRCC2 gene,
            determining sensitivity to DNA-damaging agents
  JOURNAL   Hum Mol Genet 4 (1), 113-120 (1995)
   PUBMED   7711722
REFERENCE   10 (bases 1 to 4771)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF035587.1 and AC003109.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005431.1.
            
            Summary: This gene encodes a member of the RecA/Rad51-related
            protein family that participates in homologous recombination to
            maintain chromosome stability and repair DNA damage. This gene is
            involved in the repair of DNA double-strand breaks by homologous
            recombination and it functionally complements Chinese hamster irs1,
            a repair-deficient mutant that exhibits hypersensitivity to a
            number of different DNA-damaging agents. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313607.1, AF035587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359321.2/ ENSP00000352271.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3049              AF035587.1         25-3073
            3050-4771           AC003109.1         33904-35625
FEATURES             Location/Qualifiers
     source          1..4771
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..4771
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /note="X-ray repair cross complementing 2"
                     /db_xref="GeneID:7516"
                     /db_xref="HGNC:HGNC:12829"
                     /db_xref="MIM:600375"
     exon            1..101
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..905
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /note="Xrcc2; X-ray repair cross-complementing protein 2;
                     X-ray repair complementing defective repair in Chinese
                     hamster cells 2; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="DNA repair protein XRCC2"
                     /protein_id="NP_005422.1"
                     /db_xref="CCDS:CCDS5933.1"
                     /db_xref="GeneID:7516"
                     /db_xref="HGNC:HGNC:12829"
                     /db_xref="MIM:600375"
                     /translation="MCSAFHRAESGTELLARLEGRSSLKEIEPNLFADEDSPVHGDIL
                     EFHGPEGTGKTEMLYHLTARCILPKSEGGLEVEVLFIDTDYHFDMLRLVTILEHRLSQ
                     SSEEIIKYCLGRFFLVYCSSSTHLLLTLYSLESMFCSHPSLCLLILDSLSAFYWIDRV
                     NGGESVNLQESTLRKCSQCLEKLVNDYRLVLFATTQTIMQKASSSSEEPSHASRRLCD
                     VDIDYRPYLCKAWQQLVKHRMFFSKQDDSQSSNQFSLVSRCLKSNSLKKHFFIIGESG
                     VEFC"
     exon            102..183
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /inference="alignment:Splign:2.1.0"
     exon            184..4771
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /note="hexamer: AGTAAA"
     polyA_site      1508
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /note="major polyA site"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /note="hexamer: ATTAAA"
     polyA_site      1563
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /note="major polyA site"
     regulatory      4750..4755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /note="hexamer: ACTAAA"
     polyA_site      4771
                     /gene="XRCC2"
                     /gene_synonym="FANCU; POF17; SPGF50"
                     /note="major polyA site"
ORIGIN      
        1 agttggtgaa tggcgttggt ggcgggaaag ttgagtctct cctgcgccga gccttcgggg
       61 cgatgtgtag tgccttccat agggctgagt ctgggaccga gctccttgcc cgacttgaag
      121 gtagaagttc cttgaaagaa atagaaccaa atctgtttgc tgatgaagat tcacctgtgc
      181 atggtgatat tcttgaattt catggcccag aaggaacagg aaaaacagaa atgctttatc
      241 acctaacagc acgatgtata cttcccaaat cagaaggtgg cctggaagta gaagtcttat
      301 ttattgatac agattaccac tttgatatgc tccggctagt tacaattctt gagcacagac
      361 tatcccaaag ctctgaagaa ataatcaaat actgcctggg aagatttttt ttggtgtact
      421 gcagtagtag cacccactta cttcttacac tttactcact agaaagtatg ttttgtagtc
      481 acccatctct ctgccttttg attttggata gcctgtcagc tttttactgg atagaccgcg
      541 tcaatggagg agaaagtgtg aacttacagg agtctactct gaggaaatgt tctcagtgct
      601 tagagaagct tgtaaatgac tatcgcctgg ttctttttgc aacgacacaa actataatgc
      661 agaaagcctc gagctcatca gaagaacctt ctcatgcctc tcgacgactg tgtgatgtgg
      721 acatagacta cagaccttat ctctgtaagg catggcagca actggtgaag cacaggatgt
      781 ttttctccaa acaagatgat tctcaaagca gcaaccaatt ttcattagtt tcacgttgtt
      841 taaaaagtaa cagtttaaaa aaacattttt ttattattgg agaaagtggg gttgaatttt
      901 gttgatatac atcataaaat agtcttttgc agggtactac gcaagcctta aaatttttct
      961 taagacagag tcttgctctg tctcccaggc tggagtgcag tggcacaatc atggctcact
     1021 gcagccttga actcctggcc tcaagggatc ctcctatgtg tgcctcctag agtgcaggga
     1081 ttacaggcgt gagccactgc tcgtggccaa aagttttctt tttttttttt tttctttttg
     1141 aaacagtctt actctgtctc ccaggctgct ggagtgcagt ggcacaatct cggcccgctg
     1201 cagcctctgc ctcttgggtt caagtgattc ttccacctca gcctcccagg tagctgggat
     1261 tacaggcacc caccaccacg cctggctaat ttttgtattt ttaatagaga cggggtttca
     1321 ccatgttggc caggctggtc tcgaactcct gacctcaagt gatccaccca cctcggcctc
     1381 ccaaagtgct aggattacag gcccgtgccc agccctaaag ttttaaactc taggggaatt
     1441 aacagtattt ctttacagaa tggatttgtt aaactagcac agtaaaagta aagactattc
     1501 tgtttctagg ctgttgaatc aaagtgattt tagcaattaa actttgtatt aatttaccac
     1561 caatatttct tcacaaagga acttttaaaa gattatctca gaaagtaaat ctgagaggta
     1621 agaagtaata atgagtaaat ggtaagtact tgagtaaatc taaagaaata ttgatagtaa
     1681 ggcaatccta agcaaaaaga acaaagctgg aggcatcacg ctacccagct tcaaactata
     1741 ctacaaggct acagtaacca aaacagcata gtactggcac aaaaacacac gtagactgat
     1801 ggaacagaat agagaattta gaaatgagac cacacaccta taattttttt gatcttcgat
     1861 gaacctgaca aaaacaagca atgggcaatg gattctctat tcaataaatc gtgctgggat
     1921 aactggccag ccatatggaa aagattgaaa atggacgcct tccttatgcc atatacaaaa
     1981 attaactcaa gatggattaa agacttaatg taaaacccaa aacagtaaaa atcctggaag
     2041 acaacccagg cagtaccatt caggacatag gcacaggcaa agatttcatg acgaagacgc
     2101 caaaaacaat tgcaacagaa gcaaaaattc acaaatggga tctaattaaa ctaaagagct
     2161 gcacagcaaa agaaactatc aagagagtaa acagacagct tacagaatgg gagaaaattg
     2221 ttgcaaacta tgcatctgag aaaggtctga aatccagcat ctatacgtaa tttaaacaaa
     2281 tttagaagaa aaaaccaccc cattaaaaag tgggcaaagg acatgaacag acacttttca
     2341 aaagaagaca tctgtggcca acaatcctat ggaaaaaagc ccagcatcac tgatcattag
     2401 agaaatgcaa atcgaaacaa caacgagata ccatctcaca ccagtccaaa tggctattat
     2461 aaaaatgtca gaaaataaca gatgctggtg aggttgtgga gaaaaagata tgcttataca
     2521 ctgttggtgg aaatgtaaat taaattagtt cagccattgt ggaagacagt gtggggataa
     2581 agacagagat accattcaac ccagcaatct cattactggg tatataccca aaggaataga
     2641 aatcattgtt ataaagacac atgcacgcgt atgttcgttg cagcactgcc catcagtgac
     2701 agactggatt aaaaaaatgt ggtacataca caccagggaa tactatacag ccataaaaag
     2761 gaacaagact gactgggcgt ggtggctcat gcctgtgatc ctagcacttt gcgaggccga
     2821 ggtgggtgga ttgcccgcgc tcaggaggtc aagaccagcc tgggcaacac ggtgaaaccc
     2881 catctctatt aaaatacaaa aaattagctg ggcatggtgg tgcgtgcctg tagtgccagc
     2941 tactcaggag gccgaggcag gagaattgct ggaacccagg aggtggaggt tgcagtgagc
     3001 tgagatcgcg ccattgcact cccgcctggg cgactccatc tctaaaaaat aaaaaataaa
     3061 atataaggaa caagatcata cctttgccag ggacatggat ggagctggac gctattatcc
     3121 ttagcaaact aacataggaa cagaaaacca gatactgcat gttttcactt ataagtggga
     3181 gctaaatgat gagaactcct ggatacaaag aagggaacaa cacacacaca cacacacaca
     3241 cacaccctct cacagactta gaatacgtgg caagaaaagc atataatttg acattaggag
     3301 cagaagaatt agtgtgctaa ggtccttgca ttgtccggga gaaggggaaa agtatcaaca
     3361 ttagacattg ataaagggtc tgcacctttt gatttcttaa ccactcaagg atagaaaagg
     3421 ggcataactt taaaatgaaa caggaaaatg gtgggctgat ttttaaattt aaaagaaccg
     3481 aatacagcag gacagatcca aagcacagag gagatggtgt atttaactcc atccacacca
     3541 atcattacat tacatgcaaa gggactgagg actccagtta aaatgacagt tttaggctgg
     3601 tttttaaaat acatatttgc tgttttattt ttagagacaa ggtctcgctc cgttgcccag
     3661 gctggagtgc agtggcatca taactcactg cagcctcgaa ctcctgggtt ccagtgagcc
     3721 tccacctcag cctccaaagt agctgtgatt acaggtgtgt gccaccttgc ctagctgagt
     3781 cccttgaatt gataaaaggt atatacaaaa atccctcagt aaacattagt taatagtgaa
     3841 atattagaag tgtctctttt aaaatcaaga acaagagtgc ctgctattac tacttgtatt
     3901 caacattgta ctgaaagtgt caacacagta aagcaaggaa aatgaaaaag catgaaaaaa
     3961 aggcatatgg aagaaacaaa actgtcattc tttaaaggtt agatgattgt atgtatggaa
     4021 atccaatatc atctataagc agattattag aattaagagt ttagcaaatt tgcgagctaa
     4081 aacatcaaca tttaagtttt tctaagtacc agcaacagaa ttaaaaaata gaattttagg
     4141 ctgagtgcag tggctcacaa ctgtaatccc agcactttgg gaggccaagg agggaggatt
     4201 gcttgagtcc taggagttca agaccagcct gggcaacata gtgtaagacc ctgtctctat
     4261 aaaaataaat tttaaaaaag aaaatggaat tttaaatata tataatattt aatcataact
     4321 aaaaatataa agtttctaga aataaatcta ataaaaatat gcaagacctt tttggagaaa
     4381 attacaaagc tttattgtaa gaagcagagt ttaacccttt tcccatttag aaaaaaaaag
     4441 tgcagctcac tgccagcgct catttaattt tacgtaaaca cactcttgga ggctgaagca
     4501 aatcttactg attttcaatg tgaaaataaa atataaaaac tattcttgga gttatttcta
     4561 aacagaacta acatcagaat catctgaatc atcagaatca tctctttcag aaaaatcgga
     4621 ctcatcgaat gaatcttcgg ctaactgttg agaacgatgt taacatcacg tgtaggaata
     4681 ctacattttc caggatttga cattttcagc gatcaagaat tactatgttt tgtaaatgga
     4741 aataccacta ctaaagacag aatgctataa a
//
