LOCUS       NM_006297               2052 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens X-ray repair cross complementing 1 (XRCC1), mRNA.
ACCESSION   NM_006297
VERSION     NM_006297.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Wu,H., Gao,W., Ma,Y., Zhong,X., Qian,J., Huang,D. and Ge,J.
  TITLE     TRIM25-mediated XRCC1 ubiquitination accelerates atherosclerosis by
            inducing macrophage M1 polarization and programmed death
  JOURNAL   Inflamm Res 73 (9), 1445-1458 (2024)
   PUBMED   38896288
  REMARK    GeneRIF: TRIM25-mediated XRCC1 ubiquitination accelerates
            atherosclerosis by inducing macrophage M1 polarization and
            programmed death.
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Almohdar,D., Gulkis,M., Ortiz,A., Tang,Q., Sobol,R.W. and
            Caglayan,M.
  TITLE     Impact of polbeta/XRCC1 Interaction Variants on the Efficiency of
            Nick Sealing by DNA Ligase IIIalpha in the Base Excision Repair
            Pathway
  JOURNAL   J Mol Biol 436 (4), 168410 (2024)
   PUBMED   38135179
  REMARK    GeneRIF: Impact of polbeta/XRCC1 Interaction Variants on the
            Efficiency of Nick Sealing by DNA Ligase IIIalpha in the Base
            Excision Repair Pathway.
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Zhang,W., Su,Y., Yue,G., Zhao,L., Li,H., Jia,M., Wang,Y., Liu,D.,
            Wang,H. and Gao,Y.
  TITLE     Correlations of SDF-1a and XRCC1 gene polymorphisms with the risk
            of renal cancer development and bioinformatics studies of
            SDF-1alpha and XRCC1 and the prognosis of renal cancer
  JOURNAL   Sci Rep 14 (1), 3367 (2024)
   PUBMED   38337001
  REMARK    GeneRIF: Correlations of SDF-1a and XRCC1 gene polymorphisms with
            the risk of renal cancer development and bioinformatics studies of
            SDF-1alpha and XRCC1 and the prognosis of renal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Wang,G., Li,Y., Pan,R., Yin,X., Jia,C., She,Y., Huang,L., Yang,G.,
            Chi,H. and Tian,G.
  TITLE     XRCC1: a potential prognostic and immunological biomarker in LGG
            based on systematic pan-cancer analysis
  JOURNAL   Aging (Albany NY) 16 (1), 872-910 (2024)
   PUBMED   38217545
  REMARK    GeneRIF: XRCC1: a potential prognostic and immunological biomarker
            in LGG based on systematic pan-cancer analysis.
REFERENCE   5  (bases 1 to 2052)
  AUTHORS   Ghorab,R.A., Fouad,S.H., Elsaadawy,Y., Hamdy,M. and Taha,S.I.
  TITLE     Association of XRCC1 p. Arg194Trp gene polymorphism with the risk
            of hepatocellular carcinoma in HCV Egyptian population: A pilot
            case-control study
  JOURNAL   Int J Immunopathol Pharmacol 38, 3946320241265263 (2024)
   PUBMED   38898405
  REMARK    GeneRIF: Association of XRCC1 p. Arg194Trp gene polymorphism with
            the risk of hepatocellular carcinoma in HCV Egyptian population: A
            pilot case-control study.
REFERENCE   6  (bases 1 to 2052)
  AUTHORS   Wei,Q., Xu,X., Cheng,L., Legerski,R.J. and Ali-Osman,F.
  TITLE     Simultaneous amplification of four DNA repair genes and beta-actin
            in human lymphocytes by multiplex reverse transcriptase-PCR
  JOURNAL   Cancer Res 55 (21), 5025-5029 (1995)
   PUBMED   7585546
REFERENCE   7  (bases 1 to 2052)
  AUTHORS   Lamerdin,J.E., Montgomery,M.A., Stilwagen,S.A., Scheidecker,L.K.,
            Tebbs,R.S., Brookman,K.W., Thompson,L.H. and Carrano,A.V.
  TITLE     Genomic sequence comparison of the human and mouse XRCC1 DNA repair
            gene regions
  JOURNAL   Genomics 25 (2), 547-554 (1995)
   PUBMED   7789989
REFERENCE   8  (bases 1 to 2052)
  AUTHORS   Gyapay,G., Morissette,J., Vignal,A., Dib,C., Fizames,C.,
            Millasseau,P., Marc,S., Bernardi,G., Lathrop,M. and Weissenbach,J.
  TITLE     The 1993-94 Genethon human genetic linkage map
  JOURNAL   Nat Genet 7 (2 Spec No), 246-339 (1994)
   PUBMED   7545953
REFERENCE   9  (bases 1 to 2052)
  AUTHORS   Thompson,L.H., Brookman,K.W., Jones,N.J., Allen,S.A. and
            Carrano,A.V.
  TITLE     Molecular cloning of the human XRCC1 gene, which corrects defective
            DNA strand break repair and sister chromatid exchange
  JOURNAL   Mol Cell Biol 10 (12), 6160-6171 (1990)
   PUBMED   2247054
REFERENCE   10 (bases 1 to 2052)
  AUTHORS   Thompson,L.H., Bachinski,L.L., Stallings,R.L., Dolf,G., Weber,C.A.,
            Westerveld,A. and Siciliano,M.J.
  TITLE     Complementation of repair gene mutations on the hemizygous
            chromosome 9 in CHO: a third repair gene on human chromosome 19
  JOURNAL   Genomics 5 (4), 670-679 (1989)
   PUBMED   2591959
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP349667.1, AB208781.1,
            AK315332.1 and AC018758.2.
            
            On Nov 21, 2019 this sequence version replaced NM_006297.2.
            
            Summary: The protein encoded by this gene is involved in the
            efficient repair of DNA single-strand breaks formed by exposure to
            ionizing radiation and alkylating agents. This protein interacts
            with DNA ligase III, polymerase beta and poly (ADP-ribose)
            polymerase to participate in the base excision repair pathway. It
            may play a role in DNA processing during meiogenesis and
            recombination in germ cells. A rare microsatellite polymorphism in
            this gene is associated with cancer in patients of varying
            radiosensitivity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023593.2, AB208781.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262887.10/ ENSP00000262887.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BP349667.1         52-77
            27-1964             AB208781.1         1-1938
            1965-1971           AK315332.1         2005-2011
            1972-2051           AB208781.1         1946-2025
            2052-2052           AC018758.2         175224-175224       c
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2052
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /note="X-ray repair cross complementing 1"
                     /db_xref="GeneID:7515"
                     /db_xref="HGNC:HGNC:12828"
                     /db_xref="MIM:194360"
     exon            1..120
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1971
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /note="X-ray repair cross-complementing protein 1; X-ray
                     repair complementing defective repair in Chinese hamster
                     cells 1"
                     /codon_start=1
                     /product="DNA repair protein XRCC1"
                     /protein_id="NP_006288.2"
                     /db_xref="CCDS:CCDS12624.1"
                     /db_xref="GeneID:7515"
                     /db_xref="HGNC:HGNC:12828"
                     /db_xref="MIM:194360"
                     /translation="MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTIS
                     VVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESRSG
                     SNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPFGLSFVRFHSPPDKDEAEA
                     PSQKVTVTKLGQFRVKEEDESANSLRPGALFFSRINKTSPVTASDPAGPSYAAATLQA
                     SSAASSASPVSRAIGSTSKPQESPKGKRKLDLNQEEKKTPSKPPAQLSPSVPKRPKLP
                     APTRTPATAPVPARAQGAVTGKPRGEGTEPRRPRAGPEELGKILQGVVVVLSGFQNPF
                     RSELRDKALELGAKYRPDWTRDSTHLICAFANTPKYSQVLGLGGRIVRKEWVLDCHRM
                     RRRLPSQRYLMAGPGSSSEEDEASHSGGSGDEAPKLPQKQPQTKTKPTQAAGPSSPQK
                     PPTPEETKAASPVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRRVAEQKEHRLPPGQE
                     ENGEDPYAGSTDENTDSEEHQEPPDLPVPELPDFFQGKHFFLYGEFPGDERRKLIRYV
                     TAFNGELEDYMSDRVQFVITAQEWDPSFEEALMDNPSLAFVRPRWIYSCNEKQKLLPH
                     QLYGVVPQA"
     exon            121..213
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            214..324
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            325..483
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            484..558
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            559..670
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            671..780
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            781..892
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1151
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1268
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1362
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1495
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1550
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1690
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1781
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1857
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2052
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2031..2036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /note="hexamer: AATAAA"
     polyA_site      2052
                     /gene="XRCC1"
                     /gene_synonym="RCC; SCAR26"
                     /note="major polyA site"
ORIGIN      
        1 actctccctg cccctcggac cccatactct acctcatcct tctggccagg cgaagcccac
       61 gacgttgaca tgccggagat ccgcctccgc catgtcgtgt cctgcagcag ccaggactcg
      121 actcactgtg cagaaaatct tctcaaggca gacacttacc gaaaatggcg ggcagccaag
      181 gcaggcgaga agaccatctc tgtggtccta cagttggaga aggaggagca gatacacagt
      241 gtggacattg ggaatgatgg ctcagctttc gtggaggtgc tggtgggcag ttcagctgga
      301 ggcgctgggg agcaagacta tgaggtcctt ctggtcacct catctttcat gtccccttcc
      361 gagagccgca gtggctcaaa ccccaaccgc gttcgcatgt ttgggcctga caagctggtc
      421 cgggcagccg ccgagaagcg ctgggaccgg gtcaaaattg tttgcagcca gccctacagc
      481 aaggactccc cctttggctt gagttttgta cggtttcata gccccccaga caaagatgag
      541 gcagaggccc cgtcccagaa ggtgacagtg accaagcttg gccagttccg tgtgaaggag
      601 gaggatgaga gcgccaactc tctgaggccg ggggctctct tcttcagccg gatcaacaag
      661 acatccccag tcacagccag cgacccagca ggacctagct atgcagctgc taccctccag
      721 gcttctagtg ctgcctcctc agcctctcca gtctccaggg ccataggcag cacctccaag
      781 ccccaggagt ctcccaaagg gaagaggaag ttggatttga accaagaaga aaagaagacc
      841 cccagcaaac caccagccca gctgtcgcca tctgttccca agagacctaa attgccagct
      901 ccaactcgta ccccagccac agccccagtc cctgcccgag cacagggggc agtgacaggc
      961 aaaccccgag gagaaggcac cgagcccaga cgaccccgag ctggcccaga ggagctgggg
     1021 aagatccttc agggtgtggt agtggtgctg agtggcttcc agaacccctt ccgctccgag
     1081 ctgcgagata aggccctaga gcttggggcc aagtatcggc cagactggac ccgggacagc
     1141 acgcacctca tctgtgcctt tgccaacacc cccaagtaca gccaggtcct aggcctggga
     1201 ggccgcatcg tgcgtaagga gtgggtgctg gactgtcacc gcatgcgtcg gcggctgccc
     1261 tcccagaggt acctcatggc agggccaggt tccagcagtg aggaggatga ggcctctcac
     1321 agcggtggca gcggagatga agcccccaag cttcctcaga agcaacccca gaccaaaacc
     1381 aagcccactc aggcagctgg acccagctca ccccagaagc ccccaacccc tgaagagacc
     1441 aaagcagcct caccagtgct ccaggaagat atagacattg agggggtaca gtcagaagga
     1501 caggacaatg gggcggaaga ttctggggac acagaggatg agctgaggag ggtggcagag
     1561 cagaaggaac acagactgcc ccctggccag gaggagaatg gggaagaccc gtatgcaggc
     1621 tccacggatg agaacacgga cagtgaggaa caccaggagc ctcctgatct gccagtccct
     1681 gagctcccag atttcttcca gggcaagcac ttctttcttt acggggagtt ccctggggac
     1741 gagcggcgga aactcatccg atacgtcaca gccttcaatg gggagctcga ggactatatg
     1801 agtgaccggg ttcagtttgt gatcacagca caggaatggg atcccagctt tgaggaggcc
     1861 ctgatggaca acccctccct ggcattcgtt cgtccccgat ggatctacag ttgcaatgag
     1921 aagcagaagt tacttcctca ccagctctat ggggtggtgc cgcaagcctg aagtatgtgc
     1981 tatacacaca cacacacaca cacacacaca cacacacaca cgatgcattt aataaagatg
     2041 agttggttct ca
//
