LOCUS       NM_004736               8484 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens xenotropic and polytropic retrovirus receptor 1
            (XPR1), transcript variant 1, mRNA.
ACCESSION   NM_004736
VERSION     NM_004736.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8484)
  AUTHORS   Yan,R., Chen,H., Liu,C., Zhao,J., Wu,D., Jiang,J., Gong,J. and
            Jiang,D.
  TITLE     Human XPR1 structures reveal phosphate export mechanism
  JOURNAL   Nature 633 (8031), 960-967 (2024)
   PUBMED   39169184
  REMARK    GeneRIF: Human XPR1 structures reveal phosphate export mechanism.
REFERENCE   2  (bases 1 to 8484)
  AUTHORS   Hu,Y., Bai,J., Zhou,D., Zhang,L., Chen,X., Chen,L., Liu,Y.,
            Zhang,B., Li,H. and Yin,C.
  TITLE     The miR-4732-5p/XPR1 axis suppresses the invasion, metastasis, and
            epithelial-mesenchymal transition of lung adenocarcinoma via the
            PI3K/Akt/GSK3beta/Snail pathway
  JOURNAL   Mol Omics 18 (5), 417-429 (2022)
   PUBMED   35388387
  REMARK    GeneRIF: The miR-4732-5p/XPR1 axis suppresses the invasion,
            metastasis, and epithelial-mesenchymal transition of lung
            adenocarcinoma via the PI3K/Akt/GSK3beta/Snail pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8484)
  AUTHORS   Bondeson,D.P., Paolella,B.R., Asfaw,A., Rothberg,M.V.,
            Skipper,T.A., Langan,C., Mesa,G., Gonzalez,A., Surface,L.E.,
            Ito,K., Kazachkova,M., Colgan,W.N., Warren,A., Dempster,J.M.,
            Krill-Burger,J.M., Ericsson,M., Tang,A.A., Fung,I., Chambers,E.S.,
            Abdusamad,M., Dumont,N., Doench,J.G., Piccioni,F., Root,D.E.,
            Boehm,J., Hahn,W.C., Mannstadt,M., McFarland,J.M., Vazquez,F. and
            Golub,T.R.
  TITLE     Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a
            therapeutic vulnerability in ovarian cancer
  JOURNAL   Nat Cancer 3 (6), 681-695 (2022)
   PUBMED   35437317
  REMARK    GeneRIF: Phosphate dysregulation via the XPR1-KIDINS220 protein
            complex is a therapeutic vulnerability in ovarian cancer.
REFERENCE   4  (bases 1 to 8484)
  AUTHORS   Zou,H. and Xiang,C.
  TITLE     Clinical implication of xenotropic and polytropic retrovirus
            receptor 1 in papillary thyroid carcinoma
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 50 (1), 90-96 (2021)
   PUBMED   34117845
  REMARK    GeneRIF: Clinical implication of xenotropic and polytropic
            retrovirus receptor 1 in papillary thyroid carcinoma.
REFERENCE   5  (bases 1 to 8484)
  AUTHORS   Vaughan,A.E., Mendoza,R., Aranda,R., Battini,J.L. and Miller,A.D.
  TITLE     Xpr1 is an atypical G-protein-coupled receptor that mediates
            xenotropic and polytropic murine retrovirus neurotoxicity
  JOURNAL   J Virol 86 (3), 1661-1669 (2012)
   PUBMED   22090134
REFERENCE   6  (bases 1 to 8484)
  AUTHORS   Van Hoeven,N.S. and Miller,A.D.
  TITLE     Use of different but overlapping determinants in a retrovirus
            receptor accounts for non-reciprocal interference between
            xenotropic and polytropic murine leukemia viruses
  JOURNAL   Retrovirology 2, 76 (2005)
   PUBMED   16354307
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8484)
  AUTHORS   Battini,J.L., Rasko,J.E. and Miller,A.D.
  TITLE     A human cell-surface receptor for xenotropic and polytropic murine
            leukemia viruses: possible role in G protein-coupled signal
            transduction
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1385-1390 (1999)
   PUBMED   9990033
REFERENCE   8  (bases 1 to 8484)
  AUTHORS   Tailor,C.S., Nouri,A., Lee,C.G., Kozak,C. and Kabat,D.
  TITLE     Cloning and characterization of a cell surface receptor for
            xenotropic and polytropic murine leukemia viruses
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 927-932 (1999)
   PUBMED   9927670
REFERENCE   9  (bases 1 to 8484)
  AUTHORS   Yang,Y.L., Guo,L., Xu,S., Holland,C.A., Kitamura,T., Hunter,K. and
            Cunningham,J.M.
  TITLE     Receptors for polytropic and xenotropic mouse leukaemia viruses
            encoded by a single gene at Rmc1
  JOURNAL   Nat Genet 21 (2), 216-219 (1999)
   PUBMED   9988277
REFERENCE   10 (bases 1 to 8484)
  AUTHORS   Ramos,E.M., Oliveira,J., Sobrido,M.J. and Coppola,G.
  TITLE     Primary Familial Brain Calcification
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301594
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB461474.1, AF115389.1,
            BC041142.1, AL162431.17 and AA425354.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004736.3.
            
            Summary: The protein encoded by this gene is a receptor for the
            xenotropic and polytropic classes of murine leukemia viruses. The
            encoded protein is involved in phosphate homeostasis by mediating
            phosphate export from the cell. Defects in this gene have been
            associated with idiopathic basal ganglia calcification-6. [provided
            by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.125822.1,
                                           SRR1660809.221971.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367590.9/ ENSP00000356562.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               DB461474.1         13-192
            181-1802            AF115389.1         1-1622
            1803-2340           BC041142.1         1598-2135
            2341-8072           AL162431.17        26242-31973
            8073-8484           AA425354.1         5-416               c
FEATURES             Location/Qualifiers
     source          1..8484
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..8484
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="xenotropic and polytropic retrovirus receptor 1"
                     /db_xref="GeneID:9213"
                     /db_xref="HGNC:HGNC:12827"
                     /db_xref="MIM:605237"
     exon            1..249
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2271
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     X-receptor; protein SYG1 homolog; solute carrier family 53
                     (phosphate exporter), member 1; xenotropic and polytropic
                     murine leukemia virus receptor X3; phosphate exporter
                     SLC53A1; solute carrier family 53 member 1"
                     /codon_start=1
                     /product="solute carrier family 53 member 1 isoform 1"
                     /protein_id="NP_004727.2"
                     /db_xref="CCDS:CCDS1340.1"
                     /db_xref="GeneID:9213"
                     /db_xref="HGNC:HGNC:12827"
                     /db_xref="MIM:605237"
                     /translation="MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDE
                     DTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKEST
                     GVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKIL
                     KKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRL
                     RVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGF
                     LLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLAC
                     FFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFA
                     DFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEESGICHKYTYGVRAI
                     VQCIPAWLRFIQCLRRYRDTKRAFPHLVNAGKYSTTFFMVTFAALYSTHKERGHSDTM
                     VFFYLWIVFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIED
                     VILRFAWTIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFR
                     AVRDISVAPLNADDQTLLEQMMDQDDGVRNRQKNRSWKYNQSISLRRPRLASQSKARD
                     TKVLIEDTDDEANT"
     exon            250..301
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            302..403
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            404..627
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            628..777
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..861
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            862..943
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1134
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1314
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1486
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1681
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1848
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1988
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2210
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..8484
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4308..4313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="hexamer: AATAAA"
     polyA_site      4331
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="major polyA site"
     regulatory      4524..4529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="hexamer: AATAAA"
     polyA_site      4549
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="major polyA site"
     regulatory      8391..8396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="hexamer: AATAAG"
     polyA_site      8411
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="major polyA site"
     regulatory      8430..8435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="hexamer: ATTACA"
     polyA_site      8456
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="major polyA site"
     polyA_site      8484
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
ORIGIN      
        1 atggagagga ggaggaagat ggcgggcggg ctgctctgaa gagacctcgg cggcggcgga
       61 ggaggagaga agcgcagcgc cgcgccgcgc cggggcccat gtggggagga gtcggagtcg
      121 ctgttgccgc cgccgcctgt agctgctgga cccgagtggg agtgaggggg aaacggcagg
      181 atgaagttcg ccgagcacct ctccgcgcac atcactcccg agtggaggaa gcaatacatc
      241 cagtatgagg ctttcaagga tatgctgtat tcagctcagg accaggcacc ttctgtggaa
      301 gttacagatg aggacacagt aaagaggtat tttgccaagt ttgaagagaa gtttttccaa
      361 acctgtgaaa aagaacttgc caaaatcaac acattttatt cagagaagct cgcagaggct
      421 cagcgcaggt ttgctacact tcagaatgag cttcagtcat cactggatgc acagaaagaa
      481 agcactggtg ttactacgct gcgacaacgc agaaagccag tcttccactt gtcccatgag
      541 gaacgtgtcc aacatagaaa tattaaagac cttaaactgg ccttcagtga gttctacctc
      601 agtctaatcc tgctgcagaa ctatcagaat ctgaatttta cagggtttcg aaaaatcctg
      661 aaaaagcatg acaagatcct ggaaacatct cgtggagcag attggcgagt ggctcacgta
      721 gaggtggccc cattttatac atgcaagaaa atcaaccagc ttatctctga aactgaggct
      781 gtagtgacca atgaacttga agatggtgac agacaaaagg ctatgaagcg tttacgtgtc
      841 ccccctttgg gagctgctca gcctgcacca gcatggacta cttttagagt tggcctattt
      901 tgtggaatat tcattgtact gaatattacc cttgtgcttg ccgctgtatt taaacttgaa
      961 acagatagaa gtatatggcc cttgataaga atctatcggg gtggctttct tctgattgaa
     1021 ttcctttttc tactgggcat caacacgtat ggttggagac aggctggagt aaaccatgta
     1081 ctcatctttg aacttaatcc gagaagcaat ttgtctcatc aacatctctt tgagattgct
     1141 ggattcctcg ggatattgtg gtgcctgagc cttctggcat gcttctttgc tccaattagt
     1201 gtcatcccca catatgtgta tccacttgcc ctttatggat ttatggtttt cttccttatc
     1261 aaccccacca aaactttcta ctataaatcc cggttttggc tgcttaaact gctgtttcga
     1321 gtatttacag cccccttcca taaggtaggc tttgctgatt tctggctggc ggatcagctg
     1381 aacagcctgt cagtgatact gatggacctg gaatatatga tctgcttcta cagtttggag
     1441 ctcaaatggg atgaaagtaa gggcctgttg ccaaataatt cagaagaatc aggaatttgc
     1501 cacaaatata catatggtgt gcgggccatt gttcagtgca ttcctgcttg gcttcgcttc
     1561 atccagtgcc tgcgccgata tcgagacaca aaaagggcct ttcctcattt agttaatgct
     1621 ggcaaatact ccacaacttt cttcatggtg acgtttgcag ccctttacag cactcacaaa
     1681 gaacgaggtc actcggacac tatggtgttc ttttacctgt ggattgtctt ttatatcatc
     1741 agttcctgct ataccctcat ctgggatctc aagatggact ggggtctctt cgataagaat
     1801 gctggagaga acactttcct ccgggaagag attgtatacc cccaaaaagc ctactactac
     1861 tgtgccataa tagaggatgt gattctgcgc tttgcttgga ctatccaaat ctcgattacc
     1921 tctacaactt tgttgcctca ttctggggac atcattgcta ctgtctttgc cccacttgag
     1981 gttttccggc gatttgtgtg gaacttcttc cgcctggaga atgaacatct gaataactgt
     2041 ggtgaattcc gtgctgtgcg ggacatctct gtggcccccc tgaacgcaga tgatcagact
     2101 ctcctagaac agatgatgga ccaggatgat ggggtacgaa accgccagaa gaatcggtca
     2161 tggaagtaca accagagcat atccctgcgc cggcctcgcc tcgcttctca atccaaggct
     2221 cgtgacacta aggtattgat agaagacaca gatgatgaag ctaacacttg aattttctga
     2281 agtctagctt aacatctttg gttttcctac tctacaatcc tttcctcgac caacgcaacc
     2341 tctagtacct ttccagccga aaacaggaga aaacacataa cacattttcc gagctcttcc
     2401 ggatcggatc ctatggactc caaacaagct cactgtgttt cttttctttt cttctggttt
     2461 aattttaatt ttctattttc aaaacaaata tttacttcat ttgccaatca gaggatgttt
     2521 taagaaacaa aacatagtat cttatggatt gtttacaatc acaaggacat agatacctat
     2581 caggatgaag aacaggcatt gcaaggaccc tctgatggga cggtactgag atatctcggc
     2641 ttccgctcag cccggttttg actggttgaa accggacatt ggtttttaaa ttttttgtca
     2701 gtttatgtgg agaatttttt tctttccttc atacccagcg caaaggcact ggccgcactt
     2761 gcaggaaaag tgcaacttaa agcagtacct tcattcatga agctactttt taatttgatg
     2821 taacttttct tattttggga agggttgctg ggtgggtggg aaatatgatg tatttgttac
     2881 acatagtttt ctcattattt atgaaactta accatacaga atgatataac tcctgtgcaa
     2941 tgaaggtgat aacagtaaaa gaaggcaggg gaaacttacg ttggatgaca tttatgaggg
     3001 tcagtcccac atacctcttt caggagacaa cttgcaccag tttgaccttt tcttttcttt
     3061 gtttttattt taagccaaag tttcattgct aacttcttaa gttgctgctg ctttagagtc
     3121 ctgagcatat ctctcataac aaggaatccc acacttcaca ccaccggctg aatttcatgg
     3181 aagaggttct gataattttt ttaacttttt aaggaacaga tgtggaatac actggcccat
     3241 atttcaacct taacagctga agctatgcct tattatgcat ccacatgtat ggtccctgta
     3301 gcgtgacctt tactagctct gaatcagaag acagagctat ttcagaggct ctgtgtgccc
     3361 tcactagata gtttttcttc tgggttcaac cactttagcc agaatttgat caaattaaaa
     3421 gtctgtcatg gggaaactat atttttgagc acatggaaca aattatactt cctcattcat
     3481 attatgttga tacaaaagac cttggcagcc atttctccca gcagttttaa aggatgaaca
     3541 ttggatttca tgccatccca tagaaaacct gttttaaaat tttagggatc tttacttggt
     3601 catacatgaa aagtacactg cttagaaatt atagactatt atgatctgtc cacagtgccc
     3661 attgtcactt ctttgtctca tttcttccct ttgttcctta gtcatccaaa taagcctgaa
     3721 aaccataaga gatattactt tattgaatat ggttggcatt aaatttagca tttcattatc
     3781 taacaaaatt aatataaatt ccaggacatg gtaaaatgtg ttttaataac ccccagaccc
     3841 aaatgaaaat ttcaaagtca ataccagcag attcatgaaa gtaaatttag tcctataatt
     3901 ttcagcttaa ttataaacaa aggaacaaat aagtggaagg gcagctatta ccattcgctt
     3961 agtcaaaaca ttcggttact gccctttaat acactcctat catcagcact tccaccatgt
     4021 attacaagtc ttgacccatc cctgtcgtaa ctccagtaaa agttactgtt actagaaaat
     4081 ttttatcaat taactgacaa atagtttctt tttaaagtag tttcttccat ctttattctg
     4141 actagcttcc aaaatgtgtt ccctttttga atcgaggttt ttttgttttg ttttgttttc
     4201 tgaaaaaatc atacaacttt gtgcttctat tgcttttttg tgttttgtta agcatgtccc
     4261 ttggcccaaa tggaagagga aatgtttaat taatgctttt tagtttaaat aaattgaatc
     4321 atttataata atcagtgtta acaatttagt gacccttggt aggttaaagg ttgcattatt
     4381 tatacttgag atttttttcc cctaactatt ctgttttttg tactttaaaa ctatggggga
     4441 aatatcactg gtctgtcaag aaacagcagt aattattact gagttaaatt gaaaagtcca
     4501 gtggaccagg catttcttat ataaataaaa ttggtggtac taatgtgtat ccagagacat
     4561 ttgaattatt aactttattc tttattagtg aatctctatg atggcacaca taaaatctta
     4621 cagttgactt ctgctgtttg aattccccag tgtttttaca ttaatgtatc ctatggccag
     4681 tttagtcttt cttcaactgt tacagttcta ggccctaatc ggtcttattc tttcacatat
     4741 gatgcaatga tagatgtaat ccttttctga agtgtttgtc ggattggcat agtctattca
     4801 aaaataaggc ttatgtaact ttcagcttgc tatgtgacag aagtttaaat gtgtatttaa
     4861 gtacacagct ttatgttcct cttaaagctg taaagagaaa agaggacttt tcctcatcaa
     4921 gagagcttgg gagacaaagc atacatttaa tttttttctt tcaaaaaagg caatgtgcac
     4981 tttcctctcc taaattttat atgccctagc agttgcgaat gttgtgtcca ccttacaatt
     5041 tgattggagg ctcccataca ctgaaactct caatagaatt cttaaaaatg aacatcagct
     5101 gggcgcagtg gctcacgtct gtaatcccag cactttggga ggccaaggtg ggcagatcac
     5161 gagctcagga gttcgagacc agcctgacca acatggtgaa accccgtctc tactaaaaat
     5221 acaaaaatta gctgggcgtg gtggcgcatg cctgtaatcc cagctactca ggagactgag
     5281 gcaggagaat tgcttaaacc tgggaagcag aggttgcagt gagactagat catgccactg
     5341 cactccactg ccactgcctg ggcaacagag caagactcca tctcaaaaac aaacaaaaaa
     5401 aatcacagac tcattttaaa ggagcagcaa cctaaccaaa tacaaacttc atttgatttt
     5461 aggtttagaa attctagttt tattttggag aatcactcag tttttaatat caattaaaat
     5521 agtcctcaaa ggaatgaaga ggaagtctaa ataaatgaat aaaactcatt tttcatttta
     5581 tggtagtata gaaagcattg atgtgtgtag agaaattaaa agacaagagt ggtttactgt
     5641 ctatgcacaa atgagtgcct atatttaagg ctgcctatac cattacagtg gcgtaattgg
     5701 tgatttcata gcatacagag aaacaatgaa atcaaagatt aaatcattag gttatgatgg
     5761 tcatttgtaa gattggaaag tagtcaaaaa cccatgtgca actttttttc agcactctac
     5821 cattaggctc cttaggcaag ctgcttaact tccgtcagaa gcaaaggtgt gggagaacac
     5881 cattcacctc agtagtaact tataaaaacc gtttaaagaa ggaaaatggg ccccagcccc
     5941 taggatccct gacttcctga tattctaaac atgagagttc tgtgacttta actgagctct
     6001 ttaccagaag taacgtgttg atgtatatta tctttccacc atgctttgac caaagtacat
     6061 tcacagtaac tagagaaagc agatcatcca tttctggata ggtgaactac ggcaaggtaa
     6121 gaacagaaaa aagtaaagta gtattgagtc atgcaggtat cagattaaca gacattcatt
     6181 gaagataagt gaaataactt tggagatagc agagaagagc aagaagatgt tggacgttgg
     6241 cagtaagccg cagcaaggca gttaggaaag tacgtgagcc tgatgacgcg aaggtgatgc
     6301 ctccatctgt ccgcttagtg gttattaaat tgctgggaaa gacctgcctt tattttccta
     6361 tcatcttttc cccattactt tgcattattc aggaaataat tatttattcc caaatgcagt
     6421 tttctaagca gtgaccacaa aaatttctta ttctaaggaa aataattaag aaaataaccc
     6481 tatctgtggc attgttttaa aatgtgggat acaaatctgg taagcagatt tcaggtcatt
     6541 attgttttct tttaatggtt tacatgaaat tttcctctca aaaaacaagt acctcttact
     6601 gtataacatt tgagttttta aaattgagat agcttctgag agaaaaaaag aaagttgaat
     6661 ttgtagctct ctcaactaca aaatcaccac acttttctca aatctaatag gaattcagtg
     6721 tcattacaga tacggtctct agtgaccagg tgaagacaat tgaagctttg gtagaacttc
     6781 tgcaaaagtt aggtaaagaa gaataaatcc aatttatcag ctttgttcat attctttttc
     6841 tgagtgatct aaatttttct tgcttgtgat cattagctaa gacaaggagt gttaaaggtt
     6901 ttctaaatgc aaacacatac gtttctgcat ttcagaagtc agtcttgata gtaaatccta
     6961 caaactctca actttctgca ttgtatttta agtctataca atgttagagc acatggtaat
     7021 gtgggacaga gttgattata tgatagcatg agaaatttgc actggttggt gttacaaacc
     7081 aatgatctaa ccagcatact ctccaaatat gaaaaagtaa aaacatctca ttaggtttgg
     7141 aagagcctaa ggtagtccat acaggaagtt tgcctgagaa cagagaggag cctgttgatt
     7201 ggcatggctc atgatgcctt tcttgtatga attatcaaaa ctgatactga gttgccccta
     7261 gaaaacagcc ttccagaata tgtttgctta tttatggtgg aagaggaagt gagaacaaga
     7321 tgagagtttc ccttaaagtg aggagaatca ttatacaact ttgcaactga agtatgtttc
     7381 cttgtagcaa acctttggtt tattttatcg tcaaatcaaa gccaccctca gttttttgta
     7441 tggtgccatc aacctaagga ggacaatcaa ataacctatt gtttgccttg gattcagtat
     7501 atctactaag tacacagtct cgtatacctt caaaccagtt acttgactaa acttccacca
     7561 tattacctta gttcttccta tgccctttcc tctgtgccac cacaaatcag agggaaagac
     7621 tgcagtactt ctagaaagtt gtggacttct aagaaagagc caggcttcca tctcactatc
     7681 ccttgatcat tatctctgaa gtccctacct gcacttccct gattgccctg tagcaacacc
     7741 agcatggtgg gaattggagg gaaagattgt ggaaaatccc taaagggtca ttgttcatga
     7801 cgttattttg aattgtaaaa ttgtgagcca ctcacatttc aattacaaaa agaacagaac
     7861 tcttaatcac gttgtgaaga ttaatttctt gccattttct ggattagcac agaagcttgt
     7921 atcaatgaag agtatttagg aggggaatag ggggaaaatt gtatttttct gttcaaactc
     7981 tctccttcta tttgtgtttc cttcacccct ctccctccac cacactgtgt tggtcaaatg
     8041 atactattct atgaaaccct gagctatagt tgtcaaaagt aactatggat tgtgattagt
     8101 cctctgtggg tgcttccttc cctctttttt ctccctcact ctctttctca gtctccactc
     8161 tggtaaatgg aaaaggtgat gtcgaagaat tgatgcttgc ttggactcat gttgtatctg
     8221 tgactatgct attagctgtc tcctttttcc ttcctatatg ggtagaattc ttatgactta
     8281 tgaagttccc ttcttgataa gtaggttaaa tgcacaatgt ggtactgttt tatagtttct
     8341 agatggttgt ataaagcaaa aagttaatgt ggttatgtgt ttttaaagaa aataagtgat
     8401 tggtcactaa actctgtcct tttttcatta ttacaatttc tctctgtttt ccaacagttt
     8461 gctgactcct ttgtcactgg tgaa
//
