LOCUS       NM_001135669            8289 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens xenotropic and polytropic retrovirus receptor 1
            (XPR1), transcript variant 2, mRNA.
ACCESSION   NM_001135669
VERSION     NM_001135669.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8289)
  AUTHORS   Yan,R., Chen,H., Liu,C., Zhao,J., Wu,D., Jiang,J., Gong,J. and
            Jiang,D.
  TITLE     Human XPR1 structures reveal phosphate export mechanism
  JOURNAL   Nature 633 (8031), 960-967 (2024)
   PUBMED   39169184
  REMARK    GeneRIF: Human XPR1 structures reveal phosphate export mechanism.
REFERENCE   2  (bases 1 to 8289)
  AUTHORS   Hu,Y., Bai,J., Zhou,D., Zhang,L., Chen,X., Chen,L., Liu,Y.,
            Zhang,B., Li,H. and Yin,C.
  TITLE     The miR-4732-5p/XPR1 axis suppresses the invasion, metastasis, and
            epithelial-mesenchymal transition of lung adenocarcinoma via the
            PI3K/Akt/GSK3beta/Snail pathway
  JOURNAL   Mol Omics 18 (5), 417-429 (2022)
   PUBMED   35388387
  REMARK    GeneRIF: The miR-4732-5p/XPR1 axis suppresses the invasion,
            metastasis, and epithelial-mesenchymal transition of lung
            adenocarcinoma via the PI3K/Akt/GSK3beta/Snail pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8289)
  AUTHORS   Bondeson,D.P., Paolella,B.R., Asfaw,A., Rothberg,M.V.,
            Skipper,T.A., Langan,C., Mesa,G., Gonzalez,A., Surface,L.E.,
            Ito,K., Kazachkova,M., Colgan,W.N., Warren,A., Dempster,J.M.,
            Krill-Burger,J.M., Ericsson,M., Tang,A.A., Fung,I., Chambers,E.S.,
            Abdusamad,M., Dumont,N., Doench,J.G., Piccioni,F., Root,D.E.,
            Boehm,J., Hahn,W.C., Mannstadt,M., McFarland,J.M., Vazquez,F. and
            Golub,T.R.
  TITLE     Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a
            therapeutic vulnerability in ovarian cancer
  JOURNAL   Nat Cancer 3 (6), 681-695 (2022)
   PUBMED   35437317
  REMARK    GeneRIF: Phosphate dysregulation via the XPR1-KIDINS220 protein
            complex is a therapeutic vulnerability in ovarian cancer.
REFERENCE   4  (bases 1 to 8289)
  AUTHORS   Zou,H. and Xiang,C.
  TITLE     Clinical implication of xenotropic and polytropic retrovirus
            receptor 1 in papillary thyroid carcinoma
  JOURNAL   Zhejiang Da Xue Xue Bao Yi Xue Ban 50 (1), 90-96 (2021)
   PUBMED   34117845
  REMARK    GeneRIF: Clinical implication of xenotropic and polytropic
            retrovirus receptor 1 in papillary thyroid carcinoma.
REFERENCE   5  (bases 1 to 8289)
  AUTHORS   Vaughan,A.E., Mendoza,R., Aranda,R., Battini,J.L. and Miller,A.D.
  TITLE     Xpr1 is an atypical G-protein-coupled receptor that mediates
            xenotropic and polytropic murine retrovirus neurotoxicity
  JOURNAL   J Virol 86 (3), 1661-1669 (2012)
   PUBMED   22090134
REFERENCE   6  (bases 1 to 8289)
  AUTHORS   Van Hoeven,N.S. and Miller,A.D.
  TITLE     Use of different but overlapping determinants in a retrovirus
            receptor accounts for non-reciprocal interference between
            xenotropic and polytropic murine leukemia viruses
  JOURNAL   Retrovirology 2, 76 (2005)
   PUBMED   16354307
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8289)
  AUTHORS   Battini,J.L., Rasko,J.E. and Miller,A.D.
  TITLE     A human cell-surface receptor for xenotropic and polytropic murine
            leukemia viruses: possible role in G protein-coupled signal
            transduction
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1385-1390 (1999)
   PUBMED   9990033
REFERENCE   8  (bases 1 to 8289)
  AUTHORS   Tailor,C.S., Nouri,A., Lee,C.G., Kozak,C. and Kabat,D.
  TITLE     Cloning and characterization of a cell surface receptor for
            xenotropic and polytropic murine leukemia viruses
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 927-932 (1999)
   PUBMED   9927670
REFERENCE   9  (bases 1 to 8289)
  AUTHORS   Yang,Y.L., Guo,L., Xu,S., Holland,C.A., Kitamura,T., Hunter,K. and
            Cunningham,J.M.
  TITLE     Receptors for polytropic and xenotropic mouse leukaemia viruses
            encoded by a single gene at Rmc1
  JOURNAL   Nat Genet 21 (2), 216-219 (1999)
   PUBMED   9988277
REFERENCE   10 (bases 1 to 8289)
  AUTHORS   Ramos,E.M., Oliveira,J., Sobrido,M.J. and Coppola,G.
  TITLE     Primary Familial Brain Calcification
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301594
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB461474.1, BC041142.1,
            AL162431.17 and AA425354.1.
            
            On May 31, 2019 this sequence version replaced NM_001135669.1.
            
            Summary: The protein encoded by this gene is a receptor for the
            xenotropic and polytropic classes of murine leukemia viruses. The
            encoded protein is involved in phosphate homeostasis by mediating
            phosphate export from the cell. Defects in this gene have been
            associated with idiopathic basal ganglia calcification-6. [provided
            by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041142.1, SRR1803614.7650.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB461474.1         13-22
            11-2940             BC041142.1         1-2930
            2941-7877           AL162431.17        27037-31973
            7878-8289           AA425354.1         5-416               c
FEATURES             Location/Qualifiers
     source          1..8289
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..8289
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="xenotropic and polytropic retrovirus receptor 1"
                     /db_xref="GeneID:9213"
                     /db_xref="HGNC:HGNC:12827"
                     /db_xref="MIM:605237"
     exon            1..249
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2076
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     X-receptor; protein SYG1 homolog; solute carrier family 53
                     (phosphate exporter), member 1; xenotropic and polytropic
                     murine leukemia virus receptor X3; phosphate exporter
                     SLC53A1; solute carrier family 53 member 1"
                     /codon_start=1
                     /product="solute carrier family 53 member 1 isoform 2"
                     /protein_id="NP_001129141.1"
                     /db_xref="CCDS:CCDS44284.1"
                     /db_xref="GeneID:9213"
                     /db_xref="HGNC:HGNC:12827"
                     /db_xref="MIM:605237"
                     /translation="MKFAEHLSAHITPEWRKQYIQYEAFKDMLYSAQDQAPSVEVTDE
                     DTVKRYFAKFEEKFFQTCEKELAKINTFYSEKLAEAQRRFATLQNELQSSLDAQKEST
                     GVTTLRQRRKPVFHLSHEERVQHRNIKDLKLAFSEFYLSLILLQNYQNLNFTGFRKIL
                     KKHDKILETSRGADWRVAHVEVAPFYTCKKINQLISETEAVVTNELEDGDRQKAMKRL
                     RVPPLGAAQPAPAWTTFRVGLFCGIFIVLNITLVLAAVFKLETDRSIWPLIRIYRGGF
                     LLIEFLFLLGINTYGWRQAGVNHVLIFELNPRSNLSHQHLFEIAGFLGILWCLSLLAC
                     FFAPISVIPTYVYPLALYGFMVFFLINPTKTFYYKSRFWLLKLLFRVFTAPFHKVGFA
                     DFWLADQLNSLSVILMDLEYMICFYSLELKWDESKGLLPNNSEERGHSDTMVFFYLWI
                     VFYIISSCYTLIWDLKMDWGLFDKNAGENTFLREEIVYPQKAYYYCAIIEDVILRFAW
                     TIQISITSTTLLPHSGDIIATVFAPLEVFRRFVWNFFRLENEHLNNCGEFRAVRDISV
                     APLNADDQTLLEQMMDQDDGVRNRQKNRSWKYNQSISLRRPRLASQSKARDTKVLIED
                     TDDEANT"
     exon            250..301
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            302..403
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            404..627
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            628..777
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..861
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            862..943
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1134
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1314
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1486
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1653
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1793
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..2015
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..8289
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4113..4118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="hexamer: AATAAA"
     polyA_site      4136
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="major polyA site"
     regulatory      4329..4334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="hexamer: AATAAA"
     polyA_site      4354
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="major polyA site"
     regulatory      8196..8201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="hexamer: AATAAG"
     polyA_site      8216
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="major polyA site"
     regulatory      8235..8240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="hexamer: ATTACA"
     polyA_site      8261
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
                     /note="major polyA site"
     polyA_site      8289
                     /gene="XPR1"
                     /gene_synonym="IBGC6; SLC53A1; SYG1; X3"
ORIGIN      
        1 atggagagga ggaggaagat ggcgggcggg ctgctctgaa gagacctcgg cggcggcgga
       61 ggaggagaga agcgcagcgc cgcgccgcgc cggggcccat gtggggagga gtcggagtcg
      121 ctgttgccgc cgccgcctgt agctgctgga cccgagtggg agtgaggggg aaacggcagg
      181 atgaagttcg ccgagcacct ctccgcgcac atcactcccg agtggaggaa gcaatacatc
      241 cagtatgagg ctttcaagga tatgctgtat tcagctcagg accaggcacc ttctgtggaa
      301 gttacagatg aggacacagt aaagaggtat tttgccaagt ttgaagagaa gtttttccaa
      361 acctgtgaaa aagaacttgc caaaatcaac acattttatt cagagaagct cgcagaggct
      421 cagcgcaggt ttgctacact tcagaatgag cttcagtcat cactggatgc acagaaagaa
      481 agcactggtg ttactacgct gcgacaacgc agaaagccag tcttccactt gtcccatgag
      541 gaacgtgtcc aacatagaaa tattaaagac cttaaactgg ccttcagtga gttctacctc
      601 agtctaatcc tgctgcagaa ctatcagaat ctgaatttta cagggtttcg aaaaatcctg
      661 aaaaagcatg acaagatcct ggaaacatct cgtggagcag attggcgagt ggctcacgta
      721 gaggtggccc cattttatac atgcaagaaa atcaaccagc ttatctctga aactgaggct
      781 gtagtgacca atgaacttga agatggtgac agacaaaagg ctatgaagcg tttacgtgtc
      841 ccccctttgg gagctgctca gcctgcacca gcatggacta cttttagagt tggcctattt
      901 tgtggaatat tcattgtact gaatattacc cttgtgcttg ccgctgtatt taaacttgaa
      961 acagatagaa gtatatggcc cttgataaga atctatcggg gtggctttct tctgattgaa
     1021 ttcctttttc tactgggcat caacacgtat ggttggagac aggctggagt aaaccatgta
     1081 ctcatctttg aacttaatcc gagaagcaat ttgtctcatc aacatctctt tgagattgct
     1141 ggattcctcg ggatattgtg gtgcctgagc cttctggcat gcttctttgc tccaattagt
     1201 gtcatcccca catatgtgta tccacttgcc ctttatggat ttatggtttt cttccttatc
     1261 aaccccacca aaactttcta ctataaatcc cggttttggc tgcttaaact gctgtttcga
     1321 gtatttacag cccccttcca taaggtaggc tttgctgatt tctggctggc ggatcagctg
     1381 aacagcctgt cagtgatact gatggacctg gaatatatga tctgcttcta cagtttggag
     1441 ctcaaatggg atgaaagtaa gggcctgttg ccaaataatt cagaagaacg aggtcactcg
     1501 gacactatgg tgttctttta cctgtggatt gtcttttata tcatcagttc ctgctatacc
     1561 ctcatctggg atctcaagat ggactggggt ctcttcgata agaatgctgg agagaacact
     1621 ttcctccggg aagagattgt atacccccaa aaagcctact actactgtgc cataatagag
     1681 gatgtgattc tgcgctttgc ttggactatc caaatctcga ttacctctac aactttgttg
     1741 cctcattctg gggacatcat tgctactgtc tttgccccac ttgaggtttt ccggcgattt
     1801 gtgtggaact tcttccgcct ggagaatgaa catctgaata actgtggtga attccgtgct
     1861 gtgcgggaca tctctgtggc ccccctgaac gcagatgatc agactctcct agaacagatg
     1921 atggaccagg atgatggggt acgaaaccgc cagaagaatc ggtcatggaa gtacaaccag
     1981 agcatatccc tgcgccggcc tcgcctcgct tctcaatcca aggctcgtga cactaaggta
     2041 ttgatagaag acacagatga tgaagctaac acttgaattt tctgaagtct agcttaacat
     2101 ctttggtttt cctactctac aatcctttcc tcgaccaacg caacctctag tacctttcca
     2161 gccgaaaaca ggagaaaaca cataacacat tttccgagct cttccggatc ggatcctatg
     2221 gactccaaac aagctcactg tgtttctttt cttttcttct ggtttaattt taattttcta
     2281 ttttcaaaac aaatatttac ttcatttgcc aatcagagga tgttttaaga aacaaaacat
     2341 agtatcttat ggattgttta caatcacaag gacatagata cctatcagga tgaagaacag
     2401 gcattgcaag gaccctctga tgggacggta ctgagatatc tcggcttccg ctcagcccgg
     2461 ttttgactgg ttgaaaccgg acattggttt ttaaattttt tgtcagttta tgtggagaat
     2521 ttttttcttt ccttcatacc cagcgcaaag gcactggccg cacttgcagg aaaagtgcaa
     2581 cttaaagcag taccttcatt catgaagcta ctttttaatt tgatgtaact tttcttattt
     2641 tgggaagggt tgctgggtgg gtgggaaata tgatgtattt gttacacata gttttctcat
     2701 tatttatgaa acttaaccat acagaatgat ataactcctg tgcaatgaag gtgataacag
     2761 taaaagaagg caggggaaac ttacgttgga tgacatttat gagggtcagt cccacatacc
     2821 tctttcagga gacaacttgc accagtttga ccttttcttt tctttgtttt tattttaagc
     2881 caaagtttca ttgctaactt cttaagttgc tgctgcttta gagtcctgag catatctctc
     2941 ataacaagga atcccacact tcacaccacc ggctgaattt catggaagag gttctgataa
     3001 tttttttaac tttttaagga acagatgtgg aatacactgg cccatatttc aaccttaaca
     3061 gctgaagcta tgccttatta tgcatccaca tgtatggtcc ctgtagcgtg acctttacta
     3121 gctctgaatc agaagacaga gctatttcag aggctctgtg tgccctcact agatagtttt
     3181 tcttctgggt tcaaccactt tagccagaat ttgatcaaat taaaagtctg tcatggggaa
     3241 actatatttt tgagcacatg gaacaaatta tacttcctca ttcatattat gttgatacaa
     3301 aagaccttgg cagccatttc tcccagcagt tttaaaggat gaacattgga tttcatgcca
     3361 tcccatagaa aacctgtttt aaaattttag ggatctttac ttggtcatac atgaaaagta
     3421 cactgcttag aaattataga ctattatgat ctgtccacag tgcccattgt cacttctttg
     3481 tctcatttct tccctttgtt ccttagtcat ccaaataagc ctgaaaacca taagagatat
     3541 tactttattg aatatggttg gcattaaatt tagcatttca ttatctaaca aaattaatat
     3601 aaattccagg acatggtaaa atgtgtttta ataaccccca gacccaaatg aaaatttcaa
     3661 agtcaatacc agcagattca tgaaagtaaa tttagtccta taattttcag cttaattata
     3721 aacaaaggaa caaataagtg gaagggcagc tattaccatt cgcttagtca aaacattcgg
     3781 ttactgccct ttaatacact cctatcatca gcacttccac catgtattac aagtcttgac
     3841 ccatccctgt cgtaactcca gtaaaagtta ctgttactag aaaattttta tcaattaact
     3901 gacaaatagt ttctttttaa agtagtttct tccatcttta ttctgactag cttccaaaat
     3961 gtgttccctt tttgaatcga ggtttttttg ttttgttttg ttttctgaaa aaatcataca
     4021 actttgtgct tctattgctt ttttgtgttt tgttaagcat gtcccttggc ccaaatggaa
     4081 gaggaaatgt ttaattaatg ctttttagtt taaataaatt gaatcattta taataatcag
     4141 tgttaacaat ttagtgaccc ttggtaggtt aaaggttgca ttatttatac ttgagatttt
     4201 tttcccctaa ctattctgtt ttttgtactt taaaactatg ggggaaatat cactggtctg
     4261 tcaagaaaca gcagtaatta ttactgagtt aaattgaaaa gtccagtgga ccaggcattt
     4321 cttatataaa taaaattggt ggtactaatg tgtatccaga gacatttgaa ttattaactt
     4381 tattctttat tagtgaatct ctatgatggc acacataaaa tcttacagtt gacttctgct
     4441 gtttgaattc cccagtgttt ttacattaat gtatcctatg gccagtttag tctttcttca
     4501 actgttacag ttctaggccc taatcggtct tattctttca catatgatgc aatgatagat
     4561 gtaatccttt tctgaagtgt ttgtcggatt ggcatagtct attcaaaaat aaggcttatg
     4621 taactttcag cttgctatgt gacagaagtt taaatgtgta tttaagtaca cagctttatg
     4681 ttcctcttaa agctgtaaag agaaaagagg acttttcctc atcaagagag cttgggagac
     4741 aaagcataca tttaattttt ttctttcaaa aaaggcaatg tgcactttcc tctcctaaat
     4801 tttatatgcc ctagcagttg cgaatgttgt gtccacctta caatttgatt ggaggctccc
     4861 atacactgaa actctcaata gaattcttaa aaatgaacat cagctgggcg cagtggctca
     4921 cgtctgtaat cccagcactt tgggaggcca aggtgggcag atcacgagct caggagttcg
     4981 agaccagcct gaccaacatg gtgaaacccc gtctctacta aaaatacaaa aattagctgg
     5041 gcgtggtggc gcatgcctgt aatcccagct actcaggaga ctgaggcagg agaattgctt
     5101 aaacctggga agcagaggtt gcagtgagac tagatcatgc cactgcactc cactgccact
     5161 gcctgggcaa cagagcaaga ctccatctca aaaacaaaca aaaaaaatca cagactcatt
     5221 ttaaaggagc agcaacctaa ccaaatacaa acttcatttg attttaggtt tagaaattct
     5281 agttttattt tggagaatca ctcagttttt aatatcaatt aaaatagtcc tcaaaggaat
     5341 gaagaggaag tctaaataaa tgaataaaac tcatttttca ttttatggta gtatagaaag
     5401 cattgatgtg tgtagagaaa ttaaaagaca agagtggttt actgtctatg cacaaatgag
     5461 tgcctatatt taaggctgcc tataccatta cagtggcgta attggtgatt tcatagcata
     5521 cagagaaaca atgaaatcaa agattaaatc attaggttat gatggtcatt tgtaagattg
     5581 gaaagtagtc aaaaacccat gtgcaacttt ttttcagcac tctaccatta ggctccttag
     5641 gcaagctgct taacttccgt cagaagcaaa ggtgtgggag aacaccattc acctcagtag
     5701 taacttataa aaaccgttta aagaaggaaa atgggcccca gcccctagga tccctgactt
     5761 cctgatattc taaacatgag agttctgtga ctttaactga gctctttacc agaagtaacg
     5821 tgttgatgta tattatcttt ccaccatgct ttgaccaaag tacattcaca gtaactagag
     5881 aaagcagatc atccatttct ggataggtga actacggcaa ggtaagaaca gaaaaaagta
     5941 aagtagtatt gagtcatgca ggtatcagat taacagacat tcattgaaga taagtgaaat
     6001 aactttggag atagcagaga agagcaagaa gatgttggac gttggcagta agccgcagca
     6061 aggcagttag gaaagtacgt gagcctgatg acgcgaaggt gatgcctcca tctgtccgct
     6121 tagtggttat taaattgctg ggaaagacct gcctttattt tcctatcatc ttttccccat
     6181 tactttgcat tattcaggaa ataattattt attcccaaat gcagttttct aagcagtgac
     6241 cacaaaaatt tcttattcta aggaaaataa ttaagaaaat aaccctatct gtggcattgt
     6301 tttaaaatgt gggatacaaa tctggtaagc agatttcagg tcattattgt tttcttttaa
     6361 tggtttacat gaaattttcc tctcaaaaaa caagtacctc ttactgtata acatttgagt
     6421 ttttaaaatt gagatagctt ctgagagaaa aaaagaaagt tgaatttgta gctctctcaa
     6481 ctacaaaatc accacacttt tctcaaatct aataggaatt cagtgtcatt acagatacgg
     6541 tctctagtga ccaggtgaag acaattgaag ctttggtaga acttctgcaa aagttaggta
     6601 aagaagaata aatccaattt atcagctttg ttcatattct ttttctgagt gatctaaatt
     6661 tttcttgctt gtgatcatta gctaagacaa ggagtgttaa aggttttcta aatgcaaaca
     6721 catacgtttc tgcatttcag aagtcagtct tgatagtaaa tcctacaaac tctcaacttt
     6781 ctgcattgta ttttaagtct atacaatgtt agagcacatg gtaatgtggg acagagttga
     6841 ttatatgata gcatgagaaa tttgcactgg ttggtgttac aaaccaatga tctaaccagc
     6901 atactctcca aatatgaaaa agtaaaaaca tctcattagg tttggaagag cctaaggtag
     6961 tccatacagg aagtttgcct gagaacagag aggagcctgt tgattggcat ggctcatgat
     7021 gcctttcttg tatgaattat caaaactgat actgagttgc ccctagaaaa cagccttcca
     7081 gaatatgttt gcttatttat ggtggaagag gaagtgagaa caagatgaga gtttccctta
     7141 aagtgaggag aatcattata caactttgca actgaagtat gtttccttgt agcaaacctt
     7201 tggtttattt tatcgtcaaa tcaaagccac cctcagtttt ttgtatggtg ccatcaacct
     7261 aaggaggaca atcaaataac ctattgtttg ccttggattc agtatatcta ctaagtacac
     7321 agtctcgtat accttcaaac cagttacttg actaaacttc caccatatta ccttagttct
     7381 tcctatgccc tttcctctgt gccaccacaa atcagaggga aagactgcag tacttctaga
     7441 aagttgtgga cttctaagaa agagccaggc ttccatctca ctatcccttg atcattatct
     7501 ctgaagtccc tacctgcact tccctgattg ccctgtagca acaccagcat ggtgggaatt
     7561 ggagggaaag attgtggaaa atccctaaag ggtcattgtt catgacgtta ttttgaattg
     7621 taaaattgtg agccactcac atttcaatta caaaaagaac agaactctta atcacgttgt
     7681 gaagattaat ttcttgccat tttctggatt agcacagaag cttgtatcaa tgaagagtat
     7741 ttaggagggg aataggggga aaattgtatt tttctgttca aactctctcc ttctatttgt
     7801 gtttccttca cccctctccc tccaccacac tgtgttggtc aaatgatact attctatgaa
     7861 accctgagct atagttgtca aaagtaacta tggattgtga ttagtcctct gtgggtgctt
     7921 ccttccctct tttttctccc tcactctctt tctcagtctc cactctggta aatggaaaag
     7981 gtgatgtcga agaattgatg cttgcttgga ctcatgttgt atctgtgact atgctattag
     8041 ctgtctcctt tttccttcct atatgggtag aattcttatg acttatgaag ttcccttctt
     8101 gataagtagg ttaaatgcac aatgtggtac tgttttatag tttctagatg gttgtataaa
     8161 gcaaaaagtt aatgtggtta tgtgttttta aagaaaataa gtgattggtc actaaactct
     8221 gtcctttttt cattattaca atttctctct gttttccaac agtttgctga ctcctttgtc
     8281 actggtgaa
//
