LOCUS       NM_007235               6370 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens exportin for tRNA (XPOT), mRNA.
ACCESSION   NM_007235
VERSION     NM_007235.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6370)
  AUTHORS   Dai,H., Yang,X., Sheng,X., Wang,Y., Zhang,S., Zhang,X., Hu,L.,
            Zhang,Z., Dong,X., Yin,W., Yao,L. and Lu,J.
  TITLE     XPOT Disruption Suppresses TNBC Growth through Inhibition of
            Specific tRNA Nuclear Exportation and TTC19 Expression to Induce
            Cytokinesis Failure
  JOURNAL   Int J Biol Sci 19 (16), 5319-5336 (2023)
   PUBMED   37928256
  REMARK    GeneRIF: XPOT Disruption Suppresses TNBC Growth through Inhibition
            of Specific tRNA Nuclear Exportation and TTC19 Expression to Induce
            Cytokinesis Failure.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6370)
  AUTHORS   Pan,L.J., Chen,J.L., Wu,Z.X. and Wu,Y.M.
  TITLE     Exportin-T: A Novel Prognostic Predictor and Potential Therapeutic
            Target for Neuroblastoma
  JOURNAL   Technol Cancer Res Treat 20, 15330338211039132 (2021)
   PUBMED   34469238
  REMARK    GeneRIF: Exportin-T: A Novel Prognostic Predictor and Potential
            Therapeutic Target for Neuroblastoma.
REFERENCE   3  (bases 1 to 6370)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6370)
  AUTHORS   Gupta,A., Kailasam,S. and Bansal,M.
  TITLE     Insights into the Structural Dynamics of Nucleocytoplasmic
            Transport of tRNA by Exportin-t
  JOURNAL   Biophys J 110 (6), 1264-1279 (2016)
   PUBMED   27028637
REFERENCE   5  (bases 1 to 6370)
  AUTHORS   Okamura,M., Inose,H. and Masuda,S.
  TITLE     RNA Export through the NPC in Eukaryotes
  JOURNAL   Genes (Basel) 6 (1), 124-149 (2015)
   PUBMED   25802992
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6370)
  AUTHORS   Kutay,U., Hartmann,E., Treichel,N., Calado,A., Carmo-Fonseca,M.,
            Prehn,S., Kraft,R., Gorlich,D. and Bischoff,F.R.
  TITLE     Identification of two novel RanGTP-binding proteins belonging to
            the importin beta superfamily
  JOURNAL   J Biol Chem 275 (51), 40163-40168 (2000)
   PUBMED   11024021
REFERENCE   7  (bases 1 to 6370)
  AUTHORS   Kruse,C., Willkomm,D.K., Grunweller,A., Vollbrandt,T., Sommer,S.,
            Busch,S., Pfeiffer,T., Brinkmann,J., Hartmann,R.K. and Muller,P.K.
  TITLE     Export and transport of tRNA are coupled to a multi-protein complex
  JOURNAL   Biochem J 346 Pt 1 (Pt 1), 107-115 (2000)
   PUBMED   10657246
REFERENCE   8  (bases 1 to 6370)
  AUTHORS   Arts,G.J., Kuersten,S., Romby,P., Ehresmann,B. and Mattaj,I.W.
  TITLE     The role of exportin-t in selective nuclear export of mature tRNAs
  JOURNAL   EMBO J 17 (24), 7430-7441 (1998)
   PUBMED   9857198
REFERENCE   9  (bases 1 to 6370)
  AUTHORS   Arts,G.J., Fornerod,M. and Mattaj,I.W.
  TITLE     Identification of a nuclear export receptor for tRNA
  JOURNAL   Curr Biol 8 (6), 305-314 (1998)
   PUBMED   9512417
REFERENCE   10 (bases 1 to 6370)
  AUTHORS   Kutay,U., Lipowsky,G., Izaurralde,E., Bischoff,F.R.,
            Schwarzmaier,P., Hartmann,E. and Gorlich,D.
  TITLE     Identification of a tRNA-specific nuclear export receptor
  JOURNAL   Mol Cell 1 (3), 359-369 (1998)
   PUBMED   9660920
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR979468.1, AK292884.1,
            BC020569.1 and AC135279.3.
            
            On Nov 22, 2018 this sequence version replaced NM_007235.5.
            
            Summary: This gene encodes a protein belonging to the RAN-GTPase
            exportin family that mediates export of tRNA from the nucleus to
            the cytoplasm. Translocation of tRNA to the cytoplasm occurs once
            exportin has bound both tRNA and GTP-bound RAN. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.209463.1,
                                           SRR1803617.214523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332707.10/ ENSP00000327821.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               CR979468.1         20-187
            169-2195            AK292884.1         1-2027
            2196-2618           BC020569.1         1794-2216
            2619-3691           AK292884.1         2451-3523
            3692-3929           BC020569.1         3290-3527
            3930-6370           AC135279.3         34575-37015         c
FEATURES             Location/Qualifiers
     source          1..6370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.2"
     gene            1..6370
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /note="exportin for tRNA"
                     /db_xref="GeneID:11260"
                     /db_xref="HGNC:HGNC:12826"
                     /db_xref="MIM:603180"
     exon            1..413
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            414..547
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..3376
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /note="tRNA exportin; exportin(tRNA); exportin, tRNA
                     (nuclear export receptor for tRNAs)"
                     /codon_start=1
                     /product="exportin-T"
                     /protein_id="NP_009166.2"
                     /db_xref="CCDS:CCDS31852.1"
                     /db_xref="GeneID:11260"
                     /db_xref="HGNC:HGNC:12826"
                     /db_xref="MIM:603180"
                     /translation="MDEQALLGLNPNADSDFRQRALAYFEQLKISPDAWQVCAEALAQ
                     RTYSDDHVKFFCFQVLEHQVKYKYSELTTVQQQLIRETLISWLQAQMLNPQPEKTFIR
                     NKAAQVFALLFVTEYLTKWPKFFFDILSVVDLNPRGVDLYLRILMAIDSELVDRDVVH
                     TSEEARRNTLIKDTMREQCIPNLVESWYQILQNYQFTNSEVTCQCLEVVGAYVSWIDL
                     SLIANDRFINMLLGHMSIEVLREEACDCLFEVVNKGMDPVDKMKLVESLCQVLQSAGF
                     FSIDQEEDVDFLARFSKLVNGMGQSLIVSWSKLIKNGDIKNAQEALQAIETKVALMLQ
                     LLIHEDDDISSNIIGFCYDYLHILKQLTVLSDQQKANVEAIMLAVMKKLTYDEEYNFE
                     NEGEDEAMFVEYRKQLKLLLDRLAQVSPELLLASVRRVFSSTLQNWQTTRFMEVEVAI
                     RLLYMLAEALPVSHGAHFSGDVSKASALQDMMRTLVTSGVSSYQHTSVTLEFFETVVR
                     YEKFFTVEPQHIPCVLMAFLDHRGLRHSSAKVRSRTAYLFSRFVKSLNKQMNPFIEDI
                     LNRIQDLLELSPPENGHQSLLSSDDQLFIYETAGVLIVNSEYPAERKQALMRNLLTPL
                     MEKFKILLEKLMLAQDEERQASLADCLNHAVGFASRTSKAFSNKQTVKQCGCSEVYLD
                     CLQTFLPALSCPLQKDILRSGVRTFLHRMIICLEEEVLPFIPSASEHMLKDCEAKDLQ
                     EFIPLINQITAKFKIQVSPFLQQMFMPLLHAIFEVLLRPAEENDQSAALEKQMLRRSY
                     FAFLQTVTGSGMSEVIANQGAENVERVLVTVIQGAVEYPDPIAQKTCFIILSKLVELW
                     GGKDGPVGFADFVYKHIVPACFLAPLKQTFDLADAQTVLALSECAVTLKTIHLKRGPE
                     CVQYLQQEYLPSLQVAPEIIQEFCQALQQPDAKVFKNYLKVFFQRAKP"
     exon            548..630
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            631..687
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            688..757
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            758..976
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1161
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1330
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1567
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1606
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1669
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1794
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1939
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2059
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2154
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2224
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2463
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2749
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2939
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3056
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3172
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3220
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3292
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3349
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..6370
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3909..3914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /note="hexamer: AATAAA"
     polyA_site      3929
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /note="major polyA site"
     regulatory      6346..6351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPOT"
                     /gene_synonym="XPO3"
                     /note="hexamer: AATAAA"
     polyA_site      6370
                     /gene="XPOT"
                     /gene_synonym="XPO3"
ORIGIN      
        1 actctccaag agactgctgg cgccggcgcc cgcccgcgcg gcaccgacgc ggggagcgcg
       61 cttcgcgctg actcagcggc ggcggcggct gcggcggcgg cggcggcgtt agccggccct
      121 cgcgctcttt cccttcctgg ggcgccgacc ccgcccgctt gcttgcttgc ttgcttgcct
      181 gcctgcctgc ctgcccggcg ccacgcaaga gaaggtgcca ggggacgcag agcgactaga
      241 ggcgcgcggt cccggccagc accgtctctg gcgttgtagc tgcggccgtg gcggaggact
      301 acggcgacaa ggacgagggc cgctctccca gctctctgcg tgccgcgccg ctccgctccg
      361 ctggctgacc atctggagtg caggctggga ggcgggatgg agtgataggg aagatgttta
      421 taaattcttc tgtgggatca gagggcacgc ctattacaac cagaaaacta caagtataac
      481 agcgaggatg gatgaacagg ctctattagg gctaaatcca aatgctgatt cagactttag
      541 acaaagggcc ctggcctatt ttgagcagtt aaaaatttcc ccagatgcct ggcaggtgtg
      601 tgcagaagct ctagcccaga ggacatacag tgatgatcat gtgaagtttt tctgctttca
      661 agtactggaa catcaagtta aatacaaata ctcagaacta accactgttc aacaacagct
      721 aattagggag acgctcatat catggctgca agctcagatg ctgaatcccc aaccagagaa
      781 gacctttata cgaaataaag ccgcccaagt cttcgccttg ctttttgtta cagagtatct
      841 cactaagtgg cccaagtttt tttttgacat tctctcagta gtggacctaa atccaagggg
      901 agtagatctc tacctgcgaa tcctcatggc tattgattca gagttggtgg atcgtgatgt
      961 ggtgcataca tcagaggagg ctcgtaggaa tactctcata aaagatacca tgagggaaca
     1021 gtgcattcca aatctggtgg aatcatggta ccaaatatta caaaattatc agtttactaa
     1081 ttctgaagtg acgtgtcagt gccttgaagt agttggggct tatgtctctt ggatagactt
     1141 atcccttata gccaatgata ggtttataaa tatgctgcta ggtcatatgt caatagaagt
     1201 tctacgggaa gaagcatgtg actgtttatt tgaagttgta aataaaggaa tggaccctgt
     1261 tgataaaatg aaactagtgg aatctttgtg tcaagtatta cagtctgctg ggtttttcag
     1321 cattgaccag gaagaagatg ttgacttcct ggccagattt tctaagttgg taaatggaat
     1381 gggacagtca ttgatagtta gttggagtaa attaattaag aatggggata ttaagaatgc
     1441 tcaagaggca ctacaagcta ttgaaacaaa agtggcactg atgttgcagc tactaattca
     1501 tgaggatgat gatatttctt ctaatattat tggattttgt tacgattatc ttcatatttt
     1561 gaaacagctt acagtgctct cggatcagca aaaagctaat gtagaggcaa tcatgttggc
     1621 cgttatgaaa aaattgactt acgatgaaga atataacttt gaaaatgagg gtgaagatga
     1681 agccatgttt gtagaatata gaaaacaact gaagttactg ttggacaggc ttgctcaagt
     1741 ttcaccagag ttactactgg cctctgttcg cagagttttt agttctacac tgcagaattg
     1801 gcagactaca cggtttatgg aagttgaagt agcaataaga ttgctgtata tgttggcaga
     1861 agctcttcca gtatctcatg gtgctcactt ctcaggtgat gtttcaaaag ctagtgcttt
     1921 gcaggatatg atgcgaactc tggtaacatc aggagtcagt tcctatcagc atacatctgt
     1981 gacattggag ttcttcgaaa ctgttgttag atatgaaaag tttttcacag ttgaacctca
     2041 gcacattcca tgtgtactaa tggctttctt agatcacaga ggtctgcggc attccagtgc
     2101 aaaagttcgg agcaggacgg cttacctgtt ttctagattt gtcaaatctc tcaataagca
     2161 aatgaatcct ttcattgagg atattttgaa tagaatacaa gatttattag agctttctcc
     2221 acctgagaat ggccaccagt ccttactgag cagcgatgat caacttttta tttatgagac
     2281 agctggagtg ctgattgtta atagtgaata tccggcagaa aggaaacaag ccttaatgag
     2341 gaatctgttg actccactaa tggagaagtt taaaattctg ttagaaaagt tgatgctggc
     2401 acaagatgaa gaaaggcaag cctctctagc agactgtctt aaccatgctg ttggatttgc
     2461 aagtcgaacc agtaaagctt tcagcaacaa acagactgtg aaacaatgtg gctgttccga
     2521 agtttatctg gactgtttac agacattctt gccagccctc agttgtccct tacaaaagga
     2581 tattctcaga agtggagtcc gtactttcct tcatcgaatg attatttgcc tggaggaaga
     2641 agttcttccg ttcattccat ctgcttcaga acatatgctc aaagattgtg aagcaaaaga
     2701 tctccaggag ttcattcctc ttatcaacca gattacggcc aaattcaaga tacaggtatc
     2761 cccgttttta caacagatgt tcatgcccct gcttcatgca atttttgaag tgctgctccg
     2821 gccagcagaa gaaaatgacc agtctgctgc tttagagaag cagatgttgc ggaggagtta
     2881 ctttgctttc ctgcaaacag tcacaggcag tgggatgagc gaagttatag caaatcaagg
     2941 tgcagagaat gtagaaagag tgttggttac tgttatccaa ggagcagttg aatatccaga
     3001 tccaattgca cagaaaacat gttttatcat cctctcaaag ttggtagaac tctggggagg
     3061 taaagatgga ccagtgggat ttgctgattt tgtttataag cacattgtcc ccgcatgttt
     3121 cctagcacct ttaaaacaaa cctttgacct ggcagatgca caaacagtat tggctttatc
     3181 tgagtgtgca gtgacactga aaacaattca tctcaaacgg ggcccagaat gtgttcagta
     3241 tcttcaacaa gaatacctgc cctccttgca agtagctcca gaaataattc aggagttttg
     3301 tcaagcgctt cagcagcctg atgctaaagt ttttaaaaat tacttaaagg tgttcttcca
     3361 gagagcaaag ccctgaggac tggatttccc tgtgcctact tcatgatcat gaattccagt
     3421 taatttataa agaggcgatt tttgtgtgcc attcacactg gtctttttca cattgttttg
     3481 agcttattgc agtatatgtt ttgggatttt tctgtaaaat gggtgtaatt ttcctaatac
     3541 aggtatgtaa caacaaaaga agttgcctgc atgccggtcc aaattgttct gtataaagat
     3601 gctcttaaaa gacacaagag ttatcctaga accttaattc ttttttattt gaaattttaa
     3661 gtcaagtcct ttataaagac catagcagtg gaaaacagtg tactttttaa aaaattgctg
     3721 aatataaaat ctttgaaaat tttctttatg tgtgaagaca caaagtatgg gggaagacag
     3781 caatcaaaac taactttttg tagatagcca tttcatttct ttaaactgtt tcaacgccaa
     3841 tatgtattct acaaaagaga atggttttag gctccagtgt tatacttttt tttatatata
     3901 tatataaaaa taaactttac gtagtgaaat cttccaagtc ttttctggaa ttattataaa
     3961 tactttagtt ttattttctc atcttaatct ctccataatt tcccatttaa aggtttacaa
     4021 atatgagtgt gtggatgctt taattcattt aacctcactc ctcaaaggta acatgcaact
     4081 tagttctgtt atatgagagt ctttttcttt aatgtactgg aaaaagccta tgtgaatctg
     4141 ttgatagaat ttaaaattcc aggccgggcg tggtggctca cgactgtaat cccagaactt
     4201 tgggaggcca aggcaggtgg atcacttgag gtcaggagtt cgagactagc ctggccaaca
     4261 tggtgaaacc ccatctctac taaaaataca acagccaggt gtgatggtgc acgctcgtaa
     4321 tcccggctac tcaggaggct gaggcaggag aatcgcttga acccggaagg cagaggttgc
     4381 agtgagctga gattgtgcca ctgcacgcca gcctgggcaa gagagtaaga ctctctctca
     4441 aaaaaaaaaa aaaagaattt aaaatcccaa tttattttct aactctttta ttggatgtat
     4501 ttagaacaca gtatacctat agtataccta tgtgtttatt atgtttgtaa atggtaactg
     4561 acatttaatt attagaagta cttacccctg ccttcctcca tttttattca tggctacttg
     4621 agaaagcaaa aggaaaaaat aatagttatc agtagtgtca ctggaaagaa gagaggaggg
     4681 acaaaactga gcagcagaat tcgtatagac atttacgttt aaattctaaa agcccaattg
     4741 agatgttcag ggagggtttg ttttgccctt tggcctcatg aatgggtttc atgaatgggc
     4801 ttcagtggct tataaactct gtaaaattct attctaaatt ttgtacattt attttgttcc
     4861 ggttaattcc agaagacatt tcaaacattt ttcttacacc atataataaa aatacttaac
     4921 taaattgaca gttataaaaa taaatcagtg aaatgtacct tatactttaa taaaaaatgt
     4981 tttcagaaat agataagtga aagctgagtg tttctttgat aggttcccct gtactatagg
     5041 agtgataatt gcagctattg caatagtagt aattgttaaa tggatactaa tgaatagcat
     5101 agcatagtgg gtaagagttt atatagcaca ggctctagaa tcagattaag taggttcaaa
     5161 taccagttct gccagtaact ggttttagaa ccttgggcaa gttaaagaat gtctcccagc
     5221 ctcagtttcc ctatttgtaa aatggaaata atggtagcta cctcaaacct cattacgaat
     5281 tcaatgagtt aaacttgaaa agacttatta cagtagctgg cacataaaga cttgatagta
     5341 gtttatatgg atgctatctc atattagcat atatggaatt aatagtgtat cactatactt
     5401 tttttttctt tttttttttt gaatagagat cagtctatca cccaggctgg agtgcagtgg
     5461 tgacatcata gctcactgta acttctccca tactctacca atcctcctgc ctcagcatcc
     5521 agactagctg tgattacagg tgtgcaccac cacacccagc tacatttttt tttggtagag
     5581 acagggtctc actatgttac ccagtctggt ctcaaactcc cggcctcaag caatcctccc
     5641 actggcctca caatgttggg attacaggta taagccactg cacacggcct tactatgcta
     5701 tcaattccat atatggaaag gtgttttccc tttcagagct ctttaaagct ctgcagaaga
     5761 tttacatgtg tttatagagc taagagaaat cagggcatgg aaattgagtg tgtaataaaa
     5821 attaaactct tcatgttata taatcatgca taacttctat cttcattctc tgaagttgcc
     5881 tagagcacca tcacagctag gaagcttcca tcatgaatta ccttatttcc aaaagcaagt
     5941 actcaaataa ttgtctcaag agaggaagga caaaactgtt acaagctgaa atatttgggg
     6001 atttgtttga cttgactagg gaaccacaag ttttcatata atgcctgatt tagccctgtg
     6061 cctaacagtt taaatcttaa tgctaatgtt aattgcttcc cagttggttg accttataag
     6121 aaaacactgt gtggtatttt aatgtggtaa acatgtgaat gaaggcctgt ggctcagtta
     6181 atcactccca caactttgag ctgtgagttt tactggtgga aggaacttta acaggtcttc
     6241 gctcttgtca ttagatatca aagaactgaa attagttgga attgtaagca gtgaatagat
     6301 gtgttgttag aatgattcca tcacttatac attgtttaaa atgctaataa agtaacttgc
     6361 tttgtaagaa
//
