LOCUS       NP_055839               1087 aa            linear   PRI 28-APR-2025
DEFINITION  exportin-7 isoform b [Homo sapiens].
ACCESSION   NP_055839
VERSION     NP_055839.3
DBSOURCE    REFSEQ: accession NM_015024.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1087)
  AUTHORS   Hu,X., Wang,J., Yang,K., Fan,H., Wu,J., Ren,J., Han,G., Li,J.,
            Xue,Z., Liu,X. and Lv,X.
  TITLE     The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene
  JOURNAL   FASEB J 38 (10), e23666 (2024)
   PUBMED   38780091
  REMARK    GeneRIF: The GWAS SNP rs80207740 modulates erythrocyte traits via
            allele-specific binding of IKZF1 and targeting XPO7 gene.
REFERENCE   2  (residues 1 to 1087)
  AUTHORS   Li,L.Z., Yang,K., Jing,Y., Fan,Y., Jiang,X., Wang,S., Liu,G.H.,
            Qu,J., Ma,S. and Zhang,W.
  TITLE     CRISPR-based screening identifies XPO7 as a positive regulator of
            senescence
  JOURNAL   Protein Cell 14 (8), 623-628 (2023)
   PUBMED   36897256
  REMARK    GeneRIF: CRISPR-based screening identifies XPO7 as a positive
            regulator of senescence.
REFERENCE   3  (residues 1 to 1087)
  AUTHORS   Lin,Y., Zhan,M. and Xu,B.
  TITLE     Exportin XPO7 acts as an oncogenic factor in prostate cancer via
            upregulation of TCF3
  JOURNAL   J Cancer Res Clin Oncol 149 (10), 7663-7677 (2023)
   PUBMED   37000263
  REMARK    GeneRIF: Exportin XPO7 acts as an oncogenic factor in prostate
            cancer via upregulation of TCF3.
REFERENCE   4  (residues 1 to 1087)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (residues 1 to 1087)
  AUTHORS   Innes,A.J., Sun,B., Wagner,V., Brookes,S., McHugh,D., Pombo,J.,
            Porreca,R.M., Dharmalingam,G., Vernia,S., Zuber,J., Vannier,J.B.,
            Garcia-Escudero,R. and Gil,J.
  TITLE     XPO7 is a tumor suppressor regulating p21CIP1-dependent senescence
  JOURNAL   Genes Dev 35 (5-6), 379-391 (2021)
   PUBMED   33602872
  REMARK    GeneRIF: XPO7 is a tumor suppressor regulating p21(CIP1)-dependent
            senescence.
REFERENCE   6  (residues 1 to 1087)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   7  (residues 1 to 1087)
  AUTHORS   Dorfman,J. and Macara,I.G.
  TITLE     STRADalpha regulates LKB1 localization by blocking access to
            importin-alpha, and by association with Crm1 and exportin-7
  JOURNAL   Mol Biol Cell 19 (4), 1614-1626 (2008)
   PUBMED   18256292
  REMARK    GeneRIF: STRADalpha facilitates nuclear export of LKB1 by serving
            as an adaptor between LKB1 and exportins CRM1 and exportin7.
REFERENCE   8  (residues 1 to 1087)
  AUTHORS   Mingot,J.M., Bohnsack,M.T., Jakle,U. and Gorlich,D.
  TITLE     Exportin 7 defines a novel general nuclear export pathway
  JOURNAL   EMBO J 23 (16), 3227-3236 (2004)
   PUBMED   15282546
  REMARK    GeneRIF: Exportin 7-dependent nuclear export signals differ
            fundamentally from the leucine-rich, CRM1-dependent ones
REFERENCE   9  (residues 1 to 1087)
  AUTHORS   Kutay,U., Hartmann,E., Treichel,N., Calado,A., Carmo-Fonseca,M.,
            Prehn,S., Kraft,R., Gorlich,D. and Bischoff,F.R.
  TITLE     Identification of two novel RanGTP-binding proteins belonging to
            the importin beta superfamily
  JOURNAL   J Biol Chem 275 (51), 40163-40168 (2000)
   PUBMED   11024021
REFERENCE   10 (residues 1 to 1087)
  AUTHORS   Koch,P., Bohlmann,I., Schafer,M., Hansen-Hagge,T.E., Kiyoi,H.,
            Wilda,M., Hameister,H., Bartram,C.R. and Janssen,J.W.
  TITLE     Identification of a novel putative Ran-binding protein and its
            close homologue
  JOURNAL   Biochem Biophys Res Commun 278 (1), 241-249 (2000)
   PUBMED   11071879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087363.17, DB460798.1, AF064729.1, BC014219.2 and CN479571.1.
            
            On Aug 2, 2007 this sequence version replaced NP_055839.2.
            
            Summary: The transport of protein and large RNAs through the
            nuclear pore complexes (NPC) is an energy-dependent and regulated
            process. The import of proteins with a nuclear localization signal
            (NLS) is accomplished by recognition of one or more clusters of
            basic amino acids by the importin-alpha/beta complex; see MIM
            600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a
            key role in NLS-dependent protein import. RAN-binding protein-16 is
            a member of the importin-beta superfamily of nuclear transport
            receptors.[supplied by OMIM, Jul 2002].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.136472.1,
                                           SRR1660803.163220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252512.14/ ENSP00000252512.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1087
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     Protein         1..1087
                     /product="exportin-7 isoform b"
                     /note="RAN binding protein 16"
                     /calculated_mol_wt=123777
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.5,
                     ECO:0007744|PubMed:19413330; propagated from
                     UniProtKB/Swiss-Prot (Q9UIA9.3)"
     Region          29..>305
                     /region_name="CRM1"
                     /note="Importin beta-related nuclear transport receptor
                     [Nuclear structure / Intracellular trafficking and
                     secretion]; COG5101"
                     /db_xref="CDD:227432"
     Region          30..96
                     /region_name="IBN_N"
                     /note="Importin-beta N-terminal domain; smart00913"
                     /db_xref="CDD:197981"
     Site            570
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9UIA9.3)"
     CDS             1..1087
                     /gene="XPO7"
                     /gene_synonym="EXP7; RANBP16"
                     /coded_by="NM_015024.5:110..3373"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS47818.1"
                     /db_xref="GeneID:23039"
                     /db_xref="HGNC:HGNC:14108"
                     /db_xref="MIM:606140"
ORIGIN      
        1 madhvqslaq lenlckqlye ttdtttrlqa ekalveftns pdclskcqll lergsssysq
       61 llaatcltkl vsrtnnplpl eqridirnyv lnylatrpkl atfvtqaliq lyaritklgw
      121 fdcqkddyvf rnaitdvtrf lqdsveycii gvtilsqltn einqadtthp ltkhrkiass
      181 frdsslfdif tlscnllkqa sgknlnlnde sqhgllmqll klthnclnfd figtstdess
      241 ddlctvqipt swrsafldss tlqlffdlyh sippsfsplv lsclvqiasv rrslfnnaer
      301 akflshlvdg vkrilenpqs lsdpnnyhef crllarlksn yqlgelvkve nypevirlia
      361 nftvtslqhw efapnsvhyl lslwqrlaas vpyvkateph mletytpevt kayitsrles
      421 vhiilrdgle dpledtglvq qqldqlstig rceyektcal lvqlfdqsaq syqellqsas
      481 aspmdiavqe grltwlvyii gaviggrvsf astdeqdamd gelvcrvlql mnltdsrlaq
      541 agneklelam lsffeqfrki yigdqvqkss klyrrlsevl glndetmvls vfigkiitnl
      601 kywgrcepit sktlqllndl sigyssvrkl vklsavqfml nnhtsehfsf lginnqsnlt
      661 dmrcrttfyt algrllmvdl gededqyeqf mlpltaafea vaqmfstnsf neqeakrtlv
      721 glvrdlrgia fafnaktsfm mlfewiypsy mpilqraiel wyhdpacttp vlklmaelvh
      781 nrsqrlqfdv sspngillfr etskmitmyg nriltlgevp kdqvyalklk gisicfsmlk
      841 aalsgsyvnf gvfrlygdda ldnalqtfik lllsiphsdl ldypklsqsy ysllevltqd
      901 hmnfiaslep hvimyilssi segltaldtm vctgccscld hivtylfkql srstkkrttp
      961 lnqesdrflh imqqhpemiq qmlstvlnii ifedcrnqws msrpllglil lnekyfsdlr
     1021 nsivnsqppe kqqamhlcfe nlmegiernl ltknrdrftq nlsafrrevn dsmknstygv
     1081 nsndmms
//
