LOCUS       NM_015171               4537 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens exportin 6 (XPO6), transcript variant 2, mRNA.
ACCESSION   NM_015171
VERSION     NM_015171.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4537)
  AUTHORS   Zhu,C., Kim,S.J., Mooradian,A., Wang,F., Li,Z., Holohan,S.,
            Collins,P.L., Wang,K., Guo,Z., Hoog,J., Ma,C.X., Oltz,E.M.,
            Held,J.M. and Shao,J.
  TITLE     Cancer-associated exportin-6 upregulation inhibits the
            transcriptionally repressive and anticancer effects of nuclear
            profilin-1
  JOURNAL   Cell Rep 34 (7), 108749 (2021)
   PUBMED   33596420
  REMARK    GeneRIF: Cancer-associated exportin-6 upregulation inhibits the
            transcriptionally repressive and anticancer effects of nuclear
            profilin-1.
REFERENCE   2  (bases 1 to 4537)
  AUTHORS   Boruchowicz,H., Hawkins,J., Cruz-Palomar,K. and Lippe,R.
  TITLE     The XPO6 Exportin Mediates Herpes Simplex Virus 1 gM Nuclear
            Release Late in Infection
  JOURNAL   J Virol 94 (21), e00753-20 (2020)
   PUBMED   32817212
  REMARK    GeneRIF: The XPO6 Exportin Mediates Herpes Simplex Virus 1 gM
            Nuclear Release Late in Infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4537)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 4537)
  AUTHORS   Fiore,A.P.Z.P., Spencer,V.A., Mori,H., Carvalho,H.F., Bissell,M.J.
            and Bruni-Cardoso,A.
  TITLE     Laminin-111 and the Level of Nuclear Actin Regulate Epithelial
            Quiescence via Exportin-6
  JOURNAL   Cell Rep 19 (10), 2102-2115 (2017)
   PUBMED   28591581
  REMARK    GeneRIF: These results shed light on the crucial role of LN1 in
            quiescence and differentiation and how defects in the
            LN1/PI3K/XPO6/N-actin axis explain the loss of tissue homeostasis
            and growth control that contributes to malignant progression.
REFERENCE   5  (bases 1 to 4537)
  AUTHORS   Fu,B., Wang,L., Li,S. and Dorf,M.E.
  TITLE     ZMPSTE24 defends against influenza and other pathogenic viruses
  JOURNAL   J Exp Med 214 (4), 919-929 (2017)
   PUBMED   28246125
REFERENCE   6  (bases 1 to 4537)
  AUTHORS   Park,S.H., Park,T.J. and Lim,I.K.
  TITLE     Reduction of exportin 6 activity leads to actin accumulation via
            failure of RanGTP restoration and NTF2 sequestration in the nuclei
            of senescent cells
  JOURNAL   Exp Cell Res 317 (7), 941-954 (2011)
   PUBMED   21195711
  REMARK    GeneRIF: Data suggest actin accumulation in senescent cells is due
            to the failure of RanGTP restoration with ATP deficiency and NTF2
            accumulation, resulting in decreased actin export via Exp6
            inactivation.
REFERENCE   7  (bases 1 to 4537)
  AUTHORS   Ambs,S., Prueitt,R.L., Yi,M., Hudson,R.S., Howe,T.M., Petrocca,F.,
            Wallace,T.A., Liu,C.G., Volinia,S., Calin,G.A., Yfantis,H.G.,
            Stephens,R.M. and Croce,C.M.
  TITLE     Genomic profiling of microRNA and messenger RNA reveals deregulated
            microRNA expression in prostate cancer
  JOURNAL   Cancer Res 68 (15), 6162-6170 (2008)
   PUBMED   18676839
REFERENCE   8  (bases 1 to 4537)
  AUTHORS   Suzuki,T., Ishigami,Y., Okada,N., Kaneko,A., Fukutomi,R. and
            Isemura,M.
  TITLE     Differentiation-associated alteration in gene expression of
            importins and exportins in human leukemia HL-60 cells
  JOURNAL   Biomed Res 29 (3), 141-145 (2008)
   PUBMED   18614847
REFERENCE   9  (bases 1 to 4537)
  AUTHORS   Suzuki,T., Tazoe,H., Taguchi,K., Koyama,Y., Ichikawa,H.,
            Hayakawa,S., Munakata,H. and Isemura,M.
  TITLE     DNA microarray analysis of changes in gene expression induced by
            1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60
            cells
  JOURNAL   Biomed Res 27 (3), 99-109 (2006)
   PUBMED   16847355
REFERENCE   10 (bases 1 to 4537)
  AUTHORS   Stuven,T., Hartmann,E. and Gorlich,D.
  TITLE     Exportin 6: a novel nuclear export receptor that is specific for
            profilin.actin complexes
  JOURNAL   EMBO J 22 (21), 5928-5940 (2003)
   PUBMED   14592989
  REMARK    GeneRIF: identify exportin 6 (Exp6) as a novel family member from
            higher eukaryotes and show that it mediates nuclear export of
            profilin.actin complexes
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC136611.2, BI465054.1,
            BX346769.2, AB002368.3, AY026388.1 and AK026172.1.
            
            On Jun 2, 2019 this sequence version replaced NM_015171.3.
            
            Summary: The protein encoded by this gene is a member of the
            importin-beta family. Members of this family are regulated by the
            GTPase Ran to mediate transport of cargo across the nuclear
            envelope. This protein has been shown to mediate nuclear export of
            profilin-actin complexes. A pseudogene of this gene is located on
            the long arm of chromosome 14. Alternative splicing results in
            multiple transcript variants that encode different protein
            isoforms. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR and initiates translation at an alternate start codon,
            compared to variant 1. The encoded isoform (2) has a distinct
            N-terminus and is longer than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3611400.1, AB002368.3
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304658.10/ ENSP00000302790.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC136611.2         40216-40262
            48-52               BI465054.1         5-9
            53-96               BX346769.2         1-44
            97-2849             AB002368.3         1-2753
            2850-4518           AY026388.1         2276-3944
            4519-4537           AK026172.1         3616-3634
FEATURES             Location/Qualifiers
     source          1..4537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..4537
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /note="exportin 6"
                     /db_xref="GeneID:23214"
                     /db_xref="HGNC:HGNC:19733"
                     /db_xref="MIM:608411"
     exon            1..600
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..3975
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ran-binding protein 20"
                     /codon_start=1
                     /product="exportin-6 isoform 2"
                     /protein_id="NP_055986.1"
                     /db_xref="CCDS:CCDS42135.1"
                     /db_xref="GeneID:23214"
                     /db_xref="HGNC:HGNC:19733"
                     /db_xref="MIM:608411"
                     /translation="MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGA
                     WRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTL
                     PYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACP
                     REDLSVARKEELRKLLLDQVQTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLL
                     SNLLQSPSSAKLLNQPIPILDVESEYICSLALECLAHLFSWIPLSASITPSLLTTIFH
                     FARFGCDIRARKMASVNGSSQNCVSGQERGRLGVLAMSCINELMSKNCVPMEFEEYLL
                     RMFQQTFYLLQKITKDNNAHTVKSRLEELDESYIEKFTDFLRLFVSVHLRRIESYSQF
                     PVVEFLTLLFKYTFHQPTHEGYFSCLDIWTLFLDYLTSKIKSRLGDKEAVLNRYEDAL
                     VLLLTEVLNRIQFRYNQAQLEELDDETLDDDQQTEWQRYLRQSLEVVAKVMELLPTHA
                     FSTLFPVLQDNLEVYLGLQQFIVTSGSGHRLNITAENDCRRLHCSLRDLSSLLQAVGR
                     LAEYFIGDVFAARFNDALTVVERLVKVTLYGSQIKLYNIETAVPSVLKPDLIDVHAQS
                     LAALQAYSHWLAQYCSEVHRQNTQQFVTLISTTMDAITPLISTKVQDKLLLSACHLLV
                     SLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQVLVCRALSNILLLPWPNLPEN
                     EQQWPVRSINHASLISALSRDYRNLKPSAVAPQRKMPLDDTKLIIHQTLSVLEDIVEN
                     ISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLSFFLTLFRGLRVQMGVP
                     FTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVVQEPGQVFKPFLPSI
                     IALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLASVQRGIAEEQME
                     NEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRTAMLFQFVNVL
                     LQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQKSVLGRNF
                     KMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL"
     exon            601..691
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            692..804
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1002
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1162
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1240
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1694
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1821
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1931
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2040
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2133
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2203
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2363
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2456
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2601
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2748
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2938
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3094
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3209
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3381
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3543
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3642
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3873
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     exon            3874..4537
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4508..4513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /note="hexamer: AATAAA"
     polyA_site      4537
                     /gene="XPO6"
                     /gene_synonym="EXP6; RANBP20"
                     /note="major polyA site"
ORIGIN      
        1 acttccggcg cgttggggct gttggtcggg ggcggccgcg cggtactagc gggcggctcc
       61 agggcgggcg cgcgcaagga tgctctaggg ggcggcggca gtggccgtgt gggttgaggc
      121 tgcgaggaca gcgcgggccc ccgggcctct cccctgagcc ggccgcctgg gccgcgcggt
      181 cgaggcctgt cagcctccgc ccgttcagcc tcggggccgg ggccgccgcc acctctgccc
      241 gcggaggccg gggagcccct gcctgggccc gcagcctccc ccgcgggggt cgggcccggg
      301 cgggggtccc gagcagctgc cctcctcgcc ggcatccgag cctcatttcc tgctttttca
      361 gtttccttgg ggaggggcgg gtgggtctgg atgaattgtc tcggggtccc ccgatgaggc
      421 gacccgggcg gccctgccct ttttagaggg tcccctcggg gcccggtggg gaaggggttg
      481 tctttgcatg ggtgggggac ttcccgagtc tgccgggacc atgacctgaa ctgtgcgagc
      541 gggacgtgtc cgaagcccaa gaaccagctc atctgagccg ccccctcccc ggccagcatg
      601 gcatctgaag aagcctctct cagggcattg gaaagtctga tgacagaatt ttttcacgat
      661 tgtacaacca atgaaagaaa acgtgagata gaggagcttc ttaataactt tgcccagcaa
      721 ataggagcct ggagattctg cctgtacttt ctctccagca ctaggaatga ctatgtaatg
      781 atgtacagtt taacagtttt tgagaatctg atcaataaaa tgtggcttgg ggtcccatct
      841 caggataaga tggaaatccg tagctgtctg cccaaactcc ttttggctca ccataaaacc
      901 ttaccttact ttatccggaa caagctctgc aaagttattg ttgatattgg acgtcaggat
      961 tggcccatgt tctaccacga cttttttact aacattttac agttgatcca gtcccctgtg
     1021 acaacccccc ttgggctgat catgttgaag acaacttcag aagagctggc ttgtccccgt
     1081 gaggacctca gtgtggctcg gaaggaggag ttgcggaagc tgctactgga ccaggtgcag
     1141 acagtgcttg ggctactgac aggtatcttg gagactgtct gggacaaaca cagtgttact
     1201 gctgccactc caccaccatc cccgacctca ggagaaagtg gtgacttact gagtaacctg
     1261 ttgcagagtc ccagttcagc caaactgttg aatcagccaa ttcccatcct tgatgtggag
     1321 agtgagtata tctgttccct ggctttggag tgcctggccc atctcttcag ttggattcct
     1381 ctgtctgcca gcatcacccc atccctcctt accaccatct tccactttgc acgatttggc
     1441 tgtgacatcc gggccagaaa gatggcgtca gttaacggca gcagccagaa ctgtgtctcg
     1501 ggtcaggagc gcggccggct gggggtcctg gccatgtcct gcatcaatga actcatgtcc
     1561 aagaactgtg tgcctatgga atttgaggag tatttactgc gtatgttcca gcagactttc
     1621 tacctcctgc agaaaatcac caaggataac aatgcccaca cagtgaagag caggctagaa
     1681 gagctcgatg agagctatat cgagaagttt actgactttc ttcggctctt tgtgagtgtt
     1741 cacctaagaa gaatcgagtc ttactcccag ttccctgtgg tggagttttt gacacttttg
     1801 ttcaagtaca catttcatca gcctactcat gaaggttact tctcttgttt ggatatctgg
     1861 acgctgtttt tggactatct gacaagtaaa attaaaagtc gtcttggaga caaggaagca
     1921 gttctcaaca ggtacgaaga tgccctggtg ctcctgctca cagaggtgtt gaatcgaatc
     1981 cagttcagat acaaccaagc ccagctggag gagttggatg atgagactct ggatgacgat
     2041 cagcagacgg agtggcagcg gtacttacgg cagagcttgg aggtggtggc caaagtgatg
     2101 gagctcctgc ccacgcacgc cttctccaca ctgttccctg ttcttcagga caatttagaa
     2161 gtttatttgg gattacaaca gtttatagtc acttcagggt caggacacag gttgaacatc
     2221 acggcggaga acgactgccg gcggctgcac tgctccctga gagacttgag ctccctgctg
     2281 caggccgtgg gccgcctggc cgagtacttt atcggggatg tgtttgctgc acggttcaat
     2341 gatgccctca cagtcgtgga aaggttggtc aaagtcactc tgtacggatc tcagataaaa
     2401 ttgtacaaca ttgaaactgc tgtgccatca gtattgaaac ctgacctcat tgatgtgcat
     2461 gctcagtccc tggctgcgct gcaggcttac tctcactggt tagcacagta ttgcagtgaa
     2521 gttcaccggc agaacacgca gcagttcgtg acactcatct ctactaccat ggatgcaatc
     2581 acacctctaa tcagcaccaa ggtccaagac aagctgctgc tatctgcgtg ccacttactg
     2641 gtctcactgg ccaccaccgt gcggcccgtc tttctgatca gcatccctgc agtgcagaaa
     2701 gtattcaaca gaatcactga tgcctctgcc ctgcgacttg tcgataaggc ccaggtgttg
     2761 gtgtgccgag ccctctctaa catcttgctg cttccgtggc caaaccttcc agagaatgag
     2821 cagcagtggc ccgtgcgctc catcaaccac gccagcctca tctctgcact ctcccgggac
     2881 tatcgcaacc tgaagcccag tgctgttgcc ccacagagaa agatgccact ggatgacacc
     2941 aaactgatta tccaccagac actcagcgtc ttagaagata ttgtggagaa tatctcgggg
     3001 gagtccacca agtctcgaca gatttgctac cagtcgctgc aggaatctgt tcaggtctcc
     3061 ctggccctct ttccagcttt tatccatcag tcagatgtga ctgatgagat gctgagcttc
     3121 ttcctcactc tgtttcgagg ccttagagta cagatgggtg tgcctttcac tgagcaaatc
     3181 atacagactt tcctcaacat gtttaccaga gagcagttag ccgagagcat cctccacgag
     3241 ggcagcacag gctgccgggt ggtggagaag tttctgaaga tcctgcaggt ggtggtccag
     3301 gagccaggcc aggtgttcaa gcccttcctc cccagcatca tcgccctgtg catggagcaa
     3361 gtgtatccca tcattgccga gcgtccctcc cctgatgtga aggccgagct gtttgagctc
     3421 cttttccgga cgctccatca caactggagg tacttcttca agtccaccgt gctggccagt
     3481 gtccagaggg ggatcgctga ggagcagatg gagaatgagc cccagttcag tgccatcatg
     3541 caggctttcg gacagtcctt tctccagccc gacatccacc tttttaaaca aaatctcttc
     3601 tacttggaga ctctcaacac caagcagaag ctgtaccaca agaagatctt ccggactgcc
     3661 atgctgttcc agtttgtgaa cgtgctgctc caggtcctgg tccacaagtc ccatgatctt
     3721 ctgcaggagg agattggcat cgccatctac aacatggcct cagtcgactt tgatggcttc
     3781 tttgccgcct tcctcccaga gttcctgacc agctgtgatg gtgtggatgc caaccagaaa
     3841 agtgtgctgg ggcggaattt caagatggat cgggacctgc cctcattcac ccagaatgtg
     3901 cacaggctgg tcaacgacct gcgctactac agactctgca acgacagcct gccccctggc
     3961 actgtgaagc tctaggcctg ctactgcctg gggacacgga cttctgctgc tgccacctgc
     4021 gccagcccta ccttccacca cagatgtctc ccagatgggc cttggtcaca ctccttggct
     4081 tctcccaccg caagcaacgc tgcctgcctc tgccgctcct ccacatcttg ccgctgccca
     4141 gcagagctgg cttctgggtc cacctgagca ctggacggtg ctcccagggc gttggagcag
     4201 gcggaggggt gtgtggccag gtactaggag gcaccaggaa atcccgcggg gtggcccatg
     4261 cagaccaggc gcacgtggct catggggcag aattgccaag gacagctcac gacagtgcca
     4321 ccttctcacc attccagcca aggagagatg tgacgttgga actgctctgg cacttctgtc
     4381 aagcctcccc cgccccaatt gccttgagat ctctgctctt tgtcagagat ttgcaaagac
     4441 tcacgttttt gttgttttct catcattcca ttgtgatact aagaaactaa gaagcttaat
     4501 gaaaagaaat aaaatgccta tgttgttgtt ctagaaa
//
