LOCUS       NM_020750               5323 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens exportin 5 (XPO5), transcript variant 1, mRNA.
ACCESSION   NM_020750
VERSION     NM_020750.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5323)
  AUTHORS   Li,C., Yoon,B., Stefani,G. and Slack,F.J.
  TITLE     Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through
            interacting with nuclear export protein XPO5
  JOURNAL   Nucleic Acids Res 51 (18), 9849-9862 (2023)
   PUBMED   37655623
  REMARK    GeneRIF: Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis
            through interacting with nuclear export protein XPO5.
REFERENCE   2  (bases 1 to 5323)
  AUTHORS   Alquraan,K.M. and Khabour,O.F.
  TITLE     Investigation of the association of the RAN (rs14035) and XPO5
            (rs11077) polymorphisms with venous thromboembolism
  JOURNAL   Rom J Intern Med 61 (3), 154-162 (2023)
   PUBMED   37311119
  REMARK    GeneRIF: Investigation of the association of the RAN (rs14035) and
            XPO5 (rs11077) polymorphisms with venous thromboembolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5323)
  AUTHORS   Chen,X., He,X., Yang,Y.Y. and Wang,Y.
  TITLE     Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Modulate
            miRNA Biogenesis through Aberrant Interactions with Exportin 5
  JOURNAL   ACS Chem Biol 17 (12), 3450-3457 (2022)
   PUBMED   36475596
  REMARK    GeneRIF: Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1
            Modulate miRNA Biogenesis through Aberrant Interactions with
            Exportin 5.
REFERENCE   4  (bases 1 to 5323)
  AUTHORS   Hussain,H.M.J., Cai,Y., Weng,Q., Tong,J., Aftab,A., Jin,Y., Liu,J.,
            Yu,S., Fang,Z., Du,W., Pan,X., Ren,H. and Xie,J.
  TITLE     Mutation in XPO5 causes adult-onset autosomal dominant familial
            focal segmental glomerulosclerosis
  JOURNAL   Hum Genomics 16 (1), 57 (2022)
   PUBMED   36371311
  REMARK    GeneRIF: Mutation in XPO5 causes adult-onset autosomal dominant
            familial focal segmental glomerulosclerosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5323)
  AUTHORS   Duman,G., Sariakcali,B., Ersan,S. and Bakir,S.
  TITLE     The impact of Dicer, Drosha, and Exportin-5 levels in polycystic
            ovary syndrome (PCOS) diagnosis and phenotyping
  JOURNAL   Endokrynol Pol 73 (1), 8-15 (2022)
   PUBMED   34855193
  REMARK    GeneRIF: The impact of Dicer, Drosha, and Exportin-5 levels in
            polycystic ovary syndrome (PCOS) diagnosis and phenotyping.
REFERENCE   6  (bases 1 to 5323)
  AUTHORS   Screaton,R.A., Kiessling,S., Sansom,O.J., Millar,C.B., Maddison,K.,
            Bird,A., Clarke,A.R. and Frisch,S.M.
  TITLE     Fas-associated death domain protein interacts with methyl-CpG
            binding domain protein 4: a potential link between genome
            surveillance and apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 100 (9), 5211-5216 (2003)
   PUBMED   12702765
REFERENCE   7  (bases 1 to 5323)
  AUTHORS   Gwizdek,C., Ossareh-Nazari,B., Brownawell,A.M., Doglio,A.,
            Bertrand,E., Macara,I.G. and Dargemont,C.
  TITLE     Exportin-5 mediates nuclear export of minihelix-containing RNAs
  JOURNAL   J Biol Chem 278 (8), 5505-5508 (2003)
   PUBMED   12509441
REFERENCE   8  (bases 1 to 5323)
  AUTHORS   Calado,A., Treichel,N., Muller,E.C., Otto,A. and Kutay,U.
  TITLE     Exportin-5-mediated nuclear export of eukaryotic elongation factor
            1A and tRNA
  JOURNAL   EMBO J 21 (22), 6216-6224 (2002)
   PUBMED   12426393
  REMARK    GeneRIF: Eukaryotic elongation factor 1A (eEF1A) and tRNA are
            RanGTP-dependent binding partners of exportin-5 (Exp5). Exp5
            stimulates nuclear export of eEF1A and tRNA.
REFERENCE   9  (bases 1 to 5323)
  AUTHORS   Bohnsack,M.T., Regener,K., Schwappach,B., Saffrich,R.,
            Paraskeva,E., Hartmann,E. and Gorlich,D.
  TITLE     Exp5 exports eEF1A via tRNA from nuclei and synergizes with other
            transport pathways to confine translation to the cytoplasm
  JOURNAL   EMBO J 21 (22), 6205-6215 (2002)
   PUBMED   12426392
  REMARK    GeneRIF: Exp5 exports eEF1A via tRNA from nuclei and synergizes
            with other transport pathways to confine translation to the
            cytoplasm.
REFERENCE   10 (bases 1 to 5323)
  AUTHORS   Brownawell,A.M. and Macara,I.G.
  TITLE     Exportin-5, a novel karyopherin, mediates nuclear export of
            double-stranded RNA binding proteins
  JOURNAL   J Cell Biol 156 (1), 53-64 (2002)
   PUBMED   11777942
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB068849.1, AF298880.1,
            AB033117.2 and BF108994.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_020750.2.
            
            Summary: This gene encodes a member of the karyopherin family that
            is required for the transport of small RNAs and double-stranded
            RNA-binding proteins from the nucleus to the cytoplasm. The encoded
            protein translocates cargo through the nuclear pore complex in a
            RanGTP-dependent process. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF298880.1, AK291452.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265351.12/ ENSP00000265351.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               DB068849.1         38-148
            112-3476            AF298880.1         1-3365
            3477-5320           AB033117.2         3453-5296
            5321-5323           BF108994.1         19-21               c
FEATURES             Location/Qualifiers
     source          1..5323
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..5323
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /note="exportin 5"
                     /db_xref="GeneID:57510"
                     /db_xref="HGNC:HGNC:17675"
                     /db_xref="MIM:607845"
     exon            1..279
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..3789
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /note="ran-binding protein 21"
                     /codon_start=1
                     /product="exportin-5"
                     /protein_id="NP_065801.1"
                     /db_xref="CCDS:CCDS47430.1"
                     /db_xref="GeneID:57510"
                     /db_xref="HGNC:HGNC:17675"
                     /db_xref="MIM:607845"
                     /translation="MAMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKC
                     PICVPCGLRLAEKTQVAIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANGT
                     LNILEEENHIKDALSRIVVEMIKREWPQHWPDMLIELDTLSKQGETQTELVMFILLRL
                     AEDVVTFQTLPPQRRRDIQQTLTQNMERIFSFLLNTLQENVNKYQQVKTDTSQESKAQ
                     ANCRVGVAALNTLAGYIDWVSMSHITAENCKLLEILCLLLNEQELQLGAAECLLIAVS
                     RKGKLEDRKPLMVLFGDVAMHYILSAAQTADGGGLVEKHYVFLKRLCQVLCALGNQLC
                     ALLGADSDVETPSNFGKYLESFLAFTTHPSQFLRSSTQMTWGALFRHEILSRDPLLLA
                     IIPKYLRASMTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQQGEVMRLA
                     CRLDPKTSFQMAGEWLKYQLSTFLDAGSVNSCSAVGTGEGSLCSVFSPSFVQWEAMTL
                     FLESVITQMFRTLNREEIPVNDGIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYR
                     PEFLPQVFSKLFSSVTFETVEESKAPRTRAVRNVRRHACSSIIKMCRDYPQLVLPNFD
                     MLYNHVKQLLSNELLLTQMEKCALMEALVLISNQFKNYERQKVFLEELMAPVASIWLS
                     QDMHRVLSDVDAFIAYVGTDQKSCDPGLEDPCGLNRARMSFCVYSILGVVKRTCWPTD
                     LEEAKAGGFVVGYTSSGNPIFRNPCTEQILKLLDNLLALIRTHNTLYAPEMLAKMAEP
                     FTKALDMLDAEKSAILGLPQPLLELNDSPVFKTVLERMQRFFSTLYENCFHILGKAGP
                     SMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSP
                     ILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQLVRMLTREVMDL
                     ITVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLI
                     TAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKGLQMHGQHDG
                     CMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQKVADKRR
                     KDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSLFKKTKPMLETEVLDNDGGGLATIFEP
                     "
     exon            280..401
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            402..474
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            475..612
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            613..795
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            796..822
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1008
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1085
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1185
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1269
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1395
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1486
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1615
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1746
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1902
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1944
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2034
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2234
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2334
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2516
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2617
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2714
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..2851
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..2949
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..2996
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3094
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3157
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3240
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3241..3348
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3349..3486
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3651
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..5323
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3810
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /note="major polyA site"
     regulatory      5297..5302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /note="hexamer: AGTAAA"
     polyA_site      5323
                     /gene="XPO5"
                     /gene_synonym="exp5"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgcagcg ccggcttctt cccagcgcga gttgctgcta acgctcctcc tccagcttcc
       61 cacccccgcc gcccgccgcg gcccggtacc aacgggtggt ctcgccgagg gagctgtcgt
      121 gcctcgtggt cccgggactg cagtggtgtg cgctctcggc gcgtggcgct aggcatggcg
      181 atggatcaag taaacgcgct gtgcgagcag ctggtgaaag cggtgacggt catgatggac
      241 cccaactcca cccagcgcta ccggctggaa gccctcaagt tttgtgagga gtttaaagaa
      301 aagtgtccta tctgtgtccc ctgtggcttg aggttggctg agaaaacaca agttgccatc
      361 gtcagacatt ttggccttca gatcctggaa cacgttgtca agtttcggtg gaacggcatg
      421 tctcgattgg agaaggtgta tctgaagaac agtgtcatgg agctgattgc aaatggaaca
      481 ttgaacattt tggaagagga gaaccatatt aaagatgctc tgtctcgaat tgtagtggaa
      541 atgatcaagc gagagtggcc acagcattgg cctgacatgc taatagaatt ggacactctt
      601 tccaaacaag gggaaacaca gacagaattg gtgatgttta tccttttgcg actggcagag
      661 gatgtagtga cttttcagac acttccccct caaagaagaa gggacatcca gcaaacatta
      721 acccagaaca tggaaaggat cttcagtttt ctgcttaaca cacttcaaga aaatgtaaac
      781 aagtatcagc aagtgaagac agatacttct caggagtcaa aggcgcaagc aaactgtcga
      841 gtaggagttg cagcactgaa tactctagca ggctatattg actgggtgtc tatgagtcac
      901 atcactgctg aaaactgtaa actcctggag atactgtgtt tgctgttgaa tgaacaggaa
      961 cttcagttgg gagccgctga gtgtcttctc attgcagtca gcagaaaagg caagttggaa
     1021 gaccggaagc ccttgatggt cttatttgga gatgttgcca tgcattatat actctccgcc
     1081 gcacagactg ctgatggagg aggtttggta gaaaaacact acgtctttct gaagaggctc
     1141 tgtcaggtgt tgtgtgcgct gggcaatcag ctgtgtgcat tgctgggtgc agattctgat
     1201 gtagaaacac catcaaactt tggaaaatac ctggaatctt ttcttgcttt cacaacccat
     1261 ccaagtcagt ttctacgctc ttcaactcag atgacttggg gagccctctt caggcatgaa
     1321 atcctgtccc gtgatccttt gctattagca ataataccaa aatatcttcg tgcttccatg
     1381 actaacttgg tcaagatggg ctttccttct aaaacagaca gccctagctg tgaatattct
     1441 cggtttgatt ttgatagcga tgaggacttc aatgctttct tcaactcctc ccgagcacaa
     1501 caaggagagg tgatgaggtt ggcatgtcgt ttggatccca aaactagctt ccagatggct
     1561 ggggagtggc taaagtatca actatcaact tttcttgatg ctggttctgt gaattcttgt
     1621 tctgcagttg gaactggaga aggaagcctc tgttccgtct tctcaccttc attcgtgcag
     1681 tgggaagcca tgactctttt tttggaaagt gttatcaccc agatgtttcg aacactaaat
     1741 agagaagaaa ttcctgttaa tgatggaata gagctattgc agatggttct gaactttgat
     1801 accaaggatc ccctcatcct gtcctgcgtc cttactaatg tctctgcact ctttccattt
     1861 gtcacctaca gaccagagtt cctgccccag gtcttctcta agctattttc atctgtcact
     1921 tttgaaactg ttgaagaaag taaggccccc agaacccggg cagtgaggaa tgtgaggagg
     1981 catgcttgtt cctccatcat caagatgtgt cgtgactacc cccagcttgt gctgcccaat
     2041 tttgacatgc tttataacca tgtgaagcaa ctcctctcca atgagctact cctgacacaa
     2101 atggagaagt gtgccctcat ggaagccctg gttctcatta gcaaccaatt taagaactac
     2161 gagcgtcaga aggtgttcct agaggagctg atggcaccag tggccagcat ctggctttct
     2221 caagacatgc acagagtgct gtcagatgtt gatgctttca ttgcgtatgt gggtacagat
     2281 cagaagagct gtgacccagg cctggaggat ccgtgtggct taaaccgtgc acgaatgagc
     2341 ttttgtgtat acagcattct gggtgtggtg aaacgaactt gctggcccac tgacctagaa
     2401 gaggccaaag ctgggggatt tgtggtgggt tatacatcca gtggaaatcc aatcttccgt
     2461 aacccctgca cagagcagat tctgaaactt cttgacaatt tgcttgcgct tataagaacc
     2521 cacaatacat tatatgcacc agaaatgcta gccaaaatgg cagagccttt caccaaggct
     2581 ctggatatgc ttgacgcgga aaaatctgct atattaggat tacctcaacc tctcttggaa
     2641 ctcaatgact ctcctgtctt caaaaccgtc ttggaaagaa tgcagcgttt cttctctacc
     2701 ctctatgaaa actgttttca tatcctaggg aaggcaggcc cttccatgca gcaagacttc
     2761 tatactgtgg aggaccttgc tacccagctt ctcagctcag cctttgtcaa cttgaacaat
     2821 attcctgact accgactcag acccatgctt cgtgtctttg taaagcctct ggtgctcttc
     2881 tgtcccccag agcactatga agccctggta tcccccatcc tcggacctct tttcacctac
     2941 ctccatatga ggctttctca gaaatggcaa gttatcaacc aaaggagcct gctgtgtgga
     3001 gaagatgagg ctgcagatga aaacccagag tctcaagaga tgctggagga gcaactggtg
     3061 aggatgttaa cccgagaagt catggaccta atcacggttt gctgtgtttc aaagaagggt
     3121 gctgaccaca gtagtgctcc cccagcagat ggagacgatg aagaaatgat ggccacagag
     3181 gtcaccccct cagctatggc agagcttaca gacctgggca aatgtctgat gaagcatgag
     3241 gatgtttgta cagcgctatt aattacagcc ttcaattccc tggcctggaa agatactctg
     3301 tcctgccaga ggacaacctc acagctctgc tggcctctcc tcaaacaagt gctgtcaggg
     3361 acactgctcg cagatgcagt tacgtggctt ttcaccagtg tgctgaaagg cttacagatg
     3421 cacgggcagc acgacgggtg catggcttcc ctggtccatc tggccttcca gatatacgag
     3481 gcactgcgcc ccaggtacct ggagataaga gctgtaatgg agcaaatccc tgaaatacag
     3541 aaggactcac tggaccagtt tgactgcaag cttttaaacc cctccctgca gaaagtggct
     3601 gacaagcgcc gaaaggacca attcaaacgc ctcattgctg gttgcattgg gaaacccttg
     3661 ggagagcagt tccgaaaaga agttcacatt aagaatcttc cctcactttt caaaaaaaca
     3721 aagccaatgc tggagacgga ggtgctggac aatgatgggg gtggcctggc caccatcttt
     3781 gaaccctgaa tcaagctttt gggcatcctt cctcggcctt tcttgtcatc tcttctttcc
     3841 ctttgtagcc gatctctagg cccttcttgc actgccacct cactttccac cactgtcagc
     3901 ctggaaagag atccaggtct ggagctggag agaacaggcc ctgtgcagga ccagaagtaa
     3961 ttatactaaa gtatcaagaa agggagttag ggcttaaact attctgtcta gatgtcccag
     4021 atagttccca ttctacttgg agatttggct tttccaagaa aagctagagc agagcagccc
     4081 ttctcccaca agccctccca cccccgtgca gccacatacc tgtacagaat ggtaactaag
     4141 ggtgctgtgc ccaaccctgc gactagcaag gctcgcagca agagcacagc cctcaactac
     4201 ttgtgccaga gtttctcttg gaccactcca actcccactg agcccttttg ctgctgggct
     4261 ggcaggaaac tttccccact ccctaagggg catgtctggg ttaggtgcta agtgctgaag
     4321 agaacttggt cagttctctc aactttgctt tgggcaagaa tctggtcacc tgatgggatc
     4381 catggtacag gctactgcta aacttggcac agtatcaagt atagtacctc caaggaccag
     4441 ggctgggaag tctttagtgc taacatcccc tttagagttc acacatcttg cccttccatg
     4501 aatgacccct cagtctggcc tccccagcct caaggtccac tcaggcacaa gagccacagt
     4561 accctagata gtgtcacatg acaccgttgt catccaagga taatacagac caactaggct
     4621 acatctgtga tgagcagcta gcaaagccgc tggtcttctc ctaggactaa gtccaggtgc
     4681 cttccacaat ctcatggtct ttcaggtccc tggttacttt tctcaaaggc catttccaaa
     4741 agaatacatg ccttcacatc acaacctgta ctgtgagtcc attctagagg tcactgaaag
     4801 gccctgtaaa gagaggacat ggatacggga cctggccctg aggttattac tggccgtaag
     4861 gcagagttaa tccatacaga aaccagtgtg tccatgtgct ctgcacaaaa acagacctgt
     4921 tgtccatcca gtccactgac aagagggttt ccccgagagc cgaagtggac tgaagctaca
     4981 gtttttagct ggtgcgggcc acaggcaggg tcagattgag aagaagcaaa gctggggaag
     5041 cagaagttgg gagtcttgtg ttgctccctc ttcctgtgtg gtgctctggg tttctgtgga
     5101 tcgtgaaggc gatctcaaga gtgtttccct ccaaacctga tagctgccta ttcctgtctg
     5161 gttggggctg tggaggatgt agttgtattt attgcattgt aatattttta acatcctgtg
     5221 acttcatgct agaaattttc tattgtttat agaaactttt tgtagaaaca ttaactctaa
     5281 agcacatctg catgtcagta aaaatctcag tttcgtacag aaa
//
