LOCUS       NM_022459               9857 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens exportin 4 (XPO4), transcript variant 1, mRNA.
ACCESSION   NM_022459
VERSION     NM_022459.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9857)
  AUTHORS   Pan,Z., Bayoumi,A., Metwally,M., George,J. and Eslam,M.
  TITLE     Exportin 4 DNA promoter methylation in liver fibrosis
  JOURNAL   PLoS One 19 (5), e0302786 (2024)
   PUBMED   38722973
  REMARK    GeneRIF: Exportin 4 DNA promoter methylation in liver fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9857)
  AUTHORS   Metwally,M., Bayoumi,A., Khan,A., Adams,L.A., Aller,R.,
            Garcia-Monzon,C., Arias-Loste,M.T., Bugianesi,E., Miele,L.,
            Anna,A., Latchoumanin,O., Han,S., Alenizi,S., Sharkawy,R.E.,
            Elattar,A., Gallego-Duran,R., Fischer,J., Berg,T., Liddle,C.,
            Romero-Gomez,M., George,J. and Eslam,M.
  TITLE     Copy number variation and expression of exportin-4 associates with
            severity of fibrosis in metabolic associated fatty liver disease
  JOURNAL   EBioMedicine 70, 103521 (2021)
   PUBMED   34388518
  REMARK    GeneRIF: Copy number variation and expression of exportin-4
            associates with severity of fibrosis in metabolic associated fatty
            liver disease.
REFERENCE   3  (bases 1 to 9857)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   4  (bases 1 to 9857)
  AUTHORS   Aksu,M., Trakhanov,S. and Gorlich,D.
  TITLE     Structure of the exportin Xpo4 in complex with RanGTP and the
            hypusine-containing translation factor eIF5A
  JOURNAL   Nat Commun 7, 11952 (2016)
   PUBMED   27306458
  REMARK    GeneRIF: Molecular structure of the exportin Xpo4 in complex with
            RanGTP and the hypusine-containing translation factor eIF5A has
            been reported.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9857)
  AUTHORS   Bhardwaj,A. and Das,S.
  TITLE     SIRT6 deacetylates PKM2 to suppress its nuclear localization and
            oncogenic functions
  JOURNAL   Proc Natl Acad Sci U S A 113 (5), E538-E547 (2016)
   PUBMED   26787900
REFERENCE   6  (bases 1 to 9857)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 9857)
  AUTHORS   Kurisaki,A., Kurisaki,K., Kowanetz,M., Sugino,H., Yoneda,Y.,
            Heldin,C.H. and Moustakas,A.
  TITLE     The mechanism of nuclear export of Smad3 involves exportin 4 and
            Ran
  JOURNAL   Mol Cell Biol 26 (4), 1318-1332 (2006)
   PUBMED   16449645
  REMARK    GeneRIF: A short peptide representing the minimal interaction
            domain in Smad3 effectively competes with Smad3 association to
            exportin 4 and blocks nuclear export of Smad3 in vivo.
REFERENCE   8  (bases 1 to 9857)
  AUTHORS   King,F.W. and Shtivelman,E.
  TITLE     Inhibition of nuclear import by the proapoptotic protein CC3
  JOURNAL   Mol Cell Biol 24 (16), 7091-7101 (2004)
   PUBMED   15282309
REFERENCE   9  (bases 1 to 9857)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   10 (bases 1 to 9857)
  AUTHORS   Lipowsky,G., Bischoff,F.R., Schwarzmaier,P., Kraft,R., Kostka,S.,
            Hartmann,E., Kutay,U. and Gorlich,D.
  TITLE     Exportin 4: a mediator of a novel nuclear export pathway in higher
            eukaryotes
  JOURNAL   EMBO J 19 (16), 4362-4371 (2000)
   PUBMED   10944119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356285.9 and AL512652.18.
            
            On Apr 13, 2021 this sequence version replaced NM_022459.4.
            
            Summary: XPO4 belongs to a large family of karyopherins (see MIM
            602738) that mediate the transport of proteins and other cargo
            between the nuclear and cytoplasmic compartments (Lipowsky et al.,
            2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051508.1, AK057924.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255305.11/ ENSP00000255305.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL356285.9         58504-58580         c
            78-183              AL356285.9         24430-24535         c
            184-325             AL356285.9         18551-18692         c
            326-464             AL356285.9         11461-11599         c
            465-581             AL512652.18        132714-132830       c
            582-735             AL512652.18        131839-131992       c
            736-848             AL512652.18        116011-116123       c
            849-1006            AL512652.18        111076-111233       c
            1007-1181           AL512652.18        110648-110822       c
            1182-1358           AL512652.18        98735-98911         c
            1359-1501           AL512652.18        98027-98169         c
            1502-1647           AL512652.18        97380-97525         c
            1648-1825           AL512652.18        96401-96578         c
            1826-1985           AL512652.18        89775-89934         c
            1986-2155           AL512652.18        89100-89269         c
            2156-2330           AL512652.18        88109-88283         c
            2331-2624           AL512652.18        85708-86001         c
            2625-2805           AL512652.18        85020-85200         c
            2806-2924           AL512652.18        79406-79524         c
            2925-3055           AL512652.18        77430-77560         c
            3056-3173           AL512652.18        76425-76542         c
            3174-3266           AL512652.18        75909-76001         c
            3267-9857           AL512652.18        66273-72863         c
FEATURES             Location/Qualifiers
     source          1..9857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..9857
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /note="exportin 4"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
     exon            1..77
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..3464
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="exportin-4 isoform 1"
                     /protein_id="NP_071904.4"
                     /db_xref="CCDS:CCDS41872.1"
                     /db_xref="GeneID:64328"
                     /db_xref="HGNC:HGNC:17796"
                     /db_xref="MIM:611449"
                     /translation="MMAAALGPPEVIAQLENAAKVLMAPPSMVNNEQRQHAEHIFLSF
                     RKSKSPFAVCKHILETSKVDYVLFQAATAIMEAVVREWILLEKGSIESLRTFLLTYVL
                     QRPNLQKYVREQILLAVAVIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSIL
                     TALLSEFSSSSKTSNIGLSMEFHGNCKRVFQEEDLRQIFMLTVEVLQEFSRRENLNAQ
                     MSSVFQRYLALANQVLSWNFLPPNLGRHYIAMFESSQNVLLKPTESWRETLLDSRVME
                     LFFTVHRKIREDSDMAQDSLQCLAQLASLHGPIFPDEGSQVDYLAHFIEGLLNTINGI
                     EIEDSEAVGISSIISNLITVFPRNVLTAIPSELFSSFVNCLTHLTCSFGRSAALEEVL
                     DKDDMVYMEAYDKLLESWLTLVQDDKHFHKGFFTQHAVQVFNSYIQCHLAAPDGTRNL
                     TANGVASREEEEISELQEDDRDQFSDQLASVGMLGRIAAEHCIPLLTSLLEERVTRLH
                     GQLQRHQQQLLASPGSSTVDNKMLDDLYEDIHWLILVTGYLLADDTQGETPLIPPEIM
                     EYSIKHSSEVDINTTLQILGSPGEKASSIPGYNRTDSVIRLLSAILRVSEVESRAIRA
                     DLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQISLPFSTAFGADTEGSQWIIGYL
                     LQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLVIQCENWWNLAKQFASRSPPL
                     NFLSSPVQRTLMKALVLGGFAHMDTETKQQYWTEVLQPLQQRFLRVINQENFQQMCQQ
                     EEVKQEITATLEALCGIAEATQIDNVAILFNFLMDFLTNCIGLMEVYKNTPETVNLII
                     EVFVEVAHKQICYLGESKAMNLYEACLTLLQVYSKNNLGRQRIDVTAEEEQYQDLLLI
                     MELLTNLLSKEFIDFSDTDEVFRGHEPGQAANRSVSAADVVLYGVNLILPLMSQDLLK
                     FPTLCNQYYKLITFICEIFPEKIPQLPEDLFKSLMYSLELGMTSMSSEVCQLCLEALT
                     PLAEQCAKAQETDSPLFLATRHFLKLVFDMLVLQKHNTEMTTAAGEAFYTLVCLHQAE
                     YSELVETLLSSQQDPVIYQRLADAFNKLTASSTPPTLDRKQKMAFLKSLEEFMANVGG
                     LLCVK"
     exon            78..183
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            184..325
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            326..464
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            465..581
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            582..735
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            736..848
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1006
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1181
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1358
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1501
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1647
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1825
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1985
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2155
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2330
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2624
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2805
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2924
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3055
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3173
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3266
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..9857
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8038..8043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /note="hexamer: ATTAAA"
     polyA_site      8055
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /note="major polyA site"
     regulatory      8264..8269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /note="hexamer: CATAAA"
     polyA_site      8311
                     /gene="XPO4"
                     /gene_synonym="exp4"
     regulatory      8903..8908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /note="hexamer: AAGAAA"
     polyA_site      8927
                     /gene="XPO4"
                     /gene_synonym="exp4"
     regulatory      9831..9836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPO4"
                     /gene_synonym="exp4"
                     /note="hexamer: AATAAA"
     polyA_site      9857
                     /gene="XPO4"
                     /gene_synonym="exp4"
ORIGIN      
        1 gagagaccat gatggcggcg gcgctggggc ccccagaagt gatcgctcag ctggagaacg
       61 cggctaaagt tctgatggca ccaccttcca tggtcaataa tgaacaacgc cagcatgcag
      121 agcacatatt cttatcattt aggaaatcaa aatcaccatt tgcagtttgc aagcatattt
      181 tggaaactag taaagtggac tatgtcctct ttcaagctgc cacagccata atggaagcag
      241 ttgtccgaga gtggattctc ttggaaaaag gtagcatcga gtctctgcga acattccttt
      301 taacctatgt cttacaaagg cccaaccttc aaaagtatgt tcgggaacag attctactag
      361 cagtagcagt aattgtaaaa agaggatcat tagataaatc aattgactgc aaaagcattt
      421 ttcatgaagt cagccagttg attagtagtg gcaatcccac tgtgcaaact ctggcctgtt
      481 ctattctgac tgcgctattg agtgaatttt caagttcaag taaaactagc aacattggat
      541 tgagcatgga attccatggt aactgcaaaa gagtttttca ggaagaagac cttcgtcaga
      601 tcttcatgtt aactgttgaa gttctgcagg agttcagcag gcgggaaaac ctcaatgctc
      661 agatgtcttc agtatttcag cgttaccttg cactcgccaa tcaagtcttg agctggaact
      721 ttcttcctcc aaatttgggc agacattata tagctatgtt tgaatcctcg caaaatgtgc
      781 tgttgaagcc aacagagtcc tggcgggaga ctcttctgga cagcagagtt atggagcttt
      841 tcttcacagt acatcgaaaa atcagagaag attcagatat ggcacaagat tctctgcagt
      901 gccttgccca gttagcttct cttcatggac ccatcttccc agatgaagga tcacaagttg
      961 attatctagc acacttcatt gagggattac tgaatactat caatggaatt gaaatagaag
     1021 attctgaagc tgtggggatc tccagcatta tcagcaacct gataaccgtg ttcccacgaa
     1081 atgttttaac tgccattcca agtgaacttt tctcctcctt tgttaactgc ctcacacacc
     1141 tcacttgttc ttttgggcga agtgctgcat tggaagaagt gcttgataaa gatgacatgg
     1201 tatacatgga agcatatgat aaattgttgg agtcctggtt aactttggtt caagatgaca
     1261 aacatttcca taaaggcttt tttacccaac atgcagttca agttttcaat tcctatattc
     1321 agtgccacct agctgctcca gatggcacaa gaaatttgac tgccaatggt gtggcctctc
     1381 gtgaggagga agaaataagt gaacttcaag aggatgatcg agaccagttt tctgatcaac
     1441 tggccagtgt aggaatgcta ggaagaattg ctgcagaaca ctgtatacct cttctgacaa
     1501 gtttattaga agaaagagta acaagactcc atggtcagtt acaacgacat cagcaacagt
     1561 tacttgcttc accgggttca agcactgttg acaacaaaat gcttgatgat ctctatgaag
     1621 atattcactg gcttatttta gttacaggct acctcttagc tgatgatact cagggagaga
     1681 ctccgctaat acctccagaa ataatggaat attccattaa gcattcatct gaagttgaca
     1741 ttaatacaac acttcaaatt ttgggatctc caggagaaaa ggcttcttcc atcccagggt
     1801 acaacagaac agattctgtg attaggctgt tgtctgccat tctcagagtt tcagaagttg
     1861 aatctcgagc aataagagca gatctcactc atctactaag tccccagatg ggcaaagata
     1921 ttgtttggtt tttaaaacgc tgggcaaaga cttatctcct ggtggatgaa aaactgtatg
     1981 atcagataag tctgccattc agtacagcgt tcggagcaga tacagagggt tctcagtgga
     2041 taattggcta cctcttacaa aaagtcatca gtaacctctc agtctggagt agtgagcagg
     2101 accttgcaaa tgacactgtg cagctccttg tcactttggt ggaaagaaga gaaagggcaa
     2161 acttagtaat tcaatgtgag aactggtgga atttagctaa gcagtttgca agccgaagcc
     2221 cacctcttaa tttcttgtca agtcctgtgc agaggacatt gatgaaggct ctagtcttag
     2281 gaggttttgc acatatggac acagaaacca aacagcagta ttggacagag gttcttcagc
     2341 cacttcagca gcgattctta agagtgataa accaagaaaa cttccagcag atgtgtcagc
     2401 aagaggaagt caagcaggaa atcactgcca cactagaggc cctgtgtggc attgctgagg
     2461 ctacccagat tgacaacgta gcaatcctgt ttaatttttt aatggacttc cttaccaatt
     2521 gcattggatt gatggaagtt tacaagaata ccccagagac tgtcaatctc attatagaag
     2581 tttttgttga agttgcacat aaacagatat gctatcttgg agagtccaaa gctatgaact
     2641 tatatgaagc ctgccttact ttgttgcaag tgtattctaa gaataattta gggcggcaaa
     2701 gaatagatgt tacagcagaa gaagagcaat accaagacct gcttctcatt atggaacttc
     2761 ttactaacct gctgtcaaaa gaattcatag atttcagtga tacagatgaa gtgtttagag
     2821 gacatgagcc aggtcaagca gcaaacagat ctgtgtcagc agcggatgtt gtgttgtatg
     2881 gagtaaacct aattctgccc ttgatgtcac aggatctctt gaagtttcca accctttgta
     2941 atcagtacta caaattaatc acatttatct gtgagatttt tcctgaaaaa ataccacagc
     3001 ttcctgagga tctgtttaaa agtctgatgt actccctaga attaggaatg acatcaatga
     3061 gttcggaggt ttgccagctt tgcctggagg ccttgacacc gttagctgaa cagtgtgcaa
     3121 aagcacaaga aacagactca ccactttttc tagcaacacg gcactttctt aagctggttt
     3181 ttgatatgct ggttttgcaa aagcacaaca cagagatgac cactgcggct ggcgaagctt
     3241 tctacacgtt ggtgtgtttg caccaggctg aatattctga actggtcgaa acattactat
     3301 caagtcagca agacccagtt atttaccaga gattagcaga tgccttcaac aagctcactg
     3361 caagcagcac tcctcctacg ctggatcgga agcagaagat ggccttctta aagagtttag
     3421 aagaatttat ggcaaatgtt ggtggtctcc tttgtgtaaa ataaacaaca gaactttatg
     3481 cttaatttag atcctttctg caaagtgcac tgaattgctg aaagttgact tgagtcttgt
     3541 cctattcctc agttcatttg gccattttgg attttggaga gcctgaaact ttgatatgta
     3601 tgtaatacag tgaaacagga gaggtcaact tggcatcagc ttctgctgtt aagtgttagc
     3661 cacaatctgt catatatatg tcttttagat tctgaatggt gatttaaaat tttcaaaatg
     3721 aaattccata tatgtgcaaa cagatatggg caccacgaaa tacatatgca gtgccttttt
     3781 tccttttaac ataggtggct agccaaagtt tagaattttt gtcattaaat atgaaatgga
     3841 tatatgctag gcagtgtttc tcaaaatctc catagatcgc ctgcatcact tgaggagctg
     3901 gtgaaaaggc agattcttag gcccaactgt agaccttcag agtcagaatg tctggttgtt
     3961 gggcccagga gtcttcatgt taataagctt ctccctttcg tcaccccaaa agttttgaat
     4021 caatgaaaga gacattgaaa actcttaaga ggttttgtgc tttctagctt ttcctccctt
     4081 tgatgattgg gttttataat tcagcaggaa ggggaaacat caccaggggt ttgttggctt
     4141 tttcttagct tgctttcttg cttgcttgct ttcttgcttt tcttgctttc tgtctctctc
     4201 tttcttttct ctctctctct cacatcaacc cagtgctgca ggttttgtgt aatacaagtc
     4261 actaatcata ctctgatgcc tgaacttgag gaggaaaata catgtatatt tttgttccgt
     4321 aaaaataacc ttaggaactg tagccatttc attgccttaa ttttaagagg aaaatacaaa
     4381 aacagctgat ttgttttagt aagaaaccac gtcttgatgc ttcagagttg gtttagggtg
     4441 ttagctgcta tgaacctgtt gcccctttcg atcgtgtatt tatgtaggtt tatcagtgaa
     4501 atgaaaggct tgtttccgtc tagtctaact ttttgagtgt gtttctatcc agccacatag
     4561 cccatatcta ctctaaatgg cttgcttaag caataattat tttaaaggat gtgaatcact
     4621 gattcacaca gactattgca cgttggggca ttaggggcaa taattcttat ccagacatgg
     4681 gagccagtga atttaatttc agagattaaa aattcacttt agatcctcta gtttgatctc
     4741 ttaatcagga tttttataca gctgccaggc tcccctaatt cagtgtgcca gcttacaatg
     4801 tggaaatgaa agctaattta tacacagcag gcatatgaaa ctccactcat tgcagtactt
     4861 tcacagcaca gtgacaggta gaggactctg gcacaggtgc actcatgaaa ctctgcttcc
     4921 accatgttcc tgacacctat ctattaaacc attctgcaaa tacggttttt ctacctgatt
     4981 gcatatagca tatgtgtcat tacatgtgat gctgtgcaaa actttgtata attctgtgtt
     5041 attaacagtt aacaaaactg gagcatctga attacatcca acctgtgcat gtgatgttag
     5101 gtagatgtga atgcagggcc ttgggccata acttacattt ctctcaattt gattagcttt
     5161 gagtcacaat taaggggaag caaaaacatc ttgaaaagac tgctaggaag gaaattaata
     5221 tcagtcatcc agaagtacac gtttctgtat tttaaaaaat actttgatgc atttattttt
     5281 aggtgttttt tttttcccct taaaaaactt gaagtgatat gcagcagtaa tctatttgtt
     5341 ttgcattgtt cttggtgttt tgtgtttccc agatccctca agctttctca gctgttgtga
     5401 attatgtgta tctgtgtgtg tgctaagtac agtctcttta ccaaagggca ctgaaacaca
     5461 caattgactg gacaggtcca cgcgccatga caaaactata atcaagttat taaaactaaa
     5521 gaggagtggg aaaggaatgc cttggtaagt aaaaaggcat ctatatttaa taacttttat
     5581 ccagatggca acatatttgc aaaatttgcc cagatcctat tacaatacta aaaatagaaa
     5641 atttcacctc catattcctg aggtgtaatt tcattagact agttttagtt taaaaagacc
     5701 ttcttcagat tggaccaaat aatacttata agatcagcag aatgttgaat attagctcac
     5761 tggggtgggg agaagccact accatttttt aggtgatggg gatgccactg agttgcaacg
     5821 gctagacctt ttcagggtgg ttgtgtccat gtttgcctga ttggatgctt attcactttg
     5881 tgttttcttt tgttttattt tgtccaattt tgtctttagc tgtgtttatt aacttctccg
     5941 gtcttgtttt gttttaatgc tcttggccca gtgggtgtca agaacactgg cttaattcaa
     6001 gtcagttgat tttttttcta ttaaaactgt tgttaaaata ttttttaaaa caaaaacatt
     6061 atttgtgccc tcttttatat atgtcaaagg gacactgtca agtatttcat ttttagattt
     6121 ttgttttata aaatttctgt tgttcatata gtatccttta acctctagtt ttccatacat
     6181 cctttgtttg tttctcattt tattttcctt gacccattta tttcccaagg cacaatcact
     6241 aaagactttg tactttcaca gtctgttaat gtggtagcac ctgtaactgt gttcttgttc
     6301 tgttaaaagg attgatttgc ttttatagtc cttgtgctgg atgagtggct gcctcagtag
     6361 caaaactacc tgacagtatt tgacagtgtc ctttccagca ccattatttg ggtctttcag
     6421 ggtggccatc tctgttagaa gacagtagca tgttaacatc actgcattga gtttttgtct
     6481 ggtgtaaagt atgactttta atgtaaacaa actgcaggtt tttttcaaac taattttaag
     6541 aatttagtct tatttcgttg taaactgtgt atctaattat attacattac tctgttcaga
     6601 tgggatggtt actaccactt gtccatgatt ttcatttgaa aagcaagtat ctatatcatt
     6661 tccccccagt cagcattatt taacactccc cttaactgtc tttgaacttt ctcttttaac
     6721 aaaaatgtca agtctttata gttgtaatat caccatgttt cccatttctg ttaatacttc
     6781 tatgaacccc taaagtattg aagggaacta gctgtcagtt tcaaggatta caagtttgag
     6841 tctcctagta ttcaacatca ttctgaaccc tgaaataata tttttctctg ttaaacaatt
     6901 tttatctgtt tgccacctct gttgttagag gtggttgtca attgacctta ctaagttagc
     6961 tgtctttgat gaggaattat tgttattggt tcctgaataa aacattaacc ttttaagtca
     7021 gaaggaacct cggtacttct taaggtttgt ttgtgttttc taaaaccaga gaataaggaa
     7081 ctgatttggc tatgaggttt aacattataa ttttctgtaa gctttcccac aaaaaaacat
     7141 tgttgatttg aggatataat aatgttttaa tctttttaaa atataagtgg ttattctctg
     7201 acttggtaac tatgttctga aaacactgca tttaagaatt tttaaaaatt ggttttctaa
     7261 aattaaaatg tccaaattag gcatattgct gagctcaaat tgatgtgaaa tgccatggtt
     7321 ccagttgaat tttaagcata ttttcattta gatataaaat atatgaagta tgctttgttg
     7381 attatagtga gaacccatga catagttaac caaagaatat gtttggttca aataaaaata
     7441 gaagcttaat actgggcatt catacttttt aaagagaatg aatgaagaaa tcggtttcct
     7501 gctgtagttc tctatgggta agtcttagta aagacgagaa tgctgaagtc ggccgtggcg
     7561 attccctcct aggaactggg aggtgtggct tgcccattac ccgcttgaag ctcacatctt
     7621 taccctcctc tcccactgtg gtttgatctt cacctattcc caggccctcc cagcaattgg
     7681 agaggtgtct ttttttttgg ttttggtttt ttttctcccc gtctgcattc ttaggcctct
     7741 tagctattag gaactgtcag atacatacta gtagctaatt ttcctagcct gaaattatat
     7801 actgcatctg cactatgtac ctactaggga tctgacctca agtgttttct gagcccaggc
     7861 ttcctggtgt ggtgtctttt accacataaa attattacaa attgcaaatg ttggtattgt
     7921 gatttgatta tctgtacaaa gaaagaagct ctatgcagtg agtttgtggt ttaatggtca
     7981 caaaaatgtt agcactgcta ccactcagca cgtgtaaaat tttttaaatt tataaatatt
     8041 aaaattttaa acttacacta agacttttca gttttattta aagacccagg gatgagtgta
     8101 ctgtttaaat atttacctct attaacataa ctaatgaagg tataaaattg catttagttt
     8161 ttcagaagat gctgcaatat gattttagga aataaggcta tgtattgagc cagttatagg
     8221 ctgaatatca ggttgataaa attttatttg tatttttaaa attcataaat gggagttaaa
     8281 atgtgtcttt tcactaaata tttttattac atttttgttt tgaccatgtg tgatttgttc
     8341 atgggtattt agctagactc ttttatgaaa tgcattgaaa tggtgctagt ttgtttacca
     8401 ttataggaag attgacactg gggacattac acggtcctaa aataatttta aatttaaaaa
     8461 aatgaagaca tctgtacaga taaaaatcaa gatttgcatc accttctggg agaacccgtg
     8521 gtactcacag aatatccagt attagaaata taaaaatttt gtctatattt tataatattt
     8581 atctcagccc acagtcttag aaacagtttc acagttacta gttaagtcat tatctttggt
     8641 gcatatttag taaatacttt tagcaagtca ttctttttgg cctttcaggg aaagtggtga
     8701 attaccatat tactgtgtgc tagatagatc caccctttgc ccagtgttaa atcttgtaaa
     8761 catatgaagt gaaaagttaa tttttaaaga aaatgcatct ttaaaatgtt catttttaac
     8821 ctgaatttgc tttgaatatt ctttgatttg taatgttgtt atttagctta tattgagatt
     8881 tattccactc caaaggtgga taaagaaaag ttgtttaaga aaaccaatta gagtgtattt
     8941 tgaatttttg tttctttcat taccaagtgt ggggccatac acacaggcta atcatctgtc
     9001 atttgagacc cacagatgat ttcaaaggtc ccaaataaat acacatctat aactgttttt
     9061 taaaagacat ctttaatggt gctctccaaa aatacaattc ggttgcttat gagtgatgcc
     9121 tttgacaggc tgattagatt ataaaacagt tttgtttttt taaacatagg gtctcagatt
     9181 gagtcttgtg cattctatgt aatctcaaat ggcagttcag tttgactttc ttttaaaact
     9241 aagtggaaat ggtatatttg gtgaaactaa tgaaagaatc ttttgctggg aaattccata
     9301 cagcaccccc agcagcatcc tgtctcagtc tggcgtataa ttcaacctcc tactgagtgt
     9361 ccctgtaaat tatttttaat atatagcatg agagtgaact gaggtaagtc attgatgttt
     9421 cccagagatg atgaatgaac aaaagcaaat aggatctgct aaacattttt attcccacag
     9481 tagtgagcag ttttgttctt gttttgataa tgttcatttc tgcctaatct taggcttcaa
     9541 atacaccttt aagaaagccc aagatgtatt gagtagtaga acttcttatt tgtacacctg
     9601 tttataactg cactgccctg gatgttatgg ttatttctaa ggactgacct ggtaaagcta
     9661 cttgaactgg tagactgcag ggtagaggca gacctagatt caatgtctaa ctaagctgct
     9721 tagggcttac attaatttcc acaggtctgt tatccatatc atgagtttat aagtgttcct
     9781 cccaaagaaa aaatttaaaa gtgatggatg aaatataata gtagatgctc aataaattcc
     9841 attgtattta aagatta
//
