LOCUS       NM_003400               4988 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens exportin 1 (XPO1), transcript variant 1, mRNA.
ACCESSION   NM_003400
VERSION     NM_003400.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4988)
  AUTHORS   Fan,J., Gillespie,K.P., Mesaros,C. and Blair,I.A.
  TITLE     HMGB2-induced calreticulin translocation required for immunogenic
            cell death and ferroptosis of cancer cells are controlled by the
            nuclear exporter XPO1
  JOURNAL   Commun Biol 7 (1), 1234 (2024)
   PUBMED   39354146
  REMARK    GeneRIF: HMGB2-induced calreticulin translocation required for
            immunogenic cell death and ferroptosis of cancer cells are
            controlled by the nuclear exporter XPO1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4988)
  AUTHORS   Blunt,M.D., Fisher,H., Schittenhelm,R.B., Mbiribindi,B., Fulton,R.,
            Khan,S., Espana-Serrano,L., Graham,L.V., Bastidas-Legarda,L.,
            Burns,D., Khakoo,S.M.S., Mansour,S., Essex,J.W., Ayala,R., Das,J.,
            Purcell,A.W. and Khakoo,S.I.
  TITLE     The nuclear export protein XPO1 provides a peptide ligand for
            natural killer cells
  JOURNAL   Sci Adv 10 (34), eado6566 (2024)
   PUBMED   39178254
  REMARK    GeneRIF: The nuclear export protein XPO1 provides a peptide ligand
            for natural killer cells.
REFERENCE   3  (bases 1 to 4988)
  AUTHORS   Daneshmandi,S., Yan,Q., Choi,J.E., Katsuta,E., MacDonald,C.R.,
            Goruganthu,M., Roberts,N., Repasky,E.A., Singh,P.K., Attwood,K.,
            Wang,J., Landesman,Y., McCarthy,P.L. and Mohammadpour,H.
  TITLE     Exportin 1 governs the immunosuppressive functions of
            myeloid-derived suppressor cells in tumors through ERK1/2 nuclear
            export
  JOURNAL   Cell Mol Immunol 21 (8), 873-891 (2024)
   PUBMED   38902348
  REMARK    GeneRIF: Exportin 1 governs the immunosuppressive functions of
            myeloid-derived suppressor cells in tumors through ERK1/2 nuclear
            export.
REFERENCE   4  (bases 1 to 4988)
  AUTHORS   Knittel,G. and Reinhardt,H.C.
  TITLE     XPO1-Mediated mRNA Export of Genome Maintenance Regulators Drives
            Chemotherapy Resistance in Aggressive Lymphoma
  JOURNAL   Cancer Res 84 (1), 3-5 (2024)
   PUBMED   37902414
  REMARK    GeneRIF: XPO1-Mediated mRNA Export of Genome Maintenance Regulators
            Drives Chemotherapy Resistance in Aggressive Lymphoma.
REFERENCE   5  (bases 1 to 4988)
  AUTHORS   Ozdas,T., Ozdas,S., Canatar,I., Cosgun,E., Senyurt,E.B. and
            Gorgulu,O.
  TITLE     CRM1 expression: association with high prognostic value in
            laryngeal cancer
  JOURNAL   Turk J Med Sci 53 (4), 909-923 (2023)
   PUBMED   38031942
  REMARK    GeneRIF: CRM1 expression: association with high prognostic value in
            laryngeal cancer.
REFERENCE   6  (bases 1 to 4988)
  AUTHORS   Fornerod,M., van Baal,S., Valentine,V., Shapiro,D.N. and
            Grosveld,G.
  TITLE     Chromosomal localization of genes encoding CAN/Nup214-interacting
            proteins--human CRM1 localizes to 2p16, whereas Nup88 localizes to
            17p13 and is physically linked to SF2p32
  JOURNAL   Genomics 42 (3), 538-540 (1997)
   PUBMED   9205132
REFERENCE   7  (bases 1 to 4988)
  AUTHORS   Bogerd,H.P., Fridell,R.A., Madore,S. and Cullen,B.R.
  TITLE     Identification of a novel cellular cofactor for the Rev/Rex class
            of retroviral regulatory proteins
  JOURNAL   Cell 82 (3), 485-494 (1995)
   PUBMED   7634337
REFERENCE   8  (bases 1 to 4988)
  AUTHORS   Fischer,U., Huber,J., Boelens,W.C., Mattaj,I.W. and Luhrmann,R.
  TITLE     The HIV-1 Rev activation domain is a nuclear export signal that
            accesses an export pathway used by specific cellular RNAs
  JOURNAL   Cell 82 (3), 475-483 (1995)
   PUBMED   7543368
REFERENCE   9  (bases 1 to 4988)
  AUTHORS   Fritz,C.C., Zapp,M.L. and Green,M.R.
  TITLE     A human nucleoporin-like protein that specifically interacts with
            HIV Rev
  JOURNAL   Nature 376 (6540), 530-533 (1995)
   PUBMED   7637788
REFERENCE   10 (bases 1 to 4988)
  AUTHORS   Pfeifer,K., Weiler,B.E., Ugarkovic,D., Bachmann,M., Schroder,H.C.
            and Muller,W.E.
  TITLE     Evidence for a direct interaction of Rev protein with nuclear
            envelop mRNA-translocation system
  JOURNAL   Eur J Biochem 199 (1), 53-64 (1991)
   PUBMED   1648487
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016727.10, BX643790.1,
            BX492941.1, BX647758.1, BX954288.1, CR749840.1, AL833550.1,
            BC032847.2, Y08614.2 and AK124769.1.
            
            On May 17, 2019 this sequence version replaced NM_003400.3.
            
            Summary: This cell-cycle-regulated gene encodes a protein that
            mediates leucine-rich nuclear export signal (NES)-dependent protein
            transport. The protein specifically inhibits the nuclear export of
            Rev and U snRNAs. It is involved in the control of several cellular
            processes by controlling the localization of cyclin B, MPAK, and
            MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
            [provided by RefSeq, Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.249384.1, BX647758.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401558.7/ ENSP00000384863.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC016727.10        105296-105368       c
            74-75               BX643790.1         5-6
            76-313              BX492941.1         82-319
            314-314             BX647758.1         225-225
            315-317             BX954288.1         207-209
            318-401             CR749840.1         218-301
            402-417             BX647758.1         311-326
            418-1029            AL833550.1         292-903
            1030-1363           AL833550.1         1896-2229
            1364-4137           BC032847.2         692-3465
            4138-4308           Y08614.2           3376-3546
            4309-4651           BX647758.1         4218-4560
            4652-4901           BX647758.1         4563-4812
            4902-4902           AK124769.1         3706-3706
            4903-4903           AL833550.1         6775-6775
            4904-4988           AC016727.10        44861-44945         c
FEATURES             Location/Qualifiers
     source          1..4988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..4988
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /note="exportin 1"
                     /db_xref="GeneID:7514"
                     /db_xref="HGNC:HGNC:12825"
                     /db_xref="MIM:602559"
     exon            1..795
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            796..927
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             802..4017
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     chromosome region maintenance 1 protein homolog;
                     exportin-1 (required for chromosome region maintenance);
                     exportin 1 (CRM1 homolog, yeast); chromosome region
                     maintenance 1 homolog"
                     /codon_start=1
                     /product="exportin-1 isoform 1"
                     /protein_id="NP_003391.1"
                     /db_xref="CCDS:CCDS33205.1"
                     /db_xref="GeneID:7514"
                     /db_xref="HGNC:HGNC:12825"
                     /db_xref="MIM:602559"
                     /translation="MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQR
                     MAQEVLTHLKEHPDAWTRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGI
                     KKYVVGLIIKTSSDPTCVEKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTS
                     ESLCQNNMVILKLLSEEVFDFSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQN
                     APLVHATLETLLRFLNWIPLGYIFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSV
                     SQYEEQFVTLFTLTMMQLKQMLPLNTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHD
                     QLIEKRLNLRETLMEALHYMLLVSEVEETEIFKICLEYWNHLAAELYRESPFSTSASP
                     LLSGSQHFDVPPRRQLYLPMLFKVRLLMVSRMAKPEEVLVVENDQGEVVREFMKDTDS
                     INLYKNMRETLVYLTHLDYVDTERIMTEKLHNQVNGTEWSWKNLNTLCWAIGSISGAM
                     HEEDEKRFLVTVIKDLLGLCEQKRGKDNKAIIASNIMYIVGQYPRFLRAHWKFLKTVV
                     NKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFVQVQVGEVMPFIDEILNNINTIICD
                     LQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLLPNQVWDSIIQQATKNVDILKDP
                     ETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNVYKCLSENISAAIQANGEMVT
                     KQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPLLDAVLIDYQRNVPAAREP
                     EVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEEYPEHRTNFFLLLQAVN
                     SHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTLLQNVAQEEAAAQSF
                     YQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKISTSLNPGNPVNNQI
                     FLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLVQIKEFAGEDT
                     SDLFLEEREIALRQADEEKHKRQMSVPGIFNPHEIPEEMCD"
     exon            928..1029
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1102
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1164
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1209
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1391
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1440
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1560
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1689
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1848
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2046
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2185
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2367
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2524
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2688
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2823
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..3007
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3114
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3309
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3478
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3613
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3773
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3870
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4988
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4883..4888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /note="hexamer: AATAAA"
     polyA_site      4903
                     /gene="XPO1"
                     /gene_synonym="CRM-1; CRM1; emb; exp1"
                     /note="major polyA site"
ORIGIN      
        1 aggttccaaa cgctccgcgg cgccatgggc tgaaaactca accgagatgg aatctcccag
       61 tctgaaccgg tttcaaccgg ttccgagttt gaggcactag gaggaggggg agaagcggct
      121 gcagcggccg cggcaggagc agcgggagct acagcatcag caagagcaac agtagctaca
      181 gccccggcgg cggtgcctgt tccagtcttt gctgctgcag tccgtgcaac cacccagagg
      241 gggagggggg aaccaccagt cgctgaggaa caagagaagg ggggaaagtt taggcgagcc
      301 ttgggggggg gggggccagc gccggagccg cgtgagagag ggagccgtgt tttggtaggg
      361 gggagtcgga ctgcaactgg cagcagagcg tctccccggc cgtgtggact ctacaccccc
      421 tactcctgcc gcttctgctg ctgcctgtgg ctggagggtc cccctggggc tgaatctttg
      481 ggacttgacc ccgttccctc ccccttccct cactccccag ccgggcggga gcatttattc
      541 cccagattaa ttcccctttt gggggggggc gggtgtgtgt gtgtgtgtgt gtgtgtgtgt
      601 gtgttggggg aagcgtccct gaaatagtaa atattattga gctctttttg cccttttcct
      661 gtccgttttt ttaatttcct tttttgaggt gggaaaactg aaacccacct tgattcgtcc
      721 cctctccccc ctccccacct tccctcgccc taatccccca acgaggaagg aaggagcagt
      781 tggttcaatc tctggtaatc tatgccagca attatgacaa tgttagcaga ccatgcagct
      841 cgtcagctgc ttgatttcag ccaaaaactg gatatcaact tattagataa tgtggtgaat
      901 tgcttatacc atggagaagg agcccagcaa agaatggctc aagaagtact gacacattta
      961 aaggagcatc ctgatgcttg gacaagagtc gacacaattt tggaattttc tcagaatatg
     1021 aatacgaaat actatggact acaaattttg gaaaatgtga taaaaacaag gtggaagatt
     1081 cttccaagga accagtgcga aggaataaaa aaatacgttg ttggcctcat tatcaagacg
     1141 tcatctgacc caacttgtgt agagaaagaa aaggtgtata tcggaaaatt aaatatgatc
     1201 cttgttcaga tactgaaaca agaatggccc aaacattggc caacttttat cagtgatatt
     1261 gttggagcaa gtaggaccag cgaaagtctc tgtcaaaata atatggtgat tcttaaactc
     1321 ttgagtgaag aagtatttga tttctctagt ggacagataa cccaagtcaa atctaagcat
     1381 ttaaaagaca gcatgtgcaa tgaattctca cagatatttc aactgtgtca gtttgtaatg
     1441 gaaaattctc aaaatgctcc acttgtacat gcaaccttgg aaacattgct cagatttctg
     1501 aactggattc ccctgggata tatttttgag accaaattaa tcagcacatt gatttataag
     1561 ttcctgaatg ttccaatgtt tcgaaatgtc tctctgaagt gcctcactga gattgctggt
     1621 gtgagtgtaa gccaatatga agaacaattt gtaacactat ttactctgac aatgatgcaa
     1681 ctaaagcaga tgcttccttt aaataccaat attcgacttg cgtactcaaa tggaaaagat
     1741 gatgaacaga acttcattca aaatctcagt ttgtttctct gcacctttct taaggaacat
     1801 gatcaactta tagaaaaaag attaaatctc agggaaactc ttatggaggc ccttcattat
     1861 atgttgttgg tatctgaagt agaagaaact gaaatcttta aaatttgtct tgaatactgg
     1921 aatcatttgg ctgctgaact ctatagagag agtccattct ctacatctgc ctctccgttg
     1981 ctttctggaa gtcaacattt tgatgttcct cccaggagac agctatattt gcccatgtta
     2041 ttcaaggtcc gtttattaat ggttagtcga atggctaaac cagaggaagt attggttgta
     2101 gagaatgatc aaggagaagt tgtgagagaa ttcatgaagg atacagattc cataaatttg
     2161 tataagaata tgagggaaac attggtttat cttactcatc tggattatgt agatacagaa
     2221 agaataatga cagagaagct tcacaatcaa gtgaatggta cagagtggtc atggaaaaat
     2281 ttgaatacat tgtgttgggc aataggctcc attagtggag caatgcatga agaggacgaa
     2341 aaacgatttc ttgttactgt tataaaggat ctattaggat tatgtgaaca gaaaagaggc
     2401 aaagataata aagctattat tgcatcaaat atcatgtaca tagtaggtca atacccacgt
     2461 tttttgagag ctcactggaa atttctgaag actgtagtta acaagctgtt cgaattcatg
     2521 catgagaccc atgatggagt ccaggatatg gcttgtgata ctttcattaa aatagcccaa
     2581 aaatgccgca ggcatttcgt tcaggttcag gttggagaag tgatgccatt tattgatgaa
     2641 attttgaaca acattaacac tattatttgt gatcttcagc ctcaacaggt tcatacgttt
     2701 tatgaagctg tggggtacat gattggtgca caaacagatc aaacagtaca agaacacttg
     2761 atagaaaagt acatgttact ccctaatcaa gtgtgggata gtataatcca gcaggcaacc
     2821 aaaaatgtgg atatactgaa agatcctgaa acagtcaagc agcttggtag cattttgaaa
     2881 acaaatgtga gagcctgcaa agctgttgga cacccctttg taattcagct tggaagaatt
     2941 tatttagata tgcttaatgt atacaagtgc ctcagtgaaa atatttctgc agctatccaa
     3001 gctaatggtg aaatggttac aaagcaacca ttgattagaa gtatgcgaac tgtaaaaagg
     3061 gaaactttaa agttaatatc tggttgggtg agccgatcca atgatccaca gatggtcgct
     3121 gaaaattttg ttccccctct gttggatgca gttctcattg attatcagag aaatgtccca
     3181 gctgctagag aaccagaagt gcttagtact atggccataa ttgtcaacaa gttaggggga
     3241 catataacag ctgaaatacc tcaaatattt gatgctgttt ttgaatgcac attgaatatg
     3301 ataaataagg actttgaaga atatcctgaa catagaacga actttttctt actacttcag
     3361 gctgtcaatt ctcattgttt cccagcattc cttgctattc cacctacaca gtttaaactt
     3421 gttttggatt ccatcatttg ggctttcaaa catactatga ggaatgtcgc agatacgggc
     3481 ttacagatac tttttacact cttacaaaat gttgcacaag aagaagctgc agctcagagt
     3541 ttttatcaaa cttatttttg tgatattctc cagcatatct tttctgttgt gacagacact
     3601 tcacatactg ctggtttaac aatgcatgca tcaattcttg catatatgtt taatttggtt
     3661 gaagaaggaa aaataagtac atcattaaat cctggaaatc cagttaacaa ccaaatcttt
     3721 cttcaggaat atgtggctaa tctccttaag tcggccttcc ctcacctaca agatgctcaa
     3781 gtaaagctct ttgtgacagg gcttttcagc ttaaatcaag atattcctgc tttcaaggaa
     3841 catttaagag atttcctagt tcaaataaag gaatttgcag gtgaagacac ttctgatttg
     3901 tttttggaag agagagaaat agccctacgg caggctgatg aagagaaaca taaacgtcaa
     3961 atgtctgtcc ctggcatctt taatccacat gagattccag aagaaatgtg tgattaaaat
     4021 ccaaattcat gctgtttttt ttctctgcaa ctcgttagca gaggaaaaca gcatgtgggt
     4081 atttgtcgac caaaatgatg ccaatttgta aattaaaatg tcacctagtg gccctttttc
     4141 ttatgtgttt ttttgtataa gaaattttct gtgaaatatc cttccattgt ttaagctttt
     4201 gttttggtca tctttattta gtttgcatga agttgaaaat taaggcattt ttaaaaattt
     4261 tacttcatgc ccatttttgt ggctgggctg gggggaggag gcaaattcga tttgaacata
     4321 tacttgtaat tctaatgcaa aattatacaa tttttcctgt aaacaatacc aatttttaat
     4381 tagggagcat tttccttcta gtctatttca gcctagaaga aaagataatg agtaaaacaa
     4441 attgcgttgt ttaaaggatt atagtgctgc attgtctgaa gttagcacct cttggactga
     4501 atcgtttgtc tagactacat gtattacaaa gtctctttgg caagattgca gcaagatcat
     4561 gtgcatatca tcccattgta aagcgacttc aaaaatatgg gaacacagtt agttattttt
     4621 acacagttct ttttgttttt gtgtgtgtgt gctgtcgctt gtcgacaaca gctttttgtt
     4681 ttcctcaatg aggagtgttg ctcatttgtg agccttcatt aactcgaagt gaaatggtta
     4741 aaaatattta tcctgttaga ataggctgca tctttttaac aactcattaa aaaacaaaac
     4801 aactctggct tttgagatga cttatactaa tttacattgt ttaccaagct gtagtgcttt
     4861 aagaacacta cttaaaaagc aaaataaact tggtttacat ttatttttcc tttattgact
     4921 catttattcc tatattaatg atagtgggta tttgtgttta agcatcaagt aacattttaa
     4981 atgaagtt
//
