LOCUS       NM_022098               7938 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens X-prolyl aminopeptidase 3 (XPNPEP3), transcript
            variant 1, mRNA.
ACCESSION   NM_022098
VERSION     NM_022098.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7938)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 7938)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7938)
  AUTHORS   Kumar,R., Kotapalli,V., Naz,A., Gowrishankar,S., Rao,S.,
            Pollack,J.R. and Bashyam,M.D.
  TITLE     XPNPEP3 is a novel transcriptional target of canonical
            Wnt/beta-catenin signaling
  JOURNAL   Genes Chromosomes Cancer 57 (6), 304-310 (2018)
   PUBMED   29383790
  REMARK    GeneRIF: results therefore suggest XPNPEP3 to be a transcriptional
            target of Wnt/beta-catenin pathway with particular significance for
            CRC
REFERENCE   4  (bases 1 to 7938)
  AUTHORS   Singh,R., Jamdar,S.N., Goyal,V.D., Kumar,A., Ghosh,B. and
            Makde,R.D.
  TITLE     Structure of the human aminopeptidase XPNPEP3 and comparison of its
            in vitro activity with Icp55 orthologs: Insights into diverse
            cellular processes
  JOURNAL   J Biol Chem 292 (24), 10035-10047 (2017)
   PUBMED   28476889
  REMARK    GeneRIF: Data suggest that human XPNPEP3, Ashbya gossypii Icp55,
            and Fusarium graminearum Icp55 exhibit structural and functional
            properties of genuine Xaa-Pro specific aminopeptidases; these
            enzymes appear to function in the previously observed mitochondrial
            role of Icp55 in processing of Nfs1 (mitochondrial cysteine
            desulfurase) substrate. [Icp55 = intermediate-cleavage
            metalloexopeptidases 55]
REFERENCE   5  (bases 1 to 7938)
  AUTHORS   Inoue,M., Kamada,H., Abe,Y., Higashisaka,K., Nagano,K., Mukai,Y.,
            Yoshioka,Y., Tsutsumi,Y. and Tsunoda,S.
  TITLE     Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex,
            induces phosphorylation of JNK1 and JNK2
  JOURNAL   J Cell Sci 128 (4), 656-669 (2015)
   PUBMED   25609706
  REMARK    GeneRIF: The findings reveal that APP3m is a new member of the
            TNF-TNFR2 signaling complex and characterize an APP3-mediated TNFR2
            signal transduction mechanism that induces activation of JNK1 and
            JNK2.
REFERENCE   6  (bases 1 to 7938)
  AUTHORS   O'Toole,J.F., Liu,Y., Davis,E.E., Westlake,C.J., Attanasio,M.,
            Otto,E.A., Seelow,D., Nurnberg,G., Becker,C., Nuutinen,M.,
            Karppa,M., Ignatius,J., Uusimaa,J., Pakanen,S., Jaakkola,E., van
            den Heuvel,L.P., Fehrenbach,H., Wiggins,R., Goyal,M., Zhou,W.,
            Wolf,M.T., Wise,E., Helou,J., Allen,S.J., Murga-Zamalloa,C.A.,
            Ashraf,S., Chaki,M., Heeringa,S., Chernin,G., Hoskins,B.E.,
            Chaib,H., Gleeson,J., Kusakabe,T., Suzuki,T., Isaac,R.E.,
            Quarmby,L.M., Tennant,B., Fujioka,H., Tuominen,H., Hassinen,I.,
            Lohi,H., van Houten,J.L., Rotig,A., Sayer,J.A., Rolinski,B.,
            Freisinger,P., Madhavan,S.M., Herzer,M., Madignier,F., Prokisch,H.,
            Nurnberg,P., Jackson,P.K., Khanna,H., Katsanis,N. and
            Hildebrandt,F.
  TITLE     Individuals with mutations in XPNPEP3, which encodes a
            mitochondrial protein, develop a nephronophthisis-like nephropathy
  JOURNAL   J Clin Invest 120 (3), 791-802 (2010)
   PUBMED   20179356
  REMARK    GeneRIF: Individuals with mutations in XPNPEP3, which encodes a
            mitochondrial protein, develop a nephronophthisis-like nephropathy.
            Erratum:[J Clin Invest. 2010 Apr;120(4):1362. Jackson, Peter
            [corrected to Jackson, Peter K]]
REFERENCE   7  (bases 1 to 7938)
  AUTHORS   Ersahin,C., Szpaderska,A.M., Orawski,A.T. and Simmons,W.H.
  TITLE     Aminopeptidase P isozyme expression in human tissues and peripheral
            blood mononuclear cell fractions
  JOURNAL   Arch Biochem Biophys 435 (2), 303-310 (2005)
   PUBMED   15708373
REFERENCE   8  (bases 1 to 7938)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   9  (bases 1 to 7938)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   10 (bases 1 to 7938)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP346902.1, BC004989.1,
            AL365514.1, AI446638.1, AL035450.1, AL080242.11 and BX648018.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022098.3.
            
            Summary: The protein encoded by this gene belongs to the family of
            X-pro-aminopeptidases that utilize a metal cofactor, and remove the
            N-terminal amino acid from peptides with a proline residue in the
            penultimate position. This protein has been shown to localize to
            the mitochondria of renal cells, and have a role in ciliary
            function. Mutations in this gene are associated with
            nephronophthisis-like nephropathy-1. Alternatively spliced
            transcript variants encoding different isoforms have been noted for
            this gene, however, expression of some of these isoforms in vivo is
            not known.[provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1, also known as APP3m).
            This isoform has been shown to be localized to the mitochondria
            (PMID:20179356).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.148658.1,
                                           SRR1803613.49857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 20179356
            MANE Ensembl match                 :: ENST00000357137.9/
                                                  ENSP00000349658.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               BP346902.1         72-199
            129-1678            BC004989.1         163-1712
            1679-2715           AL365514.1         1729-2765
            2716-3002           AI446638.1         1-287               c
            3003-4555           AL035450.1         44982-46534
            4556-7798           AL080242.11        105-3347
            7799-7938           BX648018.1         5719-5858
FEATURES             Location/Qualifiers
     source          1..7938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..7938
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /note="X-prolyl aminopeptidase 3"
                     /db_xref="GeneID:63929"
                     /db_xref="HGNC:HGNC:28052"
                     /db_xref="MIM:613553"
     exon            1..98
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1558
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /EC_number="3.4.11.9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable Xaa-Pro aminopeptidase 3; X-Pro aminopeptidase 3;
                     Intermediate Cleaving Peptidase 55; X-prolyl
                     aminopeptidase 3, mitochondrial; xaa-Pro aminopeptidase 3"
                     /codon_start=1
                     /product="xaa-Pro aminopeptidase 3 isoform 1"
                     /protein_id="NP_071381.1"
                     /db_xref="CCDS:CCDS14007.1"
                     /db_xref="GeneID:63929"
                     /db_xref="HGNC:HGNC:28052"
                     /db_xref="MIM:613553"
                     /translation="MPWLLSAPKLVPAVANVRGLSGCMLCSQRRYSLQPVPERRIPNR
                     YLGQPSPFTHPHLLRPGEVTPGLSQVEYALRRHKLMSLIQKEAQGQSGTDQTVVVLSN
                     PTYYMSNDIPYTFHQDNNFLYLCGFQEPDSILVLQSLPGKQLPSHKAILFVPRRDPSR
                     ELWDGPRSGTDGAIALTGVDEAYTLEEFQHLLPKMKAETNMVWYDWMRPSHAQLHSDY
                     MQPLTEAKAKSKNKVRGVQQLIQRLRLIKSPAEIERMQIAGKLTSQAFIETMFTSKAP
                     VEEAFLYAKFEFECRARGADILAYPPVVAGGNRSNTLHYVKNNQLIKDGEMVLLDGGC
                     ESSCYVSDITRTWPVNGRFTAPQAELYEAVLEIQRDCLALCFPGTSLENIYSMMLTLI
                     GQKLKDLGIMKNIKENNAFKAARKYCPHHVGHYLGMDVHDTPDMPRSLPLQPGMVITI
                     EPGIYIPEDDKDAPEKFRGLGVRIEDDVVVTQDSPLILSADCPKEMNDIEQICSQAS"
     exon            99..215
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..623
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..826
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..889
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1003
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1089
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1270
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1391
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..7938
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7919..7924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /note="hexamer: AATAAA"
     polyA_site      7938
                     /gene="XPNPEP3"
                     /gene_synonym="APP3; ICP55; NPHPL1"
                     /note="major polyA site"
ORIGIN      
        1 ctctttctct tcccgacgcg tgagttaggc cgtaatgcct tggctgctct cagcccccaa
       61 gctggttccc gctgtagcaa acgtccgcgg cctctcagga tgtatgttgt gttcacagcg
      121 aaggtactcc cttcagcctg tcccagaaag gaggattcca aaccgatact taggccagcc
      181 cagccccttt acacacccac acctcctcag accaggggag gtaactccag gactatctca
      241 ggtggaatat gcacttcgca gacacaaact aatgtctctg atccagaagg aagctcaagg
      301 gcagagtggg acagaccaga cagtggttgt gctctccaac cctacatact acatgagcaa
      361 cgatattccc tatactttcc accaagacaa caatttcctg tacctatgtg gattccaaga
      421 gcctgatagc attcttgtcc ttcagagcct ccctggcaaa caattaccat cacacaaagc
      481 catacttttt gtgcctcggc gagatcccag tcgagaactt tgggatggtc cgcgatctgg
      541 cactgatgga gcaatagctc taactggagt agacgaagcc tatacgctag aagaatttca
      601 acatcttcta ccaaaaatga aagctgagac gaacatggtt tggtatgact ggatgaggcc
      661 ctcacatgca cagcttcact ctgactatat gcagcccctg actgaggcca aagccaagag
      721 caagaacaag gttcggggtg ttcagcagct gatacagcgc ctccggctga tcaagtctcc
      781 tgcagaaatt gaacgaatgc agattgctgg gaagctgaca tcacaggctt tcatagaaac
      841 catgttcacc agtaaagccc ctgtggaaga agcctttctt tatgctaagt ttgaatttga
      901 atgccgggct cgtggcgcag acattttagc ctatccacct gtggtggctg gtggtaatcg
      961 gtcaaacact ttgcactatg tgaaaaataa tcaactcatc aaggatgggg aaatggtgct
     1021 tctggatgga ggttgtgagt cttcctgcta tgtgagtgac atcacacgta cgtggccagt
     1081 caatggcagg ttcaccgcac ctcaggcaga actctatgaa gccgttctag agatccaaag
     1141 agattgtttg gccctctgct tccctgggac aagcttggag aacatctaca gcatgatgct
     1201 gaccctgata ggacagaagc ttaaagactt ggggatcatg aagaacatta aggaaaataa
     1261 tgccttcaag gctgctcgaa aatactgtcc tcatcatgtt ggccactacc tcgggatgga
     1321 tgtccatgac actccagaca tgccccgttc cctccctctg cagcctggga tggtaatcac
     1381 aattgagccc ggcatttata ttccagagga tgacaaagat gccccagaga agtttcgggg
     1441 tcttggtgta cgaattgagg atgatgtagt ggtgactcag gactcacctc tcatcctttc
     1501 tgcagactgt cccaaagaga tgaatgacat tgaacagata tgcagccagg cttcttgacc
     1561 ttcactgcgg cccacatgca cctcaggttc aaaatgggtg tcttctggca gccctgcacg
     1621 tgtgctttct gagtgtctct gtgtgtgcat taatatatgc attccatttg ggagcatagc
     1681 agctgtgtga atgtatgtaa ttgtgtgtgg ggggtttttt gttttaagta gttagaagtc
     1741 tgggaaaatg aatttttgaa tagtatgtta ctgcagcttt ggtaacatta attctataga
     1801 attaatgatc agagcaagtt taatttttaa acataaaggt cttggttaca catgtccatg
     1861 cattccagtt aacacattta aacatataga aaattcactt cttctttcaa gtccttccct
     1921 ttctatactt ttgctgagat caacccaata tcataagaag tttgtgtgat gcctgtattt
     1981 ttagctaatt accaaggtct ctgcctatgc aaaaattcat ctttcggtga ttgtgggcgg
     2041 ccaatacata ccttctgtaa ctcctcccta cctattctag atcctgcata tctactggag
     2101 ccatatgagc cctcaggggc actggtgtcc tgcagtctta ctagtcagcc acagtccagg
     2161 ttccagcaac actagctacc taccaaacaa aacacttctg agcttttctt gccatttggt
     2221 tgcctgggac ctggaaagtg tttagattct tgataaagat ggaaatggaa gagaaagaaa
     2281 attatatatg tatatactaa agatccagac atcagggctg ggcacagcgg ttccgcctgt
     2341 aatcccagca ctttgggagg tccaggcagg tggatctctt gagaccagga ggtcaagacc
     2401 agcctggcca acgtggtgaa acactgtctc tactaaaaat acaaaaatga gctgggtgtg
     2461 atgatacatg cctgtaatcc tggctacttg ggaggctgag gcatgagaat tgcttgaacc
     2521 tgggaggtgg aggttgcagt gagctgagct catgcgactg cactccagcc tgggtgactg
     2581 agcaagactc tgcctcaaaa aaacaaataa ataaataaaa tcctgacatc ctgccatctt
     2641 ttctcttcaa tttaaagttg atttcttaat gatgacttca aaaattaata aaaagaaaag
     2701 aaaaaaatga tttctggccg ggcgtggtgg ctcaagcctg taatcccagc actttgggag
     2761 gccgaggtgg gcggatcacg aggtcaggag attgagacct cctggctaac acggtgaaac
     2821 cccgtcttta ctaaaaatac aaaaaaaatt agctgggcgt ggtggcggat gcctgtagtc
     2881 ccagctactc aggaggctga ggcaggagaa tggcgtgaac ccagaaggca gagcttgcag
     2941 tgagccaaga tcgcgccact gcactccagc ctgggtgaca gagcgagact ccgtctcaaa
     3001 aaaaaaaaaa aaaaagaaaa aaaaaagaaa gatttctttc gcagatatcc ctgctccctc
     3061 tatagattct taatgcactg accctcacag gttacccttt tagctgttgt gctgcgcagg
     3121 agcagatcct ctacttacgt accctgtcag agtcacagta gtagcgccca gttttcagag
     3181 aagtacccct gttatcattc tgtgatttcc tctagtgcta atagaaacaa aatatggaat
     3241 ctaccaagta cccgtaaata tcctatgatt cttatctttc tttgatacta gcactgggag
     3301 tgcagtggta aagagtcata cttctttttt tttttttttt ttggagacag agtctcgctc
     3361 tgtcgcctgg gctggatgga gtgcagtggc gtaatctcag ctcactacaa cctccaccac
     3421 ctgggttcag gcaattctcc tgcctcagcc tcccaagtaa ctgggactac aggtgcacgc
     3481 tgccatgccc agctaatttt ttgtatttta gtagagacag ggtttcaccc tgttgcccag
     3541 gccggtctca aactcctgag ctccggcaat ccgcccacct cagcctccca aagtgctagg
     3601 attacaggca tgagccactg cgcccggtgt aagagtcata tttttttaaa cacaaacatt
     3661 ggatacaatt atacagcaac tcagtttgca agatgaacag ggctagatta ccacagatag
     3721 cttatttagg agcgtctgtg atagagggaa gctttaagaa ccagtgtgtt cacctccttt
     3781 aaacctggat atgaggtcaa gatgtataaa acatgccaat tgttagaaca caaatttgag
     3841 ggtttcttaa aaaaacaatt tgtattaggg aagcacaagc taggggatta acaatctctg
     3901 taatgctgga agtttgccta tcttatcagg gaaacccagg gtacagagtg aaaagcagac
     3961 aggcagtgac ttcctcaaga gacagataat gtgaaaacaa aagtgataca aatcatatcc
     4021 tgacagtgct agcctaggaa tgcctggctt tgcgcacctt atctaagcag ctctcagaat
     4081 ggaggctgca cagctggagt ctccatcccc catacccacc ttcccacctc cctccaattt
     4141 ctcaatccag agctttttaa aaaaagggga gggaaataac tccacagctc tggctgctca
     4201 cttcccaggc tctgtgcccc caacagccct ttccttggat tgtgtttcct ttgttcattt
     4261 gtaatccagg aataaggaat ttccttttct tcttgtatca ttttcttttc ttttcttttt
     4321 tttttttttt ttgagacgga gtctcacact gtcaccgggg ctggtgtgca atagcgagac
     4381 ctcagctccc tgcaacctcc atctcccagg ttcaagcgat tctcctgcct cagcctcccg
     4441 aatagctagg aatacaggcg cctgccacca cacccggcta tttttttgta ttttaaatag
     4501 agacgaggtt tcactgtgtt ggccaggctg gtctcgaact cctgacctca tgatctgccc
     4561 gcctcggcct ccctaagtgc tgcgattaca gacgtgagcc accgcacctc ctgtatcatt
     4621 ttctatggtc taaacttttc tagctaaaag cctaggtagc ttgtatgtat agcagcatac
     4681 ttggacatga aacacacttc tggttagatt ccagtcaagt tctataggtg ttattggtag
     4741 gcagaaaggc tgttgtagaa ttcttctggt gattttcagt ccctgaccca ggtatattgt
     4801 cctttgagtc ccagattaac taactatagc agctaagcat ttgaatcaga cttctcatag
     4861 caatgttatg ggctgtctga tatattcagg atttgttgag cagataagct gtgtgtgatc
     4921 ttactcattc tcagccatgc cgcagacata cccatttccc tttagtaatt ttttaataca
     4981 gagaatgcta ttaactgtta ctggatatca aataatttta tttttctaat agtattttcc
     5041 aaatatttct taaaattctt aaaatttagg ttaaagtttg ctggtctctt acatttaata
     5101 aagctgggac ttgaagactt accatagttt tcaactgcct ttgcaagttc ataaacttct
     5161 aagggtaaaa agtgaataag ataaattcag agttttaagg taaaggcttt atattagctt
     5221 tttttttttt taaaggtttt ttgtggggtt tttttgtttt tttttttttt gagatggagt
     5281 ctcgctctgt cacccaggct ggagtgcagt ggcacgatct tggctcactg caacctccat
     5341 ctcccgggtt caggcaattc ttctgcctca gcctcctgag tagctgggac tacaggcgcg
     5401 tgccaccatg cccggctagt ttattgtatt tttagtagag atggggtttt actgtgttag
     5461 ccaggatggt ctcaatctcc tgacctcata atctgcccac ctcagcctcc caaagtgctg
     5521 ggattacagg cgtgagccac tgcacccagc ctttttaaag tttttaattg acatataatt
     5581 gtacgtattt acagggtaaa taatgatgtt ttgatacata tataatgatc agatcagaac
     5641 aattagcata tccatcacat tgaacattta tcatttattt gtgttgagcc tttagttctt
     5701 tttttttttt gagatagagt ctcactctgt cacccaggct ggagtacagt ggtgtgatct
     5761 tggctcactg caacctccac ccaccggctt caaccaattc tcctgcctca gcctccctag
     5821 taactgggat tacaggcacc tgccaccaca cccaattttt gtatttttag tagagacggg
     5881 gtttcaccat cttggccagg ccaggctggt cttgatctcc tgaccttgtg atccacccac
     5941 ctcagcttcc caaactgctg ggattacagg catgagccac ggcccccagc cagagacagt
     6001 cttgctttgt cgccaggctg gagtgtagtg gcgccatctt ggctcactgc aacctccaac
     6061 tccctggttc aagcagttct cctgcctcag cctcccaagt agctgggatt acaggcacgc
     6121 accaccatgc ccagctaatt tttgtatttt tagtagagac agggtttcac catgttggcc
     6181 aggatggtct tgatctcctg acctcgtgat ctgcccactt tggcctccca aagtgctggg
     6241 attacaggtg tgagccaccg tgcccagccg agcctttagt tctaagtata ataaataata
     6301 tatataccag gcattcctat taaaaatctt aacttaaaaa aaattactca aatgttacta
     6361 ctggaatttt tctccctgaa ttgaagatac atggttagat cattaacaat accacctaaa
     6421 tgaaggaaac atatctggat atccagtgtc acatactttt atgtatttat ttcaggaatt
     6481 actattttgt caccataatt aggaaacaga ctgtgttctt tatttgaaac acaacagtat
     6541 aaatactata gtaaagttgg gtgcagtgga tcacagctat aatcccagca ctttgggaga
     6601 ccaaggaggg atggtcactt gagcccagga gtttgagacc agcctaggca acatagagag
     6661 accttgtctc aacaaaaaaa tttaaagtta gccaggtgtg gtggtttgca cctatagtcc
     6721 cagctactca ggaggctgag gtgggaggat cgcttgagct taggaggtca aggctgcagt
     6781 gagccatgat tgtgccactt caccctgggc aacagagaaa gaccctgtct caataaaaaa
     6841 gaagagaaaa actggagtga gaactctcct cctctcataa tcatagtatc cacgttagga
     6901 aaatgcttct gagagtaact taaagtactg tgtgtgcatc ttccttcaaa accttgcttt
     6961 tttctccgtt tttgtaaggt gagaaaggga aaaaccttca ccgtagaaat actgtcttga
     7021 gattaagata caaataaaac atgttaaacc tccatctaaa gacattgcaa cttattaaaa
     7081 cagaaaaatg tacctttgtt atgtctttcc aaatatccac acccacaccc tgttcagctt
     7141 tgttaataat acagagatca gaaatgtgaa gcacaaatgc tgcttctccc cctcctgttc
     7201 ccatgtcaga gatggagaag aaagcacagt gagctgttca ccagtccagc ggtgacctcg
     7261 gagtcctttg taacagtgtt tccaataact tctgccaata aaacagaatt tgagttagaa
     7321 cctatctgct gtccctcaac tagtgtctga tagctgagaa tgtaattcgt ttgtgtgtct
     7381 attagaaaat taggcaggca ccacagacag tagcaacata aaggaacctg cttagaagag
     7441 gtttttatgg tgtgattgtg tttttttttt tttaattttt gtttcctgaa gtagaatcca
     7501 tagctcaaaa caagttttaa gcctgagaaa atataatttg aggtgttttt tatgctccta
     7561 atgaaaagat gaatgaatgc atcattaaac cttaacagta gagcagaatt tcactgttac
     7621 aaaccacatg ggttctcctg gttgtgctgc tgttctctac ctgtgtgtca ctgagtttga
     7681 gcatcattat tgtttgaatc agaggaccca ctggaatcaa ggcttcttgg aattgcgcaa
     7741 gaatctgaga aaacttcaat ctttaccagc atttcttaat gctttccatg acttttgtgc
     7801 aattatataa gttcagttta gacaaaatgc tgttactttt taaggcatta ctaataactg
     7861 aaaatagtta cgtcattgcc catcaaggga aaagcacttg taactgtcat ttaaaaaaaa
     7921 taaaactata aaacaata
//
