LOCUS       NM_212559               2856 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens XK related X-linked (XKRX), mRNA.
ACCESSION   NM_212559
VERSION     NM_212559.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Calenda,G., Peng,J., Redman,C.M., Sha,Q., Wu,X. and Lee,S.
  TITLE     Identification of two new members, XPLAC and XTES, of the XK family
  JOURNAL   Gene 370, 6-16 (2006)
   PUBMED   16431037
  REMARK    GeneRIF: XPLAC is expressed mostly in placenta and adrenal gland
            while XTES is exclusively expressed in primate testis
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z73417.1, AY589511.1 and
            AI087330.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_212559.2.
            
            Summary: This gene encodes a protein that is related to a component
            of the XK/Kell complex of the Kell blood group system. The encoded
            protein includes several transmembrane domains, is known to be
            exposed to the cell surface, and may function as a membrane
            transporter. [provided by RefSeq, May 2010].
            
            Sequence Note: An in-frame AUG is located 13 codons upstream of the
            annotated translation start site but was not annotated as a start
            site since it is poorly conserved and is in a weak Kozak sequence
            context. In addition, a 6 amino acid overlapping uORF would prevent
            its use.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY534239.1, AY589511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream ORF predicted to
                                                inhibit translation from
                                                upstream AUG
            MANE Ensembl match               :: ENST00000372956.3/
                                                ENSP00000362047.2
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 Z73417.1           11720-11727
            9-2854              AY589511.1         1-2846
            2855-2856           AI087330.1         7-8                 c
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq22.1"
     gene            1..2856
                     /gene="XKRX"
                     /gene_synonym="XKR2; XPLAC; XRG2"
                     /note="XK related X-linked"
                     /db_xref="GeneID:402415"
                     /db_xref="HGNC:HGNC:29845"
                     /db_xref="MIM:300684"
     exon            1..948
                     /gene="XKRX"
                     /gene_synonym="XKR2; XPLAC; XRG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             614..1963
                     /gene="XKRX"
                     /gene_synonym="XKR2; XPLAC; XRG2"
                     /note="X Kell blood group precursor-related, X-linked;
                     membrane protein XPLAC; XK, Kell blood group complex
                     subunit-related, X-linked; X-linked Kx blood group
                     related, X-linked"
                     /codon_start=1
                     /product="XK-related protein 2"
                     /protein_id="NP_997724.2"
                     /db_xref="CCDS:CCDS14476.2"
                     /db_xref="GeneID:402415"
                     /db_xref="HGNC:HGNC:29845"
                     /db_xref="MIM:300684"
                     /translation="MDRVYEIPEEPNVDPVSSLEEDVIRGANPRFTFPFSILFSTFLY
                     CGEAASALYMVRIYRKNSETYWMTYTFSFFMFSSIMVQLTLIFVHRDLAKDKPLSLFM
                     HLILLGPVIRCLEAMIKYLTLWKKEEQEEPYVSLTRKKMLIDGEEVLIEWEVGHSIRT
                     LAMHRNAYKRMSQIQAFLGSVPQLTYQLYVSLISAEVPLGRVVLMVFSLVSVTYGATL
                     CNMLAIQIKYDDYKIRLGPLEVLCITIWRTLEITSRLLILVLFSATLKLKAVPFLVLN
                     FLIILFEPWIKFWRSGAQMPNNIEKNFSRVGTLVVLISVTILYAGINFSCWSALQLRL
                     ADRDLVDKGQNWGHMGLHYSVRLVENVIMVLVFKFFGVKVLLNYCHSLIALQLIIAYL
                     ISIGFMLLFFQYLHPLRSLFTHNVVDYLHCVCCHQHPRTRVENSEPPFETEARQSVV"
     exon            949..1217
                     /gene="XKRX"
                     /gene_synonym="XKR2; XPLAC; XRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..2856
                     /gene="XKRX"
                     /gene_synonym="XKR2; XPLAC; XRG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2837..2842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XKRX"
                     /gene_synonym="XKR2; XPLAC; XRG2"
                     /note="hexamer: AATGAA"
     polyA_site      2856
                     /gene="XKRX"
                     /gene_synonym="XKR2; XPLAC; XRG2"
                     /note="major polyA site"
ORIGIN      
        1 caaaggtcct gagagcgcgc aggtgagcgg gccagctgat agctacagcc tagcaatagc
       61 taggatacct aggcactgaa ctgaatcccc tcttctgccc tccttcttct gcgcccgctc
      121 ttctgccctg gctcagctct ccgctgactt gagaggacac actggtcagg actctttgtg
      181 aggagctgct gagtgtcggt gcccccgaca gatcggctac accctgcctg aggggctgcg
      241 aaaggagccg ccacggaagc cgctgttctc atgactcttc acgtccctgg agttggactc
      301 tggatggggc gctgggatgc ttgcttttgt cttgttcaag tttcacagca agtatgttga
      361 cgattggaat cggggccaat caagagtcaa gttcaaagtg gtactcctgg gctttccatc
      421 ccagactcca agtcgaatct gagtctagaa gagagcggtt tcttgctcta actagtgaat
      481 ctctgttccc aaactggact tgacagagct ctcctcacct atacttggac tgtagcggcc
      541 atagggttct cttggggatg ggtgggaggg tgctatgaac acaagaccac aacattcaga
      601 aagaacctcg acaatggaca gagtttatga aattcctgag gagccaaatg tggatccggt
      661 ttcatctctg gaggaagatg tcatccgtgg agccaacccc cgatttactt ttccatttag
      721 catccttttc tccacctttt tgtactgtgg ggaggctgca tctgctttgt acatggttag
      781 aatctatcga aagaatagtg aaacttactg gatgacatac accttttctt tctttatgtt
      841 ttcatccatt atggtccagt tgaccctcat ttttgtccac agagatctag ccaaagataa
      901 accgctatca ttatttatgc atctaatcct cttgggacct gttatcagat gtttggaggc
      961 catgattaag tacctcacac tgtggaagaa agaggagcag gaggagccct atgtcagcct
     1021 cacccgaaag aagatgctaa tagatggcga ggaggtgctg atagaatggg aggtgggcca
     1081 ctccatccgg accctggcta tgcaccgcaa tgcctacaaa cgtatgtcac agatccaagc
     1141 cttcctgggc tcagtgcccc agctgaccta tcagctctat gtgagcctga tctctgcaga
     1201 ggttcccctg ggtagagttg tgctaatggt attttccctg gtatctgtca cctatggggc
     1261 caccctttgc aatatgttgg ctatccagat caagtacgat gactacaaga ttcgccttgg
     1321 gccactagaa gtcctctgca tcaccatctg gcggacattg gagatcactt cccgcctcct
     1381 gattctggtg ctcttctcag ccactttgaa attgaaggct gtgcccttcc tagtgctcaa
     1441 cttcctgatc atcctctttg agccctggat taagttctgg agaagtggtg cccagatgcc
     1501 caataacatt gagaaaaact tcagccgggt cggcactctg gtggtcctga tttcagtcac
     1561 catcctctat gctggcatca acttctcttg ctggtcagct ttgcagttga ggttggcaga
     1621 cagagatctc gtcgacaaag ggcagaactg gggacatatg ggcctgcact atagtgtgag
     1681 gttggtagag aatgtgatca tggtcttggt ttttaagttc tttggagtga aagtgttact
     1741 gaattactgt cattccttga ttgccttgca gctcattatt gcttatctga tttccattgg
     1801 cttcatgctc cttttcttcc agtacttgca tccattgcgc tcactcttca cccataatgt
     1861 agtagactac ctccattgtg tctgctgtca ccagcaccct cggaccaggg ttgagaactc
     1921 agagccaccc tttgagactg aagcaaggca aagtgttgtc tgattctatt ttctgggtat
     1981 tttaggaaga gttgggagtt gccaagagta accatgaaat tgaacgaaag gatgaggttc
     2041 atgggtgaga tacccatcag tacattttct tgacttttct gttaagccta tcagaagaaa
     2101 gagcaactcc caaataggtt ttattttctt aagagttacc actatgtttg gaaacagggg
     2161 gtatcgacta tatagttgaa agggtcagaa ataccattca cacccttctt acccaagtca
     2221 attggaataa cttgtcttca aacactttag gctctctaaa gtgaccttct agctctgctc
     2281 atttgcttga tgcatttctg agctttcctg ggctgagctg aaggcccaga atcccgctag
     2341 aatatatcct gactgatcag aggatatgac agcttaccag ctaagagtac ctcccaggaa
     2401 acagtctgac taatgtggaa cctgcaactg tcagtgtggc tggggtcttt ttaattccag
     2461 tgagaagctc tggctgagaa gaaaatcacc actattaaaa aagctgctcc ccaagcagat
     2521 tagctctctg ttaggatttt actagtggcc attcagcaag gacctctctt tacagtggca
     2581 cttcataggc acactctaag gagaaagtgc agagtagaat tccttcaggg cataagccaa
     2641 aatgactctt tttctcaggg acctgcatgg gcctccagct tgtctattgg aattgttaag
     2701 tgaagcctct cacttagtgc ctcattagca gagatttcct ccaacccagc ttttctgtgc
     2761 tcttggtatt ttactacttg atgtggacct cagagaagct gaactgtaat tgaaaatgtt
     2821 tccgatgtgt ggaagaaatg aagactgctt tgtgtc
//
