LOCUS       NM_001011720            3200 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens XK related 9 (XKR9), transcript variant 1, mRNA.
ACCESSION   NM_001011720 XM_372047
VERSION     NM_001011720.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3200)
  AUTHORS   Straub,M.S., Alvadia,C., Sawicka,M. and Dutzler,R.
  TITLE     Cryo-EM structures of the caspase-activated protein XKR9 involved
            in apoptotic lipid scrambling
  JOURNAL   Elife 10, e69800 (2021)
   PUBMED   34263724
  REMARK    GeneRIF: Cryo-EM structures of the caspase-activated protein XKR9
            involved in apoptotic lipid scrambling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3200)
  AUTHORS   Borne,Y., Soderholm,M., Barregard,L., Fagerberg,B., Persson,M.,
            Melander,O., Thevenod,F., Hedblad,B. and Engstrom,G.
  TITLE     Genome wide association study identifies two loci associated with
            cadmium in erythrocytes among never-smokers
  JOURNAL   Hum Mol Genet 25 (11), 2342-2348 (2016)
   PUBMED   27005419
  REMARK    GeneRIF: This genome-wide study of never smokers from the general
            population identified two independent regions related to
            erythrocyte cadmium. The strongest locus covers the XKR9 and LACTB2
            genes, which both could have related functions in cadmium
            absorption and metabolism
REFERENCE   3  (bases 1 to 3200)
  AUTHORS   Estrada,K., Styrkarsdottir,U., Evangelou,E., Hsu,Y.H., Duncan,E.L.,
            Ntzani,E.E., Oei,L., Albagha,O.M., Amin,N., Kemp,J.P., Koller,D.L.,
            Li,G., Liu,C.T., Minster,R.L., Moayyeri,A., Vandenput,L.,
            Willner,D., Xiao,S.M., Yerges-Armstrong,L.M., Zheng,H.F.,
            Alonso,N., Eriksson,J., Kammerer,C.M., Kaptoge,S.K., Leo,P.J.,
            Thorleifsson,G., Wilson,S.G., Wilson,J.F., Aalto,V., Alen,M.,
            Aragaki,A.K., Aspelund,T., Center,J.R., Dailiana,Z., Duggan,D.J.,
            Garcia,M., Garcia-Giralt,N., Giroux,S., Hallmans,G., Hocking,L.J.,
            Husted,L.B., Jameson,K.A., Khusainova,R., Kim,G.S., Kooperberg,C.,
            Koromila,T., Kruk,M., Laaksonen,M., Lacroix,A.Z., Lee,S.H.,
            Leung,P.C., Lewis,J.R., Masi,L., Mencej-Bedrac,S., Nguyen,T.V.,
            Nogues,X., Patel,M.S., Prezelj,J., Rose,L.M., Scollen,S.,
            Siggeirsdottir,K., Smith,A.V., Svensson,O., Trompet,S., Trummer,O.,
            van Schoor,N.M., Woo,J., Zhu,K., Balcells,S., Brandi,M.L.,
            Buckley,B.M., Cheng,S., Christiansen,C., Cooper,C., Dedoussis,G.,
            Ford,I., Frost,M., Goltzman,D., Gonzalez-Macias,J., Kahonen,M.,
            Karlsson,M., Khusnutdinova,E., Koh,J.M., Kollia,P., Langdahl,B.L.,
            Leslie,W.D., Lips,P., Ljunggren,O., Lorenc,R.S., Marc,J.,
            Mellstrom,D., Obermayer-Pietsch,B., Olmos,J.M.,
            Pettersson-Kymmer,U., Reid,D.M., Riancho,J.A., Ridker,P.M.,
            Rousseau,F., Slagboom,P.E., Tang,N.L., Urreizti,R., Van Hul,W.,
            Viikari,J., Zarrabeitia,M.T., Aulchenko,Y.S.,
            Castano-Betancourt,M., Grundberg,E., Herrera,L., Ingvarsson,T.,
            Johannsdottir,H., Kwan,T., Li,R., Luben,R., Medina-Gomez,C.,
            Palsson,S.T., Reppe,S., Rotter,J.I., Sigurdsson,G., van Meurs,J.B.,
            Verlaan,D., Williams,F.M., Wood,A.R., Zhou,Y., Gautvik,K.M.,
            Pastinen,T., Raychaudhuri,S., Cauley,J.A., Chasman,D.I.,
            Clark,G.R., Cummings,S.R., Danoy,P., Dennison,E.M., Eastell,R.,
            Eisman,J.A., Gudnason,V., Hofman,A., Jackson,R.D., Jones,G.,
            Jukema,J.W., Khaw,K.T., Lehtimaki,T., Liu,Y., Lorentzon,M.,
            McCloskey,E., Mitchell,B.D., Nandakumar,K., Nicholson,G.C.,
            Oostra,B.A., Peacock,M., Pols,H.A., Prince,R.L., Raitakari,O.,
            Reid,I.R., Robbins,J., Sambrook,P.N., Sham,P.C., Shuldiner,A.R.,
            Tylavsky,F.A., van Duijn,C.M., Wareham,N.J., Cupples,L.A.,
            Econs,M.J., Evans,D.M., Harris,T.B., Kung,A.W., Psaty,B.M.,
            Reeve,J., Spector,T.D., Streeten,E.A., Zillikens,M.C.,
            Thorsteinsdottir,U., Ohlsson,C., Karasik,D., Richards,J.B.,
            Brown,M.A., Stefansson,K., Uitterlinden,A.G., Ralston,S.H.,
            Ioannidis,J.P., Kiel,D.P. and Rivadeneira,F.
  TITLE     Genome-wide meta-analysis identifies 56 bone mineral density loci
            and reveals 14 loci associated with risk of fracture
  JOURNAL   Nat Genet 44 (5), 491-501 (2012)
   PUBMED   22504420
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022731.4 and AY534247.1.
            
            On May 17, 2019 this sequence version replaced NM_001011720.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1, 3 and 4 encode the same isoform (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY534247.1, BC137104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408926.8/ ENSP00000386141.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC022731.4         129622-129647
            27-3200             AY534247.1         1-3174
FEATURES             Location/Qualifiers
     source          1..3200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.3"
     gene            1..3200
                     /gene="XKR9"
                     /gene_synonym="hXKR9; XRG9"
                     /note="XK related 9"
                     /db_xref="GeneID:389668"
                     /db_xref="HGNC:HGNC:20937"
     exon            1..200
                     /gene="XKR9"
                     /gene_synonym="hXKR9; XRG9"
                     /inference="alignment:Splign:2.1.0"
     exon            201..282
                     /gene="XKR9"
                     /gene_synonym="hXKR9; XRG9"
                     /inference="alignment:Splign:2.1.0"
     exon            283..832
                     /gene="XKR9"
                     /gene_synonym="hXKR9; XRG9"
                     /inference="alignment:Splign:2.1.0"
     CDS             561..1682
                     /gene="XKR9"
                     /gene_synonym="hXKR9; XRG9"
                     /note="isoform 2 is encoded by transcript variant 1; X
                     Kell blood group precursor-related family, member 9;
                     XK-related protein 9; X-linked Kx blood group related 9;
                     XK, Kell blood group complex subunit-related family,
                     member 9"
                     /codon_start=1
                     /product="XK-related protein 9 isoform 2"
                     /protein_id="NP_001011720.1"
                     /db_xref="CCDS:CCDS34905.1"
                     /db_xref="GeneID:389668"
                     /db_xref="HGNC:HGNC:20937"
                     /translation="MKYTKQNFMMSVLGIIIYVTDLIVDIWVSVRFFHEGQYVFSALA
                     LSFMLFGTLVAQCFSYSWFKADLKKAGQESQHCFLLLHCLQGGVFTRYWFALKRGYHA
                     AFKYDSNTSNFVEEQIDLHKEVIDRVTDLSMLRLFETYLEGCPQLILQLYILLEHGQA
                     NFSQYAAIMVSCCAISWSTVDYQVALRKSLPDKKLLNGLCPKITYLFYKLFTLLSWML
                     SVVLLLFLNVKIALFLLLFLWLLGIIWAFKNNTQFCTCISMEFLYRIVVGFILIFTFF
                     NIKGQNTKCPMSCYYIVRVLGTLGILTVFWVCPLTIFNPDYFIPISITIVLTLLLGIL
                     FLIVYYGSFHPNRSAETKCDEIDGKPVLRECRMRYFLME"
     exon            833..1053
                     /gene="XKR9"
                     /gene_synonym="hXKR9; XRG9"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..3200
                     /gene="XKR9"
                     /gene_synonym="hXKR9; XRG9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1730..1735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XKR9"
                     /gene_synonym="hXKR9; XRG9"
                     /note="hexamer: AGTAAA"
     polyA_site      1749
                     /gene="XKR9"
                     /gene_synonym="hXKR9; XRG9"
                     /note="major polyA site"
ORIGIN      
        1 agaggtcacg tgacgccgcg cgggctgcgc gggcagtggt gggaaggctg gcgcgaggcg
       61 tgaggtggcg tgaggcgaag ctggaatctg cctctgtcac gggggctggt gcctcacggg
      121 tttgtgtcct agacaggcga gtggatccaa gtgggcgaga gacattttaa tctggaagag
      181 tcttgtgatt tgggagacag tgaagaagaa gtaaaatatt cacaagatga agatttttcc
      241 agaagggact ttgagtcaaa gatggctttt tatatttgac aagtcttgtc atctgtaatg
      301 aagatcattg tgaaacagaa gattgattaa agccttgtaa cattggacct agattagaga
      361 tttagaaaag aaagtcaaaa ttagtcactt tagtgttagt gttcccattt cataatattt
      421 attctttctt ctaaatagat ttagggagta gaaattaaaa ttcaatgcta taccaaaggg
      481 tatactaata tttgtttggc tttttttccc tttttgtgag ggagaaaaaa gtagataacg
      541 aaaagctata gtcattcgta atgaaatata ctaaacagaa ttttatgatg tcagttcttg
      601 gcattataat ctacgtaact gatttaattg tggacatatg ggtatctgtc agatttttcc
      661 atgaaggaca gtatgttttt agtgctttag cgttaagctt tatgcttttt ggaacacttg
      721 tggctcagtg ttttagttat tcttggttca aggctgattt aaagaaagca ggccaagaaa
      781 gtcagcattg ttttcttcta cttcattgct tgcaaggagg agtttttaca aggtattggt
      841 ttgccttaaa aaggggttac catgcagctt ttaaatatga cagcaatact agtaacttcg
      901 tggaagaaca aattgatcta cataaagaag ttatagatag agtgactgat ttgagcatgc
      961 tcagactatt tgagacctac ctggaaggct gcccacaact tattcttcaa ctctacattc
     1021 ttctggagca tggacaagcg aatttcagtc agtatgcggc catcatggtc tcttgctgtg
     1081 ctatttcttg gtcaactgtt gattatcaag tagctttaag aaaatccttg cctgacaaaa
     1141 agcttcttaa tggattatgt cccaaaatca catatctctt ttacaagttg tttacattat
     1201 tatcgtggat gctgagtgtt gtacttctac tattcttaaa tgttaagatt gctttatttc
     1261 tgttgttatt tctttggttg ttaggtataa tatgggcatt taaaaacaac acccagtttt
     1321 gtacttgtat aagtatggaa ttcttatata ggattgttgt tggattcatt cttatcttta
     1381 cattttttaa tattaaggga cagaatacca agtgtccaat gtcttgttat tatattgtta
     1441 gggtactggg cactttgggg atattgactg tattctgggt ttgccccctc actattttta
     1501 atccagacta ttttatacct atcagtataa ctatagttct tactcttctt cttggaattc
     1561 tttttcttat tgtttattat gggagttttc acccaaacag aagtgcagaa acaaaatgtg
     1621 atgaaattga tggaaaacca gttctaagag aatgtagaat gagatatttc ctaatggaat
     1681 aagctattca tttatgatat atattttctt atattttgtt tcattggtta gtaaagaaaa
     1741 tgtgtgttat gtgggtgtgt tgtctcttat ttttgccacc tttaatttga aattagttca
     1801 gtgaaatagg agatacatag tagtatttta tttttaaaat taatttctca tttggttttg
     1861 aagatcttga gtactcagat atctttctac tgcctggtag agctgccatc ttgagcctga
     1921 aatataagaa atggtctggt tttcataatg agaaggctgg aattgagctt ccctcccatt
     1981 ttccttgttc ctgaactaat actactgtac ctgttatgga ggactgcaaa gggaagagaa
     2041 aagcagaaca ctgtattatt ttttccttta ttgtcttcag tgcatatatt tgcagttggg
     2101 gacaggttga gtagaggaaa agggaaagaa gggaaagcag aaaacaaatt tttagcatct
     2161 gctgtgcttt catccatgaa atctccaatt cagtaagtgc aaaagagaat tggtgtgcat
     2221 ctgagaggtc tgacatttca ttatttactt atttcctagc ttttctgaat taatgcactc
     2281 ttaacatata attatattaa tcctatttgt gctagaatag ttgtatctaa atcatatttt
     2341 aaaattattt ttatttttaa aaaattatgg taaaaacata taaaatttac catcttaatc
     2401 actttgagtg tacagttcat cagtgttaac tgtattcacc ttgtgcaaca gatctcaagg
     2461 actttttcac cttgtaaaac taagattctc tatttattga acaaatcccc atttcctcct
     2521 tccccaagtc tctctcaact gaaattataa ttttttgttt ctatgagttt gaatacttta
     2581 gataccttgt tgccatggtt tgaatgtgcc ccccagattt catgtgtgtg aaacttaatc
     2641 tccaaatttg tatgttgatg gcatttggaa gtggtgggga ctttgtttat ttatttattt
     2701 ttaatttttt aattttatat tattattatt attattatac tttaaggttt agggtacatg
     2761 tgcacaatgt gcaggttagt tacatatgta tacatgtgcc atgctggtgt gctgcaccca
     2821 ttaactcgtc atttatcatt aggtatatct cctaaagcta tccctccccc ctccccccac
     2881 cccacaacag tccccagagt gtgatgatcc ccttcctgtg tccatgtgtt ctcattgttc
     2941 agttcccacc tatgagtgag aatatgcagt gtttggtttt ttgttcttgc gatagtttac
     3001 tgagaatgat gatttccagc ttcatccatg tccctacaaa ggacatgaac tcatcatttt
     3061 ttatggctgc atagtattcc atggtgtata tgtgccacat tttcttaatc cagtctattg
     3121 ttgttggaca tttgggttgg ttccaagtct ttgctattgt gaatagtgct gcaataaaca
     3181 tacgtgtgca tgtgtcttta
//
