LOCUS       NM_018053               2178 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens XK related 8 (XKR8), mRNA.
ACCESSION   NM_018053
VERSION     NM_018053.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2178)
  AUTHORS   Sakuragi,T., Kanai,R., Otani,M., Kikkawa,M., Toyoshima,C. and
            Nagata,S.
  TITLE     The role of the C-terminal tail region as a plug to regulate XKR8
            lipid scramblase
  JOURNAL   J Biol Chem 300 (3), 105755 (2024)
   PUBMED   38364890
  REMARK    GeneRIF: The role of the C-terminal tail region as a plug to
            regulate XKR8 lipid scramblase.
REFERENCE   2  (bases 1 to 2178)
  AUTHORS   Sakuragi,T., Kanai,R., Tsutsumi,A., Narita,H., Onishi,E.,
            Nishino,K., Miyazaki,T., Baba,T., Kosako,H., Nakagawa,A.,
            Kikkawa,M., Toyoshima,C. and Nagata,S.
  TITLE     The tertiary structure of the human Xkr8-Basigin complex that
            scrambles phospholipids at plasma membranes
  JOURNAL   Nat Struct Mol Biol 28 (10), 825-834 (2021)
   PUBMED   34625749
  REMARK    GeneRIF: The tertiary structure of the human Xkr8-Basigin complex
            that scrambles phospholipids at plasma membranes.
REFERENCE   3  (bases 1 to 2178)
  AUTHORS   Kim,G.W., Nam,G.H., Kim,I.S. and Park,S.Y.
  TITLE     Xk-related protein 8 regulates myoblast differentiation and
            survival
  JOURNAL   FEBS J 284 (21), 3575-3588 (2017)
   PUBMED   28881496
  REMARK    GeneRIF: The Xkr8 influences myogenesis by acting as a positive
            regulator of terminal differentiation and myoblast survival.
REFERENCE   4  (bases 1 to 2178)
  AUTHORS   Suzuki,J., Imanishi,E. and Nagata,S.
  TITLE     Xkr8 phospholipid scrambling complex in apoptotic
            phosphatidylserine exposure
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9509-9514 (2016)
   PUBMED   27503893
  REMARK    GeneRIF: Xkr8-BSG/NPTN complex is required for phosphatidylserine
            scrambling in apoptotic cell membranes.
REFERENCE   5  (bases 1 to 2178)
  AUTHORS   Bevers,E.M. and Williamson,P.L.
  TITLE     Getting to the Outer Leaflet: Physiology of Phosphatidylserine
            Exposure at the Plasma Membrane
  JOURNAL   Physiol Rev 96 (2), 605-645 (2016)
   PUBMED   26936867
  REMARK    GeneRIF: facilitates transbilayer migration of lipids [review]
            Review article
REFERENCE   6  (bases 1 to 2178)
  AUTHORS   Suzuki,J., Denning,D.P., Imanishi,E., Horvitz,H.R. and Nagata,S.
  TITLE     Xk-related protein 8 and CED-8 promote phosphatidylserine exposure
            in apoptotic cells
  JOURNAL   Science 341 (6144), 403-406 (2013)
   PUBMED   23845944
  REMARK    GeneRIF: findings show the Xk-family protein Xkr8 mediates
            phosphatidylserine exposure in response to apoptotic stimuli;
            Xk-family proteins have evolutionarily conserved roles in promoting
            phagocytosis of dying cells by altering the phospholipid
            distribution in the plasma membrane
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512288.19.
            
            On Jul 29, 2019 this sequence version replaced NM_018053.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK091615.1, AK026024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373884.6/ ENSP00000362991.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AL512288.19        74360-74749         c
            391-587             AL512288.19        71029-71225         c
            588-2178            AL512288.19        66629-68219         c
FEATURES             Location/Qualifiers
     source          1..2178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..2178
                     /gene="XKR8"
                     /gene_synonym="hXkr8; XRG8"
                     /note="XK related 8"
                     /db_xref="GeneID:55113"
                     /db_xref="HGNC:HGNC:25508"
                     /db_xref="MIM:619940"
     exon            1..390
                     /gene="XKR8"
                     /gene_synonym="hXkr8; XRG8"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1285
                     /gene="XKR8"
                     /gene_synonym="hXkr8; XRG8"
                     /note="X Kell blood group precursor-related family, member
                     8; X-linked Kx blood group related 8; XK, Kell blood group
                     complex subunit-related family, member 8"
                     /codon_start=1
                     /product="XK-related protein 8"
                     /protein_id="NP_060523.2"
                     /db_xref="CCDS:CCDS315.1"
                     /db_xref="GeneID:55113"
                     /db_xref="HGNC:HGNC:25508"
                     /db_xref="MIM:619940"
                     /translation="MPWSSRGALLRDLVLGVLGTAAFLLDLGTDLWAAVQYALGGRYL
                     WAALVLALLGLASVALQLFSWLWLRADPAGLHGSQPPRRCLALLHLLQLGYLYRCVQE
                     LRQGLLVWQQEEPSEFDLAYADFLALDISMLRLFETFLETAPQLTLVLAIMLQSGRAE
                     YYQWVGICTSFLGISWALLDYHRALRTCLPSKPLLGLGSSVIYFLWNLLLLWPRVLAV
                     ALFSALFPSYVALHFLGLWLVLLLWVWLQGTDFMPDPSSEWLYRVTVATILYFSWFNV
                     AEGRTRGRAIIHFAFLLSDSILLVATWVTHSSWLPSGIPLQLWLPVGCGCFFLGLALR
                     LVYYHWLHPSCCWKPDPDQVDGARSLLSPEGYQLPQNRRMTHLAQKFFPKAKDEAASP
                     VKG"
     exon            391..587
                     /gene="XKR8"
                     /gene_synonym="hXkr8; XRG8"
                     /inference="alignment:Splign:2.1.0"
     exon            588..2178
                     /gene="XKR8"
                     /gene_synonym="hXkr8; XRG8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XKR8"
                     /gene_synonym="hXkr8; XRG8"
                     /note="hexamer: AATAAA"
     polyA_site      2178
                     /gene="XKR8"
                     /gene_synonym="hXkr8; XRG8"
                     /note="major polyA site"
ORIGIN      
        1 gagggctgcg cccacctcct tcctgcctcg gcaaccccgg gccctgaggg caggccccaa
       61 ccgcggagga gcaggagagg gcggaggccg gcgggccatg ccctggtcgt cccgcggcgc
      121 cctccttcgg gacctggtcc tgggcgtgct gggcaccgcc gccttcctgc tcgacctggg
      181 caccgacctg tgggccgccg tccagtatgc gctcggcggc cgctacctgt gggcggcgct
      241 ggtgctggcg ctgctgggcc tggcctccgt ggcgctgcag ctcttcagct ggctctggct
      301 gcgcgctgac cctgccggcc tgcacgggtc gcagcccccg cgccgctgcc tggcgctgct
      361 gcatctcctg cagctgggtt acctgtacag gtgcgtgcag gagctgcggc aggggctgct
      421 ggtgtggcag caggaggagc cctctgagtt tgacttggcc tacgccgact tcctcgccct
      481 ggacatcagc atgctgcggc tcttcgagac cttcttggag acggcaccac agctcacgct
      541 ggtgctggcc atcatgctgc agagtggccg ggctgagtac taccagtggg ttggcatctg
      601 cacatccttc ctgggcatct cgtgggcact gctcgactac caccgggcct tgcgcacctg
      661 cctcccctcc aagccgctcc tgggcctggg ctcctccgtg atctacttcc tgtggaacct
      721 gctgctgctg tggccccgag tcctggctgt ggccctgttc tcagccctct tccccagcta
      781 tgtggccctg cacttcctgg gcctgtggct ggtactgctg ctctgggtct ggcttcaggg
      841 cacagacttc atgccggacc ccagctccga gtggctgtac cgggtgacgg tggccaccat
      901 cctctatttc tcctggttca acgtggctga gggccgcacc cgaggccggg ccatcatcca
      961 cttcgccttc ctcctgagtg acagcattct cctggtggcc acctgggtga ctcatagctc
     1021 ctggctgccc agcgggattc cactgcagct gtggctgcct gtgggatgcg gctgcttctt
     1081 tctgggcctg gctctgcggc ttgtgtacta ccactggctg caccctagct gctgctggaa
     1141 gcccgaccct gaccaggtag acggggcccg gagtctgctt tctccagagg ggtatcagct
     1201 gcctcagaac aggcgcatga cccatttagc acagaagttt ttccccaagg ctaaggatga
     1261 ggctgcttcg ccagtgaagg gataggtgaa cggcgtcctt tgaagcagga tcagacccag
     1321 ccagcagaga tggagagtga ctctgttggc agaaggcagg cgaggataag ctaacgatgc
     1381 tgctgtggcc tctatgcact cagcaagagc gggacgcctg tgctgggccg ggcaccaggg
     1441 atggtgctga gtcgggcaga ggcctccttt caaggagttc acagtgaaca agatgagaag
     1501 ggctgggccc tggagggtca agagccccaa ttatgtacaa gacactttgg gaggaaagaa
     1561 gactaccttt tccccctgcc attggtatag ctggtgcccc aaaacttcca cctccctccc
     1621 tggctacctc taaaatgact ggtataggtg ctgccccacc ccttagctcc cctatcctgg
     1681 gctaggaggc cacaggggct gtcctctaga attcttcctt ccctccccca caccattcat
     1741 tcaattcatg aaacaaatct ttgccaagag cagtttatgt gccaggaaca tcattctgtc
     1801 cttgcaacct ggaacaagac cagctaccag cctagcttca tccgctactt gcaccaacca
     1861 gtcccgggtt agatcccaaa tgctagaagc cagggatgcc caactctggg tggccccagt
     1921 cagaacctct gggatctcag tgaagctggc ctggcctctg ctcctgctct caaggggctg
     1981 cttttcaacc aagagccttg tgagcctggt ctgagccttg cacagccact gagtattttt
     2041 tttgccttag ccagtgtacc tcctacctca gtctatgtga gaggaagaga atgtgtgtgc
     2101 ctgtgggtct ctacaagtga cagatgtgtt gttttcaaca gtattattag gttatgaata
     2161 aagcctcatg aaatcctc
//
