LOCUS       NM_173683               4327 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens XK related 6 (XKR6), transcript variant 1, mRNA.
ACCESSION   NM_173683 NM_001012239 XM_088376
VERSION     NM_173683.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4327)
  AUTHORS   Li,K.G., Yin,R.X., Huang,F., Chen,W.X., Wu,J.Z. and Cao,X.L.
  TITLE     XKR6 rs7014968 SNP Increases Serum Total Cholesterol Levels and the
            Risk of Coronary Heart Disease and Ischemic Stroke
  JOURNAL   Clin Appl Thromb Hemost 26, 1076029620902844 (2020)
   PUBMED   32024373
  REMARK    GeneRIF: XKR6 rs7014968 SNP Increases Serum Total Cholesterol
            Levels and the Risk of Coronary Heart Disease and Ischemic Stroke.
REFERENCE   2  (bases 1 to 4327)
  AUTHORS   Zheng,P.F., Yin,R.X., Deng,G.X., Guan,Y.Z., Wei,B.L. and Liu,C.X.
  TITLE     Association between the XKR6 rs7819412 SNP and serum lipid levels
            and the risk of coronary artery disease and ischemic stroke
  JOURNAL   BMC Cardiovasc Disord 19 (1), 202 (2019)
   PUBMED   31429711
  REMARK    GeneRIF: XKR6 rs7819412 A allele was related to increased serum
            triglyceride levels in coronary artery disease, total cholesterol
            levels in ischemic stroke patients and high risk of CAD and
            ischemic stroke.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4327)
  AUTHORS   Joo,Y.B., Lim,J., Tsao,B.P., Nath,S.K., Kim,K. and Bae,S.C.
  TITLE     Genetic variants in systemic lupus erythematosus susceptibility
            loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a
            Korean cohort
  JOURNAL   Sci Rep 8 (1), 9962 (2018)
   PUBMED   29967481
  REMARK    GeneRIF: XKR6 single nucleotide polymorphism rs7460469 is
            associated with childhood-onset systemic lupus erythematosus.
            Erratum:[Sci Rep. 2018 Jul 31;8(1):11713. doi:
            10.1038/s41598-018-30082-9.. PMID: 30065249]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4327)
  AUTHORS   Ferreira,M.A., Matheson,M.C., Tang,C.S., Granell,R., Ang,W.,
            Hui,J., Kiefer,A.K., Duffy,D.L., Baltic,S., Danoy,P., Bui,M.,
            Price,L., Sly,P.D., Eriksson,N., Madden,P.A., Abramson,M.J.,
            Holt,P.G., Heath,A.C., Hunter,M., Musk,B., Robertson,C.F., Le
            Souef,P., Montgomery,G.W., Henderson,A.J., Tung,J.Y.,
            Dharmage,S.C., Brown,M.A., James,A., Thompson,P.J., Pennell,C.,
            Martin,N.G., Evans,D.M., Hinds,D.A. and Hopper,J.L.
  CONSRTM   Australian Asthma Genetics Consortium Collaborators
  TITLE     Genome-wide association analysis identifies 11 risk variants
            associated with the asthma with hay fever phenotype
  JOURNAL   J Allergy Clin Immunol 133 (6), 1564-1571 (2014)
   PUBMED   24388013
REFERENCE   5  (bases 1 to 4327)
  AUTHORS   Appel,S., Filter,M., Reis,A., Hennies,H.C., Bergheim,A.,
            Ogilvie,E., Arndt,S., Simmons,A., Lovett,M., Hide,W., Ramsay,M.,
            Reichwald,K., Zimmermann,W. and Rosenthal,A.
  TITLE     Physical and transcriptional map of the critical region for
            keratolytic winter erythema (KWE) on chromosome 8p22-p23 between
            D8S550 and D8S1759
  JOURNAL   Eur J Hum Genet 10 (1), 17-25 (2002)
   PUBMED   11896452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF131215.2, AY534244.1, BC024146.2 and AC011008.10.
            
            On May 17, 2019 this sequence version replaced NM_173683.3.
            
            Transcript Variant: This variant (1) is the protein-coding variant.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY534244.1, SRR3476690.1043288.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2158800
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416569.3/ ENSP00000416707.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AF131215.2         178601-179067       c
            468-3405            AY534244.1         1-2938
            3406-4228           BC024146.2         2242-3064
            4229-4327           AC011008.10        5435-5533
FEATURES             Location/Qualifiers
     source          1..4327
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..4327
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /note="XK related 6"
                     /db_xref="GeneID:286046"
                     /db_xref="HGNC:HGNC:27806"
     exon            1..1258
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             495..2420
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /note="X Kell blood group precursor-related family, member
                     6; X-linked Kx blood group related 6; Transmembrane
                     protein C8orf5; XK, Kell blood group complex
                     subunit-related family, member 6"
                     /codon_start=1
                     /product="XK-related protein 6"
                     /protein_id="NP_775954.2"
                     /db_xref="CCDS:CCDS5978.2"
                     /db_xref="GeneID:286046"
                     /db_xref="HGNC:HGNC:27806"
                     /translation="MAAKSDGGGVGVGFAQLHNLDEAVGSGGEEDGEPGGGGCGGGGD
                     GSEPGESSSMHICHCCNTSSCYWGCRSACLRSLLGRKPRRSAAADGGDQPLQPPAAPG
                     AGRQPPTPSAARPEPPPPQVERPWLDCLWIVLALLVFFGDVGTDLWLALDYYRKGDYV
                     YFGLTLFFVLVPSLLVQSLSFRWFVQDYTGGGLGAVEGLTSRGPPMMGAGYVHGAARG
                     GPGVRVSPTPGAQRLCRLSVWIWQSVIHLLQMGQVWRYIRTMYLGIQSQRRKEHQRRF
                     YWAMMYEYADVNMLRLLETFLESAPQLVLQLYIMLQKNSAETLPCVSSVTSLMSLAWV
                     LASYHKLLRDSRDDKKSMSYRGAIIQVFWRLFTISSRVISFALFASIFQLYFGIFVVV
                     HWCAMAFWIIHGGTDFCMSKWEEILFNMVVGIVYIFCWFNVKEGRTRYRMFAYYTIVL
                     TENAALTFLWYFYRDPETTDSYAVPALCCVFISFVAGIAMMLLYYGVLHPTGPRAKIL
                     ASSCCAELLWGIPLPPDVEPMAPEIPGYRGTQVTPTRAVTEQQEDLTADTCLPVFQVR
                     PMGPPTPLGRPYLPEGPLIKIDMPRKRYPAWDAHFVDRRLRRTINILQYVTPTAVGIR
                     YRDGPLLYELLQYESSL"
     exon            1259..1455
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..4327
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2654..2659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /note="hexamer: AGTAAA"
     polyA_site      2672
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /note="major polyA site"
     regulatory      3071..3076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /note="hexamer: AAGAAA"
     polyA_site      3091
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
     regulatory      3652..3657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /note="hexamer: TATAAA"
     polyA_site      3679
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /note="major polyA site"
     regulatory      4308..4313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
                     /note="hexamer: AGTAAA"
     polyA_site      4327
                     /gene="XKR6"
                     /gene_synonym="C8orf21; C8orf5; C8orf7; XRG6"
ORIGIN      
        1 gttagggggc gtttctccag gaggaaagct gtgagctgcg acgctgagga aggggacccc
       61 aaaacgtctg gcactgcccc ctccagggat cactttggac cgcctcactc gggccagccg
      121 gattctgaaa cgccgagggg tcaacctgat gggtttcggg gtcaacggaa gaggggaagg
      181 ggagccctgg cggggagaac cccccggtcc cccgcccagc agctgaggca caggagggcg
      241 gccatcttgg ccgggagggt agggctgggg agctgcgggc gccgtgcgat tggggggctc
      301 gcccggaagt gacgccaact acccggaagc ggagggggtt ccctggccca ctcccccctc
      361 gttcgtttgc tcccccgctt cctccccgcc ccccttcctc tccattcgtt tccccccctc
      421 cccgttccct gccttcttcc cccccccccc gccgtccctc ccccccaacc tccggagctg
      481 ggaagagagt caagatggcg gcgaaatccg atggcggtgg cgtgggggtg ggcttcgctc
      541 agctgcacaa cctggacgag gcggtgggca gcggcggcga ggaggacggg gagcccgggg
      601 gaggcggctg cggcggcggc ggcgacggca gcgagcccgg cgagagcagc tcgatgcaca
      661 tctgccactg ctgcaacacc tcctcgtgct actggggctg ccgctccgcc tgcctgcgct
      721 ccctcctggg caggaagccg cgccgcagcg ccgccgccga cgggggggac cagccgctgc
      781 agcctcccgc ggcccccggc gccggccgcc aacccccgac gccctcggcc gcgcggccgg
      841 agccgccgcc gccgcaggtg gagcggccgt ggctcgactg cctgtggatc gtgctggcgc
      901 tgctggtgtt cttcggggac gtgggcaccg acctgtggct ggccctcgac tactaccgca
      961 agggggacta cgtctacttc gggctgaccc tcttcttcgt gctggtgccg tcgctgctgg
     1021 tgcagagcct gagcttccgc tggttcgtgc aggactacac gggcggcggg ctgggcgccg
     1081 tggaggggct caccagccgg ggccccccca tgatgggggc cggctacgtc cacggcgcgg
     1141 cccgcggtgg cccaggcgtg agggtctccc ccacgccggg ggcgcagcgc ctgtgtcgcc
     1201 tctccgtgtg gatctggcag tcggtcatcc acctgctgca gatggggcag gtgtggaggt
     1261 atatccgcac catgtacctg gggattcaga gccagcggcg gaaggaacac cagcgacgct
     1321 tctactgggc tatgatgtat gaatatgcag acgtcaacat gctgcgcctc ctggagacct
     1381 tcctggagag cgcgccccaa ctggtgctac agctctacat catgctccag aagaacagcg
     1441 ccgagaccct gccctgtgtc tcctctgtga cttccctgat gtccctggct tgggtgctag
     1501 cctcctatca caagctgctg cgggactcca gggacgacaa gaagagcatg agctacagag
     1561 gggccatcat ccaggtcttc tggcgcctct tcaccatctc atcccgagtg atctcttttg
     1621 ccctctttgc ttccatcttc cagctctatt ttgggatctt cgtggtggtt cactggtgcg
     1681 ccatggcctt ctggatcatc catggcggaa cagacttctg catgtccaag tgggaggaga
     1741 tcctcttcaa catggtggta gggatcgtgt acattttctg ctggtttaac gtcaaggaag
     1801 ggcggactcg atatcgaatg tttgcatatt atacgatagt cttgaccgag aatgctgcct
     1861 tgacgttcct ttggtatttt tacagagacc cggagaccac tgactcctat gcggtgccag
     1921 cactgtgttg tgtctttatt agctttgtgg ctgggatcgc aatgatgctc ttatactatg
     1981 gcgtgctgca tcccacagga ccacgagcta agatccttgc cagctcctgt tgtgccgagc
     2041 tgctctgggg catccctttg ccccccgatg ttgagcccat ggcgcctgag atccctgggt
     2101 accgggggac ccaggttacg cccaccagag ccgtaacgga acaacaggag gatctcacgg
     2161 ctgacacttg cttgcctgtt ttccaagtga gacccatggg gccccctacc ccgttggggc
     2221 gtccttacct cccagaaggg cccctcatta agattgacat gccaagaaag cgatacccag
     2281 cttgggatgc tcattttgta gacaggaggc tgagaaggac tattaacatt ctacaatatg
     2341 tcacccccac cgcagtaggc attcgatatc gagacggacc actcctctat gagttgctac
     2401 agtatgagtc ttcactctaa gagcatcttg accaagttga gaaggggacc ttaagtttgg
     2461 tttgcggcaa acagcacttg caagaaatat aaccctccct tcccccaata cacagaacca
     2521 ccgccaccac caccaacacc gccacaccaa caccaccact acaaaaaaaa aagaattaat
     2581 aagtcacaac cccttcaaat aagctttctt tccagtcgct gtatgtatac aaagatattc
     2641 tctatgtttt gtaagtaaaa acaaaaagaa aacctttctt ttgtttttta cacataagaa
     2701 acagtattga aaaatcccac gctatggttc atagggtgga gaaggaggag ttatctccac
     2761 tccaaaagaa aaaaaaaaag ttttttacct tacaccaagt gtagatcatt tatgggattg
     2821 gtgctgattg aaagaacaaa acaaaacaaa acaaacacaa acaaacaaaa aaccttcaac
     2881 tgccttatgc ccttaggtgc tgagtttcat taagtactgt cacgttttct catgcaaaac
     2941 tctctggtga tttttgcacc agaagaggga aaattaaaca attaaatgaa acaaatctaa
     3001 aagtgaaaca aaaaccaacc aacaaataca acacaaagca attattcttc ctatctgatt
     3061 atttgtattg aagaaaacaa atttaccaaa agcaaaagca taaacccctc cctcttttca
     3121 gtttctcccc ctcctctcct gaccttctcc ccactttgca gagccttcta ggagctcaag
     3181 ggctgtttga aactcaaatg gctggagaag ctacttgaag gctgattatg tgccatttta
     3241 gcatttgcct agcaagaatc acattcgttt cccagtgaaa agcaaaccag aacaaaacaa
     3301 aaagccaccg caataattcg gtaaggacag gatattctaa agcaaattaa aggagatttc
     3361 tgtacacata gtcagtaata ataaaactca gcatagtagc aaaaagaacg acatcagttt
     3421 aaaggcacaa tacttaatca gtgactggca acaacgatta gttccatcat tttaaggctg
     3481 tgaatggtag acatttatca catgtgatat tgtgtaaagc ctcttctgtt tccatttggt
     3541 gggaagcctt aaattgatct ggaaagaatt cttcattttt catttgtgct tttttaaaaa
     3601 aaaaaataac acaaagagga aaactagaat atatatatat atatacatat atataaaaag
     3661 tcaaaattgt aataactgac ccatttcaaa gactgtttgg tgcttctgtc tttcaccatt
     3721 gtggttggct gaaaatcatt cagctcacct ggtgcatctg ggttgaatgg gaaattttgt
     3781 gtgtgtagta tgtgtgtgtt tgtgtgtgta tgtgtgtgtg tgcccatagc acacgtatat
     3841 atgtgtgtgt ccctgctgca aagtcttgcc agagatatac aaaactgatg taagacgaac
     3901 ttggatcacg gcttggttca gcagagcatg ggggcggggg ctctggagtg gtggggaagt
     3961 gatgctgcct gcccacgagc cctggtttgg gtggcaagac tcacaccagc agcggactgc
     4021 aggccttaga ggccatgcca tttgggtgag gatttgattc cactgtttat tttctcattg
     4081 tatcaagttg aatttctgca ggtgttgcaa gtatgttcaa cgatttaaat ttttttttat
     4141 ttttcaaagt attgttcctt taaagaatat ttctgttcta gggcatcgtt tcaatcgcat
     4201 cgtatctcta cttgggcaca aaaaaaaagg aaaagaaaaa aaatcacaaa aaagatatat
     4261 aataagtata tatatatata tatatataaa cacacacaat atttttaagt aaatactgtt
     4321 agtcttt
//
