LOCUS       NM_207411               4773 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens XK related 5 (XKR5), transcript variant 1, mRNA.
ACCESSION   NM_207411
VERSION     NM_207411.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4773)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY534242.1 and AY534243.1.
            
            On May 17, 2019 this sequence version replaced NM_207411.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY534242.1, AY358489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618742.3/ ENSP00000483879.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AY534242.1         121-146
            27-236              AY534243.1         1-210
            237-4773            AY534242.1         357-4893
FEATURES             Location/Qualifiers
     source          1..4773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..4773
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /note="XK related 5"
                     /db_xref="GeneID:389610"
                     /db_xref="HGNC:HGNC:20782"
     exon            1..89
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..2092
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /note="isoform a is encoded by transcript variant 1; X
                     Kell blood group precursor-related family, member 5; XK,
                     Kell blood group complex subunit-related family, member 5;
                     XK-related protein 5a; X-linked Kx blood group related 5"
                     /codon_start=1
                     /product="XK-related protein 5 isoform a"
                     /protein_id="NP_997294.3"
                     /db_xref="CCDS:CCDS47763.2"
                     /db_xref="GeneID:389610"
                     /db_xref="HGNC:HGNC:20782"
                     /translation="MHARLLGLSALLQAAEQSARLYTVAYYFTTGRLLWGWLALAVLL
                     PGFLVQALSYLWFRADGHPGHCSLMMLHLLQLGVWKRHWDAALTSLQKELEAPHRGWL
                     QLQEADLSALRLLEALLQTGPHLLLQTYVFLASDFTDIVPGVSTLFSWSSLSWALVSY
                     TRFMGFMKPGHLAMPWAALFCQQLWRMGMLGTRVLSLVLFYKAYHFWVFVVAGAHWLV
                     MTFWLVAQQSDIIDSTCHWRLFNLLVGAVYILCYLSFWDSPSRNRMVTFYMVMLLENI
                     ILLLLATDFLQGASWTSLQTIAGVLSGFLIGSVSLVIYYSLLHPKSTDIWQGCLRKSC
                     GIAGGDKTERRDSPRATDLAGKRTESSGSCQGASYEPTILGKPPTPEQVPPEAGLGTQ
                     VAVEDSFLSHHHWLWVKLALKTGNVSKINAAFGDNSPAYCPPAWGLSQQDYLQRKALS
                     AQQELPSSSRDPSTLENSSAFEGVPKAEADPLETSSYVSFASDQQDEAPTQNPAATQG
                     EGTPKEGADAVSGTQGKGTGGQQRGGEGQQSSTLYFSATAEVATSSQQEGSPATLQTA
                     HSGRRLGKSSPAQPASPHPVGLAPFPDTMADISPILGTGPCRGFCPSAGFPGRTLSIS
                     ELEEPLEPKRELSHHAAVGVWVSLPQLRTAHEPCLTSTPKSESIQTDCSCREQMKQEP
                     SFFI"
     exon            90..273
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /inference="alignment:Splign:2.1.0"
     exon            274..458
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /inference="alignment:Splign:2.1.0"
     exon            459..668
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /inference="alignment:Splign:2.1.0"
     exon            669..838
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /inference="alignment:Splign:2.1.0"
     exon            839..950
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /inference="alignment:Splign:2.1.0"
     exon            951..4773
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2506..2511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /note="hexamer: AATATA"
     polyA_site      2535
                     /gene="XKR5"
                     /gene_synonym="HARL2754; UNQ2754; XRG5A; XRG5BM"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgcag gctgcggggt cggcacggaa gatgcacgcg aggctcctgg ggctctcggc
       61 cctgctgcag gcggccgagc agagcgcgcg cctttacacc gtggcttact acttcaccac
      121 aggacggctt ctgtgggggt ggctggccct tgctgtcctc ctgcccgggt tcttggtcca
      181 ggccctgagc tacctgtggt tccgagcaga cgggcatcca gggcattgct ccttgatgat
      241 gctgcacctc ctacagcttg gtgtttggaa gcggcactgg gacgctgcac tgaccagtct
      301 gcagaaggaa ctggaggctc cccaccgagg ctggctgcag ctgcaggagg ccgacctgtc
      361 ggcccttcga ctcttggagg ccctgctgca gactgggccc cacctgctgc ttcagacata
      421 tgtttttcta gcctcagact tcacagatat tgtgccaggg gtgagcaccc tgttttcctg
      481 gtcctcactc tcctgggcac tggtgtccta cactcgcttc atgggcttca tgaagccagg
      541 ccacctggcc atgccatggg ccgccctctt ctgccagcag ctctggagga tgggcatgtt
      601 gggaacccgc gtgctgagtc tggttctgtt ctacaaagcc taccactttt gggtttttgt
      661 ggttgcaggt gcccactggc tggtgatgac attctggctt gtcgcccagc agagtgacat
      721 catcgacagc acctgccact ggaggctgtt caacctgctc gtgggggccg tgtacatcct
      781 ctgctacctc agcttctggg acagcccttc tagaaatagg atggtcacgt tctacatggt
      841 catgctgttg gagaacatca tcctgttgct gttggccacc gactttctcc agggggcatc
      901 gtggaccagc ctgcagacca tagctggggt cctgtctgga tttctgattg gcagtgtctc
      961 actggtaatt tattacagcc tgctgcatcc aaaatccaca gacatctggc agggctgcct
     1021 aaggaagtcc tgtggcattg caggaggtga taaaacagag agaagagatt ctccccgggc
     1081 cacagatcta gctgggaaga gaaccgagag ctcaggctca tgccaagggg caagttatga
     1141 accaaccatt ttagggaagc cccctacccc tgagcaggtc cccccagagg ctgggctggg
     1201 gacccaggtt gctgtggagg actctttcct cagtcatcac cactggctgt gggtgaaact
     1261 tgccctaaaa acaggaaatg tgtctaagat caatgccgcc tttggagata acagtcctgc
     1321 ctattgtcca cctgcatggg ggttgagtca acaggactac ctgcagagaa aggccttgtc
     1381 tgcccagcaa gagctcccat cctcatcccg tgacccctca accttagaga acagctctgc
     1441 gtttgaaggt gtccctaaag cagaggccga cccattggaa acctcaagtt acgtatcttt
     1501 tgccagcgat cagcaggatg aagcacctac ccagaaccca gcagccacgc agggggaggg
     1561 caccccaaag gaaggagctg acgctgtttc tgggacacag gggaagggga caggtgggca
     1621 gcagagagga ggggaaggac agcagagttc cacgttgtac ttcagcgcca ctgcagaagt
     1681 ggccacatcc tcacaacaag aaggcagccc agctactctg caaacggccc actctggaag
     1741 gaggctggga aagagcagcc ctgcccagcc tgcatcgccc cacccagtgg gcttggcgcc
     1801 cttccccgac accatggccg acattagccc catcctaggc acaggcccat gtagaggctt
     1861 ctgccccagt gcaggcttcc ctggaagaac cctcagtatc tcagagctag aggagccgct
     1921 ggagcccaaa agggagctaa gtcaccatgc agctgttggt gtgtgggtgt cattgccaca
     1981 gctgaggact gcccatgagc cctgcctcac gtccacccct aagtctgagt ctatccaaac
     2041 ggactgcagc tgcagggaac agatgaagca agagccgagt tttttcatct gaccacagtc
     2101 atggtgggat aagacaacag gctgacaaac caagctggcc atttggtacc gtgagaaagg
     2161 aaatcccact tctgacacct gtgtccttgg gcacatcact gtcacctctg aatctccatc
     2221 tgcatccctg aaaaatgaag aaacagggct ggatgatttt gcaggtccaa tgcaaacatc
     2281 acagacccca cccatgcata ggagagactc taacatactt tagaggagga gaaagagatt
     2341 ccagtcaaaa ttgtctgcta ccttttatga gctgtaggtt cccttatttt atctttttgc
     2401 tgtggcttct aggaaacaca aaggtaaaac ccagattcct attttatttg aggttcttgt
     2461 tacaattagc tttgcctcac atttagcggt tatgaatctc attttaatat attctaactg
     2521 tattatgtta tgaaatctct tggtaagata atttgcatgc tttctgggag taggtaaggc
     2581 ctgtgtgctt gtaataacta acataactga aagtgcaaat gtcattctaa gattcccata
     2641 tcttttggtt aggggacaat attagagctt ttaaaaagga agggtagact cacttagctc
     2701 agcctcaccc atgctaaggg cacatgcaca cattttctgc aattcactct cagaccatca
     2761 gcatcctcct ggccagctgc ataaatgtat ttttctgtga aatgtgctgc tcccctttgt
     2821 gcaggctggc cagccaagag ttcccttcca gctcccactg ctgctttcca ccccatctcc
     2881 tttatgtcca agctttgttc ccacttccat tcaatgtgag acactatcca tgatttaagc
     2941 ccatccaaaa agaagggagg aaacgtccat tcctctcgca ctctccttct ctctgactcc
     3001 tccactctaa agtgttcttt gtggctaggt atttccataa tttctttaag ccttcctttg
     3061 tagctgatta aggaagtcta gtcataaact atcaaagaga aaggcacaca gagagctgga
     3121 tgctatttag ggatgggtat ttttgttttg ttttgtttca tttcatttgt ttatttgttg
     3181 agacagggcc tctctgtcac ccaggctgga gtgcagtggc atgatcatgg ctcactgcag
     3241 cctcaacctc cagggcttaa gcaatcctct cacctcagcc tctcgagtag ctgggactac
     3301 tggcaggtgg gcaccatgcc tggctacttt tttgtatttt ttgtagagac aggttcttgc
     3361 caggtggctc aggctggtct ccaactcctg agctcaagcg atctgcccat ctcggcctcc
     3421 caaagtgctg ggattacagg cgtgagccac cgtgcccagc cagaatgggt agtttttatt
     3481 ctctccaaac acttttggat tagggtacaa tattagagct ctaaaaagga atagtagaat
     3541 aacttagctc agcctgacac atactaaggg cacctgcaga cactttctgc aataagctct
     3601 cagaccatca gcatcctcct ggccagccac ataagccaat cggggatgca gacaagtggc
     3661 tacaaacttt ccatacaaca ggtgaagata acgagacttt gggtcggatg caggggctca
     3721 caccggtaat cccagcactt tgagaggctg aggcgggaag atcacttgag gccagaagtt
     3781 cgagaccagc ctgggcaatg tagtgagacc ccatcactac taaaaataca taaattatcc
     3841 tggtgtggtg gcacacacct gtagtcccag ctgctcgaga ggctgaggca cgagaatcag
     3901 ttgaactggg aggcagaggt tgcagtgagc tgagatcgta ccatggcact ccagcctggg
     3961 cgacagagca agactctatc taaaaaaaaa gcttgttaat agaacaaaat cattcatagt
     4021 tccattcact gtgctatccc agcatctcag tccttcctcc atgcagtctc tcgcccagcc
     4081 aggtgagagc atgagcactt ccctgagtcc tcaccagccc tccccatttg tcctccaaga
     4141 ctccactcaa acatctcctc ttggtgcctt cctgggccct ccccagctcc agctctccca
     4201 gacctaccct ctgtccccag gttgtattcc actgcccttt gccctctggt gacctcttcc
     4261 taaacttgaa gccctgcctc cctgaaggct aattaagggt tgcagtcctc cttctgggct
     4321 aactccaagg tccagcagag tgtccagcaa aagtaggcgt tagagcattc aacagcatga
     4381 attcactaac gagcggggct gtgggcatga atttcagctt gagtgcatat cctggatcaa
     4441 cggcatttgt gttatggggt aaaagtaagg gtgggatatg gggaatttgc tcattctttt
     4501 caaactttct agcccttgaa tagcctggaa agctagaaat actcttcatt cattcattca
     4561 tttaaggaat attagttgag tatgacaggc actgagtatg cagaaatcaa ggcatgtact
     4621 tgctgttcga ggccctgtgg accaacatcg gcttctcaga tggcttcctc acttcatgcc
     4681 tccagaaagc atattgcccg gtgatgaaaa ggatcagaaa atatacacta tatttattag
     4741 agaagactaa taaatggaca cttaattcaa aaa
//
