LOCUS       NM_001386955            1650 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens XK related 3 (XKR3), transcript variant 3, mRNA.
ACCESSION   NM_001386955 XM_017028600
VERSION     NM_001386955.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Zhou,M.H. and Yang,Q.M.
  TITLE     NUP214 fusion genes in acute leukemia (Review)
  JOURNAL   Oncol Lett 8 (3), 959-962 (2014)
   PUBMED   25120641
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Le Goff,G.C., Bres,J.C., Rigal,D., Blum,L.J. and Marquette,C.A.
  TITLE     Robust, high-throughput solution for blood group genotyping
  JOURNAL   Anal Chem 82 (14), 6185-6192 (2010)
   PUBMED   20560530
  REMARK    GeneRIF: Observational study of genetic testing. (HuGE Navigator)
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Levin,J.Z., Berger,M.F., Adiconis,X., Rogov,P., Melnikov,A.,
            Fennell,T., Nusbaum,C., Garraway,L.A. and Gnirke,A.
  TITLE     Targeted next-generation sequencing of a cancer transcriptome
            enhances detection of sequence variants and novel fusion
            transcripts
  JOURNAL   Genome Biol 10 (10), R115 (2009)
   PUBMED   19835606
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Calenda,G., Peng,J., Redman,C.M., Sha,Q., Wu,X. and Lee,S.
  TITLE     Identification of two new members, XPLAC and XTES, of the XK family
  JOURNAL   Gene 370, 6-16 (2006)
   PUBMED   16431037
  REMARK    GeneRIF: XPLAC is expressed mostly in placenta and adrenal gland
            while XTES is exclusively expressed in primate testis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007064.27 and AC005301.22.
            
            On Sep 16, 2020 this sequence version replaced XM_017028600.1.
            
            Summary: XKRX (MIM 300684) and XKR3 are homologs of the Kell blood
            group precursor XK (MIM 314850), which is a putative membrane
            transporter and a component of the XK/Kell complex of the Kell
            blood group system (Calenda et al., 2006 [PubMed
            16431037]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2315541.1,
                                           SRR14038195.428306.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142853 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684488.1/ ENSP00000507478.1
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC007064.27        64994-65114         c
            122-466             AC007064.27        47442-47786         c
            467-720             AC007064.27        39474-39727         c
            721-1650            AC005301.22        100596-101525       c
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.1"
     gene            1..1650
                     /gene="XKR3"
                     /gene_synonym="XRG3; XTES"
                     /note="XK related 3"
                     /db_xref="GeneID:150165"
                     /db_xref="HGNC:HGNC:28778"
                     /db_xref="MIM:611674"
     exon            1..121
                     /gene="XKR3"
                     /gene_synonym="XRG3; XTES"
                     /inference="alignment:Splign:2.1.0"
     exon            122..466
                     /gene="XKR3"
                     /gene_synonym="XRG3; XTES"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1511
                     /gene="XKR3"
                     /gene_synonym="XRG3; XTES"
                     /note="expressed in testis; X-linked Kx blood group
                     related 3; X Kell blood group precursor-related family,
                     member 3; x Kell blood group-related 3; XK, Kell blood
                     group complex subunit-related family, member 3"
                     /codon_start=1
                     /product="XK-related protein 3"
                     /protein_id="NP_001373884.1"
                     /db_xref="CCDS:CCDS42975.1"
                     /db_xref="GeneID:150165"
                     /db_xref="HGNC:HGNC:28778"
                     /db_xref="MIM:611674"
                     /translation="METVFEEMDEESTGGVSSSKEEIVLGQRLHLSFPFSIIFSTVLY
                     CGEVAFGLYMFEIYRKANDTFWMSFTISFIIVGAILDQIILMFFNKDLRRNKAALLFW
                     HILLLGPIVRCLHTIRNYHKWLKNLKQEKEETQVSITKRNTMLEREIAFSIRDNFMQQ
                     KAFKYMSVIQAFLGSVPQLILQMYISLTIREWPLNRALLMTFSLLSVTYGAIRCNILA
                     IQISNDDTTIKLPPIEFFCVVMWRFLEVISRVVTLAFFIASLKLKSLPVLLIIYFVSL
                     LAPWLEFWKSGAHLPGNKENNSNMVGTVLMLFLITLLYAAINFSCWSAVKLQLSDDKI
                     IDGRQRWGHRILHYSFQFLENVIMILVFRFFGGKTLLNCCDSLIAVQLIISYLLATGF
                     MLLFYQYLYPWQSGKVLPGRTENQPEAPYYYVNIEKTEKNKNKQLRNYCHSCNRVGYF
                     SIRKSMTCS"
     exon            467..720
                     /gene="XKR3"
                     /gene_synonym="XRG3; XTES"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1650
                     /gene="XKR3"
                     /gene_synonym="XRG3; XTES"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1622..1627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XKR3"
                     /gene_synonym="XRG3; XTES"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="XKR3"
                     /gene_synonym="XRG3; XTES"
                     /note="major polyA site"
ORIGIN      
        1 acctgcaaag caaaggacgt agtgttgaaa acgagaccag aaatggtgct gttaaagagg
       61 tgaacaaaag catttacttt ttgaacgagt ttcaaaactg tgagggtggc aaataggcaa
      121 gcaccctgag aatggagaca gtgtttgaag agatggatga agaaagcaca ggaggagttt
      181 catcttcgaa agaagaaata gtccttggcc agagactcca tctaagcttt ccttttagca
      241 ttatcttctc aactgttctc tactgtggtg aggttgcctt tggtttatac atgtttgaaa
      301 tttatcgaaa agctaatgac acattctgga tgtcatttac catcagcttt attattgtgg
      361 gggcaatttt ggatcaaatt atcctgatgt ttttcaacaa agacttgagg agaaataagg
      421 ctgcattact tttttggcac attcttcttt taggacctat tgtgaggtgt ttgcacacca
      481 ttagaaatta ccacaaatgg ttgaaaaatc ttaaacagga gaaggaagag actcaagtta
      541 gcatcacaaa gagaaacacg atgctggaaa gggagattgc attctcaatc cgggataatt
      601 tcatgcagca gaaggctttc aagtacatgt cagtgattca ggcttttctc ggttctgttc
      661 cacaattaat tttgcagatg tatatcagtc tcactatacg agaatggcct ttgaatagag
      721 cattgctgat gacattttcc ctgttatcag ttacttatgg ggccattcgc tgcaatatac
      781 tggccatcca gatcagcaat gatgatacta ccattaagct accgccgata gaattcttct
      841 gtgtcgtgat gtggcgtttt ttggaggtta tctcacgtgt agtgactctg gcatttttca
      901 ttgcatctct gaaactgaag agcctacccg ttttgttaat catatatttt gtatcattgt
      961 tggcaccgtg gctggagttt tggaaaagtg gagctcatct tcctggcaac aaagaaaata
     1021 attccaatat ggtgggtaca gtactgatgc ttttcttgat cacactgcta tatgctgcca
     1081 tcaacttctc ctgctggtca gcagtgaaac tgcagttgtc agatgacaaa ataattgacg
     1141 ggagacagag gtggggccat agaatcctac actacagctt tcagttttta gaaaatgtga
     1201 taatgatatt ggtatttagg ttctttggag ggaaaacttt gctgaattgt tgtgactcat
     1261 taattgccgt gcagctcatc ataagctacc tattggccac tggctttatg ctcctcttct
     1321 atcagtattt gtacccatgg cagtcaggca aagtgttgcc aggacgtact gaaaatcagc
     1381 cagaagcacc gtactattat gtaaacatcg agaaaactga aaagaataaa aataagcagc
     1441 tgaggaatta ctgtcactcc tgcaataggg ttggatattt ttcaatcaga aaaagtatga
     1501 catgttcata aaatatacat atatactttc acagaacaat gagtaaagat gctgaatgtg
     1561 acttgttaag aggctcttaa atttaaaaaa tatacacagc aaaatcttgg aagtggtttc
     1621 taataaaatt catttatgtt ctcctgtgaa
//
