LOCUS       NM_152381              12682 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens xin actin binding repeat containing 2 (XIRP2),
            transcript variant 1, mRNA.
ACCESSION   NM_152381 XM_496606 XM_496607
VERSION     NM_152381.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12682)
  AUTHORS   Huang,L., Wu,K.H., Zhang,L., Wang,Q., Tang,S., Wu,Q., Jiang,P.H.,
            Lin,J.J., Guo,J., Wang,L., Loh,S.H. and Cheng,J.
  TITLE     Critical Roles of Xirp Proteins in Cardiac Conduction and Their
            Rare Variants Identified in Sudden Unexplained Nocturnal Death
            Syndrome and Brugada Syndrome in Chinese Han Population
  JOURNAL   J Am Heart Assoc 7 (1), e006320 (2018)
   PUBMED   29306897
  REMARK    GeneRIF: Report pathogenic XIRP1/2 rare variants in arrhythmogenic
            disorders such as sudden unexplained nocturnal death syndrome and
            Brugada syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12682)
  AUTHORS   Schaarschmidt,H., Ellinghaus,D., Rodriguez,E., Kretschmer,A.,
            Baurecht,H., Lipinski,S., Meyer-Hoffert,U., Harder,J., Lieb,W.,
            Novak,N., Folster-Holst,R., Esparza-Gordillo,J., Marenholz,I.,
            Ruschendorf,F., Hubner,N., Reischl,E., Waldenberger,M., Gieger,C.,
            Illig,T., Kabesch,M., Zhang,X.J., Xiao,F.L., Lee,Y.A., Franke,A.
            and Weidinger,S.
  TITLE     A genome-wide association study reveals 2 new susceptibility loci
            for atopic dermatitis
  JOURNAL   J Allergy Clin Immunol 136 (3), 802-806 (2015)
   PUBMED   25865352
  REMARK    GeneRIF: A genome-wide association study reveals 2 new
            susceptibility loci for atopic dermatitis, XIRP2 and DMRTA1.
REFERENCE   3  (bases 1 to 12682)
  AUTHORS   Abu-Amero,K.K., Bosley,T.M., Kondkar,A.A., Oystreck,D.T. and
            Khan,A.O.
  TITLE     CCDD Phenotype Associated with a Small Chromosome 2 Deletion
  JOURNAL   Semin Ophthalmol 30 (5-6), 435-442 (2015)
   PUBMED   24475916
  REMARK    GeneRIF: Genetic information from this patient implies that genes
            involved in development and maintenance of extraocular muscles can
            cause congenital ocular motility disorders as well.
REFERENCE   4  (bases 1 to 12682)
  AUTHORS   Nielsen,D.A., Ji,F., Yuferov,V., Ho,A., He,C., Ott,J. and
            Kreek,M.J.
  TITLE     Genome-wide association study identifies genes that may contribute
            to risk for developing heroin addiction
  JOURNAL   Psychiatr Genet 20 (5), 207-214 (2010)
   PUBMED   20520587
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   5  (bases 1 to 12682)
  AUTHORS   Huang,H.T., Brand,O.M., Mathew,M., Ignatiou,C., Ewen,E.P.,
            McCalmon,S.A. and Naya,F.J.
  TITLE     Myomaxin is a novel transcriptional target of MEF2A that encodes a
            Xin-related alpha-actinin-interacting protein
  JOURNAL   J Biol Chem 281 (51), 39370-39379 (2006)
   PUBMED   17046827
REFERENCE   6  (bases 1 to 12682)
  AUTHORS   Blasi,F., Bacchelli,E., Carone,S., Toma,C., Monaco,A.P.,
            Bailey,A.J. and Maestrini,E.
  CONSRTM   International Molecular Genetic Study of Autism Consortium (IMGSAC)
  TITLE     SLC25A12 and CMYA3 gene variants are not associated with autism in
            the IMGSAC multiplex family sample
  JOURNAL   Eur J Hum Genet 14 (1), 123-126 (2006)
   PUBMED   16205742
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 12682)
  AUTHORS   Pacholsky,D., Vakeel,P., Himmel,M., Lowe,T., Stradal,T.,
            Rottner,K., Furst,D.O. and van der Ven,P.F.
  TITLE     Xin repeats define a novel actin-binding motif
  JOURNAL   J Cell Sci 117 (Pt 22), 5257-5268 (2004)
   PUBMED   15454575
  REMARK    GeneRIF: Xin and XIRP2 define a novel actin-binding motif
REFERENCE   8  (bases 1 to 12682)
  AUTHORS   Pan,P.W., Li,K., Tuggle,C.K., Yu,M., Liu,B. and Zhao,S.H.
  TITLE     Sequencing, tissue distribution and physical mapping of the porcine
            homologue of cardiomyopathy associated 3 (CMYA3)
  JOURNAL   Anim Genet 34 (6), 473-474 (2003)
   PUBMED   14687087
  REMARK    Erratum:[Anim Genet. 2004 Feb;35(1):77]
REFERENCE   9  (bases 1 to 12682)
  AUTHORS   Sinn,H.W., Balsamo,J., Lilien,J. and Lin,J.J.
  TITLE     Localization of the novel Xin protein to the adherens junction
            complex in cardiac and skeletal muscle during development
  JOURNAL   Dev Dyn 225 (1), 1-13 (2002)
   PUBMED   12203715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092601.3, AC108494.4 and AC093684.4.
            
            On Nov 21, 2019 this sequence version replaced NM_152381.5.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968968, SAMEA1970526
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409195.6/ ENSP00000386840.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC092601.3         7394-7471
            79-504              AC092601.3         22379-22804
            505-658             AC108494.4         43352-43505
            659-819             AC093684.4         67678-67838
            820-954             AC093684.4         75109-75243
            955-1065            AC093684.4         96798-96908
            1066-1138           AC093684.4         97607-97679
            1139-1272           AC093684.4         98720-98853
            1273-10651          AC093684.4         99512-108890
            10652-10785         AC093684.4         110975-111108
            10786-12682         AC093684.4         114800-116696
FEATURES             Location/Qualifiers
     source          1..12682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.3"
     gene            1..12682
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /note="xin actin binding repeat containing 2"
                     /db_xref="GeneID:129446"
                     /db_xref="HGNC:HGNC:14303"
                     /db_xref="MIM:609778"
     exon            1..78
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            79..504
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..10746
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     xeplin; xin actin-binding repeat-containing protein 2;
                     cardiomyopathy associated 3; xin repeat protein 2;
                     beta-xin; cardiomyopathy-associated protein 3; myomaxin"
                     /codon_start=1
                     /product="xin actin-binding repeat-containing protein 2
                     isoform 1"
                     /protein_id="NP_689594.4"
                     /db_xref="CCDS:CCDS42769.1"
                     /db_xref="GeneID:129446"
                     /db_xref="HGNC:HGNC:14303"
                     /db_xref="MIM:609778"
                     /translation="MFPMQKGSLNLLRQKWESCDYQRSECHPRDSHCTIFQPQESKLL
                     APEGEVVSAPQSLDPTSLPYSTGEEMWSSKPEEKDSVDKSNNTREYGRPEVLKEDSLS
                     SRRRIERFSIALDELRSVFEAPKSGNKPAEYGGKEVEIERSLCSPAFKSHPGSQLEDS
                     VKDSDKKGKETSFDKMSPESGHSRIFEATAGPNKPESGFAEDSAARGEGVSDLHEVVS
                     LKERMARYQAAVSRGDCRSFSANMMEESEMCAVPGGLAKVKKQFEDEITSSRNTFAQY
                     QYQHQNRSEQEAIHSSQVGTSRSSQEMARNEQEGSKVQKIDVHGTEMVSHLEKHTEEV
                     NQASQFHQYVQETVIDTPEDEEIPKVSTKLLKEQFEKSAQEKILYSDKEMTTPAKQIK
                     TESEYEETFKPSSVVSTSSTSCVSTSQRKETSTTRYSDHSVTSSTLAQINATSSGMTE
                     EFPPPPPDVLQTSVDVTAFSQSPELPSPPRRLPVPKDVYSKQRNLYELNRLYKHIHPE
                     LRKNLEKDYISEVSEIVSSQMNSGSSVSADVQQARYVFENTNDSSQKDLNSEREYLEW
                     DEILKGEVQSIRWIFENQPLDSINNGSPDEGDISRGIADQEIIAGGDVKYTTWMFETQ
                     PIDTLGAYSSDTVENAEKIPELARGDVCTARWMFETRPLDSMNKMHQSQEESAVTISK
                     DITGGDVKTVRYMFETQHLDQLGQLHSVDEVHLLQLRSELKEIKGNVKRSIKCFETQP
                     LYVIRDGSGQMLEIKTVHREDVEKGDVRTARWMFETQPLDTINKDITEIKVVRGISME
                     ENVKGGVSKAKWLFETQPLEKIKESEEVIIEKEKIIGTDVSRKCWMFETQPLDILKEV
                     PDADSLQREEIIGGDVQTTKHLFETLPIEALKDSPDIGKLQKITASEEEKGDVRHQKW
                     IFETQPLEDIRKDKKEYTRTVKLEEVDRGDVKNYTHIFESNNLIKFDASHKIEVEGVT
                     RGAVELNKSLFETTPLYAIQDPLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFD
                     ESIHKFQIIRGISAQEIQTGNVKSAKWLFETQPLDSIKYFSDVEETESKTEQTRDIVK
                     GDVKTCKWLFETQPMESLYEKVSLMTSSEEIHKGDVKTCTWLFETQPLDTIKDDSETA
                     VKLQTVKQEEIQGGDVRTACFLFETENLDSIQGEEVKEIKPVEMDIQAGDVSSMRYKF
                     ENQSLDSISSSSEEVLKKIKTLKTEDIQKGNVLNCRWLFENQPIDKIKESQEGDECVK
                     TVTDIQGGDVRKGCFIFETFSLDEIKEESDYISTKKTITEEVIQGDVKSYRMLFETQP
                     LYAIQDREGSYHEVTTVKKEEVIHGDVRGTRWLFETKPLDSINKSETVYVIKSVTQED
                     IQKGDVSSVRYRFETQPLDQISEESHNIMPSIDHIQGGNVKTSRQFFESENFDKNNYI
                     RTVSVNEIQKGNVKTSTWLFETHTMDELRGEGLEYENIKTVTQEDVQKGDVKQAVWLF
                     ENRTFDSIMEAHKGITKMTKEEIPPSDVKTTTWLFETTPLHEFNETRVEKIEIIGKSI
                     KETLEDLYSQKVIQAPGIIIEADEIGDVRMAKYKLMNQASPEIQKEEIIRADLRNIMV
                     NLLSKRDCTEREILISEEEKGNVNLTKTQLLNRSTEFHAEKEEIVKGDVQQAIKNLFS
                     EERSVKKGILIQEDEKGDINMTIYCLLHENDGDTIEREEVIGGDVKRTIHNLLSSTSN
                     NKISERAKIDASERGNVQFFTTCIEAGALDYLKQLHTESNETLTAKKQEGEKEIIGGD
                     VEGTKLLLKKRQSLVERTVSETDIIPGDVHNTVKVFMTEPQSTFGKIPKEEIIKGDLT
                     STLNSLSQAVNQKTVTKTEEIIKGNMLATLKSLKESSHRWKESKQPDAIPGDIEKAIE
                     CLEKATNTKTEILKKELLKDDLETSLRSLKEAQRSFKEVHKEGVIKKDAKAVMAGSSG
                     EQKTDIHQVAVQRNKNSLLQPKPGPFEPAAKWQGGADTLSQTMGKSCHGNLVEERTEV
                     NLPKAPKGTVKIVIDREQNNDALEKSLRRLSNSHHKSNVLESGDKTGVWTDTTGEQHL
                     RDEYMSRQLTSTVSVKNNLTTKESDRAVRELKKDDVFNSIQSAGKTVGKQQTYELRND
                     HQKMEGFHIKSPKKTKNIKILTDTQSSKPSPTQHPVSMPVGGTYDLSGDFQKQTLLKQ
                     ETKYSNKDIKKKNINLQPMWQLLPVEQDTSNVTEMKVSEKSHNTFKATNKKRETDVHL
                     KSQDFLMKTNTSTGLKMAMERSLNPINFNPENNVKESECPLPPPSPPPPPPSNASSEI
                     EFPLPPPPPLMMFPEKNGFLPSLSTEKIKAEFESFPGLPLPPPPVDEKSERESSSMFL
                     PPPPPPTPSQKPAHLLSSSAPEKHSGDFMQQYSQKEASNSQNSQAKIITGKTGVLPPP
                     TLPKPKLPKHIKDNKNDFSPKVELATSLSDMECKITTSKDQKKVMVMTSSEHTETKQN
                     VISKSLDERKQLSIDSANCLSHTVPGTSAPRKKQIAPLIKSHSFPESSGQQNPKPYMR
                     KFKTPLMIAEEKYRQQKEEIEKQKQESSYYNIVKTQSQNQHITEVEKEMPLQKTNEEV
                     SLSGIDSECTVVQPSPGSQSNARILGVCSDNQLSTTSPETVAAKRLHHVLAASEDKDK
                     MKKEVLQSSRDIMQSKSACEIKQSHQECSTQQTQQKKYLEQLHLPQSKPISPNFKVKT
                     IKLPTLDHTLNETDHSYESHKQQSEIDVQTFTKKQYLKTKKTEASTECSHKQSLAERH
                     YQLPKKEKRVTVQLPTESIQKNQEDKLKMVPRKQREFSGSDRGKLPGSEEKNQGPSMI
                     GRKEERLITERKHEHLKNKSAPKVVKQKVIDAHLDSQTQNFQQTQIQTAESKAEHKKL
                     PQPYNSLQEEKCLEVKGIQEKQVFSNTKDSKQEITQNKSFFSSVKESQRDDGKGALNI
                     VEFLRKREELQQILSRVKQFEAEPNKSGLKTFQTLLNTIPGWLISEDKREYAVHIAME
                     NNLEKVKEEITHIKTQAEDMLVSYENIIQTAMMSSKTGKPGNKPTSLDETSSKVSNVH
                     VSNNKNSEQKENKIAKEKTVQHQVAAHHEATVRSHVKTHQEIKLDDSNIPPPSLKTRP
                     PSPTFITIESTARRTENPTKNELSQSPKKDSYVEPPPRRPMSQKSEIHRANTSPSPPR
                     SRSEQLVRLKDTTAKLSKGAIPCPAATPVPIVEKRSEIIMSPATLRRQIKIETRGRDS
                     PPTITIPVNINHAASGSFRESVDAQEEIRKVEKRATYVHKDGLNSTDHMVPDTESYDA
                     VEIIRKVAVPPRLSEHTQRYEAANRTVQMAENFVNDPENEINRWFREFEHGPVSEAKS
                     NRRVYAKGETNHNIQQESRTFCKEEFGLTSLGNTSFTDFSCKHPRELREKIPVKQPRI
                     CSETRSLSEHFSGMDAFESQIVESKMKTSSSHSSEAGKSGCDFKHAPPTYEDVIAGHI
                     LDISDSPKEVRKNFQKTWQESGRVFKGLGYATADASATEMRTTFQEESAFISEAAAPR
                     QGNMYTLSKDSLSNGVPSGRQAEFS"
     exon            505..658
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..819
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            820..954
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1065
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1138
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1272
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..10651
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            10652..10785
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            10786..12682
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11335..11340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /note="hexamer: AATGAA"
     polyA_site      11367
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
     regulatory      12649..12654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /note="hexamer: AATAAA"
     polyA_site      12682
                     /gene="XIRP2"
                     /gene_synonym="CMYA3"
                     /note="major polyA site"
ORIGIN      
        1 attatttgga gaaatctggc aggtctctag gcagacaaaa gggaacatct ggtagggact
       61 gggacatgta gaaaaaagga caacctggac ccatccatgt tcccaatgca gaagggctcc
      121 ctcaacctcc tgaggcagaa atgggaatct tgtgattatc agagaagtga gtgtcatccc
      181 agggacagcc attgtacaat tttccagcct caggaaagca aattgcttgc gcctgaagga
      241 gaggtagtat cagcacctca atctttggat cccacaagtc tgccctacag tacaggggaa
      301 gagatgtgga gttcgaagcc ggaagagaag gattctgtgg acaagagtaa caacaccagg
      361 gaatatggtc ggccagaagt gctgaaggag gattccctga gcagtcggcg caggattgaa
      421 cgcttttcca ttgcccttga tgagctgagg agtgtgtttg aggctcctaa gagtggaaac
      481 aaaccagctg agtacggtgg aaaggaagtg gaaattgagc gaagtttgtg ctcgccagct
      541 tttaagagtc accctgggag ccagctggag gattctgtga aagattcaga caagaaaggc
      601 aaggaaacat cttttgacaa gatgtcacct gaaagtggtc acagccgcat ctttgaagcg
      661 actgctggcc ctaataagcc tgagagtgga tttgcagaag acagtgctgc tcggggcgag
      721 ggtgtgtcag acctccacga agtggtctcc ctgaaggagc ggatggcgag gtaccaggca
      781 gctgtttcca ggggtgactg ccgcagcttc tctgctaata tgatggaaga atcagaaatg
      841 tgcgcagtgc ctggtggttt ggccaaggtg aagaaacaat ttgaggacga aattacttct
      901 tcccgtaata cctttgctca ataccaatat caacatcaga acagatctga gcaggaggca
      961 attcatagca gccaggttgg cacttcaaga agcagccagg aaatggcaag aaatgaacaa
     1021 gaagggtcca aagtacagaa aattgatgtt catggaacag aaatggtctc tcatcttgaa
     1081 aagcacaccg aggaagtaaa ccaagcatct cagtttcatc aatatgttca agaaactgtc
     1141 attgatacac ctgaggatga agagattcca aaggtttcga ctaagttgtt aaaagagcag
     1201 tttgaaaagt ctgcccagga aaagatcctt tattctgaca aagagatgac aaccccagcc
     1261 aagcagatta agactgaaag tgaatatgaa gagactttca agccatcatc agttgtgagt
     1321 acctcttcca cttcttgcgt ttcaaccagc cagaggaagg aaacatcaac tacaagatat
     1381 agtgatcaca gtgtcacttc ctcaactctg gcacaaatta atgctacttc ttcaggaatg
     1441 acagaagaat ttcctcctcc cccacctgac gtacttcaaa cttcagtaga tgtgacagca
     1501 ttttcccagt cccctgaact gcccagtcct cctagaagac taccagtccc caaagatgta
     1561 tattccaagc aaagaaattt gtatgaatta aaccgtttat ataaacacat ccatcctgag
     1621 ttaagaaaaa acttagaaaa agattatatc agtgaagttt ctgagattgt ttctagtcaa
     1681 atgaactcag ggagttcagt ctcagcagat gtgcaacaag cccggtatgt ttttgaaaac
     1741 acaaatgaca gttctcaaaa agatctgaac tcagaaagag aatacttgga atgggatgaa
     1801 attctgaagg gagaggtgca gtccattaga tggatctttg agaatcaacc attggattcc
     1861 atcaacaatg gctctcctga tgaaggtgat atttccaggg gcattgctga tcaagaaatc
     1921 attgctggtg gtgatgtgaa atataccaca tggatgtttg aaacccaacc catcgacaca
     1981 cttggggctt attcttctga cactgtagaa aatgcagaga aaattcctga gctagccaga
     2041 ggagatgtct gcacagctcg gtggatgttt gaaacaaggc cattggactc aatgaataaa
     2101 atgcatcaaa gtcaagaaga atcagcggta actatcagta aggacataac tgggggggat
     2161 gtcaagactg tgagatacat gtttgaaact caacatctag atcaacttgg acagcttcat
     2221 tcagtggatg aggttcattt actgcagctt aggtctgagc tcaaagaaat taagggaaat
     2281 gttaaaagaa gtataaaatg tttcgaaact caaccattat atgttattag agatggttcg
     2341 ggccaaatgc tggaaattaa aactgttcac agagaagacg ttgaaaaggg agatgtaaga
     2401 acagcacggt ggatgtttga aacacagccg ttggacacaa ttaacaaaga tatcacagaa
     2461 attaaagttg tccgaggaat atccatggaa gaaaatgtca aaggtggggt gagtaaggca
     2521 aagtggttat ttgaaaccca acctttggag aaaatcaaag agtcagaaga ggtcatcatt
     2581 gaaaaggaaa aaataatagg tacagatgtc tccagaaagt gttggatgtt tgaaacccag
     2641 ccattagaca ttctaaaaga agttcctgat gcagattctc tacaacgtga ggagataata
     2701 ggtggtgatg tacaaactac taagcatcta tttgaaacac ttccaattga agcattaaaa
     2761 gacagtcctg atataggaaa gcttcaaaaa atcactgcct ctgaagaaga aaaaggggat
     2821 gttaggcatc aaaaatggat ttttgaaacc caacctctgg aagacattag aaaagataaa
     2881 aaggagtaca cacgaacagt gaaacttgaa gaagttgaca gaggagatgt gaagaattac
     2941 acacatatct ttgaatcaaa caatttaatt aaatttgatg catcacataa aatagaggtg
     3001 gaaggagtta caagaggtgc tgtagagtta aataaatctc tcttcgagac aacaccactg
     3061 tatgccattc aagatcccct tggaaaatat catcaagtaa agacagtcca gcaagaagaa
     3121 atcgtaagag gtgatgtaag aagctgtagg tggctttttg aaacaaggcc cattgaccag
     3181 tttgatgaaa gcattcataa atttcaaata attagaggaa tatctgctca agaaatacag
     3241 actggaaatg tgaaatctgc caaatggttg tttgaaaccc aacctcttga ttcaattaaa
     3301 tattttagtg atgtggaaga aacagaaagt aaaactgaac aaactagaga tattgttaaa
     3361 ggggatgtca aaacctgtaa atggcttttt gagacccagc caatggagtc tctttatgaa
     3421 aaagtttcgt taatgaccag cagtgaagaa attcataagg gagatgtcaa aacttgtact
     3481 tggctctttg aaactcagcc acttgatacc ataaaagatg actctgaaac agcagtcaaa
     3541 ttgcaaactg taaaacagga ggagatccaa ggtggggatg ttcgtacagc atgttttctt
     3601 tttgagacag aaaatttgga cagcatacaa ggagaagaag tgaaggaaat caagcctgtt
     3661 gaaatggata tacaagctgg agatgtttcc agcatgaggt ataaatttga aaatcagtcc
     3721 ttagattcta taagttctag ttcagaggaa gttttgaaaa agatcaaaac cttaaaaact
     3781 gaagatattc agaaaggcaa tgttttaaat tgtaggtggc tttttgaaaa ccaaccaatt
     3841 gataagataa aagaaagcca agaaggtgat gaatgtgtta agacggtgac agacatacaa
     3901 ggtggggatg taagaaaggg gtgctttatt tttgagactt tttctttaga tgagattaaa
     3961 gaagaatctg actatatcag caccaagaaa acaattactg aagaagtaat acagggtgat
     4021 gtaaaaagct acagaatgct ctttgaaacc cagccactct atgcaattca agaccgagaa
     4081 gggtcctatc atgaagtgac cacagttaaa aaagaagagg taattcatgg agatgtgcga
     4141 ggaacaaggt ggctttttga aacaaagcca ttagactcta ttaataaatc agaaactgtg
     4201 tatgttatta aatctgtcac acaagaagac attcagaagg gagatgttag ttctgtcaga
     4261 tacagatttg aaactcagcc actggatcag atttctgaag aatcacataa tattatgccc
     4321 agtattgacc atatacaagg tggcaatgta aagacaagta gacaattctt tgagtctgaa
     4381 aattttgata agaataacta tatacgaaca gtaagtgtca atgaaataca aaagggcaat
     4441 gttaaaacat ctacttggct atttgaaacc cacactatgg atgaactgag aggagaaggg
     4501 ttagaatatg aaaatatcaa gacagtcact caggaagatg tgcagaaagg tgatgttaag
     4561 caggctgtgt ggctttttga aaatcgaact ttcgattcta ttatggaagc acataaaggt
     4621 atcacaaaaa tgaccaagga agaaatccct ccttctgatg tcaaaacaac cacatggctc
     4681 tttgaaacaa caccacttca tgaatttaat gaaactagag tagaaaagat agaaattatt
     4741 ggcaagagca ttaaagaaac cttagaagat ctctactctc aaaaagttat ccaggctcct
     4801 ggaatcatca ttgaagctga tgaaataggg gatgttcgaa tggcaaaata caagctaatg
     4861 aaccaagcat ctcctgagat acagaaagaa gaaattatca gggctgatct cagaaatata
     4921 atggtgaacc tactttccaa aagggactgt actgaaagag agattttgat tagtgaagaa
     4981 gagaagggaa atgttaattt gactaaaact caattattaa acagatcaac tgaatttcat
     5041 gctgaaaaag aagagatagt gaaaggtgat gtacaacaag caataaaaaa cctgttctct
     5101 gaggaaagat ctgtaaagaa aggcatctta attcaggaag atgaaaaagg agatattaac
     5161 atgactatct attgtcttct tcatgaaaat gatggtgaca caattgagcg tgaagaagta
     5221 ataggtggtg atgtcaaacg taccattcat aatttattgt cttccacatc aaacaataaa
     5281 atatctgaaa gggctaaaat tgatgcctct gagagaggaa atgttcagtt tttcacaacc
     5341 tgcatagaag ctggagcttt ggattatctg aaacaactcc acacagagtc aaatgaaaca
     5401 ctgacagcta agaaacaaga aggagagaaa gaaatcattg gtggtgatgt tgaaggtaca
     5461 aaactgttac tgaagaaaag gcagtctctg gttgaacgta ctgttagtga aactgacatc
     5521 atccctggag atgtgcataa cacagttaag gtttttatga ccgagcctca gagtacattt
     5581 ggtaagatac ccaaagaaga gattataaaa ggtgatttga catcaaccct aaattccctc
     5641 agccaggctg taaatcagaa aacagtgacg aaaacagaag aaattataaa aggtaacatg
     5701 ctagccacac tcaagtcact taaagaatca agccatcgat ggaaagaatc taaacagcct
     5761 gatgccatcc ctggtgatat tgaaaaagct attgaatgcc ttgaaaaagc tacaaataca
     5821 aagacagaaa ttctgaaaaa ggagcttctc aaagatgacc tggaaacatc actaaggtct
     5881 ttgaaagaag cacaaagaag tttcaaagag gtacataaag aaggtgtaat aaaaaaagat
     5941 gctaaagctg tgatggcagg atcctcggga gagcagaaaa cagatattca tcaggttgct
     6001 gtccagagga acaaaaatag tcttcttcag ccaaagccag gtccatttga gccagcggcc
     6061 aagtggcaag ggggagcaga tactctcagt caaactatgg ggaaatcttg ccatggcaat
     6121 ttagtagaag aaagaactga ggttaatctt ccaaaagccc ccaaaggcac tgtaaagatt
     6181 gtcatagatc gtgaacaaaa caatgatgct ctggagaaaa gccttagaag actatctaat
     6241 tcacaccata aatctaatgt tttggaatca ggagacaaaa cgggtgtctg gactgatact
     6301 acaggagaac agcatcttag agatgaatat atgagcagac aattaacttc aactgtgtca
     6361 gttaagaata atctaacaac taaagaatca gacagggcag tgagagagct gaagaaggat
     6421 gatgtcttta attccatcca atctgctggt aaaaccgttg gaaagcaaca gacatatgaa
     6481 ctgagaaatg accaccagaa aatggagggt tttcatataa agagtcctaa aaagaccaaa
     6541 aatattaaaa tattaactga tacacaaagc tccaagccca gtcccaccca gcatccagtc
     6601 agcatgccag ttggaggaac ttacgacctt tcaggggact ttcagaagca aactttgtta
     6661 aagcaagaaa caaaatattc taataaggat ataaagaaaa agaatataaa ccttcaacca
     6721 atgtggcagc ttttgcctgt agagcaagac acatccaatg taacagaaat gaaagtctct
     6781 gaaaaaagtc acaatacatt taaggcaacc aacaaaaagc gggagactga tgttcacttg
     6841 aaaagccagg actttctaat gaaaacaaat acttccacag gcttaaaaat ggcaatggaa
     6901 aggtccttga atccaatcaa ctttaaccct gagaataatg taaaagaaag tgagtgcccc
     6961 cttccacctc catctccacc tcctccacca ccttctaatg catcatctga aattgaattt
     7021 cctcttcctc ctccacctcc tttgatgatg tttcctgaaa aaaatgggtt tcttccctca
     7081 ctgtccacag agaagataaa ggctgaattt gaaagttttc caggcctccc tcttcctcca
     7141 cctccagtag atgagaaatc tgaaagagaa agttcatcga tgtttctgcc gcctcctcct
     7201 cctccaactc catctcaaaa gccagcacat ctcctttcct cctctgctcc ggaaaagcac
     7261 agtggagact tcatgcaaca atattcccaa aaagaagcct cgaactctca gaattctcag
     7321 gctaaaatca taacaggaaa aaccggtgtg ttgccacctc ccacattgcc caaacccaaa
     7381 cttcccaagc atataaaaga taataagaac gatttttccc ccaaagttga actggcaacc
     7441 tccctgtcag atatggaatg taaaattact acctcaaagg atcagaaaaa agtaatggtg
     7501 atgaccagca gtgaacacac ggagacaaag cagaacgtta ttagtaagag tcttgatgaa
     7561 agaaaacaat tatctattga ctctgcaaac tgtctctcac acacagttcc aggaacttca
     7621 gcacccagga aaaaacagat tgcgcctctt ataaaatctc attcatttcc agagagttca
     7681 ggacaacaaa atccaaaacc ttatatgaga aaatttaaga cacctttaat gattgctgaa
     7741 gaaaaatata gacaacaaaa agaagaaatt gaaaaacaga aacaggagag ttcttactac
     7801 aacattgtta aaactcaaag ccaaaatcaa cacataacag aggtggaaaa ggaaatgcca
     7861 ttacaaaaaa ccaatgagga ggtttcccta tctggaattg attcagaatg cactgtggtt
     7921 caacccagcc caggctctca aagtaatgct cggatactag gagtgtgttc tgataaccaa
     7981 ctctccacaa catcgccaga aacagtcgct gccaagaggc tccaccatgt tttagcagct
     8041 tcagaagaca aagataagat gaaaaaggaa gttttacaaa gctcaaggga cattatgcaa
     8101 tccaaatcag cttgcgaaat taaacaaagt caccaagaat gtagtaccca acaaacacaa
     8161 cagaagaagt atttggagca gttgcacttg ccccaaagca aaccaatttc cccaaatttc
     8221 aaagttaaaa ccatcaaact tccaactcta gatcatacat taaatgaaac agaccacagc
     8281 tatgaaagtc ataaacagca atctgagatt gatgttcaaa cctttaccaa aaaacaatat
     8341 ctgaaaacca agaaaactga agcaagcact gaatgtagtc ataagcaatc tctggctgaa
     8401 agacattatc agttacctaa gaaggagaaa agagtgacag tacaattgcc tacagaatcc
     8461 atacagaaga accaggaaga taagctcaag atggttccca ggaagcaaag agaatttagc
     8521 ggatctgaca gagggaaact tccaggaagt gaagaaaaaa atcagggacc atcaatgatt
     8581 ggtcgaaaag aagagagatt aataactgaa agaaaacacg aacatctgaa gaataaatca
     8641 gcaccaaagg tcgtcaagca aaaggttatc gatgcacatc ttgattcaca gactcagaat
     8701 tttcagcaaa cacaaataca gaccgctgaa agtaaagctg aacataaaaa attgccccag
     8761 ccatataata gtctgcagga agaaaaatgt ctcgaagtca agggcataca agagaaacaa
     8821 gtcttctcta atactaaaga ttcaaagcaa gagattacac agaacaaatc tttcttttcc
     8881 tctgtgaaag aatcccagcg ggatgatgga aaaggtgcct taaatatagt ggaattcttg
     8941 agaaaacgtg aagaactgca acagattttg tcgagagtga aacagtttga agcagagcca
     9001 aataaaagtg gccttaaaac atttcagaca ctattaaata ctatcccagg atggctgata
     9061 agtgaagata agagagaata tgcagttcac attgccatgg agaataattt agaaaaagta
     9121 aaagaagaaa taacacatat taaaactcaa gcggaagata tgcttgtgtc ctatgaaaat
     9181 ataattcaga cagccatgat gtcctccaaa acaggaaaac cgggaaataa acccactagt
     9241 cttgatgaaa catcatccaa agtatctaat gttcatgtca gcaataataa aaatagtgaa
     9301 cagaaagaaa ataaaattgc caaagagaaa acagtacagc accaagtagc agctcatcat
     9361 gaagcaactg ttcgtagtca cgtgaaaacc catcaggaaa ttaaacttga tgatagcaac
     9421 attcctcctc cctctttaaa aacacgccca ccgtcaccaa cttttatcac aatagaatct
     9481 actgcccgac gaacagaaaa ccctactaag aacgagcttt ctcagtcccc taaaaaggac
     9541 agttatgttg aacccccacc aagaaggccc atgtcgcaaa aatctgaaat tcacagagca
     9601 aacacttccc cttctccacc caggagtcgc tctgaacaac ttgtcagact caaagacacc
     9661 actgcaaagt tatccaaagg ggccatccca tgtccagcag caaccccggt tccaattgta
     9721 gagaagaggt ctgaaatcat catgtctcct gcaacacttc gtcgtcaaat taagatagaa
     9781 actcgtggta gggactctcc acctacaatc acaataccag taaatataaa tcatgctgct
     9841 agtggttcct tcagagaatc tgtggacgct caagaggaaa tcaggaaagt ggagaagaga
     9901 gctacttatg ttcataaaga tggactaaat tccactgatc acatggtgcc cgacactgaa
     9961 agttatgatg cagttgaaat catccgcaag gttgcagtgc ctcctcgcct gtcagagcac
    10021 acacagagat atgaagcggc caaccgaact gttcaaatgg ctgaaaattt cgtgaatgac
    10081 cctgaaaatg aaataaacag atggttcagg gaatttgagc atggcccagt ttctgaagca
    10141 aagtcaaata gaagagttta tgcaaaggga gaaacaaacc ataacataca acaagaaagt
    10201 cgtacatttt gtaaggagga atttggatta acatctttag gaaacacgag ttttacagac
    10261 ttttcttgca aacatcctag agaactgcga gaaaagattc ctgttaagca gcccaggatc
    10321 tgctctgaaa ccaggtctct aagtgaacat ttctcaggca tggatgcatt tgagagtcaa
    10381 attgttgagt cgaagatgaa aacctcttca tcacatagct cagaagctgg caaatctggc
    10441 tgtgacttca agcatgcccc accaacctat gaggatgtca ttgctggaca tattttagat
    10501 atctctgatt cacctaaaga agtaagaaaa aattttcaaa agacgtggca agagagtgga
    10561 agagttttta aaggcctggg atatgcaacc gcagatgctt ctgcaactga gatgagaacc
    10621 accttccaag aggaatctgc atttataagt gaagctgctg ctccaagaca aggaaatatg
    10681 tatactttgt caaaagacag tttatccaat ggagtgccta gtggcagaca agcagaattt
    10741 tcataagtcc tgcttccgat gccaccattg caacagtaaa ctaagtttgg gaaattatgc
    10801 atcacttcat ggacaaatat actgtaaacc tcactttaaa caacttttca aatccaaagg
    10861 aaattatgat gaaggttttg gacataagca gcataaagat agatggaact gcaaaaacca
    10921 aagcagatca gtggacttta ttcctaatga agaaccaaat atgtgtaaaa atattgcaga
    10981 aaacaccctt gtacctggag atcgtaatga acatttagat gctggtaaca gtgaagggca
    11041 aaggaatgat ttgagaaaat taggggaaag gggaaaatta aaagtcattt ggcctccttc
    11101 caaggagatc cctaagaaaa ccttaccctt tgaggaagag ctcaaaatga gtaaacctaa
    11161 gtggccacct gaaatgacaa ccctgctatc ccctgaattt aaaagtgaat ctctgctaga
    11221 agatgttaga actccagaaa ataaaggaca aagacaagat cactttccat ttttgcagcc
    11281 ttatctacag tccacccatg tttgtcagaa agaggatgtt ataggaatca aagaaatgaa
    11341 aatgcctgaa ggaagaaaag atgaaaagaa ggaaggaagg aagaatgtgc aagataggcc
    11401 gagtgaagct gaagacacaa agagtaacag gaaaagtgct atggatctta atgacaacaa
    11461 taatgtgatt gtgcagagtg ctgaaaagga gaaaaatgaa aaaactaacc aaactaatgg
    11521 tgcagaagtt ttacaggtta ctaacactga tgatgagatg atgccagaaa atcataaaga
    11581 aaatttgaat aagaataata ataacaatta tgtagcagtc tcatatctga ataattgcag
    11641 gcagaagaca tctattttag aatttcttga tctattaccc ttgtcgagtg aagcaaatga
    11701 cactgcaaat gaatatgaaa ttgagaagtt agaaaataca tctagaatct cagagttact
    11761 tggtatattt gaatctgaaa agacttattc gaggaatgta ctagcaatgg ctctgaagaa
    11821 acagactgac agagcagctg ctggcagtcc tgtgcagcct gctccaaaac caagcctcag
    11881 cagaggcctt atggtaaagg ggggaagttc aatcatctct cctgatacaa atctcttaaa
    11941 cattaaagga agccattcaa agagcaaaaa tttacacttt ttcttttcta acaccgtgaa
    12001 aatcactgca ttttccaaga aaaatgagaa cattttcaat tgtgatttaa tagattctgt
    12061 agatcaaatt aaaaatatgc catgcttgga tttaagggaa tttggaaagg atgttaaacc
    12121 ttggcatgtt gaaacaacag aagctgcccg caataatgaa aacacaggtt ttgatgctct
    12181 gagccatgaa tgtacagcta agcctttgtt tcccagagtg gaggtgcagt cagaacaact
    12241 cacggtggaa gagcagatta aaagaaacag gtgctacagt gacactgagt aaaatatcta
    12301 tggccactga cagtccacac ttaggcactg agagatattg atgttctgaa ataagatttt
    12361 atgaatttgg ataccctttt gaggaacttg atgtaaacat ggtgttcaga aatctcgtgt
    12421 ctatctcaat gggatatttc ttgtattaca ccttgtcatt tttttcacaa tttatttaca
    12481 tctacttttg tttgaactgg aatgaagaga tgaaacacta tggatatgtt ttccattcaa
    12541 atggcacttt agcatattgt tctgttttcc tgtaaaacat catgggtgtg atttttatac
    12601 tgctgctgct tgtcacaatt attataactt ctctgtaatt tcctctgaaa taaaattgaa
    12661 tcacctgagg tgcaaaccaa aa
//
