LOCUS       NM_001204401            8409 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens X-linked inhibitor of apoptosis (XIAP), transcript
            variant 2, mRNA.
ACCESSION   NM_001204401
VERSION     NM_001204401.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8409)
  AUTHORS   Dissanayake,D., Firouzabady,A., Massumi,M., de Paz Linares,G.A.,
            Marshall,C., Freeman,S.A., Laxer,R.M. and Yeung,R.S.M.
  TITLE     Interleukin-1-mediated hyperinflammation in XIAP deficiency is
            associated with defective autophagy
  JOURNAL   Blood 144 (11), 1183-1192 (2024)
   PUBMED   38820590
  REMARK    GeneRIF: Interleukin-1-mediated hyperinflammation in XIAP
            deficiency is associated with defective autophagy.
REFERENCE   2  (bases 1 to 8409)
  AUTHORS   Qi,Q., Zhu,M., Li,P., Mi,Q., Xie,Y., Li,J. and Wang,C.
  TITLE     Systematic analysis of PANoptosis-related genes identifies XIAP as
            a functional oncogene in breast cancer
  JOURNAL   Gene 912, 148355 (2024)
   PUBMED   38467314
  REMARK    GeneRIF: Systematic analysis of PANoptosis-related genes identifies
            XIAP as a functional oncogene in breast cancer.
REFERENCE   3  (bases 1 to 8409)
  AUTHORS   Lee,J., Sim,K.M., Kang,M., Oh,H.J., Choi,H.J., Kim,Y.E., Pack,C.G.,
            Kim,K., Kim,K.M., Oh,S.H., Kim,I. and Chang,I.
  TITLE     Understanding the molecular mechanism of pathogenic variants of
            BIR2 domain in XIAP-deficient inflammatory bowel disease
  JOURNAL   Sci Rep 14 (1), 853 (2024)
   PUBMED   38191507
  REMARK    GeneRIF: Understanding the molecular mechanism of pathogenic
            variants of BIR2 domain in XIAP-deficient inflammatory bowel
            disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8409)
  AUTHORS   Patterson,L.L., Byerly,C.D., Solomon,R., Pittner,N., Bui,D.C.,
            Patel,J. and McBride,J.W.
  TITLE     Ehrlichia Notch signaling induction promotes XIAP stability and
            inhibits apoptosis
  JOURNAL   Infect Immun 91 (9), e0000223 (2023)
   PUBMED   37594275
  REMARK    GeneRIF: Ehrlichia Notch signaling induction promotes XIAP
            stability and inhibits apoptosis.
REFERENCE   5  (bases 1 to 8409)
  AUTHORS   Deveraux,Q.L., Takahashi,R., Salvesen,G.S. and Reed,J.C.
  TITLE     X-linked IAP is a direct inhibitor of cell-death proteases
  JOURNAL   Nature 388 (6639), 300-304 (1997)
   PUBMED   9230442
REFERENCE   6  (bases 1 to 8409)
  AUTHORS   Farahani,R., Fong,W.G., Korneluk,R.G. and MacKenzie,A.E.
  TITLE     Genomic organization and primary characterization of miap-3: the
            murine homologue of human X-linked IAP
  JOURNAL   Genomics 42 (3), 514-518 (1997)
   PUBMED   9205126
REFERENCE   7  (bases 1 to 8409)
  AUTHORS   Rajcan-Separovic,E., Liston,P., Lefebvre,C. and Korneluk,R.G.
  TITLE     Assignment of human inhibitor of apoptosis protein (IAP) genes
            xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 37 (3), 404-406 (1996)
   PUBMED   8938457
REFERENCE   8  (bases 1 to 8409)
  AUTHORS   Duckett,C.S., Nava,V.E., Gedrich,R.W., Clem,R.J., Van Dongen,J.L.,
            Gilfillan,M.C., Shiels,H., Hardwick,J.M. and Thompson,C.B.
  TITLE     A conserved family of cellular genes related to the baculovirus iap
            gene and encoding apoptosis inhibitors
  JOURNAL   EMBO J 15 (11), 2685-2694 (1996)
   PUBMED   8654366
REFERENCE   9  (bases 1 to 8409)
  AUTHORS   Liston,P., Roy,N., Tamai,K., Lefebvre,C., Baird,S.,
            Cherton-Horvat,G., Farahani,R., McLean,M., Ikeda,J.E., MacKenzie,A.
            and Korneluk,R.G.
  TITLE     Suppression of apoptosis in mammalian cells by NAIP and a related
            family of IAP genes
  JOURNAL   Nature 379 (6563), 349-353 (1996)
   PUBMED   8552191
REFERENCE   10 (bases 1 to 8409)
  AUTHORS   Meyer,L., Hines,M., Zhang,K. and Nichols,K.E.
  TITLE     X-Linked Lymphoproliferative Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301580
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313883.1, AL121601.13 and
            H09548.1.
            
            On Feb 21, 2020 this sequence version replaced NM_001204401.1.
            
            Summary: This gene encodes a protein that belongs to a family of
            apoptotic suppressor proteins. Members of this family share a
            conserved motif termed, baculovirus IAP repeat, which is necessary
            for their anti-apoptotic function. This protein functions through
            binding to tumor necrosis factor receptor-associated factors TRAF1
            and TRAF2 and inhibits apoptosis induced by menadione, a potent
            inducer of free radicals, and interleukin 1-beta converting enzyme.
            This protein also inhibits at least two members of the caspase
            family of cell-death proteases, caspase-3 and caspase-7. Mutations
            in this gene are the cause of X-linked lymphoproliferative
            syndrome. Alternate splicing results in multiple transcript
            variants. Pseudogenes of this gene are found on chromosomes 2 and
            11.[provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313883.1, SRR14038195.463587.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               AK313883.1         3-528
            527-527             AL121601.13        14187-14187
            528-1391            AK313883.1         530-1393
            1392-1392           AL121601.13        28783-28783
            1393-1618           AK313883.1         1395-1620
            1619-8222           AL121601.13        35304-41907
            8223-8409           H09548.1           17-203              c
FEATURES             Location/Qualifiers
     source          1..8409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq25"
     gene            1..8409
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /note="X-linked inhibitor of apoptosis"
                     /db_xref="GeneID:331"
                     /db_xref="HGNC:HGNC:592"
                     /db_xref="MIM:300079"
     exon            1..92
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            93..1001
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1618
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /EC_number="2.3.2.27"
                     /note="baculoviral IAP repeat-containing protein 4;
                     X-linked IAP; inhibitor of apoptosis protein 3; X-linked
                     inhibitor of apoptosis, E3 ubiquitin protein ligase;
                     RING-type E3 ubiquitin transferase XIAP; IAP-like protein
                     1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase XIAP"
                     /protein_id="NP_001191330.1"
                     /db_xref="CCDS:CCDS14606.1"
                     /db_xref="GeneID:331"
                     /db_xref="HGNC:HGNC:592"
                     /db_xref="MIM:300079"
                     /translation="MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSA
                     STLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSA
                     TQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAM
                     YSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWS
                     EHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI
                     YSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQK
                     GQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKI
                     MEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLC
                     KICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS"
     exon            1002..1101
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1180
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1223
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1424
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..8409
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8385..8390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /note="hexamer: AATAAA"
     polyA_site      8409
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /note="major polyA site"
ORIGIN      
        1 cttactgccc ccatccggtt cggggaggtg gcgggacctt ggcggcgccc ggagccggcg
       61 tggcgctcat cgagggacgc ccggcccaag tgaaaaggtg gacaagtcct attttcaaga
      121 gaagatgact tttaacagtt ttgaaggatc taaaacttgt gtacctgcag acatcaataa
      181 ggaagaagaa tttgtagaag agtttaatag attaaaaact tttgctaatt ttccaagtgg
      241 tagtcctgtt tcagcatcaa cactggcacg agcagggttt ctttatactg gtgaaggaga
      301 taccgtgcgg tgctttagtt gtcatgcagc tgtagataga tggcaatatg gagactcagc
      361 agttggaaga cacaggaaag tatccccaaa ttgcagattt atcaacggct tttatcttga
      421 aaatagtgcc acgcagtcta caaattctgg tatccagaat ggtcagtaca aagttgaaaa
      481 ctatctggga agcagagatc attttgcctt agacaggcca tctgagacac atgcagacta
      541 tcttttgaga actgggcagg ttgtagatat atcagacacc atatacccga ggaaccctgc
      601 catgtatagt gaagaagcta gattaaagtc ctttcagaac tggccagact atgctcacct
      661 aaccccaaga gagttagcaa gtgctggact ctactacaca ggtattggtg accaagtgca
      721 gtgcttttgt tgtggtggaa aactgaaaaa ttgggaacct tgtgatcgtg cctggtcaga
      781 acacaggcga cactttccta attgcttctt tgttttgggc cggaatctta atattcgaag
      841 tgaatctgat gctgtgagtt ctgataggaa tttcccaaat tcaacaaatc ttccaagaaa
      901 tccatccatg gcagattatg aagcacggat ctttactttt gggacatgga tatactcagt
      961 taacaaggag cagcttgcaa gagctggatt ttatgcttta ggtgaaggtg ataaagtaaa
     1021 gtgctttcac tgtggaggag ggctaactga ttggaagccc agtgaagacc cttgggaaca
     1081 acatgctaaa tggtatccag ggtgcaaata tctgttagaa cagaagggac aagaatatat
     1141 aaacaatatt catttaactc attcacttga ggagtgtctg gtaagaacta ctgagaaaac
     1201 accatcacta actagaagaa ttgatgatac catcttccaa aatcctatgg tacaagaagc
     1261 tatacgaatg gggttcagtt tcaaggacat taagaaaata atggaggaaa aaattcagat
     1321 atctgggagc aactataaat cacttgaggt tctggttgca gatctagtga atgctcagaa
     1381 agacagtatg caagatgagt caagtcagac ttcattacag aaagagatta gtactgaaga
     1441 gcagctaagg cgcctgcaag aggagaagct ttgcaaaatc tgtatggata gaaatattgc
     1501 tatcgttttt gttccttgtg gacatctagt cacttgtaaa caatgtgctg aagcagttga
     1561 caagtgtccc atgtgctaca cagtcattac tttcaagcaa aaaattttta tgtcttaatc
     1621 taactctata gtaggcatgt tatgttgttc ttattaccct gattgaatgt gtgatgtgaa
     1681 ctgactttaa gtaatcagga ttgaattcca ttagcatttg ctaccaagta ggaaaaaaaa
     1741 tgtacatggc agtgttttag ttggcaatat aatctttgaa tttcttgatt tttcagggta
     1801 ttagctgtat tatccatttt ttttactgtt atttaattga aaccatagac taagaataag
     1861 aagcatcata ctataactga acacaatgtg tattcatagt atactgattt aatttctaag
     1921 tgtaagtgaa ttaatcatct ggatttttta ttcttttcag ataggcttaa caaatggagc
     1981 tttctgtata taaatgtgga gattagagtt aatctcccca atcacataat ttgttttgtg
     2041 tgaaaaagga ataaattgtt ccatgctggt ggaaagatag agattgtttt tagaggttgg
     2101 ttgttgtgtt ttaggattct gtccattttc ttttaaagtt ataaacacgt acttgtgcga
     2161 attatttttt taaagtgatt tgccattttt gaaagcgtat ttaatgatag aatactatcg
     2221 agccaacatg tactgacatg gaaagatgtc aaagatatgt taagtgtaaa atgcaagtgg
     2281 caaaacacta tgtatagtct gagccagatc aaagtatgta tgtttttaat atgcatagaa
     2341 caaaagattt ggaaagatat acaccaaact gttaaatgtg gtttctcttc ggggaggggg
     2401 ggattggggg aggggcccca gaggggtttt ataggggcct tttcactttc tacttttttc
     2461 attttgttct gttcgaattt tttataagta tgtattactt ttgtaatcag aatttttaga
     2521 aagtattttg ctgatttaaa ggcttaggca tgttcaaacg cctgcaaaac tacttatcac
     2581 tcagctttag tttttctaat ccaagaaggc agggcagtta acctttttgg tgccaatgtg
     2641 aaatgtaaat gattttatgt ttttcctgct ttgtggatga aaaatatttc tgagtggtag
     2701 ttttttgaca ggtagaccat gtcttatctt gtttcaaaat aagtatttct gattttgtaa
     2761 aatgaaatat aaaatatgtc tcagatcttc caattaatta gtaaggattc atccttaatc
     2821 cttgctagtt taagcctgcc taagtcactt tactaaaaga tctttgttaa ctcagtattt
     2881 taaacatctg tcagcttatg taggtaaaag tagaagcatg tttgtacact gcttgtagtt
     2941 atagtgacag ctttccatgt tgagattctc atatcatctt gtatcttaaa gtttcatgtg
     3001 agtttttacc gttaggatga ttaagatgta tataggacaa aatgttaagt ctttcctcta
     3061 cctacatttg ttttcttggc tagtaatagt agtagatact tctgaaataa atgttctctc
     3121 aagatcctta aaacctcttg gaaattataa aaatattggc aagaaaagaa gaatagttgt
     3181 ttaaatattt tttaaaaaac acttgaataa gaatcagtag ggtataaact agaagtttaa
     3241 aaatgcttca tagaacgtcc agggtttaca ttacaagatt ctcacaacaa acctattgta
     3301 gaggtgagta aggcatgtta ctacagagga aagtttgaga gtaaaactgt aaaaaattat
     3361 atttttgttg tactttctaa gagaaagagt attgttatgt tctcctaact tctgttgatt
     3421 actactttaa gtgatattca tttaaaacat tgcaaattta ttttatttat ttaattttct
     3481 ttttgagatg gagtcttgct tgtcacccag gctggagtgc agtggagtga tctctgctca
     3541 ctgcaacctc cgccttctgg gttcaagcga ttctcgtgcc tcagcttcct gagtagctgg
     3601 aattacaggc aggtgccacc atgcccgact aatttttttt tatttttagt agagacgggg
     3661 tttcaccatg ttggccaggc tggtatcaaa ctcctgacct caagagatcc actcgccttg
     3721 ccctcccaaa gtgctgggat tacaggcttg agccaccacg cccggctaaa acattgcaaa
     3781 tttaaatgag agttttaaaa attaaataat gactgccctg tttctgtttt agtatgtaaa
     3841 tcctcagttc ttcacctttg cactgtctgc cacttagttt ggttatatag tcattaactt
     3901 gaatttggtc tgtatagtct agactttaaa tttaaagttt tctacaaggg gagaaaagtg
     3961 ttaaaatttt taaaatatgt tttccaggac acttcacttc caagtcaggt aggtagttca
     4021 atctagttgt tagccaagga ctcaaggact gaattgtttt aacataaggc ttttcctgtt
     4081 ctgggagccg cacttcatta aaattcttct aaaacttgta tgtttagagt taagcaagac
     4141 tttttttctt cctctccatg agttgtgaaa tttaatgcac aacgctgatg tggctaacaa
     4201 gtttatttta agaattgttt agaaatgctg ttgcttcagg ttcttaaaat cactcagcac
     4261 tccaacttct aatcaaattt ttggagactt aacagcattt gtctgtgttt gaactataaa
     4321 aagcaccgga tcttttccat ctaattccgc aaaaattgat catttgcaaa gtcaaaacta
     4381 tagccatatc caaatctttt ccccctccca agagttctca gtgtctacat gtagactatt
     4441 ccttttctgt ataaagttca ctctaggatt tcaagtcacc acttatttta cattttagtc
     4501 atgcaaagat tcaagtagtt ttgcaataag tacttatctt tatttgtaat aatttagtct
     4561 gctgatcaaa agcattgtct taatttttga gaactggttt tagcatttac aaactaaatt
     4621 ccagttaatt aattaatagc tttatattgc ctttcctgct acatttggtt ttttcccctg
     4681 tccctttgat tacgggctaa ggtagggtag agtgggtgta gtgagtgtat ataatgtgat
     4741 ttggccctgt gtattatgat attttgttat ttttgttgtt atattattta catttcagta
     4801 gttgtttttt gtgtttccat tttagtggat aaaatttgta ttttgaacta tgaatggaga
     4861 ctaccgcccc agcattagtt tcacatgata taccctttaa acccgaatca ttgttttatt
     4921 tcctgattac acaggtgttg aatggggaaa ggggctagta tatcagtagg atatactatg
     4981 ggatgtatat atatcattgc tgttagagaa atgaaataaa atggggctgg gctcagtggc
     5041 tcacgcctgt aatcccagca ctttgggagg ctgaggcagg tggatcacga ggtcaggaga
     5101 tcgagaccat cctggctaac acggtgaaac cccgtctcta ctaaaaaaca gaaaattagc
     5161 cgggcgtggt ggcgggcgcc tgtagtccca gctactcggg aggctgaggc aggagaatgg
     5221 tgtgaacccg ggaggcagag cttgcagtga gccgagatct cgccactgca ctccagcctg
     5281 ggcaacagag caagactctg tctcaaaaaa aaaaaaaaaa gaaataagaa aatgggaagc
     5341 aatatttgac atagttcttt ttagtcaaat ctacttgtta aaaaaagggt agcagtttat
     5401 tcatctgtga aaggaaaata atacttatct tacaaggttg caagagctca aggagaccat
     5461 gtatgtaaag ttcctgctgt aaatatgaac tcccatccta ataccctttt acctctctgt
     5521 gggtttgtct tgacctggaa atttgggcta aaacttagaa aaaattctta catgataact
     5581 cagtgatgct tactcatagt ttttggtgtt tctcatagat aagatataaa tcagctgggc
     5641 gcggtggctc atgcctgtaa tcccagcact ttgggaggcc gaggcgggca gatcacctga
     5701 ggtcgggagg tcgagaccag cctgaccaac atggagaaac cccgtctcta ctaaaaatac
     5761 aaaattagct gggcgtggtg gctcatgcct gtaatcccag ctacttggga ggctgaggca
     5821 ggagaatcgc ttgaacccag gaggcggagg ttgtggtgag cgaagatcgt gccattgcac
     5881 tccagcctgg gcaacaagag caaaactctg tctcaaaaaa aaaaaaagat ataaatcaca
     5941 ataaataaat aggtcaatac aaatgttagc caggcgtggt ggcacatgcc catagtcgca
     6001 gctactctgg aggcagaggc aggaggatca cttgagccca tgaatttgag gcagcagtga
     6061 gctatgattg tgccactgta ctccagtctg ggtgacagag tgagacccca tctctaaata
     6121 aataggtcaa acccttaaaa atatttaaat tcttaaaaaa ttgaaaagat tattcttctc
     6181 aaatttagtt gagctttcta agagaagcaa ttggcttttt cccacttcaa taatcatttt
     6241 cagtttgact catacagtta acacaatgtg aatttcttcc tcagcataac agagttatag
     6301 aatgacaggg ctggaagtga ccttagagag tatccagttc tttcatttta caggtgaggc
     6361 aactgagact caaaggtgat gtaatttgtg caaagattat agctaattag tagcagagcc
     6421 ctgactggga catagtttga aggtgaaaaa cttcaccaag ctacctttct tgaaaggtcc
     6481 aaatgtttat gttttcaact actctttcca ctgtaccata actttcacta catattaaat
     6541 gacactttat aactaatata ataggacaat catcaatgca tatatagcca gcccttcata
     6601 tctgtgggtt ttgcatccat ggattcaacc aaggaggaat tgaaaacact gagaaaaaaa
     6661 aaaaagacca cacaataaaa aaaaaaaata caaaataata caaagaaaaa gccaaaattg
     6721 tcatactgtt gttaagcaac agtataacaa ctatttacat agcattaagg ttggtgcaaa
     6781 aatgcaaaaa aaaaaaaagc aattattttt aaaccaacct aatatattgt attaggtatt
     6841 aaagtcatct ggacatgaat taaagtatat gatgccagcc tggacaaaag gcaaaaccct
     6901 gtctctacaa aaaatacaaa aattagctgg gcatggtggt gtgtgcctgt agtcctggct
     6961 actccggagc ctgaggtggg aggatcgctt gagtctggga ggcagaggct gcattgagct
     7021 atgatcatgg cactgcattc cagcctgggt gacagtgcaa gaccttgtct cagaataaat
     7081 aaagtatgtg atgaagatgt gcatacatta tatgcaaata ctgttttttt tttttttaat
     7141 ttaaacagtc tcactgtgtt gcccaggatg gagtgcaatg gcacaatctt ggctcatggc
     7201 aaactctgcc tcgcaagcag ctgggactac aggcatgctc cacggtgccc agttaatttt
     7261 ttttgtattc ttagtagaga cagggtttca ccatgttggc caggctagtc ttgaatttct
     7321 gacctcaagt gattcatctc ccaaagtgct gggattacag gcgtgagcca ccacggccgg
     7381 ctaatttttg tattttttag tagtgactgg tttcgcggtg ttgaccaggc tggtctcgaa
     7441 ctcctgatct caggtgatct gcctgcctcg gcctcacaaa gtgctgggat tacaggtgtg
     7501 aaccactgct cccggccttg tgtgatttta tctaagggac ttaagcgtcc tcaggtccta
     7561 gggggtcgtg aaaccaaaac cccagggata gcaagggaca attgtatctt caaagtagac
     7621 aaatggcgcc gggcacggtg gctcacgcct gtaatcccag cagtttccga ggctgaggca
     7681 ggcggctcac ctgaggtcag gagttggaga ccagcctggc caacatgctg aaaccctgtc
     7741 tgtacaaaaa tacaaaaata gctgggcatg gtggcgcatg cctgtagtcc cagctactag
     7801 agcgactgag gcaggagaat tgcttgaacc tgggaggcgg aggttgcagg gagccaagat
     7861 ggcgccaccg cactccagcc taggtgatag agtgagactc cctctcaaaa acaaaacaaa
     7921 acaaaaaaat tagacaaatg ctacattaat gtttgggtgg tcagattcta ctttgaatct
     7981 gaagtttgca gatatgccta tagatttttg gagtttacca ctttcttatt ctgtatcatt
     8041 aatgtaatat tttaaattac tatatatgtt accatttttc tggatttagt aagaaatttg
     8101 cagttttggt ttgatgtaac aagggtttta atgtaattta tgttagattt tgcatttttt
     8161 tcattactgt tatattttaa cctgactgac tgatctaatt gtattagtat tgtgaataat
     8221 catgtgaaat gttttgagac agagtactat atttgtgaat ataattttat ggtttttttc
     8281 acttagaacc tttctgtgtg gaaaactaag aaaattgctt tctgctgtat aatctggcat
     8341 tcattgtaga ttaaagctta tttttctgtg aataaaacgt attcaataaa atactattct
     8401 ttaaaatta
//
