LOCUS       NM_001167               8558 bp    mRNA    linear   PRI 12-JUN-2025
DEFINITION  Homo sapiens X-linked inhibitor of apoptosis (XIAP), transcript
            variant 1, mRNA.
ACCESSION   NM_001167
VERSION     NM_001167.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8558)
  AUTHORS   Dissanayake,D., Firouzabady,A., Massumi,M., de Paz Linares,G.A.,
            Marshall,C., Freeman,S.A., Laxer,R.M. and Yeung,R.S.M.
  TITLE     Interleukin-1-mediated hyperinflammation in XIAP deficiency is
            associated with defective autophagy
  JOURNAL   Blood 144 (11), 1183-1192 (2024)
   PUBMED   38820590
  REMARK    GeneRIF: Interleukin-1-mediated hyperinflammation in XIAP
            deficiency is associated with defective autophagy.
REFERENCE   2  (bases 1 to 8558)
  AUTHORS   Qi,Q., Zhu,M., Li,P., Mi,Q., Xie,Y., Li,J. and Wang,C.
  TITLE     Systematic analysis of PANoptosis-related genes identifies XIAP as
            a functional oncogene in breast cancer
  JOURNAL   Gene 912, 148355 (2024)
   PUBMED   38467314
  REMARK    GeneRIF: Systematic analysis of PANoptosis-related genes identifies
            XIAP as a functional oncogene in breast cancer.
REFERENCE   3  (bases 1 to 8558)
  AUTHORS   Lee,J., Sim,K.M., Kang,M., Oh,H.J., Choi,H.J., Kim,Y.E., Pack,C.G.,
            Kim,K., Kim,K.M., Oh,S.H., Kim,I. and Chang,I.
  TITLE     Understanding the molecular mechanism of pathogenic variants of
            BIR2 domain in XIAP-deficient inflammatory bowel disease
  JOURNAL   Sci Rep 14 (1), 853 (2024)
   PUBMED   38191507
  REMARK    GeneRIF: Understanding the molecular mechanism of pathogenic
            variants of BIR2 domain in XIAP-deficient inflammatory bowel
            disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8558)
  AUTHORS   Patterson,L.L., Byerly,C.D., Solomon,R., Pittner,N., Bui,D.C.,
            Patel,J. and McBride,J.W.
  TITLE     Ehrlichia Notch signaling induction promotes XIAP stability and
            inhibits apoptosis
  JOURNAL   Infect Immun 91 (9), e0000223 (2023)
   PUBMED   37594275
  REMARK    GeneRIF: Ehrlichia Notch signaling induction promotes XIAP
            stability and inhibits apoptosis.
REFERENCE   5  (bases 1 to 8558)
  AUTHORS   Farahani,R., Fong,W.G., Korneluk,R.G. and MacKenzie,A.E.
  TITLE     Genomic organization and primary characterization of miap-3: the
            murine homologue of human X-linked IAP
  JOURNAL   Genomics 42 (3), 514-518 (1997)
   PUBMED   9205126
REFERENCE   6  (bases 1 to 8558)
  AUTHORS   Rajcan-Separovic,E., Liston,P., Lefebvre,C. and Korneluk,R.G.
  TITLE     Assignment of human inhibitor of apoptosis protein (IAP) genes
            xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 37 (3), 404-406 (1996)
   PUBMED   8938457
REFERENCE   7  (bases 1 to 8558)
  AUTHORS   Duckett,C.S., Nava,V.E., Gedrich,R.W., Clem,R.J., Van Dongen,J.L.,
            Gilfillan,M.C., Shiels,H., Hardwick,J.M. and Thompson,C.B.
  TITLE     A conserved family of cellular genes related to the baculovirus iap
            gene and encoding apoptosis inhibitors
  JOURNAL   EMBO J 15 (11), 2685-2694 (1996)
   PUBMED   8654366
REFERENCE   8  (bases 1 to 8558)
  AUTHORS   Liston,P., Roy,N., Tamai,K., Lefebvre,C., Baird,S.,
            Cherton-Horvat,G., Farahani,R., McLean,M., Ikeda,J.E., MacKenzie,A.
            and Korneluk,R.G.
  TITLE     Suppression of apoptosis in mammalian cells by NAIP and a related
            family of IAP genes
  JOURNAL   Nature 379 (6563), 349-353 (1996)
   PUBMED   8552191
REFERENCE   9  (bases 1 to 8558)
  AUTHORS   Meyer,L., Hines,M., Zhang,K. and Nichols,K.E.
  TITLE     X-Linked Lymphoproliferative Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301580
REFERENCE   10 (bases 1 to 8558)
  AUTHORS   Kunsch,C., Ruben,S.M. and Rosen,C.A.
  TITLE     Selection of optimal kappa B/Rel DNA-binding motifs: interaction of
            both subunits of NF-kappa B with DNA is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 12 (10), 4412-4421 (1992)
   PUBMED   1406630
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB113777.1, DA316362.1,
            U32974.1, AL121601.13 and H09548.1.
            
            On Feb 21, 2020 this sequence version replaced NM_001167.3.
            
            Summary: This gene encodes a protein that belongs to a family of
            apoptotic suppressor proteins. Members of this family share a
            conserved motif termed, baculovirus IAP repeat, which is necessary
            for their anti-apoptotic function. This protein functions through
            binding to tumor necrosis factor receptor-associated factors TRAF1
            and TRAF2 and inhibits apoptosis induced by menadione, a potent
            inducer of free radicals, and interleukin 1-beta converting enzyme.
            This protein also inhibits at least two members of the caspase
            family of cell-death proteases, caspase-3 and caspase-7. Mutations
            in this gene are the cause of X-linked lymphoproliferative
            syndrome. Alternate splicing results in multiple transcript
            variants. Pseudogenes of this gene are found on chromosomes 2 and
            11.[provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2738096.1,
                                           SRR11853559.34203.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371199.8/ ENSP00000360242.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DB113777.1         26-101
            77-114              DB113777.1         103-140
            115-195             DA316362.1         81-161
            196-1540            U32974.1           4-1348
            1541-1541           AL121601.13        28783-28783
            1542-1851           U32974.1           1350-1659
            1852-8371           AL121601.13        35388-41907
            8372-8558           H09548.1           17-203              c
FEATURES             Location/Qualifiers
     source          1..8558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq25"
     gene            1..8558
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /note="X-linked inhibitor of apoptosis"
                     /db_xref="GeneID:331"
                     /db_xref="HGNC:HGNC:592"
                     /db_xref="MIM:300079"
     exon            1..241
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..1150
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1767
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /EC_number="2.3.2.27"
                     /note="baculoviral IAP repeat-containing protein 4;
                     X-linked IAP; inhibitor of apoptosis protein 3; X-linked
                     inhibitor of apoptosis, E3 ubiquitin protein ligase;
                     RING-type E3 ubiquitin transferase XIAP; IAP-like protein
                     1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase XIAP"
                     /protein_id="NP_001158.2"
                     /db_xref="CCDS:CCDS14606.1"
                     /db_xref="GeneID:331"
                     /db_xref="HGNC:HGNC:592"
                     /db_xref="MIM:300079"
                     /translation="MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSA
                     STLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSA
                     TQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAM
                     YSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWS
                     EHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWI
                     YSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQK
                     GQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKI
                     MEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLC
                     KICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS"
     exon            1151..1250
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1329
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1372
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1573
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..8558
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8534..8539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /note="hexamer: AATAAA"
     polyA_site      8558
                     /gene="XIAP"
                     /gene_synonym="API3; BIRC4; hIAP-3; hIAP3; IAP-3; ILP1;
                     MIHA; XLP2"
                     /note="major polyA site"
ORIGIN      
        1 gaggccctga cgtggacaca cttcgggttt cacgactccg ggtttctcca ggggatgggc
       61 cggccggtag aggcgcgtga gggagacgaa gggacttccg tttccttcac ctaggctggg
      121 gccaagccgc agagcggagt tggcatttcc agattggggc tcgggccgcg cctcctccgg
      181 gaccctcccc ttggaccgag ccgatcgccg cggggcagtt cgggccggct gtcctggcgc
      241 gaaaaggtgg acaagtccta ttttcaagag aagatgactt ttaacagttt tgaaggatct
      301 aaaacttgtg tacctgcaga catcaataag gaagaagaat ttgtagaaga gtttaataga
      361 ttaaaaactt ttgctaattt tccaagtggt agtcctgttt cagcatcaac actggcacga
      421 gcagggtttc tttatactgg tgaaggagat accgtgcggt gctttagttg tcatgcagct
      481 gtagatagat ggcaatatgg agactcagca gttggaagac acaggaaagt atccccaaat
      541 tgcagattta tcaacggctt ttatcttgaa aatagtgcca cgcagtctac aaattctggt
      601 atccagaatg gtcagtacaa agttgaaaac tatctgggaa gcagagatca ttttgcctta
      661 gacaggccat ctgagacaca tgcagactat cttttgagaa ctgggcaggt tgtagatata
      721 tcagacacca tatacccgag gaaccctgcc atgtatagtg aagaagctag attaaagtcc
      781 tttcagaact ggccagacta tgctcaccta accccaagag agttagcaag tgctggactc
      841 tactacacag gtattggtga ccaagtgcag tgcttttgtt gtggtggaaa actgaaaaat
      901 tgggaacctt gtgatcgtgc ctggtcagaa cacaggcgac actttcctaa ttgcttcttt
      961 gttttgggcc ggaatcttaa tattcgaagt gaatctgatg ctgtgagttc tgataggaat
     1021 ttcccaaatt caacaaatct tccaagaaat ccatccatgg cagattatga agcacggatc
     1081 tttacttttg ggacatggat atactcagtt aacaaggagc agcttgcaag agctggattt
     1141 tatgctttag gtgaaggtga taaagtaaag tgctttcact gtggaggagg gctaactgat
     1201 tggaagccca gtgaagaccc ttgggaacaa catgctaaat ggtatccagg gtgcaaatat
     1261 ctgttagaac agaagggaca agaatatata aacaatattc atttaactca ttcacttgag
     1321 gagtgtctgg taagaactac tgagaaaaca ccatcactaa ctagaagaat tgatgatacc
     1381 atcttccaaa atcctatggt acaagaagct atacgaatgg ggttcagttt caaggacatt
     1441 aagaaaataa tggaggaaaa aattcagata tctgggagca actataaatc acttgaggtt
     1501 ctggttgcag atctagtgaa tgctcagaaa gacagtatgc aagatgagtc aagtcagact
     1561 tcattacaga aagagattag tactgaagag cagctaaggc gcctgcaaga ggagaagctt
     1621 tgcaaaatct gtatggatag aaatattgct atcgtttttg ttccttgtgg acatctagtc
     1681 acttgtaaac aatgtgctga agcagttgac aagtgtccca tgtgctacac agtcattact
     1741 ttcaagcaaa aaatttttat gtcttaatct aactctatag taggcatgtt atgttgttct
     1801 tattaccctg attgaatgtg tgatgtgaac tgactttaag taatcaggat tgaattccat
     1861 tagcatttgc taccaagtag gaaaaaaaat gtacatggca gtgttttagt tggcaatata
     1921 atctttgaat ttcttgattt ttcagggtat tagctgtatt atccattttt tttactgtta
     1981 tttaattgaa accatagact aagaataaga agcatcatac tataactgaa cacaatgtgt
     2041 attcatagta tactgattta atttctaagt gtaagtgaat taatcatctg gattttttat
     2101 tcttttcaga taggcttaac aaatggagct ttctgtatat aaatgtggag attagagtta
     2161 atctccccaa tcacataatt tgttttgtgt gaaaaaggaa taaattgttc catgctggtg
     2221 gaaagataga gattgttttt agaggttggt tgttgtgttt taggattctg tccattttct
     2281 tttaaagtta taaacacgta cttgtgcgaa ttattttttt aaagtgattt gccatttttg
     2341 aaagcgtatt taatgataga atactatcga gccaacatgt actgacatgg aaagatgtca
     2401 aagatatgtt aagtgtaaaa tgcaagtggc aaaacactat gtatagtctg agccagatca
     2461 aagtatgtat gtttttaata tgcatagaac aaaagatttg gaaagatata caccaaactg
     2521 ttaaatgtgg tttctcttcg gggagggggg gattggggga ggggccccag aggggtttta
     2581 taggggcctt ttcactttct acttttttca ttttgttctg ttcgaatttt ttataagtat
     2641 gtattacttt tgtaatcaga atttttagaa agtattttgc tgatttaaag gcttaggcat
     2701 gttcaaacgc ctgcaaaact acttatcact cagctttagt ttttctaatc caagaaggca
     2761 gggcagttaa cctttttggt gccaatgtga aatgtaaatg attttatgtt tttcctgctt
     2821 tgtggatgaa aaatatttct gagtggtagt tttttgacag gtagaccatg tcttatcttg
     2881 tttcaaaata agtatttctg attttgtaaa atgaaatata aaatatgtct cagatcttcc
     2941 aattaattag taaggattca tccttaatcc ttgctagttt aagcctgcct aagtcacttt
     3001 actaaaagat ctttgttaac tcagtatttt aaacatctgt cagcttatgt aggtaaaagt
     3061 agaagcatgt ttgtacactg cttgtagtta tagtgacagc tttccatgtt gagattctca
     3121 tatcatcttg tatcttaaag tttcatgtga gtttttaccg ttaggatgat taagatgtat
     3181 ataggacaaa atgttaagtc tttcctctac ctacatttgt tttcttggct agtaatagta
     3241 gtagatactt ctgaaataaa tgttctctca agatccttaa aacctcttgg aaattataaa
     3301 aatattggca agaaaagaag aatagttgtt taaatatttt ttaaaaaaca cttgaataag
     3361 aatcagtagg gtataaacta gaagtttaaa aatgcttcat agaacgtcca gggtttacat
     3421 tacaagattc tcacaacaaa cctattgtag aggtgagtaa ggcatgttac tacagaggaa
     3481 agtttgagag taaaactgta aaaaattata tttttgttgt actttctaag agaaagagta
     3541 ttgttatgtt ctcctaactt ctgttgatta ctactttaag tgatattcat ttaaaacatt
     3601 gcaaatttat tttatttatt taattttctt tttgagatgg agtcttgctt gtcacccagg
     3661 ctggagtgca gtggagtgat ctctgctcac tgcaacctcc gccttctggg ttcaagcgat
     3721 tctcgtgcct cagcttcctg agtagctgga attacaggca ggtgccacca tgcccgacta
     3781 attttttttt atttttagta gagacggggt ttcaccatgt tggccaggct ggtatcaaac
     3841 tcctgacctc aagagatcca ctcgccttgc cctcccaaag tgctgggatt acaggcttga
     3901 gccaccacgc ccggctaaaa cattgcaaat ttaaatgaga gttttaaaaa ttaaataatg
     3961 actgccctgt ttctgtttta gtatgtaaat cctcagttct tcacctttgc actgtctgcc
     4021 acttagtttg gttatatagt cattaacttg aatttggtct gtatagtcta gactttaaat
     4081 ttaaagtttt ctacaagggg agaaaagtgt taaaattttt aaaatatgtt ttccaggaca
     4141 cttcacttcc aagtcaggta ggtagttcaa tctagttgtt agccaaggac tcaaggactg
     4201 aattgtttta acataaggct tttcctgttc tgggagccgc acttcattaa aattcttcta
     4261 aaacttgtat gtttagagtt aagcaagact ttttttcttc ctctccatga gttgtgaaat
     4321 ttaatgcaca acgctgatgt ggctaacaag tttattttaa gaattgttta gaaatgctgt
     4381 tgcttcaggt tcttaaaatc actcagcact ccaacttcta atcaaatttt tggagactta
     4441 acagcatttg tctgtgtttg aactataaaa agcaccggat cttttccatc taattccgca
     4501 aaaattgatc atttgcaaag tcaaaactat agccatatcc aaatcttttc cccctcccaa
     4561 gagttctcag tgtctacatg tagactattc cttttctgta taaagttcac tctaggattt
     4621 caagtcacca cttattttac attttagtca tgcaaagatt caagtagttt tgcaataagt
     4681 acttatcttt atttgtaata atttagtctg ctgatcaaaa gcattgtctt aatttttgag
     4741 aactggtttt agcatttaca aactaaattc cagttaatta attaatagct ttatattgcc
     4801 tttcctgcta catttggttt tttcccctgt ccctttgatt acgggctaag gtagggtaga
     4861 gtgggtgtag tgagtgtata taatgtgatt tggccctgtg tattatgata ttttgttatt
     4921 tttgttgtta tattatttac atttcagtag ttgttttttg tgtttccatt ttagtggata
     4981 aaatttgtat tttgaactat gaatggagac taccgcccca gcattagttt cacatgatat
     5041 accctttaaa cccgaatcat tgttttattt cctgattaca caggtgttga atggggaaag
     5101 gggctagtat atcagtagga tatactatgg gatgtatata tatcattgct gttagagaaa
     5161 tgaaataaaa tggggctggg ctcagtggct cacgcctgta atcccagcac tttgggaggc
     5221 tgaggcaggt ggatcacgag gtcaggagat cgagaccatc ctggctaaca cggtgaaacc
     5281 ccgtctctac taaaaaacag aaaattagcc gggcgtggtg gcgggcgcct gtagtcccag
     5341 ctactcggga ggctgaggca ggagaatggt gtgaacccgg gaggcagagc ttgcagtgag
     5401 ccgagatctc gccactgcac tccagcctgg gcaacagagc aagactctgt ctcaaaaaaa
     5461 aaaaaaaaag aaataagaaa atgggaagca atatttgaca tagttctttt tagtcaaatc
     5521 tacttgttaa aaaaagggta gcagtttatt catctgtgaa aggaaaataa tacttatctt
     5581 acaaggttgc aagagctcaa ggagaccatg tatgtaaagt tcctgctgta aatatgaact
     5641 cccatcctaa taccctttta cctctctgtg ggtttgtctt gacctggaaa tttgggctaa
     5701 aacttagaaa aaattcttac atgataactc agtgatgctt actcatagtt tttggtgttt
     5761 ctcatagata agatataaat cagctgggcg cggtggctca tgcctgtaat cccagcactt
     5821 tgggaggccg aggcgggcag atcacctgag gtcgggaggt cgagaccagc ctgaccaaca
     5881 tggagaaacc ccgtctctac taaaaataca aaattagctg ggcgtggtgg ctcatgcctg
     5941 taatcccagc tacttgggag gctgaggcag gagaatcgct tgaacccagg aggcggaggt
     6001 tgtggtgagc gaagatcgtg ccattgcact ccagcctggg caacaagagc aaaactctgt
     6061 ctcaaaaaaa aaaaaagata taaatcacaa taaataaata ggtcaataca aatgttagcc
     6121 aggcgtggtg gcacatgccc atagtcgcag ctactctgga ggcagaggca ggaggatcac
     6181 ttgagcccat gaatttgagg cagcagtgag ctatgattgt gccactgtac tccagtctgg
     6241 gtgacagagt gagaccccat ctctaaataa ataggtcaaa cccttaaaaa tatttaaatt
     6301 cttaaaaaat tgaaaagatt attcttctca aatttagttg agctttctaa gagaagcaat
     6361 tggctttttc ccacttcaat aatcattttc agtttgactc atacagttaa cacaatgtga
     6421 atttcttcct cagcataaca gagttataga atgacagggc tggaagtgac cttagagagt
     6481 atccagttct ttcattttac aggtgaggca actgagactc aaaggtgatg taatttgtgc
     6541 aaagattata gctaattagt agcagagccc tgactgggac atagtttgaa ggtgaaaaac
     6601 ttcaccaagc tacctttctt gaaaggtcca aatgtttatg ttttcaacta ctctttccac
     6661 tgtaccataa ctttcactac atattaaatg acactttata actaatataa taggacaatc
     6721 atcaatgcat atatagccag cccttcatat ctgtgggttt tgcatccatg gattcaacca
     6781 aggaggaatt gaaaacactg agaaaaaaaa aaaagaccac acaataaaaa aaaaaaatac
     6841 aaaataatac aaagaaaaag ccaaaattgt catactgttg ttaagcaaca gtataacaac
     6901 tatttacata gcattaaggt tggtgcaaaa atgcaaaaaa aaaaaaagca attattttta
     6961 aaccaaccta atatattgta ttaggtatta aagtcatctg gacatgaatt aaagtatatg
     7021 atgccagcct ggacaaaagg caaaaccctg tctctacaaa aaatacaaaa attagctggg
     7081 catggtggtg tgtgcctgta gtcctggcta ctccggagcc tgaggtggga ggatcgcttg
     7141 agtctgggag gcagaggctg cattgagcta tgatcatggc actgcattcc agcctgggtg
     7201 acagtgcaag accttgtctc agaataaata aagtatgtga tgaagatgtg catacattat
     7261 atgcaaatac tgtttttttt ttttttaatt taaacagtct cactgtgttg cccaggatgg
     7321 agtgcaatgg cacaatcttg gctcatggca aactctgcct cgcaagcagc tgggactaca
     7381 ggcatgctcc acggtgccca gttaattttt tttgtattct tagtagagac agggtttcac
     7441 catgttggcc aggctagtct tgaatttctg acctcaagtg attcatctcc caaagtgctg
     7501 ggattacagg cgtgagccac cacggccggc taatttttgt attttttagt agtgactggt
     7561 ttcgcggtgt tgaccaggct ggtctcgaac tcctgatctc aggtgatctg cctgcctcgg
     7621 cctcacaaag tgctgggatt acaggtgtga accactgctc ccggccttgt gtgattttat
     7681 ctaagggact taagcgtcct caggtcctag ggggtcgtga aaccaaaacc ccagggatag
     7741 caagggacaa ttgtatcttc aaagtagaca aatggcgccg ggcacggtgg ctcacgcctg
     7801 taatcccagc agtttccgag gctgaggcag gcggctcacc tgaggtcagg agttggagac
     7861 cagcctggcc aacatgctga aaccctgtct gtacaaaaat acaaaaatag ctgggcatgg
     7921 tggcgcatgc ctgtagtccc agctactaga gcgactgagg caggagaatt gcttgaacct
     7981 gggaggcgga ggttgcaggg agccaagatg gcgccaccgc actccagcct aggtgataga
     8041 gtgagactcc ctctcaaaaa caaaacaaaa caaaaaaatt agacaaatgc tacattaatg
     8101 tttgggtggt cagattctac tttgaatctg aagtttgcag atatgcctat agatttttgg
     8161 agtttaccac tttcttattc tgtatcatta atgtaatatt ttaaattact atatatgtta
     8221 ccatttttct ggatttagta agaaatttgc agttttggtt tgatgtaaca agggttttaa
     8281 tgtaatttat gttagatttt gcattttttt cattactgtt atattttaac ctgactgact
     8341 gatctaattg tattagtatt gtgaataatc atgtgaaatg ttttgagaca gagtactata
     8401 tttgtgaata taattttatg gtttttttca cttagaacct ttctgtgtgg aaaactaaga
     8461 aaattgcttt ctgctgtata atctggcatt cattgtagat taaagcttat ttttctgtga
     8521 ataaaacgta ttcaataaaa tactattctt taaaatta
//
