LOCUS       NM_001024644            5039 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens X-C motif chemokine receptor 1 (XCR1), transcript
            variant 2, mRNA.
ACCESSION   NM_001024644
VERSION     NM_001024644.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5039)
  AUTHORS   Cui,L., Zhu,L., Chen,J., Li,C., Yu,Y. and Xu,S.
  TITLE     Systematic Pan-Cancer Analysis Reveals X-C Motif Chemokine Receptor
            1 as a Prognostic and Immunological Biomarker
  JOURNAL   Genes (Basel) 14 (10), 1961 (2023)
   PUBMED   37895310
  REMARK    GeneRIF: Systematic Pan-Cancer Analysis Reveals X-C Motif Chemokine
            Receptor 1 as a Prognostic and Immunological Biomarker.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5039)
  AUTHORS   Thibord,F., Chan,M.V., Chen,M.H. and Johnson,A.D.
  TITLE     A year of COVID-19 GWAS results from the GRASP portal reveals
            potential genetic risk factors
  JOURNAL   HGG Adv 3 (2), 100095 (2022)
   PUBMED   35224516
REFERENCE   3  (bases 1 to 5039)
  AUTHORS   Wu,L., Zhu,J., Liu,D., Sun,Y. and Wu,C.
  TITLE     An integrative multiomics analysis identifies putative causal genes
            for COVID-19 severity
  JOURNAL   Genet Med 23 (11), 2076-2086 (2021)
   PUBMED   34183789
REFERENCE   4  (bases 1 to 5039)
  AUTHORS   Baranova,A., Cao,H. and Zhang,F.
  TITLE     Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative
            Analyses
  JOURNAL   Front Med (Lausanne) 8, 738687 (2021)
   PUBMED   34557504
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5039)
  AUTHORS   Ellinghaus,D., Degenhardt,F., Bujanda,L., Buti,M., Albillos,A.,
            Invernizzi,P., Fernandez,J., Prati,D., Baselli,G., Asselta,R.,
            Grimsrud,M.M., Milani,C., Aziz,F., Kassens,J., May,S., Wendorff,M.,
            Wienbrandt,L., Uellendahl-Werth,F., Zheng,T., Yi,X., de Pablo,R.,
            Chercoles,A.G., Palom,A., Garcia-Fernandez,A.E.,
            Rodriguez-Frias,F., Zanella,A., Bandera,A., Protti,A., Aghemo,A.,
            Lleo,A., Biondi,A., Caballero-Garralda,A., Gori,A., Tanck,A.,
            Carreras Nolla,A., Latiano,A., Fracanzani,A.L., Peschuck,A.,
            Julia,A., Pesenti,A., Voza,A., Jimenez,D., Mateos,B., Nafria
            Jimenez,B., Quereda,C., Paccapelo,C., Gassner,C., Angelini,C.,
            Cea,C., Solier,A., Pestana,D., Muniz-Diaz,E., Sandoval,E.,
            Paraboschi,E.M., Navas,E., Garcia Sanchez,F., Ceriotti,F.,
            Martinelli-Boneschi,F., Peyvandi,F., Blasi,F., Tellez,L.,
            Blanco-Grau,A., Hemmrich-Stanisak,G., Grasselli,G., Costantino,G.,
            Cardamone,G., Foti,G., Aneli,S., Kurihara,H., ElAbd,H., My,I.,
            Galvan-Femenia,I., Martin,J., Erdmann,J., Ferrusquia-Acosta,J.,
            Garcia-Etxebarria,K., Izquierdo-Sanchez,L., Bettini,L.R., Sumoy,L.,
            Terranova,L., Moreira,L., Santoro,L., Scudeller,L., Mesonero,F.,
            Roade,L., Ruhlemann,M.C., Schaefer,M., Carrabba,M.,
            Riveiro-Barciela,M., Figuera Basso,M.E., Valsecchi,M.G.,
            Hernandez-Tejero,M., Acosta-Herrera,M., D'Angio,M., Baldini,M.,
            Cazzaniga,M., Schulzky,M., Cecconi,M., Wittig,M., Ciccarelli,M.,
            Rodriguez-Gandia,M., Bocciolone,M., Miozzo,M., Montano,N.,
            Braun,N., Sacchi,N., Martinez,N., Ozer,O., Palmieri,O., Faverio,P.,
            Preatoni,P., Bonfanti,P., Omodei,P., Tentorio,P., Castro,P.,
            Rodrigues,P.M., Blandino Ortiz,A., de Cid,R., Ferrer,R.,
            Gualtierotti,R., Nieto,R., Goerg,S., Badalamenti,S., Marsal,S.,
            Matullo,G., Pelusi,S., Juzenas,S., Aliberti,S., Monzani,V.,
            Moreno,V., Wesse,T., Lenz,T.L., Pumarola,T., Rimoldi,V., Bosari,S.,
            Albrecht,W., Peter,W., Romero-Gomez,M., D'Amato,M., Duga,S.,
            Banales,J.M., Hov,J.R., Folseraas,T., Valenti,L., Franke,A. and
            Karlsen,T.H.
  CONSRTM   Severe Covid-19 GWAS Group
  TITLE     Genomewide Association Study of Severe Covid-19 with Respiratory
            Failure
  JOURNAL   N Engl J Med 383 (16), 1522-1534 (2020)
   PUBMED   32558485
REFERENCE   6  (bases 1 to 5039)
  AUTHORS   Lei,Y. and Takahama,Y.
  TITLE     XCL1 and XCR1 in the immune system
  JOURNAL   Microbes Infect 14 (3), 262-267 (2012)
   PUBMED   22100876
  REMARK    Review article
REFERENCE   7  (bases 1 to 5039)
  AUTHORS   Maghazachi,A.A.
  TITLE     Intracellular signalling pathways induced by chemokines in natural
            killer cells
  JOURNAL   Cell Signal 11 (6), 385-390 (1999)
   PUBMED   10400311
  REMARK    Review article
REFERENCE   8  (bases 1 to 5039)
  AUTHORS   Yoshida,T., Imai,T., Kakizaki,M., Nishimura,M., Takagi,S. and
            Yoshie,O.
  TITLE     Identification of single C motif-1/lymphotactin receptor XCR1
  JOURNAL   J Biol Chem 273 (26), 16551-16554 (1998)
   PUBMED   9632725
REFERENCE   9  (bases 1 to 5039)
  AUTHORS   Heiber,M., Docherty,J.M., Shah,G., Nguyen,T., Cheng,R., Heng,H.H.,
            Marchese,A., Tsui,L.C., Shi,X., George,S.R. et al.
  TITLE     Isolation of three novel human genes encoding G protein-coupled
            receptors
  JOURNAL   DNA Cell Biol 14 (1), 25-35 (1995)
   PUBMED   7832990
REFERENCE   10 (bases 1 to 5039)
  AUTHORS   Gao,J.L., Kuhns,D.B., Tiffany,H.L., McDermott,D., Li,X., Francke,U.
            and Murphy,P.M.
  TITLE     Structure and functional expression of the human macrophage
            inflammatory protein 1 alpha/RANTES receptor
  JOURNAL   J Exp Med 177 (5), 1421-1427 (1993)
   PUBMED   7683036
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB189435.1, BC069075.1,
            BC095533.1 and AC099782.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001024644.1.
            
            Summary: The protein encoded by this gene is a chemokine receptor
            belonging to the G protein-coupled receptor superfamily. The family
            members are characterized by the presence of 7 transmembrane
            domains. The encoded protein transduces a signal by increasing the
            intracellular calcium ion level. The viral macrophage inflammatory
            protein-II is an antagonist of this receptor and blocks signaling.
            Some studies have implicated a cluster of genes at 3p21.31,
            including this gene, as associated with COVID-19 risk. The encoded
            protein may also play a role in cell proliferation and migration in
            several types of cancer. [provided by RefSeq, Jan 2023].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314277.1, DA847074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000309285.4/ ENSP00000310405.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AB189435.1         5-210
            207-1101            BC069075.1         109-1003
            1102-1247           BC095533.1         1055-1200
            1248-5039           AC099782.2         202932-206723       c
FEATURES             Location/Qualifiers
     source          1..5039
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5039
                     /gene="XCR1"
                     /gene_synonym="CCXCR1; GPR5"
                     /note="X-C motif chemokine receptor 1"
                     /db_xref="GeneID:2829"
                     /db_xref="HGNC:HGNC:1625"
                     /db_xref="MIM:600552"
     exon            1..67
                     /gene="XCR1"
                     /gene_synonym="CCXCR1; GPR5"
                     /inference="alignment:Splign:2.1.0"
     exon            68..5039
                     /gene="XCR1"
                     /gene_synonym="CCXCR1; GPR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1100
                     /gene="XCR1"
                     /gene_synonym="CCXCR1; GPR5"
                     /note="chemokine (C motif) XC receptor 1; lymphotactin
                     receptor; G protein-coupled receptor 5; chemokine (C
                     motif) receptor 1; XC chemokine receptor 1"
                     /codon_start=1
                     /product="chemokine XC receptor 1"
                     /protein_id="NP_001019815.1"
                     /db_xref="CCDS:CCDS2736.1"
                     /db_xref="GeneID:2829"
                     /db_xref="HGNC:HGNC:1625"
                     /db_xref="MIM:600552"
                     /translation="MESSGNPESTTFFYYDLQSQPCENQAWVFATLATTVLYCLVFLL
                     SLVGNSLVLWVLVKYESLESLTNIFILNLCLSDLVFACLLPVWISPYHWGWVLGDFLC
                     KLLNMIFSISLYSSIFFLTIMTIHRYLSVVSPLSTLRVPTLRCRVLVTMAVWVASILS
                     SILDTIFHKVLSSGCDYSELTWYLTSVYQHNLFFLLSLGIILFCYVEILRTLFRSRSK
                     RRHRTVKLIFAIVVAYFLSWGPYNFTLFLQTLFRTQIIRSCEAKQQLEYALLICRNLA
                     FSHCCFNPVLYVFVGVKFRTHLKHVLRQFWFCRLQAPSPASIPHSPGAFAYEGASFY"
     regulatory      2592..2597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XCR1"
                     /gene_synonym="CCXCR1; GPR5"
                     /note="hexamer: AATAAA"
     polyA_site      2619
                     /gene="XCR1"
                     /gene_synonym="CCXCR1; GPR5"
                     /note="major polyA site"
ORIGIN      
        1 aagtgaaata tgaaacagag aagcaccatt tctgcctcaa gacgcatgta aagaggtgta
       61 gattcagatg ctctaaacgt ccctgccatc tggtccagat ggagtcctca ggcaacccag
      121 agagcaccac ctttttttac tatgaccttc agagccagcc gtgtgagaac caggcctggg
      181 tctttgctac cctcgccacc actgtcctat actgcctggt gtttctcctc agcctagtgg
      241 gcaacagcct ggtcctgtgg gtcctggtga agtatgagag cctggagtcc ctcaccaaca
      301 tcttcatcct caacctgtgc ctctcagacc tggtgttcgc ctgcttgttg cctgtgtgga
      361 tctccccata ccactggggc tgggtgctgg gagacttcct ctgcaaactc ctcaatatga
      421 tcttctccat cagcctctac agcagcatct tcttcctgac catcatgacc atccaccgct
      481 acctgtcggt agtgagcccc ctctccaccc tgcgcgtccc caccctccgc tgccgggtgc
      541 tggtgaccat ggctgtgtgg gtagccagca tcctgtcctc catcctcgac accatcttcc
      601 acaaggtgct ttcttcgggc tgtgattatt ccgaactcac gtggtacctc acctccgtct
      661 accagcacaa cctcttcttc ctgctgtccc tggggattat cctgttctgc tacgtggaga
      721 tcctcaggac cctgttccgc tcacgctcca agcggcgcca ccgcacggtc aagctcatct
      781 tcgccatcgt ggtggcctac ttcctcagct ggggtcccta caacttcacc ctgtttctgc
      841 agacgctgtt tcggacccag atcatccgga gctgcgaggc caaacagcag ctagaatacg
      901 ccctgctcat ctgccgcaac ctcgccttct cccactgctg ctttaacccg gtgctctatg
      961 tcttcgtggg ggtcaagttc cgcacacacc tgaaacatgt tctccggcag ttctggttct
     1021 gccggctgca ggcacccagc ccagcctcga tcccccactc ccctggtgcc ttcgcctatg
     1081 agggcgcctc cttctactga ggggcctgtg gcggtgcagg cgcaggtgca ggtggacagg
     1141 gactggaatg ggggtcatgg agaagcgggc ctggaaggag cattgcagaa cacagcaggg
     1201 tggagacgtc tcctccgctg caggcgtgca gtgaaggtca ttcattacac cagtgggtcc
     1261 cgccagcctc tcatctgcgg gaaagtggct tcctacctgg gaattttata ctgccatcca
     1321 aaaaaacatt tcttgaactc tgagttcatc ttgcacgctc cttcatttag acatgtgttt
     1381 ctaatcactg tttagttcag aaggttctaa gacatgaaag gattctggga aaggtgcttc
     1441 cttggagact ttacagggcc taaagctcat tgtgataact gcacgatgct gacaagacaa
     1501 tgcctccctt ccctgactgt aaggttgtcc ctactggttt attcactttg gaggcgcctg
     1561 gctccgtatt cctcaggtac tgctggatga ggctgtctgg aagacaaaag tcgccatacc
     1621 ctgagataag cagtcatgtt gatatctgga ttctaaaaat ccacaactag actggagaaa
     1681 tgttctgtat cctggattca agtcctagcc cacgaactgg cccttaaaaa tttagctcat
     1741 aaatatttga ttgaaggaat gaatttaata agtgctacct tctgcactaa gtatttattc
     1801 agagaataca aagatgaatg agatacagtt gctaccctcc aggggccaac agcccagctc
     1861 caaaggctca cctaccttgg tgaacaccca ccttggtgaa ggcatctagg gtggactcct
     1921 ccgacatctc atccttccca ggtggatagt gagctgactt cacatttatc actttgtacc
     1981 taaagtgtcc tcctcctatt tggttgatgg tggtagctcc ccccacccac ccacactcca
     2041 aacctcaagt cctcttggag gcctgtgttt tcttttcctc aactcccaca gccaggtcca
     2101 aatgactatg cctgtctagt ggctttcaga gttgactcat tcttgccatt gcatgcccat
     2161 ggtttcatcc ctgaaacagg gcctcacttc cttggcatct ccccactgct cctctctttc
     2221 cccaccaggc tgttctctgc ccttacacca ggtgcttcaa aacccttagt ggctcctcat
     2281 tacttacaaa tgaagtccat acactttagc aaggctttca aggcctccac aatccgatgc
     2341 cagccaactt ttccattctt attccactct aagcctcctc cccacagcag cttgggatcc
     2401 aaccccaaaa caccactggc cttctttcag acacatatct ccccagtacc ctacctctag
     2461 gcatttgtca tgctgtcacc tgggcctgga acatgttcta gctgacaggc cagcttctcc
     2521 aggaagccct ccctaatctg caaattagaa cattctctgg gttgtcgtgg gattctgctt
     2581 gtcccctcta aaataaaaca accttgtgtt gtagttacac acatgcaatg tcttatctcc
     2641 ctgccccatc aggctgcaag cttcttgagg gcaggaacct ggtcttgaac cccagtgttc
     2701 tatcactgtg tgctcagtgg gagcaaagaa tcaacagctg ttattatcct tcagatttat
     2761 gcttcttggg gagccatgcc ctggggcaca ctttaccttc tttgtcccag gctgcttctc
     2821 tataaatatt aacctttctt tcctagtcta cactctcaga gagtagtaga aagagagtag
     2881 ggtgtagtag tagagagatt gcttatctct ctctgtggcg atggctatgc ttcaccttgc
     2941 cttctagttc atggtacgca tccctgcctc tcacactggc ccattgcttc acacccaagg
     3001 gcataaataa aagccactct ctaaactttg ccatgccaca aagacctggg cccaatctgt
     3061 gaacctgatt tggctctggc gtggggattt ggaaaagctt cccatgcgat tctgacatgc
     3121 accttcatta ggtacatttg gctgcaactt ttttaaaaaa tgaggagtcc agagtcttct
     3181 acagtccctt gagcagggat ttgcacacag aagacactca atatcttgtt attgaataaa
     3241 gtagatacca atgtagccct ctggccaacc tagagagagc ttgtaaggca tttccccttc
     3301 agttccagat gcaacttcaa tgatctattt gccaatgggg cagtagatct ggaggagttt
     3361 atcggtctag ggaagagcca gggcctagtt ttaataatga ggccagtagc acctgctgga
     3421 cagggctggg cggcatacca gtgaagggaa ggggctccca tggacctacc tgccagccta
     3481 caggtggggc cactactcac caccgatggg agaaacagca taaggaagag ataatgaggt
     3541 agtttgtggt atcagagcta agcctatggg cttctagttg gcctaatctt tcaaacacag
     3601 tttcacactg attcttaaca ttttgttcaa cttttactca gagggcaggc tgagccaggg
     3661 agcaaaaagg caaaggactc ctactcacat acccacttag caaaaccaaa gcaccttggg
     3721 ctttgaaccc acccttctta gaaggcaggt ttgggggttg aggccccttg agaagctcac
     3781 ttcaccctct ccccatgcca tcccattcct acccatccca agatgcttct cttgtatttc
     3841 tttcagcaca tccagccatc tccctgggag cgtttcatat ctgactcttt atacttccag
     3901 tgatgttttg gcatccctaa tagactggct cccaaggcag tctttaatca ggagtcttcc
     3961 cctaatctag ctcctcaaga acccaaggga agaggcacaa agagaagtat gaataggaag
     4021 atagaagggt aacccagtca gagagggagt ggcagatgac actgctgaaa aggagtttcc
     4081 agagagttgc acaccatgag ccacgctgtc tgtccctgac cacaacctcc actggccacc
     4141 acctcctggg cttcccctcc ctccacccac agaaaccatt gctcaatctc aactggactc
     4201 ttgcaggcct atctctccct ccaaacagag atgtcctgga cacagagctg cagacctcta
     4261 accactcctg gaacataaaa aaacccacgg tggttctaca gcatttacac ctccagtttc
     4321 cctcagacag aatccagaag agaagaacct cgctgatctc tgagcggagc atgtctccaa
     4381 gctcaggcca gccccagaac tccaatggcc tcaactggag tggaaatccc tcaaaggcac
     4441 aaacccagtt cctaccatct ccctcagtgc ctggcaatgt ttgtggttgg ttgagtgagt
     4501 taacaggaga ccatcttttg gccttttttc tacctctgtt ttctcttact atacttgcct
     4561 acatctcatc ttctggtcaa caccaggtac tcaccccatg agcttcttgt gaacttgtct
     4621 ggggcccacc ggcctaaaca tcatcttttt tgtttggaat taagctttgt tgaacttttc
     4681 acaggtttca tttatgcaaa tgcctgtgat gggacaaaaa ggtctgcaaa catggaaacc
     4741 tggtctaaag atgtccaaag taaactgtct gtggagtcga atgacatttg agccctggac
     4801 ctaaactcca aatccaagct ctttcccact gtgaccttgg gcctctcaag gctcagtttc
     4861 ctcacctata aactgtagag aagccaataa cagactcatc cacactatga ggctgtgcat
     4921 aaggtcatgt atgtaaaact acttgctttg ttgatcattc tgtcccagat aagtatgaat
     4981 tattatgcat catttcatta aacaagaaag cttcactgtg ttaatatgca caagtaaaa
//
