LOCUS       NP_001019815             333 aa            linear   PRI 01-JUN-2024
DEFINITION  chemokine XC receptor 1 [Homo sapiens].
ACCESSION   NP_001019815
VERSION     NP_001019815.1
DBSOURCE    REFSEQ: accession NM_001024644.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 333)
  AUTHORS   Cui,L., Zhu,L., Chen,J., Li,C., Yu,Y. and Xu,S.
  TITLE     Systematic Pan-Cancer Analysis Reveals X-C Motif Chemokine Receptor
            1 as a Prognostic and Immunological Biomarker
  JOURNAL   Genes (Basel) 14 (10), 1961 (2023)
   PUBMED   37895310
  REMARK    GeneRIF: Systematic Pan-Cancer Analysis Reveals X-C Motif Chemokine
            Receptor 1 as a Prognostic and Immunological Biomarker.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 333)
  AUTHORS   Thibord,F., Chan,M.V., Chen,M.H. and Johnson,A.D.
  TITLE     A year of COVID-19 GWAS results from the GRASP portal reveals
            potential genetic risk factors
  JOURNAL   HGG Adv 3 (2), 100095 (2022)
   PUBMED   35224516
REFERENCE   3  (residues 1 to 333)
  AUTHORS   Wu,L., Zhu,J., Liu,D., Sun,Y. and Wu,C.
  TITLE     An integrative multiomics analysis identifies putative causal genes
            for COVID-19 severity
  JOURNAL   Genet Med 23 (11), 2076-2086 (2021)
   PUBMED   34183789
REFERENCE   4  (residues 1 to 333)
  AUTHORS   Baranova,A., Cao,H. and Zhang,F.
  TITLE     Unraveling Risk Genes of COVID-19 by Multi-Omics Integrative
            Analyses
  JOURNAL   Front Med (Lausanne) 8, 738687 (2021)
   PUBMED   34557504
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 333)
  AUTHORS   Ellinghaus,D., Degenhardt,F., Bujanda,L., Buti,M., Albillos,A.,
            Invernizzi,P., Fernandez,J., Prati,D., Baselli,G., Asselta,R.,
            Grimsrud,M.M., Milani,C., Aziz,F., Kassens,J., May,S., Wendorff,M.,
            Wienbrandt,L., Uellendahl-Werth,F., Zheng,T., Yi,X., de Pablo,R.,
            Chercoles,A.G., Palom,A., Garcia-Fernandez,A.E.,
            Rodriguez-Frias,F., Zanella,A., Bandera,A., Protti,A., Aghemo,A.,
            Lleo,A., Biondi,A., Caballero-Garralda,A., Gori,A., Tanck,A.,
            Carreras Nolla,A., Latiano,A., Fracanzani,A.L., Peschuck,A.,
            Julia,A., Pesenti,A., Voza,A., Jimenez,D., Mateos,B., Nafria
            Jimenez,B., Quereda,C., Paccapelo,C., Gassner,C., Angelini,C.,
            Cea,C., Solier,A., Pestana,D., Muniz-Diaz,E., Sandoval,E.,
            Paraboschi,E.M., Navas,E., Garcia Sanchez,F., Ceriotti,F.,
            Martinelli-Boneschi,F., Peyvandi,F., Blasi,F., Tellez,L.,
            Blanco-Grau,A., Hemmrich-Stanisak,G., Grasselli,G., Costantino,G.,
            Cardamone,G., Foti,G., Aneli,S., Kurihara,H., ElAbd,H., My,I.,
            Galvan-Femenia,I., Martin,J., Erdmann,J., Ferrusquia-Acosta,J.,
            Garcia-Etxebarria,K., Izquierdo-Sanchez,L., Bettini,L.R., Sumoy,L.,
            Terranova,L., Moreira,L., Santoro,L., Scudeller,L., Mesonero,F.,
            Roade,L., Ruhlemann,M.C., Schaefer,M., Carrabba,M.,
            Riveiro-Barciela,M., Figuera Basso,M.E., Valsecchi,M.G.,
            Hernandez-Tejero,M., Acosta-Herrera,M., D'Angio,M., Baldini,M.,
            Cazzaniga,M., Schulzky,M., Cecconi,M., Wittig,M., Ciccarelli,M.,
            Rodriguez-Gandia,M., Bocciolone,M., Miozzo,M., Montano,N.,
            Braun,N., Sacchi,N., Martinez,N., Ozer,O., Palmieri,O., Faverio,P.,
            Preatoni,P., Bonfanti,P., Omodei,P., Tentorio,P., Castro,P.,
            Rodrigues,P.M., Blandino Ortiz,A., de Cid,R., Ferrer,R.,
            Gualtierotti,R., Nieto,R., Goerg,S., Badalamenti,S., Marsal,S.,
            Matullo,G., Pelusi,S., Juzenas,S., Aliberti,S., Monzani,V.,
            Moreno,V., Wesse,T., Lenz,T.L., Pumarola,T., Rimoldi,V., Bosari,S.,
            Albrecht,W., Peter,W., Romero-Gomez,M., D'Amato,M., Duga,S.,
            Banales,J.M., Hov,J.R., Folseraas,T., Valenti,L., Franke,A. and
            Karlsen,T.H.
  CONSRTM   Severe Covid-19 GWAS Group
  TITLE     Genomewide Association Study of Severe Covid-19 with Respiratory
            Failure
  JOURNAL   N Engl J Med 383 (16), 1522-1534 (2020)
   PUBMED   32558485
REFERENCE   6  (residues 1 to 333)
  AUTHORS   Lei,Y. and Takahama,Y.
  TITLE     XCL1 and XCR1 in the immune system
  JOURNAL   Microbes Infect 14 (3), 262-267 (2012)
   PUBMED   22100876
  REMARK    Review article
REFERENCE   7  (residues 1 to 333)
  AUTHORS   Maghazachi,A.A.
  TITLE     Intracellular signalling pathways induced by chemokines in natural
            killer cells
  JOURNAL   Cell Signal 11 (6), 385-390 (1999)
   PUBMED   10400311
  REMARK    Review article
REFERENCE   8  (residues 1 to 333)
  AUTHORS   Yoshida,T., Imai,T., Kakizaki,M., Nishimura,M., Takagi,S. and
            Yoshie,O.
  TITLE     Identification of single C motif-1/lymphotactin receptor XCR1
  JOURNAL   J Biol Chem 273 (26), 16551-16554 (1998)
   PUBMED   9632725
REFERENCE   9  (residues 1 to 333)
  AUTHORS   Heiber,M., Docherty,J.M., Shah,G., Nguyen,T., Cheng,R., Heng,H.H.,
            Marchese,A., Tsui,L.C., Shi,X., George,S.R. et al.
  TITLE     Isolation of three novel human genes encoding G protein-coupled
            receptors
  JOURNAL   DNA Cell Biol 14 (1), 25-35 (1995)
   PUBMED   7832990
REFERENCE   10 (residues 1 to 333)
  AUTHORS   Gao,J.L., Kuhns,D.B., Tiffany,H.L., McDermott,D., Li,X., Francke,U.
            and Murphy,P.M.
  TITLE     Structure and functional expression of the human macrophage
            inflammatory protein 1 alpha/RANTES receptor
  JOURNAL   J Exp Med 177 (5), 1421-1427 (1993)
   PUBMED   7683036
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB189435.1, BC069075.1,
            BC095533.1 and AC099782.2.
            
            Summary: The protein encoded by this gene is a chemokine receptor
            belonging to the G protein-coupled receptor superfamily. The family
            members are characterized by the presence of 7 transmembrane
            domains. The encoded protein transduces a signal by increasing the
            intracellular calcium ion level. The viral macrophage inflammatory
            protein-II is an antagonist of this receptor and blocks signaling.
            Some studies have implicated a cluster of genes at 3p21.31,
            including this gene, as associated with COVID-19 risk. The encoded
            protein may also play a role in cell proliferation and migration in
            several types of cancer. [provided by RefSeq, Jan 2023].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314277.1, DA847074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000309285.4/ ENSP00000310405.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..333
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     Protein         1..333
                     /product="chemokine XC receptor 1"
                     /note="chemokine (C motif) XC receptor 1; lymphotactin
                     receptor; G protein-coupled receptor 5; chemokine (C
                     motif) receptor 1; XC chemokine receptor 1"
                     /calculated_mol_wt=38377
     Region          32..298
                     /region_name="7tmA_XCR1"
                     /note="XC chemokine receptor 1, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     cd15182"
                     /db_xref="CDD:341337"
     Region          32..59
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:341337"
     Site            32..59
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P46094.1)"
     Site            order(38,87,90,106,109..110,175..180,182,185..186,241,248,
                     251,262,266,269..270,273)
                     /site_type="other"
                     /note="putative chemokine binding site [polypeptide
                     binding]"
                     /db_xref="CDD:341337"
     Region          66..91
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:341337"
     Site            70..89
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P46094.1)"
     Region          102..132
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:341337"
     Site            104..125
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P46094.1)"
     Site            143..167
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P46094.1)"
     Region          144..166
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:341337"
     Region          182..211
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:341337"
     Site            191..209
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P46094.1)"
     Region          218..248
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:341337"
     Site            226..250
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P46094.1)"
     Region          266..291
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:341337"
     Site            268..291
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P46094.1)"
     CDS             1..333
                     /gene="XCR1"
                     /gene_synonym="CCXCR1; GPR5"
                     /coded_by="NM_001024644.2:99..1100"
                     /db_xref="CCDS:CCDS2736.1"
                     /db_xref="GeneID:2829"
                     /db_xref="HGNC:HGNC:1625"
                     /db_xref="MIM:600552"
ORIGIN      
        1 messgnpest tffyydlqsq pcenqawvfa tlattvlycl vfllslvgns lvlwvlvkye
       61 slesltnifi lnlclsdlvf acllpvwisp yhwgwvlgdf lckllnmifs islyssiffl
      121 timtihryls vvsplstlrv ptlrcrvlvt mavwvasils sildtifhkv lssgcdysel
      181 twyltsvyqh nlffllslgi ilfcyveilr tlfrsrskrr hrtvklifai vvayflswgp
      241 ynftlflqtl frtqiirsce akqqleyall icrnlafshc cfnpvlyvfv gvkfrthlkh
      301 vlrqfwfcrl qapspasiph spgafayega sfy
//
