LOCUS       NM_003175                562 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens X-C motif chemokine ligand 2 (XCL2), mRNA.
ACCESSION   NM_003175
VERSION     NM_003175.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 562)
  AUTHORS   Chen,W., Zou,F., Song,T., Xia,Y., Xing,J., Rao,T., Zhou,X.,
            Ning,J., Zhao,S., Yu,W. and Cheng,F.
  TITLE     Comprehensive analysis reveals XCL2 as a cancer prognosis and
            immune infiltration-related biomarker
  JOURNAL   Aging (Albany NY) 15 (21), 11891-11917 (2023)
   PUBMED   37905956
  REMARK    GeneRIF: Comprehensive analysis reveals XCL2 as a cancer prognosis
            and immune infiltration-related biomarker.
REFERENCE   2  (bases 1 to 562)
  AUTHORS   Wang,C. and Zhang,R.
  TITLE     The effect of ITLN1, XCL2 and DOT1L variants on knee osteoarthritis
            risk in the Han population
  JOURNAL   Arch Orthop Trauma Surg 143 (8), 4821-4831 (2023)
   PUBMED   36773049
  REMARK    GeneRIF: The effect of ITLN1, XCL2 and DOT1L variants on knee
            osteoarthritis risk in the Han population.
REFERENCE   3  (bases 1 to 562)
  AUTHORS   Cao,Q., Liu,D., Chen,Z., Wang,M., Wu,M. and Zeng,G.
  TITLE     Upregulated X-C motif chemokine ligand 2 (XCL2) is associated with
            poor prognosis and increased immune infiltration in clear cell
            renal cell carcinoma
  JOURNAL   Cell Signal 102, 110556 (2023)
   PUBMED   36503163
  REMARK    GeneRIF: Upregulated X-C motif chemokine ligand 2 (XCL2) is
            associated with poor prognosis and increased immune infiltration in
            clear cell renal cell carcinoma.
REFERENCE   4  (bases 1 to 562)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 562)
  AUTHORS   von Hundelshausen,P., Agten,S.M., Eckardt,V., Blanchet,X.,
            Schmitt,M.M., Ippel,H., Neideck,C., Bidzhekov,K., Leberzammer,J.,
            Wichapong,K., Faussner,A., Drechsler,M., Grommes,J., van
            Geffen,J.P., Li,H., Ortega-Gomez,A., Megens,R.T., Naumann,R.,
            Dijkgraaf,I., Nicolaes,G.A., Doring,Y., Soehnlein,O., Lutgens,E.,
            Heemskerk,J.W., Koenen,R.R., Mayo,K.H., Hackeng,T.M. and Weber,C.
  TITLE     Chemokine interactome mapping enables tailored intervention in
            acute and chronic inflammation
  JOURNAL   Sci Transl Med 9 (384) (2017)
   PUBMED   28381538
REFERENCE   6  (bases 1 to 562)
  AUTHORS   Dowal,L., Provitera,P. and Scarlata,S.
  TITLE     Stable association between G alpha(q) and phospholipase C beta 1 in
            living cells
  JOURNAL   J Biol Chem 281 (33), 23999-24014 (2006)
   PUBMED   16754659
REFERENCE   7  (bases 1 to 562)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (bases 1 to 562)
  AUTHORS   Yoshida,T., Imai,T., Kakizaki,M., Nishimura,M., Takagi,S. and
            Yoshie,O.
  TITLE     Identification of single C motif-1/lymphotactin receptor XCR1
  JOURNAL   J Biol Chem 273 (26), 16551-16554 (1998)
   PUBMED   9632725
REFERENCE   9  (bases 1 to 562)
  AUTHORS   Yoshida,T., Imai,T., Takagi,S., Nishimura,M., Ishikawa,I., Yaoi,T.
            and Yoshie,O.
  TITLE     Structure and expression of two highly related genes encoding
            SCM-1/human lymphotactin
  JOURNAL   FEBS Lett 395 (1), 82-88 (1996)
   PUBMED   8849694
REFERENCE   10 (bases 1 to 562)
  AUTHORS   Yoshida,T., Imai,T., Kakizaki,M., Nishimura,M. and Yoshie,O.
  TITLE     Molecular cloning of a novel C or gamma type chemokine, SCM-1
  JOURNAL   FEBS Lett 360 (2), 155-159 (1995)
   PUBMED   7875320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070308.1 and BE218461.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003175.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070308.1, BE218461.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367819.3/ ENSP00000356793.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               BC070308.1         1-444
            445-562             BE218461.1         5-122               c
FEATURES             Location/Qualifiers
     source          1..562
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..562
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
                     /note="X-C motif chemokine ligand 2"
                     /db_xref="GeneID:6846"
                     /db_xref="HGNC:HGNC:10646"
                     /db_xref="MIM:604828"
     exon            1..94
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..378
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
                     /note="small inducible cytokine subfamily C, member 2;
                     cytokine SCM-1 beta; c motif chemokine 2; XC chemokine
                     ligand 2; chemokine (C motif) ligand 2"
                     /codon_start=1
                     /product="cytokine SCM-1 beta precursor"
                     /protein_id="NP_003166.1"
                     /db_xref="CCDS:CCDS1273.1"
                     /db_xref="GeneID:6846"
                     /db_xref="HGNC:HGNC:10646"
                     /db_xref="MIM:604828"
                     /translation="MRLLILALLGICSLTAYIVEGVGSEVSHRRTCVSLTTQRLPVSR
                     IKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGT
                     QQSTNTAVTLTG"
     exon            95..209
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..562
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      478..483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
                     /note="hexamer: AATAAA"
     polyA_site      503
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
     regulatory      543..548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
                     /note="hexamer: AATAAA"
     polyA_site      562
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
                     /note="major polyA site"
ORIGIN      
        1 actctccctg cacagctcag cgggacctca gccatgagac ttctcatcct ggccctcctt
       61 ggcatctgct ctctcactgc atacattgtg gaaggtgtag ggagtgaagt ctcacatagg
      121 aggacctgtg tgagcctcac tacccagcga ctgccagtta gcagaatcaa gacctacacc
      181 atcacggaag gctccttgag agcagtaatt tttattacca aacgtggcct aaaagtctgt
      241 gctgatccac aagccacgtg ggtgagagac gtggtcagga gcatggacag gaaatccaac
      301 accagaaata acatgatcca gaccaagcca acaggaaccc agcaatcgac caatacagct
      361 gtgaccctga ctggctagta gtctctggca ccctgtccgt ctccagccag ccagctcatt
      421 tcactttaca ccctcatgga ctgagattat actcaccttt tatgaaagca ctgcatgaat
      481 aaaattattc ctttgtattt ttacttttaa atgtcttctg tattcactta tatgttctaa
      541 ttaataaatt atttattatt aa
//
