LOCUS       NP_003166                114 aa            linear   PRI 01-JUN-2024
DEFINITION  cytokine SCM-1 beta precursor [Homo sapiens].
ACCESSION   NP_003166
VERSION     NP_003166.1
DBSOURCE    REFSEQ: accession NM_003175.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 114)
  AUTHORS   Chen,W., Zou,F., Song,T., Xia,Y., Xing,J., Rao,T., Zhou,X.,
            Ning,J., Zhao,S., Yu,W. and Cheng,F.
  TITLE     Comprehensive analysis reveals XCL2 as a cancer prognosis and
            immune infiltration-related biomarker
  JOURNAL   Aging (Albany NY) 15 (21), 11891-11917 (2023)
   PUBMED   37905956
  REMARK    GeneRIF: Comprehensive analysis reveals XCL2 as a cancer prognosis
            and immune infiltration-related biomarker.
REFERENCE   2  (residues 1 to 114)
  AUTHORS   Wang,C. and Zhang,R.
  TITLE     The effect of ITLN1, XCL2 and DOT1L variants on knee osteoarthritis
            risk in the Han population
  JOURNAL   Arch Orthop Trauma Surg 143 (8), 4821-4831 (2023)
   PUBMED   36773049
  REMARK    GeneRIF: The effect of ITLN1, XCL2 and DOT1L variants on knee
            osteoarthritis risk in the Han population.
REFERENCE   3  (residues 1 to 114)
  AUTHORS   Cao,Q., Liu,D., Chen,Z., Wang,M., Wu,M. and Zeng,G.
  TITLE     Upregulated X-C motif chemokine ligand 2 (XCL2) is associated with
            poor prognosis and increased immune infiltration in clear cell
            renal cell carcinoma
  JOURNAL   Cell Signal 102, 110556 (2023)
   PUBMED   36503163
  REMARK    GeneRIF: Upregulated X-C motif chemokine ligand 2 (XCL2) is
            associated with poor prognosis and increased immune infiltration in
            clear cell renal cell carcinoma.
REFERENCE   4  (residues 1 to 114)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 114)
  AUTHORS   von Hundelshausen,P., Agten,S.M., Eckardt,V., Blanchet,X.,
            Schmitt,M.M., Ippel,H., Neideck,C., Bidzhekov,K., Leberzammer,J.,
            Wichapong,K., Faussner,A., Drechsler,M., Grommes,J., van
            Geffen,J.P., Li,H., Ortega-Gomez,A., Megens,R.T., Naumann,R.,
            Dijkgraaf,I., Nicolaes,G.A., Doring,Y., Soehnlein,O., Lutgens,E.,
            Heemskerk,J.W., Koenen,R.R., Mayo,K.H., Hackeng,T.M. and Weber,C.
  TITLE     Chemokine interactome mapping enables tailored intervention in
            acute and chronic inflammation
  JOURNAL   Sci Transl Med 9 (384) (2017)
   PUBMED   28381538
REFERENCE   6  (residues 1 to 114)
  AUTHORS   Dowal,L., Provitera,P. and Scarlata,S.
  TITLE     Stable association between G alpha(q) and phospholipase C beta 1 in
            living cells
  JOURNAL   J Biol Chem 281 (33), 23999-24014 (2006)
   PUBMED   16754659
REFERENCE   7  (residues 1 to 114)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (residues 1 to 114)
  AUTHORS   Yoshida,T., Imai,T., Kakizaki,M., Nishimura,M., Takagi,S. and
            Yoshie,O.
  TITLE     Identification of single C motif-1/lymphotactin receptor XCR1
  JOURNAL   J Biol Chem 273 (26), 16551-16554 (1998)
   PUBMED   9632725
REFERENCE   9  (residues 1 to 114)
  AUTHORS   Yoshida,T., Imai,T., Takagi,S., Nishimura,M., Ishikawa,I., Yaoi,T.
            and Yoshie,O.
  TITLE     Structure and expression of two highly related genes encoding
            SCM-1/human lymphotactin
  JOURNAL   FEBS Lett 395 (1), 82-88 (1996)
   PUBMED   8849694
REFERENCE   10 (residues 1 to 114)
  AUTHORS   Yoshida,T., Imai,T., Kakizaki,M., Nishimura,M. and Yoshie,O.
  TITLE     Molecular cloning of a novel C or gamma type chemokine, SCM-1
  JOURNAL   FEBS Lett 360 (2), 155-159 (1995)
   PUBMED   7875320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070308.1 and BE218461.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070308.1, BE218461.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367819.3/ ENSP00000356793.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..114
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     Protein         1..114
                     /product="cytokine SCM-1 beta precursor"
                     /note="small inducible cytokine subfamily C, member 2;
                     cytokine SCM-1 beta; c motif chemokine 2; XC chemokine
                     ligand 2; chemokine (C motif) ligand 2"
                     /calculated_mol_wt=10322
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2263
     mat_peptide     22..114
                     /product="Cytokine SCM-1 beta. /id=PRO_0000005251"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UBD3.1)"
                     /calculated_mol_wt=10322
     Region          22..93
                     /region_name="Chemokine_C"
                     /note="C or lymphotactin subgroup, 1 of 4 subgroup
                     designations of chemokines based on the arrangement of two
                     N-terminal, conserved cysteine residues. Most of the known
                     chemokines (cd00169) belong to either the CC (cd00272) or
                     CXC (cd00273) subclass. The two...; cd00271"
                     /db_xref="CDD:238169"
     Site            order(22..46,52..56,76..93)
                     /site_type="active"
                     /note="putative receptor binding site [active]"
                     /db_xref="CDD:238169"
     Site            33..45
                     /site_type="active"
                     /note="N-loop [active]"
                     /db_xref="CDD:238169"
     Site            order(44,46,63..64,87,91)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238169"
     Site            52..56
                     /site_type="other"
                     /note="30s-loop"
                     /db_xref="CDD:238169"
     Site            order(56,78,82,86)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238169"
     Site            63..64
                     /site_type="other"
                     /note="40s-loop"
                     /db_xref="CDD:238169"
     Site            88..93
                     /site_type="other"
                     /note="C-terminal tail"
                     /db_xref="CDD:238169"
     Region          91..114
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UBD3.1)"
     CDS             1..114
                     /gene="XCL2"
                     /gene_synonym="SCM-1b; SCM1B; SCYC2"
                     /coded_by="NM_003175.4:34..378"
                     /db_xref="CCDS:CCDS1273.1"
                     /db_xref="GeneID:6846"
                     /db_xref="HGNC:HGNC:10646"
                     /db_xref="MIM:604828"
ORIGIN      
        1 mrllilallg icsltayive gvgsevshrr tcvslttqrl pvsriktyti tegslravif
       61 itkrglkvca dpqatwvrdv vrsmdrksnt rnnmiqtkpt gtqqstntav tltg
//
