LOCUS       NM_002995               1227 bp    mRNA    linear   PRI 26-JUN-2023
DEFINITION  Homo sapiens X-C motif chemokine ligand 1 (XCL1), mRNA.
ACCESSION   NM_002995
VERSION     NM_002995.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1227)
  AUTHORS   Zanetti-Polzi L, Daidone I, Iacobucci C and Amadei A.
  TITLE     Thermodynamic Evolution of a Metamorphic Protein: A
            Theoretical-Computational Study of Human Lymphotactin
  JOURNAL   Protein J 42 (3), 219-228 (2023)
   PUBMED   37233895
  REMARK    GeneRIF: Thermodynamic Evolution of a Metamorphic Protein: A
            Theoretical-Computational Study of Human Lymphotactin.
REFERENCE   2  (bases 1 to 1227)
  AUTHORS   Bandow K, Smith A, Watkins T, Shenk S, Gerami-Naini B and Garlick
            JA.
  TITLE     CC chemokine ligand 20 (CCL20) positively regulates collagen type I
            production in 3D skin equivalent tissues
  JOURNAL   Exp Dermatol 32 (4), 379-391 (2023)
   PUBMED   36398464
REFERENCE   3  (bases 1 to 1227)
  AUTHORS   Saeidi M, Vahidi Z, Nahayati MA, Rezaiyan MK, Zemorshidi F,
            Mahdifar M, Hafezi F, Moghadam SM, Saghi E, Akbarpour E, Boostani R
            and Rafatpanah H.
  TITLE     XCL1, a serum biomarker in neurological diseases; HTLV-1-associated
            myelopathy and multiple sclerosis
  JOURNAL   Microb Pathog 174, 105962 (2023)
   PUBMED   36572194
  REMARK    GeneRIF: XCL1, a serum biomarker in neurological diseases;
            HTLV-1-associated myelopathy and multiple sclerosis.
REFERENCE   4  (bases 1 to 1227)
  AUTHORS   Zhang Y, Chen X, Fan Y, Liu J and Yuan L.
  TITLE     XCL1 Aggravates Diabetic Nephropathy-Mediated Renal Glomerular
            Endothelial Cell Apoptosis and Inflammatory Response via Regulating
            p53/Nuclear Factor-Kappa B Pathway
  JOURNAL   Nephron 146 (1), 84-98 (2022)
   PUBMED   34518457
  REMARK    GeneRIF: XCL1 Aggravates Diabetic Nephropathy-Mediated Renal
            Glomerular Endothelial Cell Apoptosis and Inflammatory Response via
            Regulating p53/Nuclear Factor-Kappa B Pathway.
REFERENCE   5  (bases 1 to 1227)
  AUTHORS   Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J and
            Oppenheim JJ.
  TITLE     Many chemokines including CCL20/MIP-3alpha display antimicrobial
            activity
  JOURNAL   J Leukoc Biol 74 (3), 448-455 (2003)
   PUBMED   12949249
  REMARK    GeneRIF: XCL1 displays antimicrobial activity against E. coli and
            S. aureus.
REFERENCE   6  (bases 1 to 1227)
  AUTHORS   Dorner B, Muller S, Entschladen F, Schroder JM, Franke P, Kraft R,
            Friedl P, Clark-Lewis I and Kroczek RA.
  TITLE     Purification, structural analysis, and function of natural ATAC, a
            cytokine secreted by CD8(+) T cells
  JOURNAL   J Biol Chem 272 (13), 8817-8823 (1997)
   PUBMED   9079718
REFERENCE   7  (bases 1 to 1227)
  AUTHORS   Kennedy J, Kelner GS, Kleyensteuber S, Schall TJ, Weiss MC, Yssel
            H, Schneider PV, Cocks BG, Bacon KB and Zlotnik A.
  TITLE     Molecular cloning and functional characterization of human
            lymphotactin
  JOURNAL   J Immunol 155 (1), 203-209 (1995)
   PUBMED   7602097
REFERENCE   8  (bases 1 to 1227)
  AUTHORS   Muller S, Dorner B, Korthauer U, Mages HW, D'Apuzzo M, Senger G and
            Kroczek RA.
  TITLE     Cloning of ATAC, an activation-induced, chemokine-related molecule
            exclusively expressed in CD8+ T lymphocytes
  JOURNAL   Eur J Immunol 25 (6), 1744-1748 (1995)
   PUBMED   7615002
REFERENCE   9  (bases 1 to 1227)
  AUTHORS   Yoshida T, Imai T, Kakizaki M, Nishimura M and Yoshie O.
  TITLE     Molecular cloning of a novel C or gamma type chemokine, SCM-1
  JOURNAL   FEBS Lett 360 (2), 155-159 (1995)
   PUBMED   7875320
REFERENCE   10 (bases 1 to 1227)
  AUTHORS   Kelner GS, Kennedy J, Bacon KB, Kleyensteuber S, Largaespada DA,
            Jenkins NA, Copeland NG, Bazan JF, Moore KW, Schall TJ et al.
  TITLE     Lymphotactin: a cytokine that represents a new class of chemokine
  JOURNAL   Science 266 (5189), 1395-1399 (1994)
   PUBMED   7973732
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF433809.1 and D43768.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002995.2.
            
            Summary: This antimicrobial gene encodes a member of the chemokine
            superfamily. Chemokines function in inflammatory and immunological
            responses, inducing leukocyte migration and activation. The encoded
            protein is a member of the C-chemokine subfamily, retaining only
            two of four cysteines conserved in other chemokines, and is thought
            to be specifically chemotactic for T cells. This gene and a closely
            related family member are located on the long arm of chromosome 1.
            [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D43768.1, BC070309.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000367818.4/
                                                  ENSP00000356792.3
            Protein has antimicrobial activity :: PMID: 12949249
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BF433809.1         133-145
            14-1227             D43768.1           1-1214
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..1227
                     /gene="XCL1"
                     /gene_synonym="ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1;
                     SCM1A; SCYC1"
                     /note="X-C motif chemokine ligand 1"
                     /db_xref="GeneID:6375"
                     /db_xref="HGNC:HGNC:10645"
                     /db_xref="MIM:600250"
     exon            1..94
                     /gene="XCL1"
                     /gene_synonym="ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1;
                     SCM1A; SCYC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..378
                     /gene="XCL1"
                     /gene_synonym="ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1;
                     SCM1A; SCYC1"
                     /note="lymphotactin; small inducible cytokine subfamily C,
                     member 1 (lymphotactin); single cysteine motif 1a;
                     SCM-1-alpha; lymphotaxin; cytokine SCM-1; c motif
                     chemokine 1; XC chemokine ligand 1; small-inducible
                     cytokine C1; chemokine (C motif) ligand 1"
                     /codon_start=1
                     /product="lymphotactin precursor"
                     /protein_id="NP_002986.1"
                     /db_xref="CCDS:CCDS1274.1"
                     /db_xref="GeneID:6375"
                     /db_xref="HGNC:HGNC:10645"
                     /db_xref="MIM:600250"
                     /translation="MRLLILALLGICSLTAYIVEGVGSEVSDKRTCVSLTTQRLPVSR
                     IKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGT
                     QQSTNTAVTLTG"
     exon            95..209
                     /gene="XCL1"
                     /gene_synonym="ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1;
                     SCM1A; SCYC1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..1227
                     /gene="XCL1"
                     /gene_synonym="ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1;
                     SCM1A; SCYC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1203..1208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XCL1"
                     /gene_synonym="ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1;
                     SCM1A; SCYC1"
                     /note="hexamer: ATTAAA"
     polyA_site      1227
                     /gene="XCL1"
                     /gene_synonym="ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM1;
                     SCM1A; SCYC1"
                     /note="major polyA site"
ORIGIN      
        1 actctccttg cacagctcag caggacctca gccatgagac ttctcatcct ggccctcctt
       61 ggcatctgct ctctcactgc atacattgtg gaaggtgtag ggagtgaagt ctcagataag
      121 aggacctgtg tgagcctcac tacccagcga ctgccggtta gcagaatcaa gacctacacc
      181 atcacggaag gctccttgag agcagtaatt tttattacca aacgtggcct aaaagtctgt
      241 gctgatccac aagccacatg ggtgagagac gtggtcagga gcatggacag gaaatccaac
      301 accagaaata acatgatcca gaccaagcca acaggaaccc agcaatcgac caatacagct
      361 gtgactctga ctggctagta gtctctggca ccctgtccgt ctccagccag ccagctcatt
      421 tcactttaca cgctcatgga ctgagtttat actcaccttt tatgaaagca ctgcatgaat
      481 aaaattattc ctttgtattt ttacttttaa atgtcttctg tattcactta tatgttctaa
      541 ttaataaatt atttattatt aagaatagtt ccctagtcta ttcattatat ttagggaaag
      601 gtagtgtatc attgttgttt gatttctgac cttgtacctc tctttgatgg taaccataat
      661 ggaagagatt ctggctagtg tctatcagag gtgaaagcta tatcaatctc tcttagagtc
      721 cagcttgtaa tggttcttta cacatcagtc acaagttaca gctgtgacaa tggcaacaat
      781 ttgagatgta tttcaacttg tctctataat agaattctgt ttatagaata agggagaaaa
      841 taatccagtc ttcactgggt tcccattctg agggtccact actcaaaaat ttgcttcact
      901 caattttttt cacctctttg tgttttattt tggtgtccta ttaaaggaat aaaatgacac
      961 aacttgtccc ttttttgtcc cattagcaaa aattagaatt ttggtataaa gaaactttat
     1021 tcaagtaaaa atcaataccc tttgaattgg acaataatct cactacctta ttaggatttc
     1081 tgtatttgcc attacgctag ttatcatgca tgttatgctt tactgcgaat aagcttttaa
     1141 tgctccaaat gctgacccat gcaatatttc ctcatgtgat cacaatttgc agtaaacttt
     1201 taattaaatg ctcatctggt aactcaa
//
