LOCUS       NM_001393999            1637 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens X-box binding protein 1 (XBP1), transcript variant 3,
            mRNA.
ACCESSION   NM_001393999
VERSION     NM_001393999.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1637)
  AUTHORS   Lin,J., Lyu,Z., Feng,H., Xie,H., Peng,J., Zhang,W., Zheng,J.,
            Zheng,J., Pan,Z. and Li,Y.
  TITLE     CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by
            inhibiting palmitoylation of the GSDME-C domain to induce
            chemoresistance of colorectal cancer
  JOURNAL   Drug Resist Updat 76, 101097 (2024)
   PUBMED   38861804
  REMARK    GeneRIF: CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by
            inhibiting palmitoylation of the GSDME-C domain to induce
            chemoresistance of colorectal cancer.
REFERENCE   2  (bases 1 to 1637)
  AUTHORS   Yin,Y., Wang,Y., Yu,X., Li,Y., Zhao,Y. and Liu,Z.
  TITLE     Overactivation of XBP1 in plasma cells implies worse survival
            through innate immunity in esophageal squamous cell carcinoma
  JOURNAL   Cancer Lett 597, 217045 (2024)
   PUBMED   38871246
  REMARK    GeneRIF: Overactivation of XBP1 in plasma cells implies worse
            survival through innate immunity in esophageal squamous cell
            carcinoma.
REFERENCE   3  (bases 1 to 1637)
  AUTHORS   Yang,Z., Li,S., Zhao,C., Zhao,Z., Tan,J., Zhang,L. and Huang,Y.
  TITLE     X-Box binding protein 1 downregulates SIRT6 to promote injury in
            pancreatic ductal epithelial cells
  JOURNAL   Immun Inflamm Dis 12 (7), e1301 (2024)
   PUBMED   38967361
  REMARK    GeneRIF: X-Box binding protein 1 downregulates SIRT6 to promote
            injury in pancreatic ductal epithelial cells.
REFERENCE   4  (bases 1 to 1637)
  AUTHORS   Fernandez,J.J., Marin,A., Rosales,R., Penrice-Randal,R.,
            Mlcochova,P., Alvarez,Y., Villalon-Letelier,F., Yildiz,S.,
            Perez,E., Rathnasinghe,R., Cupic,A., Kehrer,T., Uccellini,M.B.,
            Alonso,S., Martinez,F., McGovern,B.L., Clark,J.J., Sharma,P.,
            Bayon,Y., Alonso,A., Albrecht,R.A., White,K.M., Schotsaert,M.,
            Miorin,L., Stewart,J.P., Hiscox,J.A., Gupta,R.K., Irigoyen,N.,
            Garcia-Sastre,A., Crespo,M.S. and Fernandez,N.
  TITLE     The IRE1alpha-XBP1 arm of the unfolded protein response is a host
            factor activated in SARS-CoV-2 infection
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167193 (2024)
   PUBMED   38648902
  REMARK    GeneRIF: The IRE1alpha-XBP1 arm of the unfolded protein response is
            a host factor activated in SARS-CoV-2 infection.
REFERENCE   5  (bases 1 to 1637)
  AUTHORS   Hsu,H.T., Lin,Y.M., Hsing,M.T., Yeh,K.T., Lu,J.W. and Yang,S.F.
  TITLE     Correlation Between Low Cytoplasmic Expression of XBP1 and the
            Likelihood of Surviving Hepatocellular Carcinoma
  JOURNAL   In Vivo 38 (3), 1316-1324 (2024)
   PUBMED   38688649
  REMARK    GeneRIF: Correlation Between Low Cytoplasmic Expression of XBP1 and
            the Likelihood of Surviving Hepatocellular Carcinoma.
REFERENCE   6  (bases 1 to 1637)
  AUTHORS   Ponath,P.D., Fass,D., Liou,H.C., Glimcher,L.H. and Strominger,J.L.
  TITLE     The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both
            common and distinct regulatory elements and protein complexes
  JOURNAL   J Biol Chem 268 (23), 17074-17082 (1993)
   PUBMED   8349596
REFERENCE   7  (bases 1 to 1637)
  AUTHORS   Ono,S.J., Liou,H.C., Davidon,R., Strominger,J.L. and Glimcher,L.H.
  TITLE     Human X-box-binding protein 1 is required for the transcription of
            a subset of human class II major histocompatibility genes and forms
            a heterodimer with c-fos
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4309-4312 (1991)
   PUBMED   1903538
REFERENCE   8  (bases 1 to 1637)
  AUTHORS   Liou,H.C., Eddy,R., Shows,T., Lisowska-Grospierre,B., Griscelli,C.,
            Doyle,C., Mannhalter,J., Eibl,M. and Glimcher,L.H.
  TITLE     An HLA-DR alpha promoter DNA-binding protein is expressed
            ubiquitously and maps to human chromosomes 22 and 5
  JOURNAL   Immunogenetics 34 (5), 286-292 (1991)
   PUBMED   1718857
REFERENCE   9  (bases 1 to 1637)
  AUTHORS   Yoshimura,T., Fujisawa,J. and Yoshida,M.
  TITLE     Multiple cDNA clones encoding nuclear proteins that bind to the
            tax-dependent enhancer of HTLV-1: all contain a leucine zipper
            structure and basic amino acid domain
  JOURNAL   EMBO J 9 (8), 2537-2542 (1990)
   PUBMED   2196176
REFERENCE   10 (bases 1 to 1637)
  AUTHORS   Liou,H.C., Boothby,M.R., Finn,P.W., Davidon,R., Nabavi,N.,
            Zeleznik-Le,N.J., Ting,J.P. and Glimcher,L.H.
  TITLE     A new member of the leucine zipper class of proteins that binds to
            the HLA DR alpha promoter
  JOURNAL   Science 247 (4950), 1581-1584 (1990)
   PUBMED   2321018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z93930.10.
            
            Summary: This gene encodes a transcription factor that regulates
            MHC class II genes by binding to a promoter element referred to as
            an X box. This gene product is a bZIP protein, which was also
            identified as a cellular transcription factor that binds to an
            enhancer in the promoter of the T cell leukemia virus type 1
            promoter. It may increase expression of viral proteins by acting as
            the DNA binding partner of a viral transactivator. It has been
            found that upon accumulation of unfolded proteins in the
            endoplasmic reticulum (ER), the mRNA of this gene is processed to
            an active form by an unconventional splicing mechanism that is
            mediated by the endonuclease inositol-requiring enzyme 1 (IRE1).
            The resulting loss of 26 nt from the spliced mRNA causes a
            frame-shift and an isoform XBP1(S), which is the functionally
            active transcription factor. The isoform encoded by the unspliced
            mRNA, XBP1(U), is constitutively expressed, and thought to function
            as a negative feedback regulator of XBP1(S), which shuts off
            transcription of target genes during the recovery phase of ER
            stress. A pseudogene of XBP1 has been identified and localized to
            chromosome 5. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               Z93930.10          14787-14904         c
            119-215             Z93930.10          13884-13980         c
            216-344             Z93930.10          11904-12032         c
            345-383             Z93930.10          10981-11019         c
            384-464             Z93930.10          10874-10954         c
            465-1637            Z93930.10          9387-10559          c
FEATURES             Location/Qualifiers
     source          1..1637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..1637
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /note="X-box binding protein 1"
                     /db_xref="GeneID:7494"
                     /db_xref="HGNC:HGNC:12801"
                     /db_xref="MIM:194355"
     exon            1..118
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1022
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     tax-responsive element-binding protein 5"
                     /codon_start=1
                     /product="X-box-binding protein 1 isoform 3"
                     /protein_id="NP_001380928.1"
                     /db_xref="GeneID:7494"
                     /db_xref="HGNC:HGNC:12801"
                     /db_xref="MIM:194355"
                     /translation="MRAPVFQALLLCGRRLVVQPLNSDMRKLKNRVAAQTARDRKKAR
                     MSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQELRQRLGMDALVAEEEAEAKG
                     NEVRPVAGSAESAAGAGPVVTPPEHLPMDSGGIDSSDSESDILLGILDNLDPVMFFKC
                     PSPEPASLEELPEVYPEGPSSLPASLSLSVGTSSAKLEAINELIRFDHIYTKPLVLEI
                     PSETESQANVVVKIEEAPLSPSENDHPEFIVSVKEEPVEDDLVPELGISNLLSSSHCP
                     KPSSCLLDAYSDCGYGGSLSPFSDMSSLLGVNHSWEDTFANELFPQLISV"
     exon            119..215
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            216..344
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            345..383
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..464
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..1637
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1620..1625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      1637
                     /gene="XBP1"
                     /gene_synonym="TREB-5; TREB5; XBP-1; XBP2"
                     /note="major polyA site"
ORIGIN      
        1 gtacttttta actctctcgt tagagatgac cagagctggg gatgcgggca cctgtcttcc
       61 aggccctctt gctgtgtggc cgcagactgg tggttcagcc tcttaactcg gacatgagga
      121 aactgaaaaa cagagtagca gctcagactg ccagagatcg aaagaaggct cgaatgagtg
      181 agctggaaca gcaagtggta gatttagaag aagagaacca aaaacttttg ctagaaaatc
      241 agcttttacg agagaaaact catggccttg tagttgagaa ccaggagtta agacagcgct
      301 tggggatgga tgccctggtt gctgaagagg aggcggaagc caaggggaat gaagtgaggc
      361 cagtggccgg gtctgctgag tccgcagcag gtgcaggccc agttgtcacc cctccagaac
      421 atctccccat ggattctggc ggtattgact cttcagattc agagtctgat atcctgttgg
      481 gcattctgga caacttggac ccagtcatgt tcttcaaatg cccttcccca gagcctgcca
      541 gcctggagga gctcccagag gtctacccag aaggacccag ttccttacca gcctcccttt
      601 ctctgtcagt ggggacgtca tcagccaagc tggaagccat taatgaacta attcgttttg
      661 accacatata taccaagccc ctagtcttag agataccctc tgagacagag agccaagcta
      721 atgtggtagt gaaaatcgag gaagcacctc tcagcccctc agagaatgat caccctgaat
      781 tcattgtctc agtgaaggaa gaacctgtag aagatgacct cgttccggag ctgggtatct
      841 caaatctgct ttcatccagc cactgcccaa agccatcttc ctgcctactg gatgcttaca
      901 gtgactgtgg atacgggggt tccctttccc cattcagtga catgtcctct ctgcttggtg
      961 taaaccattc ttgggaggac acttttgcca atgaactctt tccccagctg attagtgtct
     1021 aaggaatgat ccaatactgt tgcccttttc cttgactatt acactgcctg gaggatagca
     1081 gagaagcctg tctgtacttc attcaaaaag ccaaaataga gagtatacag tcctagagaa
     1141 ttcctctatt tgttcagatc tcatagatga cccccaggta ttgtcttttg acatccagca
     1201 gtccaaggta ttgagacata ttactggaag taagaaatat tactataatt gagaactaca
     1261 gcttttaaga ttgtactttt atcttaaaag ggtggtagtt ttccctaaaa tacttattat
     1321 gtaagggtca ttagacaaat gtcttgaagt agacatggaa tttatgaatg gttctttatc
     1381 atttctcttc cccctttttg gcatcctggc ttgcctccag ttttaggtcc tttagtttgc
     1441 ttctgtaagc aacgggaaca cctgctgagg gggctctttc cctcatgtat acttcaagta
     1501 agatcaagaa tcttttgtga aattatagaa atttactatg taaatgcttg atggaatttt
     1561 ttcctgctag tgtagcttct gaaaggtgct ttctccattt atttaaaact acccatgcaa
     1621 ttaaaaggta caatgca
//
