LOCUS       NM_001386970             721 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens X antigen family member 5 (XAGE5), transcript variant
            1, mRNA.
ACCESSION   NM_001386970 XM_017029320
VERSION     NM_001386970.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 721)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   2  (bases 1 to 721)
  AUTHORS   Zendman,A.J., Van Kraats,A.A., Weidle,U.H., Ruiter,D.J. and Van
            Muijen,G.N.
  TITLE     The XAGE family of cancer/testis-associated genes: alignment and
            expression profile in normal tissues, melanoma lesions and Ewing's
            sarcoma
  JOURNAL   Int J Cancer 99 (3), 361-369 (2002)
   PUBMED   11992404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244505.1.
            
            On Sep 17, 2020 this sequence version replaced XM_017029320.2.
            
            Summary: This gene is a member of the XAGE subfamily, which belongs
            to the GAGE family. The GAGE genes are expressed in a variety of
            tumors and in some fetal and reproductive tissues. The protein
            encoded by this gene shares a sequence similarity with other
            GAGE/PAGE proteins. Because of the expression pattern and the
            sequence similarity, this protein also belongs to a family of CT
            (cancer-testis) antigens. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000375501.2/ ENSP00000364651.1
            RefSeq Select criteria    :: based on manual assertion, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC244505.1         52981-53106         c
            127-298             AC244505.1         52674-52845         c
            299-378             AC244505.1         51755-51834         c
            379-484             AC244505.1         51148-51253         c
            485-610             AC244505.1         49176-49301         c
            611-721             AC244505.1         46092-46202         c
FEATURES             Location/Qualifiers
     source          1..721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..721
                     /gene="XAGE5"
                     /gene_synonym="CT12.5; GAGED5; XAGE-5"
                     /note="X antigen family member 5"
                     /db_xref="GeneID:170627"
                     /db_xref="HGNC:HGNC:30930"
                     /db_xref="MIM:301063"
     exon            1..126
                     /gene="XAGE5"
                     /gene_synonym="CT12.5; GAGED5; XAGE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            127..298
                     /gene="XAGE5"
                     /gene_synonym="CT12.5; GAGED5; XAGE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            299..378
                     /gene="XAGE5"
                     /gene_synonym="CT12.5; GAGED5; XAGE-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..633
                     /gene="XAGE5"
                     /gene_synonym="CT12.5; GAGED5; XAGE-5"
                     /note="G antigen, family D, 5; cancer/testis antigen
                     family 12, member 5; g antigen family D member 5; protein
                     XAGE-5; cancer/testis antigen 12.5"
                     /codon_start=1
                     /product="X antigen family member 5"
                     /protein_id="NP_001373899.1"
                     /db_xref="CCDS:CCDS14346.1"
                     /db_xref="GeneID:170627"
                     /db_xref="HGNC:HGNC:30930"
                     /db_xref="MIM:301063"
                     /translation="MSWRGRRYRPRRCLRLAQLVGPMLEPSVPEPQQEEPPTESQDHT
                     PGQKREDDQGAAEIQVPNLEADLQELSQSKTGDECGDSPDVQGKILPKSEQFKMPEGG
                     EGKPQL"
     exon            379..484
                     /gene="XAGE5"
                     /gene_synonym="CT12.5; GAGED5; XAGE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..610
                     /gene="XAGE5"
                     /gene_synonym="CT12.5; GAGED5; XAGE-5"
                     /inference="alignment:Splign:2.1.0"
     exon            611..721
                     /gene="XAGE5"
                     /gene_synonym="CT12.5; GAGED5; XAGE-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccattggcc cttcgcccac ccgggagctg tgatcctgca cttcgggtcc ctgaggtctg
       61 gattctttct cccctactga gacgcagcca gtaggtccac aggccgatcc aactgggagt
      121 tgaagtgggt caggacgaag gaagaaggag ggcttcggag tgcgacgggg gttaggtgaa
      181 gctggggcaa tgctggggtg ctgttggtgg tattccagtc ccagaaacgc ctggaactcc
      241 caacagagga caaattccag actcctcaag ggacatcaag gctggaatgt cgtggacgac
      301 tgaaatatga gttggcgagg aagaagatat agaccaagac gatgtttacg acttgctcag
      361 ctggttgggc ctatgcttga gcccagtgtg ccagagcctc aacaagaaga accaccaact
      421 gaaagtcagg atcatacacc tggtcagaag agagaagatg atcagggtgc agctgagatt
      481 caagtgccta acctggaagc tgatctccag gagctgtctc agtcaaagac tggggatgaa
      541 tgcggagata gtcctgatgt ccaggggaag attctgccaa aatcagagca atttaaaatg
      601 ccagaaggag gggaagggaa accacagctt taaacgaaga caaccaaaag aatgcaaact
      661 ggatttatcc gagatatttg acttttaaaa atctcaataa agttttccag ttttctccaa
      721 a
//
