LOCUS       NM_130777                627 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens X antigen family member 2 (XAGE2), mRNA.
ACCESSION   NM_130777 NM_001079538 XM_001127159
VERSION     NM_130777.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 627)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 627)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 627)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 627)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   5  (bases 1 to 627)
  AUTHORS   Zendman,A.J., Van Kraats,A.A., Weidle,U.H., Ruiter,D.J. and Van
            Muijen,G.N.
  TITLE     The XAGE family of cancer/testis-associated genes: alignment and
            expression profile in normal tissues, melanoma lesions and Ewing's
            sarcoma
  JOURNAL   Int J Cancer 99 (3), 361-369 (2002)
   PUBMED   11992404
REFERENCE   6  (bases 1 to 627)
  AUTHORS   Brinkmann,U., Vasmatzis,G., Lee,B. and Pastan,I.
  TITLE     Novel genes in the PAGE and GAGE family of tumor antigens found by
            homology walking in the dbEST database
  JOURNAL   Cancer Res 59 (7), 1445-1448 (1999)
   PUBMED   10197611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from H53211.1 and AJ318880.1.
            
            On Nov 22, 2018 this sequence version replaced NM_130777.2.
            
            Summary: This gene is a member of the XAGE subfamily, which belongs
            to the GAGE family. The GAGE genes are expressed in a variety of
            tumors and in some fetal and reproductive tissues. This gene is
            strongly expressed in normal testis, and in Ewing's sarcoma,
            rhabdomyosarcoma, a breast cancer and a germ cell tumor. The
            protein encoded by this gene shares a sequence similarity with
            other GAGE/PAGE proteins. Because of the expression pattern and the
            sequence similarity, this protein also belongs to a family of CT
            (cancer-testis) antigens. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279831.7663.1, BG623213.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286049.3/ ENSP00000286049.2
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                H53211.1           12-25
            15-627              AJ318880.1         1-613
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..627
                     /gene="XAGE2"
                     /gene_synonym="CT12.2; GAGED3; XAGE-2; XAGE2B"
                     /note="X antigen family member 2"
                     /db_xref="GeneID:9502"
                     /db_xref="HGNC:HGNC:4112"
                     /db_xref="MIM:300416"
     exon            1..194
                     /gene="XAGE2"
                     /gene_synonym="CT12.2; GAGED3; XAGE-2; XAGE2B"
                     /inference="alignment:Splign:2.1.0"
     exon            195..283
                     /gene="XAGE2"
                     /gene_synonym="CT12.2; GAGED3; XAGE-2; XAGE2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..538
                     /gene="XAGE2"
                     /gene_synonym="CT12.2; GAGED3; XAGE-2; XAGE2B"
                     /note="cancer/testis antigen family 12, member 2;
                     cancer/testis antigen 12.2; X antigen family, member 2B; G
                     antigen family D member 3"
                     /codon_start=1
                     /product="X antigen family member 2"
                     /protein_id="NP_570133.1"
                     /db_xref="CCDS:CCDS59525.1"
                     /db_xref="GeneID:9502"
                     /db_xref="HGNC:HGNC:4112"
                     /db_xref="MIM:300416"
                     /translation="MSWRGRSTYRPRPRRSLQPPELIGAMLEPTDEEPKEEKPPTKSR
                     NPTPDQKREDDQGAAEIQVPDLEADLQELCQTKTGDGCEGGTDVKGKILPKAEHFKMP
                     EAGEGKSQV"
     exon            284..389
                     /gene="XAGE2"
                     /gene_synonym="CT12.2; GAGED3; XAGE-2; XAGE2B"
                     /inference="alignment:Splign:2.1.0"
     exon            390..515
                     /gene="XAGE2"
                     /gene_synonym="CT12.2; GAGED3; XAGE-2; XAGE2B"
                     /inference="alignment:Splign:2.1.0"
     exon            516..627
                     /gene="XAGE2"
                     /gene_synonym="CT12.2; GAGED3; XAGE-2; XAGE2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      602..607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XAGE2"
                     /gene_synonym="CT12.2; GAGED3; XAGE-2; XAGE2B"
                     /note="hexamer: AATAAA"
     polyA_site      627
                     /gene="XAGE2"
                     /gene_synonym="CT12.2; GAGED3; XAGE-2; XAGE2B"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgcatg ttccttggac acctgcctca gtgtgcatgt tcactgggca tcttcccttc
       61 gacccctttg cccacgtggt gaccgctggg gagctgtgag agtgtgaggg gcacgttcca
      121 gccgtctgga ctctttctct cctactgaga cgcagcctat aggtccgcag gccagtcctc
      181 ccaggaactg aaatagtgaa atatgagttg gcgaggaaga tcaacatata ggcctaggcc
      241 aagaagaagt ttacagcctc ctgagctgat tggggctatg cttgaaccca ctgatgaaga
      301 gcctaaagaa gagaaaccac ccactaaaag tcggaatcct acacctgatc agaagagaga
      361 agatgatcag ggtgcagctg agattcaagt gcctgacctg gaagccgatc tccaggagct
      421 atgtcagaca aagactgggg atggatgtga aggtggtact gatgtcaagg ggaagattct
      481 accaaaagca gagcacttta aaatgccaga agcaggtgaa gggaaatcac aggtttaaag
      541 gaagataagc tgaaacaaca caaactgttt ttatattaga tattttactt taaaatatct
      601 taataaagtt ttaagctttt ctccaaa
//
