LOCUS       NM_001097604             464 bp    mRNA    linear   PRI 16-SEP-2022
DEFINITION  Homo sapiens X antigen family member 1B (XAGE1B), transcript
            variant a, mRNA.
ACCESSION   NM_001097604 XM_001125834 XM_001125856 XM_001125872
VERSION     NM_001097604.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 464)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 464)
  AUTHORS   Mori M, Funakoshi T, Kameyama K, Kawakami Y, Sato E, Nakayama E,
            Amagai M and Tanese K.
  TITLE     Lack of XAGE-1b and NY-ESO-1 in metastatic lymph nodes may predict
            the potential survival of stage III melanoma patients
  JOURNAL   J Dermatol 44 (6), 671-680 (2017)
   PUBMED   28105694
  REMARK    GeneRIF: In 22 melanoma patients with stage III lymph node
            metastasis, overall survival was significantly higher in the
            XAGE-1b and NY-ESO-1 double-negative group than in the other
            groups.
REFERENCE   3  (bases 1 to 464)
  AUTHORS   Ohue Y, Kurose K, Nozawa R, Isobe M, Nishio Y, Tanaka T, Doki Y,
            Hori T, Fukuoka J, Oka M and Nakayama E.
  TITLE     Survival of Lung Adenocarcinoma Patients Predicted from Expression
            of PD-L1, Galectin-9, and XAGE1 (GAGED2a) on Tumor Cells and
            Tumor-Infiltrating T Cells
  JOURNAL   Cancer Immunol Res 4 (12), 1049-1060 (2016)
   PUBMED   27799141
  REMARK    GeneRIF: We investigated tumor-infiltrating CD4 and CD8 T cells and
            the expression of PD-L1, Galectin-9, and XAGE1 in stage I to IIIA
            lung adenocarcinomas using a tissue microarray to deduce their
            contribution to overall survival, and our data showed that PD-L1
            expression was a positive indicator, whereas Galectin-9 and XAGE1
            expression was negative.
REFERENCE   4  (bases 1 to 464)
  AUTHORS   Sato S, Noguchi Y, Ohara N, Uenaka A, Shimono M, Nakagawa K,
            Koizumi F, Ishida T, Yoshino T, Shiratori Y and Nakayama E.
  TITLE     Identification of XAGE-1 isoforms: predominant expression of
            XAGE-1b in testis and tumors
  JOURNAL   Cancer Immun 7, 5 (2007)
   PUBMED   17335148
  REMARK    GeneRIF: XAGE-1b is a promising target molecule for a cancer
            vaccine against lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 464)
  AUTHORS   Nakagawa K, Noguchi Y, Uenaka A, Sato S, Okumura H, Tanaka M,
            Shimono M, Ali Eldib AM, Ono T, Ohara N, Yoshino T, Yamashita K,
            Tsunoda T, Aoe M, Shimizu N and Nakayama E.
  TITLE     XAGE-1 expression in non-small cell lung cancer and antibody
            response in patients
  JOURNAL   Clin Cancer Res 11 (15), 5496-5503 (2005)
   PUBMED   16061866
  REMARK    GeneRIF: XAGE-1b is highly and strongly expressed in lung
            adenocarcinoma and immunogenic in patients
REFERENCE   6  (bases 1 to 464)
  AUTHORS   Zendman AJ, Van Kraats AA, Weidle UH, Ruiter DJ and Van Muijen GN.
  TITLE     The XAGE family of cancer/testis-associated genes: alignment and
            expression profile in normal tissues, melanoma lesions and Ewing's
            sarcoma
  JOURNAL   Int J Cancer 99 (3), 361-369 (2002)
   PUBMED   11992404
  REMARK    GeneRIF: The XAGE family of cancer/testis-associated genes:
            alignment and expression profile in normal tissues, melanoma
            lesions and Ewing's sarcoma
REFERENCE   7  (bases 1 to 464)
  AUTHORS   Egland KA, Kumar V, Duray P and Pastan I.
  TITLE     Characterization of overlapping XAGE-1 transcripts encoding a
            cancer testis antigen expressed in lung, breast, and other types of
            cancers
  JOURNAL   Mol Cancer Ther 1 (7), 441-450 (2002)
   PUBMED   12479262
  REMARK    GeneRIF: transcription of the XAGE-1 gene is initiated from two
            distinct start sites, resulting in two overlapping transcripts,
            XAGE-1a and XAGE-1b; XAGE-1 is expressed in a diverse range of
            cancers
REFERENCE   8  (bases 1 to 464)
  AUTHORS   Zendman AJ, van Kraats AA, den Hollander AI, Weidle UH, Ruiter DJ
            and van Muijen GN.
  TITLE     Characterization of XAGE-1b, a short major transcript of
            cancer/testis-associated gene XAGE-1, induced in melanoma
            metastasis
  JOURNAL   Int J Cancer 97 (2), 195-204 (2002)
   PUBMED   11774264
REFERENCE   9  (bases 1 to 464)
  AUTHORS   Liu XF, Helman LJ, Yeung C, Bera TK, Lee B and Pastan I.
  TITLE     XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma
  JOURNAL   Cancer Res 60 (17), 4752-4755 (2000)
   PUBMED   10987281
REFERENCE   10 (bases 1 to 464)
  AUTHORS   Brinkmann U, Vasmatzis G, Lee B and Pastan I.
  TITLE     Novel genes in the PAGE and GAGE family of tumor antigens found by
            homology walking in the dbEST database
  JOURNAL   Cancer Res 59 (7), 1445-1448 (1999)
   PUBMED   10197611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX510359.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 12, 2021 this sequence version replaced NM_001097604.2.
            
            Summary: This gene is a member of the XAGE subfamily, which belongs
            to the GAGE family. The GAGE genes are expressed in a variety of
            tumors and in some fetal and reproductive tissues. This gene is
            strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma
            and normal testis. The protein encoded by this gene contains a
            nuclear localization signal and shares a sequence similarity with
            other GAGE/PAGE proteins. Because of the expression pattern and the
            sequence similarity, this protein also belongs to a family of CT
            (cancer-testis) antigens. Alternative splicing of this gene, in
            addition to alternative transcription start sites, results in
            multiple transcript variants. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (a, also known as XAGE-1b) encodes
            the longer isoform (a, also known as isoform XAGE-1b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY026584.1, BU564534.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375616.6/ ENSP00000364766.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BX510359.5         87149-87232         c
            85-226              BX510359.5         85601-85742         c
            227-353             BX510359.5         84947-85073         c
            354-464             BX510359.5         82246-82356         c
FEATURES             Location/Qualifiers
     source          1..464
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..464
                     /gene="XAGE1B"
                     /gene_synonym="CT12.1; CT12.1b; CT12.1C; CT12.1D; CT12.1E;
                     CTP9; GAGED2; XAGE-1; XAGE1; XAGE1C; XAGE1D; XAGE1E"
                     /note="X antigen family member 1B"
                     /db_xref="GeneID:653067"
                     /db_xref="HGNC:HGNC:25400"
                     /db_xref="MIM:300289"
     exon            1..84
                     /gene="XAGE1B"
                     /gene_synonym="CT12.1; CT12.1b; CT12.1C; CT12.1D; CT12.1E;
                     CTP9; GAGED2; XAGE-1; XAGE1; XAGE1C; XAGE1D; XAGE1E"
                     /inference="alignment:Splign:2.1.0"
     exon            85..226
                     /gene="XAGE1B"
                     /gene_synonym="CT12.1; CT12.1b; CT12.1C; CT12.1D; CT12.1E;
                     CTP9; GAGED2; XAGE-1; XAGE1; XAGE1C; XAGE1D; XAGE1E"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..376
                     /gene="XAGE1B"
                     /gene_synonym="CT12.1; CT12.1b; CT12.1C; CT12.1D; CT12.1E;
                     CTP9; GAGED2; XAGE-1; XAGE1; XAGE1C; XAGE1D; XAGE1E"
                     /note="isoform a is encoded by transcript variant a;
                     cancer/testis associated protein; cancer/testis antigen
                     family 12, member 1e; G antigen family D member 2; protein
                     XAGE-1; cancer/testis antigen 12.1; X antigen family,
                     member 1C; X antigen family, member 1D; cancer/testis
                     antigen family 12, member 1d; cancer/testis antigen family
                     12, member 1c; X antigen family member 1E; cancer/testis
                     antigen family 12, member 1b"
                     /codon_start=1
                     /product="X antigen family member 1 isoform a"
                     /protein_id="NP_001091073.2"
                     /db_xref="CCDS:CCDS48126.2"
                     /db_xref="GeneID:653067"
                     /db_xref="HGNC:HGNC:25400"
                     /db_xref="MIM:300289"
                     /translation="MESPKKKNQQLKVGILHLGSRQKKIRIQLRSQCATWKVICKSCI
                     SQTPGINLDLGSGVKVKIIPKEEHCKMPEAGEEQPQV"
     exon            227..353
                     /gene="XAGE1B"
                     /gene_synonym="CT12.1; CT12.1b; CT12.1C; CT12.1D; CT12.1E;
                     CTP9; GAGED2; XAGE-1; XAGE1; XAGE1C; XAGE1D; XAGE1E"
                     /inference="alignment:Splign:2.1.0"
     exon            354..464
                     /gene="XAGE1B"
                     /gene_synonym="CT12.1; CT12.1b; CT12.1C; CT12.1D; CT12.1E;
                     CTP9; GAGED2; XAGE-1; XAGE1; XAGE1C; XAGE1D; XAGE1E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      439..444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XAGE1B"
                     /gene_synonym="CT12.1; CT12.1b; CT12.1C; CT12.1D; CT12.1E;
                     CTP9; GAGED2; XAGE-1; XAGE1; XAGE1C; XAGE1D; XAGE1E"
                     /note="hexamer: AATAAA"
     polyA_site      464
                     /gene="XAGE1B"
                     /gene_synonym="CT12.1; CT12.1b; CT12.1C; CT12.1D; CT12.1E;
                     CTP9; GAGED2; XAGE-1; XAGE1; XAGE1C; XAGE1D; XAGE1E"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgggga acgcggcgga gctgtgagcc ggcgactcgg gtccctgagg tctggattct
       61 ttctccgcta ctgagacacg gcggacacac acaaacacag aaccacacag ccagtcccag
      121 gagcccagta atggagagcc ccaaaaagaa gaaccagcag ctgaaagtcg ggatcctaca
      181 cctgggcagc agacagaaga agatcaggat acagctgaga tcccagtgcg cgacatggaa
      241 ggtgatctgc aagagctgca tcagtcaaac accggggata aatctggatt tgggttccgg
      301 cgtcaaggtg aagataatac ctaaagagga acactgtaaa atgccagaag caggtgaaga
      361 gcaaccacaa gtttaaatga agacaagctg aaacaacgca agctggtttt atattagata
      421 tttgacttaa actatctcaa taaagttttg cagctttcac caaa
//
