LOCUS       NM_001097594             482 bp    mRNA    linear   PRI 13-APR-2022
DEFINITION  Homo sapiens X antigen family member 1A (XAGE1A), transcript
            variant a, mRNA.
ACCESSION   NM_001097594 XM_001127215 XM_001127224 XM_001127235
VERSION     NM_001097594.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Skou AS, Juul-Dam KL, Hansen M, Lausen B, Stratmann S, Holmfeldt L,
            Aggerholm A, Nyvold CG, Ommen HB and Hasle H.
  TITLE     Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and
            XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse
            in Childhood Acute Myeloid Leukemia
  JOURNAL   J Mol Diagn 23 (12), 1787-1799 (2021)
   PUBMED   34600138
  REMARK    GeneRIF: Measurable Residual Disease Monitoring of SPAG6, ST18,
            PRAME, and XAGE1A Expression in Peripheral Blood May Detect
            Imminent Relapse in Childhood Acute Myeloid Leukemia.
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 482)
  AUTHORS   Karia BTR, Zamuner FT, Carlin V, de Oliveira CZ, Carvalho AL and
            Vettore AL.
  TITLE     Expression and Prognostic Relevance of GAGE1 and XAGE1
            Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma
  JOURNAL   Curr Mol Med 17 (10), 707-717 (2017)
   PUBMED   29577858
  REMARK    GeneRIF: High XAGE1 expression is associated with metastasis in
            Head and Neck Squamous Cell Carcinoma.
REFERENCE   4  (bases 1 to 482)
  AUTHORS   Sato S, Noguchi Y, Ohara N, Uenaka A, Shimono M, Nakagawa K,
            Koizumi F, Ishida T, Yoshino T, Shiratori Y and Nakayama E.
  TITLE     Identification of XAGE-1 isoforms: predominant expression of
            XAGE-1b in testis and tumors
  JOURNAL   Cancer Immun 7, 5 (2007)
   PUBMED   17335148
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 482)
  AUTHORS   Nakagawa K, Noguchi Y, Uenaka A, Sato S, Okumura H, Tanaka M,
            Shimono M, Ali Eldib AM, Ono T, Ohara N, Yoshino T, Yamashita K,
            Tsunoda T, Aoe M, Shimizu N and Nakayama E.
  TITLE     XAGE-1 expression in non-small cell lung cancer and antibody
            response in patients
  JOURNAL   Clin Cancer Res 11 (15), 5496-5503 (2005)
   PUBMED   16061866
REFERENCE   6  (bases 1 to 482)
  AUTHORS   Zendman AJ, Van Kraats AA, Weidle UH, Ruiter DJ and Van Muijen GN.
  TITLE     The XAGE family of cancer/testis-associated genes: alignment and
            expression profile in normal tissues, melanoma lesions and Ewing's
            sarcoma
  JOURNAL   Int J Cancer 99 (3), 361-369 (2002)
   PUBMED   11992404
REFERENCE   7  (bases 1 to 482)
  AUTHORS   Egland KA, Kumar V, Duray P and Pastan I.
  TITLE     Characterization of overlapping XAGE-1 transcripts encoding a
            cancer testis antigen expressed in lung, breast, and other types of
            cancers
  JOURNAL   Mol Cancer Ther 1 (7), 441-450 (2002)
   PUBMED   12479262
REFERENCE   8  (bases 1 to 482)
  AUTHORS   Zendman AJ, van Kraats AA, den Hollander AI, Weidle UH, Ruiter DJ
            and van Muijen GN.
  TITLE     Characterization of XAGE-1b, a short major transcript of
            cancer/testis-associated gene XAGE-1, induced in melanoma
            metastasis
  JOURNAL   Int J Cancer 97 (2), 195-204 (2002)
   PUBMED   11774264
REFERENCE   9  (bases 1 to 482)
  AUTHORS   Liu XF, Helman LJ, Yeung C, Bera TK, Lee B and Pastan I.
  TITLE     XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma
  JOURNAL   Cancer Res 60 (17), 4752-4755 (2000)
   PUBMED   10987281
REFERENCE   10 (bases 1 to 482)
  AUTHORS   Brinkmann U, Vasmatzis G, Lee B and Pastan I.
  TITLE     Novel genes in the PAGE and GAGE family of tumor antigens found by
            homology walking in the dbEST database
  JOURNAL   Cancer Res 59 (7), 1445-1448 (1999)
   PUBMED   10197611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX510359.5.
            
            On May 17, 2019 this sequence version replaced NM_001097594.2.
            
            Summary: This gene is a member of the XAGE subfamily, which belongs
            to the GAGE family. The GAGE genes are expressed in a variety of
            tumors and in some fetal and reproductive tissues. This gene is
            strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma
            and normal testis. The protein encoded by this gene contains a
            nuclear localization signal and shares a sequence similarity with
            other GAGE/PAGE proteins. Because of the expression pattern and the
            sequence similarity, this protein also belongs to a family of CT
            (cancer-testis) antigens. Alternative splicing of this gene, in
            addition to alternative transcription start sites, results in
            multiple transcript variants. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (a, also known as XAGE-1a) encodes
            the longer isoform (a, also known as isoform XAGE-1b). This variant
            also includes a major downstream transcription start site, which
            results in the variant referred to as XAGE-1b in the literature.
            Both XAGE-1a and XAGE-1b encode the same isoform. This RefSeq
            contains an in-frame start site 65 codons upstream from the
            currently annotated site but is not being annotated as a start site
            since it is in a weak Kozak sequence context and experimental
            evidence indicates that the downstream AUG is used. (PMID: 12479262
            and PMID: 17335148).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX101350.1, AJ290447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375602.2/ ENSP00000364752.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               BX510359.5         65977-66078
            103-244             BX510359.5         67485-67626
            245-371             BX510359.5         68154-68280
            372-482             BX510359.5         70871-70981
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..482
                     /gene="XAGE1A"
                     /gene_synonym="CT12.1; CT12.1A; CT12.1B; CTP9; GAGED2;
                     XAGE-1; XAGE1; XAGE1B"
                     /note="X antigen family member 1A"
                     /db_xref="GeneID:653220"
                     /db_xref="HGNC:HGNC:4111"
                     /db_xref="MIM:300742"
     exon            1..102
                     /gene="XAGE1A"
                     /gene_synonym="CT12.1; CT12.1A; CT12.1B; CTP9; GAGED2;
                     XAGE-1; XAGE1; XAGE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            103..244
                     /gene="XAGE1A"
                     /gene_synonym="CT12.1; CT12.1A; CT12.1B; CTP9; GAGED2;
                     XAGE-1; XAGE1; XAGE1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..394
                     /gene="XAGE1A"
                     /gene_synonym="CT12.1; CT12.1A; CT12.1B; CTP9; GAGED2;
                     XAGE-1; XAGE1; XAGE1B"
                     /note="isoform a is encoded by transcript variant a;
                     cancer/testis antigen family 12, member 1b; cancer/testis
                     associated protein; G antigen family D member 2; protein
                     XAGE-1; cancer/testis antigen 12.1; X antigen family
                     member 1; X antigen family member 1B; G antigen, family D,
                     2; cancer/testis antigen family 12, member 1a"
                     /codon_start=1
                     /product="X antigen family member 1 isoform a"
                     /protein_id="NP_001091063.2"
                     /db_xref="CCDS:CCDS75982.1"
                     /db_xref="GeneID:653220"
                     /db_xref="HGNC:HGNC:4111"
                     /db_xref="MIM:300742"
                     /translation="MESPKKKNQQLKVGILHLGSRQKKIRIQLRSQCATWKVICKSCI
                     SQTPGINLDLGSGVKVKIIPKEEHCKMPEAGEEQPQV"
     exon            245..371
                     /gene="XAGE1A"
                     /gene_synonym="CT12.1; CT12.1A; CT12.1B; CTP9; GAGED2;
                     XAGE-1; XAGE1; XAGE1B"
                     /inference="alignment:Splign:2.1.0"
     exon            372..482
                     /gene="XAGE1A"
                     /gene_synonym="CT12.1; CT12.1A; CT12.1B; CTP9; GAGED2;
                     XAGE-1; XAGE1; XAGE1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccatcggcc ccttcgccag tgtggggaac gcggcggagc tgtgagccgg cgactcgggt
       61 ccctgaggtc tggattcttt ctccgctact gagacacggc ggacacacac aaacacagaa
      121 ccacacagcc agtcccagga gcccagtaat ggagagcccc aaaaagaaga accagcagct
      181 gaaagtcggg atcctacacc tgggcagcag acagaagaag atcaggatac agctgagatc
      241 ccagtgcgcg acatggaagg tgatctgcaa gagctgcatc agtcaaacac cggggataaa
      301 tctggatttg ggttccggcg tcaaggtgaa gataatacct aaagaggaac actgtaaaat
      361 gccagaagca ggtgaagagc aaccacaagt ttaaatgaag acaagctgaa acaacgcaag
      421 ctggttttat attagatatt tgacttaaac tatctcaata aagttttgca gctttcacca
      481 aa
//
