LOCUS       NM_017523               3417 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens XIAP associated factor 1 (XAF1), transcript variant 1,
            mRNA.
ACCESSION   NM_017523
VERSION     NM_017523.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3417)
  AUTHORS   Chen,B., Cheng,Y., Wu,H. and Yao,J.
  TITLE     XAF1 overexpression inhibits the malignant progression and
            cisplatin resistance of NSCLC by activating endoplasmic reticulum
            stress
  JOURNAL   Mol Biol Rep 51 (1), 435 (2024)
   PUBMED   38520543
  REMARK    GeneRIF: XAF1 overexpression inhibits the malignant progression and
            cisplatin resistance of NSCLC by activating endoplasmic reticulum
            stress.
            Erratum:[Mol Biol Rep. 2024 May 30;51(1):699. doi:
            10.1007/s11033-024-09591-6.. PMID: 38814432]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3417)
  AUTHORS   Xia,J., Ma,N., Shi,Q., Liu,Q.C., Zhang,W., Cao,H.J., Wang,Y.K.,
            Zheng,Q.W., Ni,Q.Z., Xu,S., Zhu,B., Qiu,X.S., Ding,K., Huang,J.Y.,
            Liang,X., Chen,Y., Xiang,Y.J., Zhang,X.R., Qiu,L., Chen,W., Xie,D.,
            Wang,X., Long,L. and Li,J.J.
  TITLE     XAF1 promotes colorectal cancer metastasis via VCP-RNF114-JUP axis
  JOURNAL   J Cell Biol 223 (2) (2024)
   PUBMED   38095639
  REMARK    GeneRIF: XAF1 promotes colorectal cancer metastasis via
            VCP-RNF114-JUP axis.
REFERENCE   3  (bases 1 to 3417)
  AUTHORS   Liu,B.Q., Liu,R.B., Li,W.P., Mao,X.T., Li,Y.N., Huang,T.,
            Wang,H.L., Chen,H.T., Zhong,J.Y., Yang,B., Chai,R.J., Cao,Q.,
            Jin,J. and Li,Y.Y.
  TITLE     XAF1 prevents hyperproduction of type I interferon upon viral
            infection by targeting IRF7
  JOURNAL   EMBO Rep 24 (1), e55387 (2023)
   PUBMED   36394357
REFERENCE   4  (bases 1 to 3417)
  AUTHORS   Xiao,L., Yang,Z. and Lin,S.
  TITLE     IRF9 and XAF1 as Diagnostic Markers of Primary Sjogren Syndrome
  JOURNAL   Comput Math Methods Med 2022, 1867321 (2022)
   PUBMED   36132546
  REMARK    GeneRIF: IRF9 and XAF1 as Diagnostic Markers of Primary Sjogren
            Syndrome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3417)
  AUTHORS   Lim,J.S., Lee,K.W., Ko,K.P., Jeong,S.I., Ryu,B.K., Lee,M.G. and
            Chi,S.G.
  TITLE     XAF1 destabilizes estrogen receptor alpha through the assembly of a
            BRCA1-mediated destruction complex and promotes estrogen-induced
            apoptosis
  JOURNAL   Oncogene 41 (20), 2897-2908 (2022)
   PUBMED   35430604
  REMARK    GeneRIF: XAF1 destabilizes estrogen receptor alpha through the
            assembly of a BRCA1-mediated destruction complex and promotes
            estrogen-induced apoptosis.
REFERENCE   6  (bases 1 to 3417)
  AUTHORS   Byun,D.S., Cho,K., Ryu,B.K., Lee,M.G., Kang,M.J., Kim,H.R. and
            Chi,S.G.
  TITLE     Hypermethylation of XIAP-associated factor 1, a putative tumor
            suppressor gene from the 17p13.2 locus, in human gastric
            adenocarcinomas
  JOURNAL   Cancer Res 63 (21), 7068-7075 (2003)
   PUBMED   14612497
  REMARK    GeneRIF: Epigenetic silencing of XAF1 by aberrant promoter
            methylation may contribute to the malignant progression of human
            gastric tumors.
REFERENCE   7  (bases 1 to 3417)
  AUTHORS   Leaman,D.W., Chawla-Sarkar,M., Vyas,K., Reheman,M., Tamai,K.,
            Toji,S. and Borden,E.C.
  TITLE     Identification of X-linked inhibitor of apoptosis-associated
            factor-1 as an interferon-stimulated gene that augments TRAIL
            Apo2L-induced apoptosis
  JOURNAL   J Biol Chem 277 (32), 28504-28511 (2002)
   PUBMED   12029096
  REMARK    GeneRIF: XAF1 augments TRAIL-induced apoptosis
REFERENCE   8  (bases 1 to 3417)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3417)
  AUTHORS   Liston,P., Fong,W.G., Kelly,N.L., Toji,S., Miyazaki,T., Conte,D.,
            Tamai,K., Craig,C.G., McBurney,M.W. and Korneluk,R.G.
  TITLE     Identification of XAF1 as an antagonist of XIAP anti-Caspase
            activity
  JOURNAL   Nat Cell Biol 3 (2), 128-133 (2001)
   PUBMED   11175744
REFERENCE   10 (bases 1 to 3417)
  AUTHORS   Fong,W.G., Liston,P., Rajcan-Separovic,E., St Jean,M., Craig,C. and
            Korneluk,R.G.
  TITLE     Expression and genetic analysis of XIAP-associated factor 1 (XAF1)
            in cancer cell lines
  JOURNAL   Genomics 70 (1), 113-122 (2000)
   PUBMED   11087668
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM153640.1, BM475564.1, BC058017.1, BC032776.1, BX649188.1,
            BX648588.1, AC034305.6 and BM459605.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017523.4.
            
            Summary: This gene encodes a protein which binds to and counteracts
            the inhibitory effect of a member of the IAP (inhibitor of
            apoptosis) protein family. IAP proteins bind to and inhibit
            caspases which are activated during apoptosis. The proportion of
            IAPs and proteins which interfere with their activity, such as the
            encoded protein, affect the progress of the apoptosis signaling
            pathway. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Both variants 1 and 7 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.189095.1,
                                           SRR1803614.169070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361842.8/ ENSP00000354822.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BM153640.1         209-273
            66-540              BM475564.1         46-520
            541-1364            BC058017.1         460-1283
            1365-1878           BC032776.1         1101-1614
            1879-2351           BX649188.1         4335-4807
            2352-2465           BX648588.1         2891-3004
            2466-2535           BX649188.1         4922-4991
            2536-2630           BX648588.1         3075-3169
            2631-2631           AC034305.6         26940-26940
            2632-3412           BX649188.1         5088-5868
            3413-3417           BM459605.1         708-712
FEATURES             Location/Qualifiers
     source          1..3417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3417
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /note="XIAP associated factor 1"
                     /db_xref="GeneID:54739"
                     /db_xref="HGNC:HGNC:30932"
                     /db_xref="MIM:606717"
     exon            1..65
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..939
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BIRC4-binding protein"
                     /codon_start=1
                     /product="XIAP-associated factor 1 isoform 1"
                     /protein_id="NP_059993.2"
                     /db_xref="CCDS:CCDS11080.1"
                     /db_xref="GeneID:54739"
                     /db_xref="HGNC:HGNC:30932"
                     /db_xref="MIM:606717"
                     /translation="MEGDFSVCRNCKRHVVSANFTLHEAYCLRFLVLCPECEEPVPKE
                     TMEEHCKLEHQQVGCTMCQQSMQKSSLEFHKANECQERPVECKFCKLDMQLSKLELHE
                     SYCGSRTELCQGCGQFIMHRMLAQHRDVCRSEQAQLGKGERISAPEREIYCHYCNQMI
                     PENKYFHHMGKCCPDSEFKKHFPVGNPEILPSSLPSQAAENQTSTMEKDVRPKTRSIN
                     RFPLHSESSSKKAPRSKNKTLDPLLMSEPKPRTSSPRGDKAAYDILRRCSQCGILLPL
                     PILNQHQEKCRWLASSKGKQVRNFS"
     exon            66..201
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            202..258
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..454
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..540
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..882
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..3417
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3397..3402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /note="hexamer: AATAAA"
     polyA_site      3417
                     /gene="XAF1"
                     /gene_synonym="BIRC4BP; HSXIAPAF1; XIAPAF1"
                     /note="major polyA site"
ORIGIN      
        1 gaaactcaac cgaaagcctg cagagagcag aacatggaag gagacttctc ggtgtgcagg
       61 aactgtaaaa gacatgtagt ctctgccaac ttcaccctcc atgaggctta ctgcctgcgg
      121 ttcctggtcc tgtgtccgga gtgtgaggag cctgtcccca aggaaaccat ggaggagcac
      181 tgcaagcttg agcaccagca ggttgggtgt acgatgtgtc agcagagcat gcagaagtcc
      241 tcgctggagt ttcataaggc caatgagtgc caggagcgcc ctgttgagtg taagttctgc
      301 aaactggaca tgcagctcag caagctggag ctccacgagt cctactgtgg cagccggaca
      361 gagctctgcc aaggctgtgg ccagttcatc atgcaccgca tgctcgccca gcacagagat
      421 gtctgtcgca gtgaacaggc ccagctcggg aaaggggaaa gaatttcagc tcctgaaagg
      481 gaaatctact gtcattattg caaccaaatg attccagaaa ataagtattt ccaccatatg
      541 ggtaaatgtt gtccagactc agagtttaag aaacactttc ctgttggaaa tccagaaatt
      601 cttccttcat ctcttccaag tcaagctgct gaaaatcaaa cttccacgat ggagaaagat
      661 gttcgtccaa agacaagaag tataaacaga tttcctcttc attctgaaag ttcatcaaag
      721 aaagcaccaa gaagcaaaaa caaaaccttg gatccacttt tgatgtcaga gcccaagccc
      781 aggaccagct cccctagagg agataaagca gcctatgaca ttctgaggag atgttctcag
      841 tgtggcatcc tgcttcccct gccgatccta aatcaacatc aggagaaatg ccggtggtta
      901 gcttcatcaa aaggaaaaca agtgagaaat ttcagctaga tttggaaaag gaaaggtact
      961 acaaattcaa aagatttcac ttttaacact ggcattcctg cctacttgct gtggtggtct
     1021 tgtgaaaggt gatgggtttt attcgttggg ctttaaaaga aaaggtttgg cagaactaaa
     1081 aacaaaactc acgtatcatc tcaatagata cagaaaaggc ttttgataaa attcaacttg
     1141 acttcatgtt aaaaaccctc aacaaaccag gcgtcgaagg aacatacctc aaaataataa
     1201 gagccatcta tgacaaaacc acagccaaca tcatactgaa tgagcaaaag ctggagcatt
     1261 actcttgaga agtagaacaa ggcacttcag tcctattcaa catagtactg gaagtcctcg
     1321 ccacagcaat caggcaagag aaagaaataa aaggcaacca aaaagaaagg aagtcgaagt
     1381 atctctgttt gcagacgata tgattctata tctagaaaac cccatgatct tggcccaaaa
     1441 gctcctagat ctgataaaca acttcagcta actttcagga gacaaaatca atatacaaaa
     1501 tatggtagca tttttataca ccaacgacat ccaagctgag agccaaatca agaatgcaat
     1561 cctattcaca attgccacaa aaagaataaa atacctagga atacagctaa ccagggagat
     1621 gaaagatctc tacaacaaaa attacaaaac actgctgaaa gaaatcagag atgacacaaa
     1681 tggaaaaaca ttccatactt atggatagga agaatcaata ttgttaaaat ggccatacta
     1741 cccaaagcaa tttatagatt caatgctatt cctatcaaac taccaataac attcttcaca
     1801 gaatcagaaa aaaaaagcat taaaatttat ttgaaaccaa aaaagagccc aaaaagccaa
     1861 agcaatccta agcaaaaaga acaaagctgg aggcatcgca ttacccaact tcaaactata
     1921 ctacagggct acagtaacca aaactgcatg atactggtac aaaagcatgg tgctggtaca
     1981 aaagcagaca catagatcaa tggaacagaa tagagggccc agaaataaag ctacacacct
     2041 acaaccatct aatctttgac aaagttgaca aaaatacgca atggggaaag aattccccat
     2101 tcagtaagtg gtactgggat aactagctag ccatatgcag aggattgaaa ctgaaccact
     2161 tccttacacc atatgcaaaa atcaactcaa gatggattaa agacttaaat gtaaaacccc
     2221 aaactataaa aactctggaa gataacctag gcaataccat tctggacata ggaacggaaa
     2281 aagatttcat gacaaagatc ccaaaaataa ttgtaacgaa agcaaaaatt gacaaatggg
     2341 acatgattaa acagaattac catttgactc agcaatccca ttattggtta tatacccaaa
     2401 ggaatctaaa tcattctgtc ataaagacat atatacacaa atgttcacgg cagcactata
     2461 cacaatcgca aagtcaggga atcaaactaa atgtccatca gtggtagaaa ggataaagaa
     2521 aatgtggtgg cagggagtgg tggctcatgt ctgtaatccc agcactttgg gaggctgagg
     2581 cgggtggttc acctgaggtc aggagtttga gaccagcctg gccaacatgg agaaactccg
     2641 tctccgctaa aaatacgaaa attagccagg cgtggtggcg agcacctgtc atcccagcta
     2701 cttgggaggc ctaggcgtga gaatcgcttg aacctggaag gtggtggttg cagtgagccg
     2761 agatcctgcc actgcactcc agcctgggca accaagcgag actctgcctt aaaaaaaaaa
     2821 aaaagaaaat gtggcacata tacaccatgg aatactatgc agccataaaa aagaatggga
     2881 tcatgtcctg tgcagcaacg tggatggagc tggaagccat tatcctaaat gaactcactc
     2941 agaaacagaa aaccaaatac cacatgttct cacttataag tagaagctaa acattgagta
     3001 cacatggata caaagaaggg aaccgcagac actggggcct acctgaggtc ggagcatgga
     3061 aggagggtga ggatcaaaaa actacctatc tggtactatg ctttttatct ggatgatgaa
     3121 ataatctgta caacaaaccc tggtgacatg caatttacct atatagcaag cctacacatg
     3181 tgcccctgaa cctaaaaaaa aagttaaaag aaaaacgttt ggattatttt ccctctttcg
     3241 aacaaagaca ttggtttgcc caaggactac aaataaacca acgggaaaaa agaaaggttc
     3301 cagttttgtc tgaaaattct gattaagcct ctgggcccta cagcctggag aacctggaga
     3361 atcctacacc cacagaaccc ggctttgtcc ccaaagaata aaaacacctc tctaaaa
//
