LOCUS       NM_020196               2647 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens XPA binding protein 2 (XAB2), mRNA.
ACCESSION   NM_020196
VERSION     NM_020196.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2647)
  AUTHORS   Sharma,A.B., Erasimus,H., Pinto,L., Caron,M.C., Gopaul,D.,
            Peterlini,T., Neumann,K., Nazarov,P.V., Fritah,S., Klink,B.,
            Herold-Mende,C.C., Niclou,S.P., Pasero,P., Calsou,P., Masson,J.Y.,
            Britton,S. and Van Dyck,E.
  TITLE     XAB2 promotes Ku eviction from single-ended DNA double-strand
            breaks independently of the ATM kinase
  JOURNAL   Nucleic Acids Res 49 (17), 9906-9925 (2021)
   PUBMED   34500463
  REMARK    GeneRIF: XAB2 promotes Ku eviction from single-ended DNA
            double-strand breaks independently of the ATM kinase.
REFERENCE   2  (bases 1 to 2647)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2647)
  AUTHORS   Xie,Y., Yu,Y., Wu,H., Gao,H., Yang,Z., Zhang,Y. and Zhang,X.
  TITLE     XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in
            Chinese Population: A Case-Control Study
  JOURNAL   Int J Environ Res Public Health 18 (4), 1494 (2021)
   PUBMED   33557438
  REMARK    GeneRIF: XAB2 TagSNP Is Associated with the Risk of Gastric Cancer
            in Chinese Population: A Case-Control Study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2647)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2647)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2647)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   7  (bases 1 to 2647)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   8  (bases 1 to 2647)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 2647)
  AUTHORS   Gnatt,A.L., Cramer,P., Fu,J., Bushnell,D.A. and Kornberg,R.D.
  TITLE     Structural basis of transcription: an RNA polymerase II elongation
            complex at 3.3 A resolution
  JOURNAL   Science 292 (5523), 1876-1882 (2001)
   PUBMED   11313499
REFERENCE   10 (bases 1 to 2647)
  AUTHORS   Nakatsu,Y., Asahina,H., Citterio,E., Rademakers,S., Vermeulen,W.,
            Kamiuchi,S., Yeo,J.P., Khaw,M.C., Saijo,M., Kodo,N., Matsuda,T.,
            Hoeijmakers,J.H. and Tanaka,K.
  TITLE     XAB2, a novel tetratricopeptide repeat protein involved in
            transcription-coupled DNA repair and transcription
  JOURNAL   J Biol Chem 275 (45), 34931-34937 (2000)
   PUBMED   10944529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF226051.1 and BC007208.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020196.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF226051.1, AF272147.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358368.5/ ENSP00000351137.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AF226051.1         9-226
            219-2647            BC007208.1         209-2637
FEATURES             Location/Qualifiers
     source          1..2647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2647
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /note="XPA binding protein 2"
                     /db_xref="GeneID:56949"
                     /db_xref="HGNC:HGNC:14089"
                     /db_xref="MIM:610850"
     exon            1..69
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2586
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /note="SYF1 pre-mRNA-splicing factor; crn-related protein
                     kim1; SYF1 homolog, RNA splicing factor"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor SYF1"
                     /protein_id="NP_064581.2"
                     /db_xref="CCDS:CCDS32892.1"
                     /db_xref="GeneID:56949"
                     /db_xref="HGNC:HGNC:14089"
                     /db_xref="MIM:610850"
                     /translation="MVVMARLSRPERPDLVFEEEDLPYEEEIMRNQFSVKCWLRYIEF
                     KQGAPKPRLNQLYERALKLLPCSYKLWYRYLKARRAQVKHRCVTDPAYEDVNNCHERA
                     FVFMHKMPRLWLDYCQFLMDQGRVTHTRRTFDRALRALPITQHSRIWPLYLRFLRSHP
                     LPETAVRGYRRFLKLSPESAEEYIEYLKSSDRLDEAAQRLATVVNDERFVSKAGKSNY
                     QLWHELCDLISQNPDKVQSLNVDAIIRGGLTRFTDQLGKLWCSLADYYIRSGHFEKAR
                     DVYEEAIRTVMTVRDFTQVFDSYAQFEESMIAAKMETASELGREEEDDVDLELRLARF
                     EQLISRRPLLLNSVLLRQNPHHVHEWHKRVALHQGRPREIINTYTEAVQTVDPFKATG
                     KPHTLWVAFAKFYEDNGQLDDARVILEKATKVNFKQVDDLASVWCQCGELELRHENYD
                     EALRLLRKATALPARRAEYFDGSEPVQNRVYKSLKVWSMLADLEESLGTFQSTKAVYD
                     RILDLRIATPQIVINYAMFLEEHKYFEESFKAYERGISLFKWPNVSDIWSTYLTKFIA
                     RYGGRKLERARDLFEQALDGCPPKYAKTLYLLYAQLEEEWGLARHAMAVYERATRAVE
                     PAQQYDMFNIYIKRAAEIYGVTHTRGIYQKAIEVLSDEHAREMCLRFADMECKLGEID
                     RARAIYSFCSQICDPRTTGAFWQTWKDFEVRHGNEDTIKEMLRIRRSVQATYNTQVNF
                     MASQMLKVSGSATGTVSDLAPGQSGMDDMKLLEQRAEQLAAEAERDQPLRAQSKILFV
                     RSDASREELAELAQQVNPEEIQLGEDEDEDEMDLEPNEVRLEQQSVPAAVFGSLKED"
     exon            70..218
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..342
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..540
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..675
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..840
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..985
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1137
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1257
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1389
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1521
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1635
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1798
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1989
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2112
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2284
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2414
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2524
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2647
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /note="hexamer: AATACA"
     polyA_site      2647
                     /gene="XAB2"
                     /gene_synonym="HCNP; HCRN; NTC90; SYF1"
                     /note="major polyA site"
ORIGIN      
        1 acctgggcat ccagaaaaat ggtggtgatg gcgcgactct cgcggcccga gcggccggac
       61 cttgtcttcg aggaagagga cctcccctat gaggaggaaa tcatgcggaa ccaattctct
      121 gtcaaatgct ggcttcgcta catcgagttc aaacagggcg ccccgaagcc caggctcaat
      181 cagctatacg agcgggcact caagctgctg ccctgcagct acaaactctg gtaccgatac
      241 ctgaaggcgc gtcgggcaca ggtgaagcat cgctgtgtga ccgaccctgc ctatgaagat
      301 gtcaacaact gtcatgagag ggcctttgtg ttcatgcaca agatgcctcg tctgtggcta
      361 gattactgcc agttcctcat ggaccagggg cgcgtcacac acacccgccg caccttcgac
      421 cgtgccctcc gggcactgcc catcacgcag cactctcgaa tttggcccct gtatctgcgc
      481 ttcctgcgct cacacccact gcctgagaca gctgtgcgag gctatcggcg cttcctcaag
      541 ctgagtcctg agagtgcaga ggagtacatt gagtacctca agtcaagtga ccggctggat
      601 gaggccgccc agcgcctggc caccgtggtg aacgacgagc gtttcgtgtc taaggccggc
      661 aagtccaact accagctgtg gcacgagctg tgcgacctca tctcccagaa tccggacaag
      721 gtacagtccc tcaatgtgga cgccatcatc cgcgggggcc tcacccgctt caccgaccag
      781 ctgggcaagc tctggtgttc tctcgccgac tactacatcc gcagcggcca tttcgagaag
      841 gctcgggacg tgtacgagga ggccatccgg acagtgatga ccgtgcggga cttcacacag
      901 gtgtttgaca gctacgccca gttcgaggag agcatgatcg ctgcaaagat ggagaccgcc
      961 tcggagctgg ggcgcgagga ggaggatgat gtggacctgg agctgcgcct ggcccgcttc
     1021 gagcagctca tcagccggcg gcccctgctc ctcaacagcg tcttgctgcg ccaaaaccca
     1081 caccacgtgc acgagtggca caagcgtgtc gccctgcacc agggccgccc ccgggagatc
     1141 atcaacacct acacagaggc tgtgcagacg gtggacccct tcaaggccac aggcaagccc
     1201 cacactctgt gggtggcgtt tgccaagttt tatgaggaca acggacagct ggacgatgcc
     1261 cgtgtcatcc tggagaaggc caccaaggtg aacttcaagc aggtggatga cctggcaagc
     1321 gtgtggtgtc agtgcggaga gctggagctc cgacacgaga actacgatga ggccttgcgg
     1381 ctgctgcgaa aggccacggc gctgcctgcc cgccgggccg agtactttga tggttcagag
     1441 cccgtgcaga accgcgtgta caagtcactg aaggtctggt ccatgctcgc cgacctggag
     1501 gagagcctcg gcaccttcca gtccaccaag gccgtgtacg accgcatcct ggacctgcgt
     1561 atcgcaacac cccagatcgt catcaactat gccatgttcc tggaggagca caagtacttc
     1621 gaggagagct tcaaggcgta cgagcgcggc atctcgctgt tcaagtggcc caacgtgtcc
     1681 gacatctgga gcacctacct gaccaaattc attgcccgct atgggggccg caagctggag
     1741 cgggcacggg acctgtttga acaggctctg gacggctgcc ccccaaaata tgccaagacc
     1801 ttgtacctgc tgtacgcaca gctggaggag gagtggggcc tggcccggca tgccatggcc
     1861 gtgtacgagc gtgccaccag ggccgtggag cccgcccagc agtatgacat gttcaacatc
     1921 tacatcaagc gggcggccga gatctatggg gtcacccaca cccgcggcat ctaccagaag
     1981 gccattgagg tgctgtcgga cgagcacgcg cgtgagatgt gcctgcggtt tgcagacatg
     2041 gagtgcaagc tcggggagat tgaccgcgcc cgggccatct acagcttctg ctcccagatc
     2101 tgtgaccccc ggacgaccgg cgcgttctgg cagacgtgga aggactttga ggtccggcat
     2161 ggcaatgagg acaccatcaa ggaaatgctg cgtatccggc gcagcgtgca ggccacgtac
     2221 aacacgcagg tcaacttcat ggcctcgcag atgctcaagg tctcgggcag tgccacgggc
     2281 accgtgtctg acctggcccc tgggcagagt ggcatggacg acatgaagct gctggaacag
     2341 cgggcagagc agctggcggc tgaggcggag cgtgaccagc ccttgcgcgc ccagagcaag
     2401 atcctgttcg tgaggagtga cgcctcccgg gaggagctgg cagagctggc acagcaggtc
     2461 aaccccgagg agatccagct gggcgaggac gaggacgagg acgagatgga cctggagccc
     2521 aacgaggttc ggctggagca gcagagcgtg ccagccgcag tgtttgggag cctgaaggaa
     2581 gactgacccg tccctccccc atcccccctc cccaccccct ccccaataca gctacgtttg
     2641 tacatca
//
