LOCUS       NM_015472               5037 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens WW domain containing transcription regulator 1
            (WWTR1), transcript variant 1, mRNA.
ACCESSION   NM_015472
VERSION     NM_015472.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5037)
  AUTHORS   Zeng,X., Tang,J., Zhang,Q., Wang,C., Qi,J., Wei,Y., Xu,J., Yang,K.,
            Zhou,Z., Wu,H., Luo,J., Jiang,Y., Song,Z., Wu,J. and Wu,J.
  TITLE     CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of
            Colitis and Colorectal Cancer through Promoting TAZ Translation
  JOURNAL   Adv Sci (Weinh) 11 (34), e2401588 (2024)
   PUBMED   38981023
  REMARK    GeneRIF: CircHIPK2 Contributes Cell Growth in Intestinal Epithelial
            of Colitis and Colorectal Cancer through Promoting TAZ Translation.
REFERENCE   2  (bases 1 to 5037)
  AUTHORS   Patterson,M.R., Cogan,J.A., Cassidy,R., Theobald,D.A., Wang,M.,
            Scarth,J.A., Anene,C.A., Whitehouse,A., Morgan,E.L. and
            Macdonald,A.
  TITLE     The Hippo pathway transcription factors YAP and TAZ play HPV-type
            dependent roles in cervical cancer
  JOURNAL   Nat Commun 15 (1), 5809 (2024)
   PUBMED   38987584
  REMARK    GeneRIF: The Hippo pathway transcription factors YAP and TAZ play
            HPV-type dependent roles in cervical cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5037)
  AUTHORS   Slaninova,V., Heron-Milhavet,L., Robin,M., Jeanson,L., Aissanou,A.,
            Kantar,D., Tosi,D., Brehelin,L., Gongora,C. and Djiane,A.
  TITLE     The Hippo pathway terminal effector TAZ/WWTR1 mediates oxaliplatin
            sensitivity in p53 proficient colon cancer cells
  JOURNAL   BMC Cancer 24 (1), 587 (2024)
   PUBMED   38741073
  REMARK    GeneRIF: The Hippo pathway terminal effector TAZ/WWTR1 mediates
            oxaliplatin sensitivity in p53 proficient colon cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5037)
  AUTHORS   Beyrami,M., Khodadadi,I., Tavilani,H., Razavi,A.N.E. and Karimi,J.
  TITLE     Uncovering the relationship between YAP/ WWTR1 (TAZ) genes
            expression and LncRNAs of SNHG15, HCP5 and LINC01433 in breast
            cancer tissues
  JOURNAL   Pathol Res Pract 257, 155286 (2024)
   PUBMED   38599044
  REMARK    GeneRIF: Uncovering the relationship between YAP/ WWTR1 (TAZ) genes
            expression and LncRNAs of SNHG15, HCP5 and LINC01433 in breast
            cancer tissues.
REFERENCE   5  (bases 1 to 5037)
  AUTHORS   Aravamudhan,A., Dieffenbach,P.B., Choi,K.M., Link,P.A.,
            Meridew,J.A., Haak,A.J., Fredenburgh,L.E. and Tschumperlin,D.J.
  TITLE     Non-canonical IKB kinases regulate YAP/TAZ and pathological
            vascular remodeling behaviors in pulmonary artery smooth muscle
            cells
  JOURNAL   Physiol Rep 12 (7), e15999 (2024)
   PUBMED   38610069
  REMARK    GeneRIF: Non-canonical IKB kinases regulate YAP/TAZ and
            pathological vascular remodeling behaviors in pulmonary artery
            smooth muscle cells.
REFERENCE   6  (bases 1 to 5037)
  AUTHORS   Li,B., Shi,M., Li,J., Zhang,H., Chen,B., Chen,L., Gao,W.,
            Giuliani,N. and Zhao,R.C.
  TITLE     Elevated tumor necrosis factor-alpha suppresses TAZ expression and
            impairs osteogenic potential of Flk-1+ mesenchymal stem cells in
            patients with multiple myeloma
  JOURNAL   Stem Cells Dev 16 (6), 921-930 (2007)
   PUBMED   17927494
  REMARK    GeneRIF: Decreased osteogenic potential of mesenchymal stem cells
            of myeloma patients was in part due to TNF-alpha suppressed TAZ
            expression.
REFERENCE   7  (bases 1 to 5037)
  AUTHORS   Hong,J.H., Hwang,E.S., McManus,M.T., Amsterdam,A., Tian,Y.,
            Kalmukova,R., Mueller,E., Benjamin,T., Spiegelman,B.M., Sharp,P.A.,
            Hopkins,N. and Yaffe,M.B.
  TITLE     TAZ, a transcriptional modulator of mesenchymal stem cell
            differentiation
  JOURNAL   Science 309 (5737), 1074-1078 (2005)
   PUBMED   16099986
  REMARK    GeneRIF: coactivates Runx2-dependent gene transcription while
            repressing PPARgamma-dependent gene transcription; results indicate
            that TAZ functions as a molecular rheostat that modulates
            mesenchymal stem cell differentiation
REFERENCE   8  (bases 1 to 5037)
  AUTHORS   Howell,M., Borchers,C. and Milgram,S.L.
  TITLE     Heterogeneous nuclear ribonuclear protein U associates with YAP and
            regulates its co-activation of Bax transcription
  JOURNAL   J Biol Chem 279 (25), 26300-26306 (2004)
   PUBMED   15096513
REFERENCE   9  (bases 1 to 5037)
  AUTHORS   Park,K.S., Whitsett,J.A., Di Palma,T., Hong,J.H., Yaffe,M.B. and
            Zannini,M.
  TITLE     TAZ interacts with TTF-1 and regulates expression of surfactant
            protein-C
  JOURNAL   J Biol Chem 279 (17), 17384-17390 (2004)
   PUBMED   14970209
REFERENCE   10 (bases 1 to 5037)
  AUTHORS   Kanai,F., Marignani,P.A., Sarbassova,D., Yagi,R., Hall,R.A.,
            Donowitz,M., Hisaminato,A., Fujiwara,T., Ito,Y., Cantley,L.C. and
            Yaffe,M.B.
  TITLE     TAZ: a novel transcriptional co-activator regulated by interactions
            with 14-3-3 and PDZ domain proteins
  JOURNAL   EMBO J 19 (24), 6778-6791 (2000)
   PUBMED   11118213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA760311.1, BC014052.2, AK130514.1, AC012014.20 and AL833852.1.
            
            On Jun 2, 2019 this sequence version replaced NM_015472.5.
            
            Transcript Variant: This variant 12) differs in the 5' UTR compared
            to variant 4. Variants 1 through 4 all encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.20285.1,
                                           SRR11853565.21118.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360632.8/ ENSP00000353847.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DA760311.1         77-106
            31-2027             BC014052.2         1-1997
            2028-2170           AK130514.1         365-507
            2171-4352           AC012014.20        15885-18066         c
            4353-5037           AL833852.1         4086-4770
FEATURES             Location/Qualifiers
     source          1..5037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..5037
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /note="WW domain containing transcription regulator 1"
                     /db_xref="GeneID:25937"
                     /db_xref="HGNC:HGNC:24042"
                     /db_xref="MIM:607392"
     exon            1..261
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            262..695
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1467
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /note="transcriptional co-activator with PDZ-binding
                     motif"
                     /codon_start=1
                     /product="WW domain-containing transcription regulator
                     protein 1"
                     /protein_id="NP_056287.1"
                     /db_xref="CCDS:CCDS3144.1"
                     /db_xref="GeneID:25937"
                     /db_xref="HGNC:HGNC:24042"
                     /db_xref="MIM:607392"
                     /translation="MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWR
                     KKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGA
                     AGSPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMN
                     QPLNHMNLHPAVSSTPVPQRSMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGL
                     MSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQ
                     AAVNPPTMTPDMRSITNNSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNV
                     DEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNK
                     SEPFLTWL"
     exon            696..832
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1035
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1169
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1282
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..5037
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5016..5021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /note="hexamer: AATAAA"
     polyA_site      5037
                     /gene="WWTR1"
                     /gene_synonym="TAZ"
                     /note="major polyA site"
ORIGIN      
        1 agtccgggag ctgctgcggc cgcgctgtct gcttctcctg cgcctccttt tcgcccagca
       61 ctagcgcctt aggccagctc gggggatgtg agagccgaag cccttagact gccaggcaca
      121 gagtcgggtc gggatttgtc agccaagcct cggctccagc tccgcaatct cgggactcac
      181 ccgagcgacc caggcccgac ggcaagttcg ggcgggacgg cggccgccgc gcgctcaggc
      241 tcagcttcgc tgcccgccca gaagatgaat ccggcctcgg cgccccctcc gctcccgccg
      301 cctgggcagc aagtgatcca cgtcacgcag gacctagaca cagacctcga agccctcttc
      361 aactctgtca tgaatccgaa gcctagctcg tggcggaaga agatcctgcc ggagtctttc
      421 tttaaggagc ctgattcggg ctcgcactcg cgccagtcca gcaccgactc gtcgggcggc
      481 cacccggggc ctcgactggc tgggggtgcc cagcatgtcc gctcgcactc gtcgcccgcg
      541 tccctgcagc tgggcaccgg cgcgggtgct gcgggtagcc ccgcgcagca gcacgcgcac
      601 ctccgccagc agtcctacga cgtgaccgac gagctgccac tgcccccggg ctgggagatg
      661 accttcacgg ccactggcca gaggtacttc ctcaatcaca tagaaaaaat caccacatgg
      721 caagacccta ggaaggcgat gaatcagcct ctgaatcata tgaacctcca ccctgccgtc
      781 agttccacac cagtgcctca gaggtccatg gcagtatccc agccaaatct cgtgatgaat
      841 caccaacacc agcagcagat ggcccccagt accctgagcc agcagaacca ccccactcag
      901 aacccacccg cagggctcat gagtatgccc aatgcgctga ccactcagca gcagcagcag
      961 cagaaactgc ggcttcagag aatccagatg gagagagaaa ggattcgaat gcgccaagag
     1021 gagctcatga ggcaggaagc tgccctctgt cgacagctcc ccatggaagc tgagactctt
     1081 gccccagttc aggctgctgt caacccaccc acgatgaccc cagacatgag atccatcact
     1141 aataatagct cagatccttt cctcaatgga gggccatatc attcgaggga gcagagcact
     1201 gacagtggcc tggggttagg gtgctacagt gtccccacaa ctccggagga cttcctcagc
     1261 aatgtggatg agatggatac aggagaaaac gcaggacaaa cacccatgaa catcaatccc
     1321 caacagaccc gtttccctga tttccttgac tgtcttccag gaacaaacgt tgacttagga
     1381 actttggaat ctgaagacct gatccccctc ttcaatgatg tagagtctgc tctgaacaaa
     1441 agtgagccct ttctaacctg gctgtaatca ctaccattgt aacttggatg tagccatgac
     1501 cttacatttc ctgggcctct tggaaaaagt gatggagcag agcaagtctg caggtgcacc
     1561 acttcccgcc tccatgactc gtgctccctc ctttttatgt tgccagttta atcattgcct
     1621 ggttttgatt gagagtaact taagttaaac ataaataaat attctatttt cattttctgc
     1681 aagcctgcgt tcttgtgaca gattatacag aattgtgtct gcaggattga ttatgcagaa
     1741 tacttttctc tttcttctct gctgccccat ggctaagctt tatgggtgtt aattgaaatt
     1801 tatacaccaa ttgattttaa accataaaaa gctgaccaca ggcagttact tctgagggca
     1861 tcttggtcca ggaaatgtgc acaaaattcg acctgattta cagtttcaaa aactgtattg
     1921 atgacagtag taccaaatgc tttaaaaact atttaacttg agctttaaaa atcattgtat
     1981 ggatagtaaa attctactgt atggaataca atgtaatttt gaatccatgc tggctctgat
     2041 ggctcttatt agtctgtatt tataaaggca cacagtccta ttgtagctta tctttcgtta
     2101 ttttactgca gagcatctag acaacttagt ccctccagcg ggaaagtagc agcagcagca
     2161 ttagtcacag gtcttacact acagatcttg tgaaagagac cagtttggta ctaattatga
     2221 gcattttatt caaacaaaag tttttgaaat attacaactg gggatttaaa aaattgcagc
     2281 ttagaatctg atggtttttt tttttcttga tgttgtttgt ttgtttttga gatcgagttt
     2341 tgctcttgtt gtccaggctg gaatgcaatg gcacaatctc ggctcactgc aacctctgcc
     2401 ttctgggttc aagcgattct cctgccttag cctcccgagt agctgggatt acaggcacct
     2461 gccaccacgt ccggctaatt ttttgtattt tgagtagaga cggggtttca ccataatggt
     2521 caggctgttc tcaaactcct gatctcaggt gatccaccca tctcggcctc ccaaagtgct
     2581 gggattactg gcgtgagcca ccgcacccgg ccttgatgtt tattttataa agcactgtaa
     2641 ttttgtagct gatgacaaaa ggcagccaaa tgtttttgat aaatcagtgg caactgtatt
     2701 tttgtctttt gaaataactc tgaaaacatc aggacaacat agatttcaac ctgatagcac
     2761 accacacaca gtgagctgtt gctttttaaa ttctgaagcc ttgtcaggtt tgcttcctag
     2821 atttcaagtg tttaaaataa ttctatctat gaaactgaag gatgaagcag atctctgact
     2881 gacatgtaaa aaaaaatgcc ctttgagggt gtatggtgga gataaatgtt tctgaattca
     2941 gtaaaattga ttcctaagta tattatccta atcctgtttg ctacagttgg tataaaaagg
     3001 catgaaatat gtattcaata cctcttatgt aaccaaaacc atttttaatt agcttttaag
     3061 gactgagaga gcatcatgtt caactggcat gcagtctgcc tgcattgcca atgaagtcct
     3121 caactgttta atattttgaa ctaatattat ttataatcta tgaatttaat cttttttgaa
     3181 agactttaat aatttgagtc tctgagagga tactttcaat ttccatgggg gacttatttg
     3241 ttggggatct taaataagat tccttttgat ctaccggaat atacatgtac agagtacatt
     3301 ggatcatgtt ggaaagaagg caagtgaaaa ggtcagagat gaagtagcaa agttatggaa
     3361 tatcgtggaa aggatactag ttgtgaaatg gaaagagaca agttatagta ccccaaaagc
     3421 aaaacaagca ggagatgcaa gagatgcccc aaaaggacaa agcaacaatt ttctgttgcc
     3481 acctttatac cggaagactc tgttgtagaa gaaaagaagg ctttggtgca ccttatgtgg
     3541 gaggaggagg ggcagggcat gctgatgctg agcgtacagg cagacaagag cgtagcctgc
     3601 tgttgcctcc atcactatga aatgacttat tttacctgaa ggacccatgg tttatgttcc
     3661 tctaattcct ttcactctcc ctaagccctc tgagagagat gaagatagat gattttattg
     3721 ctactaaatt gaagggagca ctatttcttt ttgtcttttg ttagcaaaaa attgcaaaaa
     3781 gaattgtaca ttcttgctaa aaataaataa ataaataaaa aattaaaaaa acaagggacc
     3841 taacaaaact cagcagtgtt actgtatttt taaaaaatat ttttatagac tcattttcag
     3901 gttattaaat gtaagagaaa cagatacccc tcttttttaa agtaggtaaa tcattgatga
     3961 tttatattac caatttttag aagtaatttt ctagtaagct tgtggcatca gaaaatacta
     4021 gaagattttt ttagttaaat tagttagaac atttatgaat gaatataata aatatttttt
     4081 cagaataaaa tatggaccct ttgtgtttac taatagataa agccagatat aattttttgt
     4141 ttttaaggcc acaaaatatg gcctttgtta aagaacacta aagttagaaa tctaaagtta
     4201 gagcaacttt ttaatggcta tttcctatta ttgtaagtgt taaaacccct gcagaattct
     4261 tgataaggtg ctatttatac tatatttctt attataagat aactgtcttt agtcttctta
     4321 gtactagtct ttttagtact aaatcaatca gtaaacatca tcatttcacc ccaaaatttt
     4381 gtcacagaaa aggcgtatca aatgaaaaat aatttcagag atctttcttt caagatattt
     4441 tttcctgata aaatacattg tcttgaagta aatacattgt caaaacctaa ttgcaattct
     4501 gttaaatcta agtaattttt agacagtgtt tcaccgtatt atttaggatg tgaaatgcca
     4561 tttctttcac tgattacacc atatacagga aacaggtaaa acagtgaaaa ctttattgtg
     4621 ctggttgatg ccaacttggt tgaaaagctc tctgcagaag aagtgatcta gactgacaga
     4681 agtgttgcta attacaagtt gtgttctcat gacgtaatta gaaagtaact tctcaaagta
     4741 caacttttat gaaaaaaata agctgttaaa aaaaggaaat cgtaggttaa tttaattggg
     4801 aaaatgggca attgacagag accattttcc taacacatat atgtgctagt actttaactt
     4861 tttaaaattt tacttctacg ttttgtaata taaaaatttc tattttaagt ttagaatgtt
     4921 atacgtaccg aaagtatgca gccaaatcga tcagatcaaa ccattttacc tggagtttgg
     4981 tactggtttt tacttctctg aatctgtata agaaaaataa agacaattga acttcca
//
