LOCUS       XM_017022880            4624 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens WW domain containing E3 ubiquitin protein
            ligase 2 (WWP2), transcript variant X9, mRNA.
ACCESSION   XM_017022880
VERSION     XM_017022880.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000016.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017022880.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4624
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
     gene            1..4624
                     /gene="WWP2"
                     /gene_synonym="AIP2; WWp2-like"
                     /note="WW domain containing E3 ubiquitin protein ligase 2;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 100 ESTs, 841 long SRA reads, 19
                     Proteins, and 98% coverage of the annotated genomic
                     feature by RNAseq alignments, including 5 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:11060"
                     /db_xref="HGNC:HGNC:16804"
                     /db_xref="MIM:602308"
     CDS             213..2825
                     /gene="WWP2"
                     /gene_synonym="AIP2; WWp2-like"
                     /codon_start=1
                     /product="NEDD4-like E3 ubiquitin-protein ligase WWP2
                     isoform X1"
                     /protein_id="XP_016878369.1"
                     /db_xref="GeneID:11060"
                     /db_xref="HGNC:HGNC:16804"
                     /db_xref="MIM:602308"
                     /translation="MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEV
                     AVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVN
                     LSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDG
                     SQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRH
                     RQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPA
                     TPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPP
                     GWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLY
                     QSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGW
                     EMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHS
                     NALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFL
                     LSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDT
                     GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKV
                     TTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYF
                     DEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFV
                     TGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREK
                     LLYAIEETEGFGQE"
     polyA_site      4624
                     /gene="WWP2"
                     /gene_synonym="AIP2; WWp2-like"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gtgctgtggc ttacgtttat aatcccatca ctttgggagg ccaaggcagg aggatggctt
       61 gagcctagga gttcaagacc agtctggaca acttggtttg atgaagagtg gacaatcgtg
      121 gagaaatacg attggacaaa agggatgaaa cagaaaggct aaagagggct ggagtcaggg
      181 gacttctctt ccaccagctt cacggtgatg atatggcatc tgccagctct agccgggcag
      241 gagtggccct gccttttgag aagtctcagc tcactttgaa agtggtgtcc gcaaagccca
      301 aggtgcataa tcgtcaacct cgaattaact cctacgtgga ggtggcggtg gatggactcc
      361 ccagtgagac caagaagact gggaagcgca ttgggagctc tgagcttctc tggaatgaga
      421 tcatcatttt gaatgtcacg gcacagagtc atttagattt aaaggtctgg agctgccata
      481 ccttgagaaa tgaactgcta ggcaccgcat ctgtcaacct ctccaacgtc ttgaagaaca
      541 atgggggcaa aatggagaac atgcagctga ccctgaacct gcagacggag aacaaaggca
      601 gcgttgtctc aggcggagag ctgacaattt tcctggacgg gccaactgtt gatctgggaa
      661 atgtgcctaa tggcagtgcc ctgacagatg gatcacagct gccttcgaga gactccagtg
      721 gaacagcagt agctccagag aaccggcacc agccccccag cacaaactgc tttggtggaa
      781 gatcccggac gcacagacat tcgggtgctt cagccagaac aaccccagca accggcgagc
      841 aaagccccgg tgctcggagc cggcaccgcc agcccgtcaa gaactcaggc cacagtggct
      901 tggccaatgg cacagtgaat gatgaaccca caacagccac tgatcccgaa gaaccttccg
      961 ttgttggtgt gacgtcccca cctgctgcac ccttgagtgt gaccccgaat cccaacacga
     1021 cttctctccc tgccccagcc acaccggctg aaggagagga acccagcact tcgggtacac
     1081 agcagctccc agcggctgcc caggcccccg acgctctgcc tgctggatgg gaacagcgag
     1141 agctgcccaa cggacgtgtc tattatgttg accacaatac caagaccacc acctgggagc
     1201 ggccccttcc tccaggctgg gaaaaacgca cagatccccg aggcaggttt tactatgtgg
     1261 atcacaatac tcggaccacc acctggcagc gtccgaccgc ggagtacgtg cgcaactatg
     1321 agcagtggca gtcgcagcgg aatcagctcc agggggccat gcagcacttc agccaaagat
     1381 tcctctacca gtcttcgagt gcttcgactg accatgatcc cctgggcccc ctccctcctg
     1441 gctgggagaa gagacaggac aatggacggg tgtattacgt gaaccataac actcgcacga
     1501 cccagtggga ggatccccgg acccagggga tgatccagga accagctctg cccccaggat
     1561 gggagatgaa atacaccagc gagggggtgc gatactttgt ggaccacaat acccgcacca
     1621 ccacctttaa ggatcctcgc ccggggtttg agtcggggac gaagcaaggt tcccctggtg
     1681 cttatgaccg cagttttcgg tggaagtatc accagttccg tttcctctgc cattcaaatg
     1741 ccctacctag ccacgtgaag atcagcgttt ccaggcagac gcttttcgaa gattccttcc
     1801 aacagatcat gaacatgaaa ccctatgacc tgcgccgccg gctctacatc atcatgcgtg
     1861 gcgaggaggg cctggactat gggggcatcg ccagagagtg gtttttcctc ctgtctcatg
     1921 aggtgctcaa ccctatgtat tgtttatttg aatatgccgg aaagaacaat tactgcctgc
     1981 agatcaaccc cgcctcctcc atcaacccgg accacctcac ctactttcgc tttataggca
     2041 gattcatcgc catggcgctg taccatggaa agttcatcga cacgggcttc accctccctt
     2101 tctacaagcg gatgctcaat aagagaccaa ccctgaaaga cctggagtcc attgaccctg
     2161 agttctacaa ctccattgtc tggatcaaag agaacaacct ggaagaatgt ggcctggagc
     2221 tgtacttcat ccaggacatg gagatactgg gcaaggtgac gacccacgag ctgaaggagg
     2281 gcggcgagag catccgggtc acagaggaga acaaggaaga gtacatcatg ctgctgactg
     2341 actggcgttt cacccgaggc gtggaagagc agaccaaagc cttcctggat ggcttcaacg
     2401 aggtggcccc gctggagtgg ctgcgctact ttgacgagaa agagctggag ctgatgctgt
     2461 gcggcatgca ggagatagac atgagcgact ggcagaagag caccatctac cggcactaca
     2521 ccaagaacag caagcagatc cagtggttct ggcaggtggt gaaggagatg gacaacgaga
     2581 agaggatccg gctgctgcag tttgtcaccg gtacctgccg cctgcccgtc gggggatttg
     2641 ccgaactcat cggtagcaac ggaccacaga agttttgcat tgacaaagtt ggcaaggaaa
     2701 cctggctgcc cagaagccac acctgcttca accgtctgga tcttccaccc tacaagagct
     2761 acgaacagct gagagagaag ctgctgtatg ccattgagga gaccgagggc tttggacagg
     2821 agtaaccgag gccgcccctc ccacgccccc cagcgcacat gtagtcctga gtcctccctg
     2881 cctgagaggc cactggcccc gcagcccttg ggaggccccc gtggatgtgg ccctgtgtgg
     2941 gaccacactg tcatctcgct gctggcagaa aagcctgatc ccaggaggcc ctgcagttcc
     3001 cccgacccgc ggatggcagt ctggaataaa gccccctagt tgcctttggc cccacctttg
     3061 caaagttcca gagggctgac cctctctgca aaactctccc ctgtcctcta gaccccaccc
     3121 tgggtgtatg tgagtgtgca agggaaggtg ttgcatcccc aggggctgcc gcagaggccg
     3181 gagacctcct ggactagttc ggcgaggaga ctggccactg ggggtggctg ttcgggactg
     3241 agagcgccaa gggtctttgc cagcaaagga ggttctgcct gtaattgagc ctctctgatg
     3301 atggagatga agtgaaggtc tgagggagcg ggccctgggg cgaggccatc tctgcctgcc
     3361 tccctagcag gcgccagcgg tggaggctga gtcgcaggac acatgccggc cagttaattc
     3421 attctcagcc aatgaaggtt tgtctaagct gcctgggtat ccacgggaca aaaacagcaa
     3481 actccctcag actttgtcca tgtataaact tgaagtggtt gtgttgtagg gttgcaggtt
     3541 ttttgttacg ctgctgtcac tttctgtcca ggagctggca ccccaggtgt tctgagacct
     3601 tgagggaccc agacctttgg gtccaagagt ttcccaaaca gccacgcctc tcaggaaccc
     3661 acctggcggt tccgtgagct caggcaggcc tgacccggcg gcacagcctg gcagggacct
     3721 cgtccccaag cctggcagaa tgagaggggt tgaggtcccg agcgccactc ctagccttgc
     3781 cgccttcaat agagaagaaa tccctttgct agatagggtc ccccaggcag tccccagtgg
     3841 cgggacacag gggtccggct gtggagctcc cctgccagcc cctggagctc caggagggcc
     3901 tgttggtccc ctgttcagaa tggagtgcag cccgccagcg gaaagtgttc attctgcata
     3961 ggtgtgaggc tttatctgca cacaggacat gaaaaccagc agaaaggccc tgagctgctg
     4021 catagcccca tctgatttct gcagttcccg ccagcctcca acacggggac tctgccgtaa
     4081 ctggaatctt cataggtcat attgaaatct tcaaggtgac catgccccac cggggtgctg
     4141 gggcagtagt catggcagac tcccggcctg ggcccccagg attctaggac ccccaggcag
     4201 ccccttggac tggtcccggg tgccttccaa gcacagtctc catgctccca gattctcgac
     4261 cttcccccgg cccgggaggt gcagcctgcg tctgcctctg tcgtgtgtgc tgatttgagt
     4321 ggcttagctt gccacagcgc agcctcttct gtccctttca gtcatttgct gtacttccct
     4381 gtggcacgtt accatggaag ccgctccagg gtgggtcagg gtgcaagctg ctggtgaggt
     4441 ttggaagcat caggctcacg ggtgttcatg tgtgttcgtg cgtgtgtgtg cgtacgtgta
     4501 tataactgaa gtgtctgtac ggaatgccct ttgctagcca tgggctggtc accagattgt
     4561 tttgtaatgc ccgccccttg cctcgatatt gccagtttct tgtgcaataa acaatcagca
     4621 gctg
//
