LOCUS       NM_007013               4877 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens WW domain containing E3 ubiquitin protein ligase 1
            (WWP1), mRNA.
ACCESSION   NM_007013 XM_005250759
VERSION     NM_007013.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4877)
  AUTHORS   Perron,T., Boissan,M., Bieche,I., Courtois,L., Dingli,F., Loew,D.,
            Chouchene,M., Colasse,S., Levy,L. and Prunier,C.
  TITLE     CYYR1 promotes the degradation of the E3 ubiquitin ligase WWP1 and
            is associated with favorable prognosis in breast cancer
  JOURNAL   J Biol Chem 300 (9), 107601 (2024)
   PUBMED   39059493
  REMARK    GeneRIF: CYYR1 promotes the degradation of the E3 ubiquitin ligase
            WWP1 and is associated with favorable prognosis in breast cancer.
REFERENCE   2  (bases 1 to 4877)
  AUTHORS   Lee,K.T., Pranoto,I.K.A., Kim,S.Y., Choi,H.J., To,N.B., Chae,H.,
            Lee,J.Y., Kim,J.E., Kwon,Y.V. and Nam,J.W.
  TITLE     Comparative interactome analysis of alpha-arrestin families in
            human and Drosophila
  JOURNAL   Elife 12, 88328 (2024)
   PUBMED   38270169
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4877)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4877)
  AUTHORS   Tung,C.H., Huang,M.F., Liang,C.H., Wu,Y.Y., Wu,J.E., Hsu,C.L.,
            Chen,Y.L. and Hong,T.M.
  TITLE     alpha-Catulin promotes cancer stemness by antagonizing
            WWP1-mediated KLF5 degradation in lung cancer
  JOURNAL   Theranostics 12 (3), 1173-1186 (2022)
   PUBMED   35154481
  REMARK    GeneRIF: alpha-Catulin promotes cancer stemness by antagonizing
            WWP1-mediated KLF5 degradation in lung cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4877)
  AUTHORS   Kishikawa,T., Higuchi,H., Wang,L., Panch,N., Maymi,V., Best,S.,
            Lee,S., Notoya,G., Toker,A., Matesic,L.E., Wulf,G.M., Wei,W.,
            Otsuka,M., Koike,K., Clohessy,J.G., Lee,Y.R. and Pandolfi,P.P.
  TITLE     WWP1 inactivation enhances efficacy of PI3K inhibitors while
            suppressing their toxicities in breast cancer models
  JOURNAL   J Clin Invest 131 (24) (2021)
   PUBMED   34907909
  REMARK    GeneRIF: WWP1 inactivation enhances efficacy of PI3K inhibitors
            while suppressing their toxicities in breast cancer models.
REFERENCE   6  (bases 1 to 4877)
  AUTHORS   Flasza,M., Gorman,P., Roylance,R., Canfield,A.E. and Baron,M.
  TITLE     Alternative splicing determines the domain structure of WWP1, a
            Nedd4 family protein
  JOURNAL   Biochem Biophys Res Commun 290 (1), 431-437 (2002)
   PUBMED   11779188
REFERENCE   7  (bases 1 to 4877)
  AUTHORS   Conkright,M.D., Wani,M.A. and Lingrel,J.B.
  TITLE     Lung Kruppel-like factor contains an autoinhibitory domain that
            regulates its transcriptional activation by binding WWP1, an E3
            ubiquitin ligase
  JOURNAL   J Biol Chem 276 (31), 29299-29306 (2001)
   PUBMED   11375995
REFERENCE   8  (bases 1 to 4877)
  AUTHORS   Mosser,E.A., Kasanov,J.D., Forsberg,E.C., Kay,B.K., Ney,P.A. and
            Bresnick,E.H.
  TITLE     Physical and functional interactions between the transactivation
            domain of the hematopoietic transcription factor NF-E2 and WW
            domains
  JOURNAL   Biochemistry 37 (39), 13686-13695 (1998)
   PUBMED   9753456
REFERENCE   9  (bases 1 to 4877)
  AUTHORS   Wood,J.D., Yuan,J., Margolis,R.L., Colomer,V., Duan,K., Kushi,J.,
            Kaminsky,Z., Kleiderlein,J.J., Sharp,A.H. and Ross,C.A.
  TITLE     Atrophin-1, the DRPLA gene product, interacts with two families of
            WW domain-containing proteins
  JOURNAL   Mol Cell Neurosci 11 (3), 149-160 (1998)
   PUBMED   9647693
REFERENCE   10 (bases 1 to 4877)
  AUTHORS   Pirozzi,G., McConnell,S.J., Uveges,A.J., Carter,J.M., Sparks,A.B.,
            Kay,B.K. and Fowlkes,D.M.
  TITLE     Identification of novel human WW domain-containing proteins by
            cloning of ligand targets
  JOURNAL   J Biol Chem 272 (23), 14611-14616 (1997)
   PUBMED   9169421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103760.2, BC036065.1, AY043361.1, BM664090.1, AW137654.1 and
            AC103817.6.
            
            On May 17, 2019 this sequence version replaced NM_007013.3.
            
            Summary: WW domain-containing proteins are found in all eukaryotes
            and play an important role in the regulation of a wide variety of
            cellular functions such as protein degradation, transcription, and
            RNA splicing. This gene encodes a protein which contains 4 tandem
            WW domains and a HECT (homologous to the E6-associated protein
            carboxyl terminus) domain. The encoded protein belongs to a family
            of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and
            regulate key trafficking decisions, including targeting of proteins
            to proteosomes or lysosomes. Alternative splicing of this gene
            generates at least 6 transcript variants; however, the full length
            nature of these transcripts has not been defined. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.74219.1,
                                           SRR1660803.42287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517970.6/ ENSP00000427793.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AC103760.2         2474-2691           c
            219-3315            BC036065.1         5-3101
            3316-3857           AY043361.1         2903-3444
            3858-3892           BC036065.1         3644-3678
            3893-4318           BM664090.1         22-447              c
            4319-4326           AW137654.1         13-20               c
            4327-4877           AC103817.6         89924-90474         c
FEATURES             Location/Qualifiers
     source          1..4877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..4877
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="WW domain containing E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:11059"
                     /db_xref="HGNC:HGNC:17004"
                     /db_xref="MIM:602307"
     exon            1..384
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..477
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..568
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     CDS             499..3267
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /EC_number="2.3.2.26"
                     /note="Nedd-4-like ubiquitin-protein ligase; atrophin-1
                     interacting protein 5; TGIF-interacting ubiquitin ligase
                     1; WW domain-containing protein 1; HECT-type E3 ubiquitin
                     transferase WWP1"
                     /codon_start=1
                     /product="NEDD4-like E3 ubiquitin-protein ligase WWP1"
                     /protein_id="NP_008944.1"
                     /db_xref="CCDS:CCDS6242.1"
                     /db_xref="GeneID:11059"
                     /db_xref="HGNC:HGNC:17004"
                     /db_xref="MIM:602307"
                     /translation="MATASPRSDTSNNHSGRLQLQVTVSSAKLKRKKNWFGTAIYTEV
                     VVDGEITKTAKSSSSSNPKWDEQLTVNVTPQTTLEFQVWSHRTLKADALLGKATIDLK
                     QALLIHNRKLERVKEQLKLSLENKNGIAQTGELTVVLDGLVIEQENITNCSSSPTIEI
                     QENGDALHENGEPSARTTARLAVEGTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPS
                     QVAARPKNTPAPKPLASEPADDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTST
                     TVEDPPVQEILTSSENNECIPSTSAELESEARSILEPDTSNSRSSSAFEAAKSRQPDG
                     CMDPVRQQSGNANTETLPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVD
                     DRRRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAA
                     ENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLQNEEPLPEGWEIRYTR
                     EGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNALPSH
                     VKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVL
                     NPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPF
                     YKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLK
                     LGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELE
                     VMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRL
                     PLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIE
                     ETEGFGQE"
     exon            569..707
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..832
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..970
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1037
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1222
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1559
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1655
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1830
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1885
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1970
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2099
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2175
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2247
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2336
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2496
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2630
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2771
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2772..2892
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..2997
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3094
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3167
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..4877
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3838..3843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="hexamer: AATACA"
     polyA_site      3854
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="major polyA site"
     regulatory      4306..4311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="hexamer: ATTAAA"
     polyA_site      4326
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="major polyA site"
     regulatory      4487..4492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="hexamer: AATACA"
     polyA_site      4506
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
     polyA_site      4572
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
     regulatory      4599..4604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="hexamer: TATAAA"
     polyA_site      4639
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
     regulatory      4709..4714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="hexamer: AGTAAA"
     regulatory      4720..4725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="hexamer: AAGAAA"
     polyA_site      4729
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
     polyA_site      4751
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
     regulatory      4805..4810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
                     /note="hexamer: ATTAAA"
     polyA_site      4827
                     /gene="WWP1"
                     /gene_synonym="AIP5; hSDRP1; Tiul1"
ORIGIN      
        1 attccgggtc cggagttgga ggctttgggc ggccgcggcg tagcgcgcgg tgccggggcc
       61 ggcggggagg cgcgcgctta gggcgcggcg ccggcgacgc ggccacgcgg cgcgctcccg
      121 aggaagggag gtgtggggtc ggctgggggt ggcgcgtgga cggggtgggg gtggggggag
      181 ggtcgggtgt cggcgagctc cgcgtgcggg ttccgagtgg ctgctggcgg cctgggctgc
      241 cggggccgac gcctgggtgg ctgctgccgc cgcgcctgct gcgagatggc gatcttgggc
      301 gcggaagggt gagggcgccc gccgcaggag gaggtgccgc tgccgtggcc gcccggctgc
      361 cgggagccga cagcttcgcg ccggggttgt ctcctcacag actatgagct ccttgaaaga
      421 gggaatcgtg tcttactcat ctttgtatcc ccagtgtcta gcagttcctg atacatagtt
      481 ttagctgaat tttgggacat ggccactgct tcaccaaggt ctgatactag taataaccac
      541 agtggaaggt tgcagttaca ggtaactgtt tctagtgcca aacttaaaag aaaaaagaac
      601 tggttcggaa cagcaatata tacagaagta gttgtagatg gagaaattac gaaaacagca
      661 aaatccagta gttcttctaa tccaaaatgg gatgaacagc taactgtaaa tgttacgcca
      721 cagactacat tggaatttca agtttggagc catcgcactt taaaagcaga tgctttatta
      781 ggaaaagcaa cgatagattt gaaacaagct ctgttgatac acaatagaaa attggaaaga
      841 gtgaaagaac aattaaaact ttccttggaa aacaagaatg gcatagcaca aactggtgaa
      901 ttgacagttg tgcttgatgg attggtgatt gagcaagaaa atataacaaa ctgcagctca
      961 tctccaacca tagaaataca ggaaaatggt gatgccttac atgaaaatgg agagccttca
     1021 gcaaggacaa ctgccaggtt ggctgttgaa ggcacgaatg gaatagataa tcatgtacct
     1081 acaagcactc tagtccaaaa ctcatgctgc tcgtatgtag ttaatggaga caacacacct
     1141 tcatctccgt ctcaggttgc tgccagaccc aaaaatacac cagctccaaa accactcgca
     1201 tctgagcctg ccgatgacac tgttaatgga gaatcatcct catttgcacc aactgataat
     1261 gcgtctgtca cgggtactcc agtagtgtct gaagaaaatg ccttgtctcc aaattgcact
     1321 agtactactg ttgaagatcc tccagttcaa gaaatactga cttcctcaga aaacaatgaa
     1381 tgtattcctt ctaccagtgc agaattggaa tctgaagcta gaagtatatt agagcctgac
     1441 acctctaatt ctagaagtag ttctgctttt gaagcagcca aatcaagaca gccagatggg
     1501 tgtatggatc ctgtacggca gcagtctggg aatgccaaca cagaaacctt gccatcaggg
     1561 tgggaacaaa gaaaagatcc tcatggtaga acctattatg tggatcataa tactcgaact
     1621 accacatggg agagaccaca acctttacct ccaggttggg aaagaagagt tgatgatcgt
     1681 agaagagttt attatgtgga tcataacacc agaacaacaa cgtggcagcg gcctaccatg
     1741 gaatctgtcc gaaattttga acagtggcaa tctcagcgga accaattgca gggagctatg
     1801 caacagttta accaacgata cctctattcg gcttcaatgt tagctgcaga aaatgaccct
     1861 tatggacctt tgccaccagg ctgggaaaaa agagtggatt caacagacag ggtttacttt
     1921 gtgaatcata acacaaaaac aacccagtgg gaagatccaa gaactcaagg cttacagaat
     1981 gaagaacccc tgccagaagg ctgggaaatt agatatactc gtgaaggtgt aaggtacttt
     2041 gttgatcata acacaagaac aacaacattc aaagatcctc gcaatgggaa gtcatctgta
     2101 actaaaggtg gtccacaaat tgcttatgaa cgcggcttta ggtggaagct tgctcacttc
     2161 cgttatttgt gccagtctaa tgcactacct agtcatgtaa agatcaatgt gtcccggcag
     2221 acattgtttg aagattcctt ccaacagatt atggcattaa aaccctatga cttgaggagg
     2281 cgcttatatg taatatttag aggagaagaa ggacttgatt atggtggcct agcgagagaa
     2341 tggtttttct tgctttcaca tgaagttttg aacccaatgt attgcttatt tgagtatgcg
     2401 ggcaagaaca actattgtct gcagataaat ccagcatcaa ccattaatcc agaccatctt
     2461 tcatacttct gtttcattgg tcgttttatt gccatggcac tatttcatgg aaagtttatc
     2521 gatactggtt tctctttacc attctacaag cgtatgttaa gtaaaaaact tactattaag
     2581 gatttggaat ctattgatac tgaattttat aactccctta tctggataag agataacaac
     2641 attgaagaat gtggcttaga aatgtacttt tctgttgaca tggagatttt gggaaaagtt
     2701 acttcacatg acctgaagtt gggaggttcc aatattctgg tgactgagga gaacaaagat
     2761 gaatatattg gtttaatgac agaatggcgt ttttctcgag gagtacaaga acagaccaaa
     2821 gctttccttg atggttttaa tgaagttgtt cctcttcagt ggctacagta cttcgatgaa
     2881 aaagaattag aggttatgtt gtgtggcatg caggaggttg acttggcaga ttggcagaga
     2941 aatactgttt atcgacatta tacaagaaac agcaagcaaa tcatttggtt ttggcagttt
     3001 gtgaaagaga cagacaatga agtaagaatg cgactattgc agttcgtcac tggaacctgc
     3061 cgtttacctc taggaggatt tgctgagctc atgggaagta atgggcctca aaagttttgc
     3121 attgaaaaag ttggcaaaga cacttggtta ccaagaagcc atacatgttt taatcgcttg
     3181 gatctaccac catataagag ttatgaacaa ctaaaggaaa aacttctttt tgcaatagaa
     3241 gagacagagg gatttggaca agaatgaatg tggcttctta ttttggagga gctcttgcat
     3301 ttaaataccc cagccaagaa aaattgcaca gatagtgtat ataagctgtt cattctgtac
     3361 agtgaatttt ccgaacctct caaagtatgt tttccgttct tccacagaaa tatgcaaaac
     3421 agttcatcct tttctacttt atttattgtt cccttgaaat gactgaccag gaaaaagatc
     3481 atccttaaat tttgaagcaa gtgagagact ttattaaaaa tacatatata tctatataaa
     3541 catatatgat agtggctcta gttttataga gctccaagtg tattaaacat gacagccatt
     3601 cattcataaa gatctggatt tgctttacct tgttaatatt atctagggga aaaagtgcaa
     3661 attgctccat gttcttctct cccttatgta acatctcctg agggtgttta gttgcatggc
     3721 tgttcagaaa ggtattaagg gcttaggcca aatcttactt tgagtatgtt aaaaaaaaaa
     3781 aaatgctgct ggcttttctg aagacaggtg cttgaacttg tcagtttgtt ttaaataaat
     3841 acaatagttg aaaatttttc tctgttacat cagtaatatt gttaaagtaa tggatagaac
     3901 cataacttac acatgaaagt catatactag atccaatact atttagttta ttatcgaaat
     3961 tggaaggatt cattgagcag catagaagtt tgtttacatg ttactttgag atgctaggta
     4021 tttgtggaat taaaaagaat caggctcttt tgtactttgt ttttaaatct gtgatgcttt
     4081 tcaaatttaa ttcataataa attgatgcaa tttcatactt aggaacatac aaaaggtaat
     4141 gtaaactctg ccactttttt gtgttcaaaa ttttggtttt tatgaagcca gatggattga
     4201 agagttacat aagcatttga atgctctaat ataaggctaa tgattttctg ttagtgtttg
     4261 aatatcttca ttcctctcaa attcataaca gttctattta actgaattaa ataaccatat
     4321 gaaaaatctt ttgggtctcc ccctttttac acagataatt atttttgtca taacactttt
     4381 taattgtttt tcatcatagg ggcctttgct gaactacaaa aatgtgtaac aaattaaaat
     4441 ctgatgtgaa tgatattaat gctactttta gcaaactggg cttcctaata caaaatttta
     4501 aatttccatt tgtatcatgc ttttaatatg cactgtaaat ttcattaact taaacatttt
     4561 ttaatagcca tggaactgac ttcttaaaat ctgttgccta taaatatttc actgctaagt
     4621 acatacagaa aaacagtaat tattgttttg ccaaaatttt atttttctac atattgagag
     4681 tgtgttctcc attttattca gaattcatag taaagacgaa agaaaggcag agatctgctt
     4741 ggttgaatag actccttttc caaatcctta ttatgaacac tctggtaatt ttcaagccta
     4801 aagaattaaa aaaaaaattc taatgtatgt gacaggttat gtgatagagg gaaactggcc
     4861 ttcaaaaagg actgcgt
//
