LOCUS       NM_016373               2241 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens WW domain containing oxidoreductase (WWOX), transcript
            variant 1, mRNA.
ACCESSION   NM_016373 NM_004916
VERSION     NM_016373.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2241)
  AUTHORS   Cheng,L., Chang,Y., Xia,Z., Liu,Y., Liu,X., Xiong,L., Liu,C.,
            Zhu,X., Wang,M. and Qiu,L.
  TITLE     Remote modulation of WWOX by an intronic variant associated with
            survival of Chinese gastric cancer patients
  JOURNAL   Int J Cancer 154 (2), 307-319 (2024)
   PUBMED   37615513
  REMARK    GeneRIF: Remote modulation of WWOX by an intronic variant
            associated with survival of Chinese gastric cancer patients.
REFERENCE   2  (bases 1 to 2241)
  AUTHORS   Shin,M.J., Kim,H.S., Lee,P., Yang,N.G., Kim,J.Y., Eun,Y.S., Lee,W.,
            Kim,D., Lee,Y., Jung,K.E., Hong,D., Shin,J.M., Lee,S.H., Lee,S.Y.,
            Kim,C.D. and Kim,J.E.
  TITLE     Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin
            Inflammation in Psoriasis
  JOURNAL   Int J Mol Sci 25 (1), 167 (2023)
   PUBMED   38203337
  REMARK    GeneRIF: Mechanistic Investigation of WWOX Function in
            NF-kB-Induced Skin Inflammation in Psoriasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2241)
  AUTHORS   Dong,X.S., Wen,X.J., Zhang,S., Wang,D.G., Xiong,Y. and Li,Z.M.
  TITLE     Identification of compound heterozygous deletion of the WWOX gene
            in WOREE syndrome
  JOURNAL   BMC Med Genomics 16 (1), 291 (2023)
   PUBMED   37974179
  REMARK    GeneRIF: Identification of compound heterozygous deletion of the
            WWOX gene in WOREE syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2241)
  AUTHORS   Cheng,H.C., Huang,P.H., Lai,F.J., Jan,M.S., Chen,Y.L., Chen,S.Y.,
            Chen,W.L., Hsu,C.K., Huang,W. and Hsu,L.J.
  TITLE     Loss of fragile WWOX gene leads to senescence escape and genome
            instability
  JOURNAL   Cell Mol Life Sci 80 (11), 338 (2023)
   PUBMED   37897534
  REMARK    GeneRIF: Loss of fragile WWOX gene leads to senescence escape and
            genome instability.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2241)
  AUTHORS   Lin,C.Y., Wang,C.L., Wang,S.S., Yang,C.K., Li,J.R., Chen,C.S.,
            Hung,S.C., Chiu,K.Y., Cheng,C.L., Ou,Y.C. and Yang,S.F.
  TITLE     WWOX Polymorphisms as Predictors of the Biochemical Recurrence of
            Localized Prostate Cancer after Radical Prostatectomy
  JOURNAL   Int J Med Sci 20 (7), 969-975 (2023)
   PUBMED   37324196
  REMARK    GeneRIF: WWOX Polymorphisms as Predictors of the Biochemical
            Recurrence of Localized Prostate Cancer after Radical
            Prostatectomy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2241)
  AUTHORS   Bednarek,A.K., Keck-Waggoner,C.L., Daniel,R.L., Laflin,K.J.,
            Bergsagel,P.L., Kiguchi,K., Brenner,A.J. and Aldaz,C.M.
  TITLE     WWOX, the FRA16D gene, behaves as a suppressor of tumor growth
  JOURNAL   Cancer Res 61 (22), 8068-8073 (2001)
   PUBMED   11719429
  REMARK    GeneRIF: WWOX, the FRA16D gene, behaves as a suppressor of tumor
            growth.
REFERENCE   7  (bases 1 to 2241)
  AUTHORS   Paige,A.J., Taylor,K.J., Taylor,C., Hillier,S.G., Farrington,S.,
            Scott,D., Porteous,D.J., Smyth,J.F., Gabra,H. and Watson,J.E.
  TITLE     WWOX: a candidate tumor suppressor gene involved in multiple tumor
            types
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11417-11422 (2001)
   PUBMED   11572989
REFERENCE   8  (bases 1 to 2241)
  AUTHORS   Chang,N.S., Pratt,N., Heath,J., Schultz,L., Sleve,D., Carey,G.B.
            and Zevotek,N.
  TITLE     Hyaluronidase induction of a WW domain-containing oxidoreductase
            that enhances tumor necrosis factor cytotoxicity
  JOURNAL   J Biol Chem 276 (5), 3361-3370 (2001)
   PUBMED   11058590
REFERENCE   9  (bases 1 to 2241)
  AUTHORS   Ried,K., Finnis,M., Hobson,L., Mangelsdorf,M., Dayan,S.,
            Nancarrow,J.K., Woollatt,E., Kremmidiotis,G., Gardner,A.,
            Venter,D., Baker,E. and Richards,R.I.
  TITLE     Common chromosomal fragile site FRA16D sequence: identification of
            the FOR gene spanning FRA16D and homozygous deletions and
            translocation breakpoints in cancer cells
  JOURNAL   Hum Mol Genet 9 (11), 1651-1663 (2000)
   PUBMED   10861292
REFERENCE   10 (bases 1 to 2241)
  AUTHORS   Bednarek,A.K., Laflin,K.J., Daniel,R.L., Liao,Q., Hawkins,K.A. and
            Aldaz,C.M.
  TITLE     WWOX, a novel WW domain-containing protein mapping to human
            chromosome 16q23.3-24.1, a region frequently affected in breast
            cancer
  JOURNAL   Cancer Res 60 (8), 2140-2145 (2000)
   PUBMED   10786676
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF211943.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016373.3.
            
            Summary: This gene encodes a member of the short-chain
            dehydrogenases/reductases (SDR) protein family. This gene spans the
            FRA16D common chromosomal fragile site and appears to function as a
            tumor suppressor gene. Expression of the encoded protein is able to
            induce apoptosis, while defects in this gene are associated with
            multiple types of cancer. Disruption of this gene is also
            associated with autosomal recessive spinocerebellar ataxia 12.
            Disruption of a similar gene in mouse results in impaired
            steroidogenesis, additionally suggesting a metabolic function for
            the protein. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF211943.1, SRR1803614.118508.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000566780.6/ ENSP00000457230.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2241              AF211943.1         1-2241
FEATURES             Location/Qualifiers
     source          1..2241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1-q23.2"
     gene            1..2241
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /note="WW domain containing oxidoreductase"
                     /db_xref="GeneID:51741"
                     /db_xref="HGNC:HGNC:12799"
                     /db_xref="MIM:605131"
     exon            1..232
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1370
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /EC_number="1.1.1.-"
                     /note="isoform 1 is encoded by transcript variant 1; WW
                     domain-containing protein WWOX; fragile site FRA16D
                     oxidoreductase; short chain dehydrogenase/reductase family
                     41C member 1"
                     /codon_start=1
                     /product="WW domain-containing oxidoreductase isoform 1"
                     /protein_id="NP_057457.1"
                     /db_xref="CCDS:CCDS42196.1"
                     /db_xref="GeneID:51741"
                     /db_xref="HGNC:HGNC:12799"
                     /db_xref="MIM:605131"
                     /translation="MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQW
                     EHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPT
                     TRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMAR
                     ASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPW
                     SLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLD
                     FSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRS
                     WWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEE
                     TARTLWALSERLIQERLGSQSG"
     exon            233..297
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..355
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..534
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..641
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..730
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..916
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1181
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..2241
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2217..2222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /note="hexamer: AATAAA"
     polyA_site      2241
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcgca ggcgtgagcg gtcgggcccc gacgcgcgcg ggtctcgttt ggagcgggag
       61 tgagttcctg agcgagtgga cccggcagcg ggcgataggg gggccaggtg cctccacagt
      121 cagccatggc agcgctgcgc tacgcggggc tggacgacac ggacagtgag gacgagctgc
      181 ctccgggctg ggaggagaga accaccaagg acggctgggt ttactacgcc aatcacaccg
      241 aggagaagac tcagtgggaa catccaaaaa ctggaaaaag aaaacgagtg gcaggagatt
      301 tgccatacgg atgggaacaa gaaactgatg agaacggaca agtgtttttt gttgaccata
      361 taaataaaag aaccacctac ttggacccaa gactggcgtt tactgtggat gataatccga
      421 ccaagccaac cacccggcaa agatacgacg gcagcaccac tgccatggaa attctccagg
      481 gccgggattt cactggcaaa gtggttgtgg tcactggagc taattcagga atagggttcg
      541 aaaccgccaa gtcttttgcc ctccatggtg cacatgtgat cttggcctgc aggaacatgg
      601 caagggcgag tgaagcagtg tcacgcattt tagaagaatg gcataaagcc aaggtagaag
      661 caatgaccct ggacctcgct ctgctccgta gcgtgcagca ttttgctgaa gcattcaagg
      721 ccaagaatgt gcctcttcat gtgcttgtgt gcaacgcagc aacttttgct ctaccctgga
      781 gtctcaccaa agatggcctg gagaccacct ttcaagtgaa tcatctgggg cacttctacc
      841 ttgtccagct cctccaggat gttttgtgcc gctcagctcc tgcccgtgtc attgtggtct
      901 cctcagagtc ccatcgattt acagatatta acgactcctt gggaaaactg gacttcagtc
      961 gcctctctcc aacaaaaaac gactattggg cgatgctggc ttataacagg tccaagctct
     1021 gcaacatcct cttctccaac gagctgcacc gtcgcctctc cccacgcggg gtcacgtcga
     1081 acgcagtgca tcctggaaat atgatgtact ccaacattca tcgcagctgg tgggtgtaca
     1141 cactgctgtt taccttggcg aggcctttca ccaagtccat gcaacaggga gctgccacca
     1201 ccgtgtactg tgctgctgtc ccagaactgg agggtctggg agggatgtac ttcaacaact
     1261 gctgccgctg catgccctca ccagaagctc agagcgaaga gacggcccgg accctgtggg
     1321 cgctcagcga gaggctgatc caagaacggc ttggcagcca gtccggctaa gtggagctca
     1381 gagcggatgg gcacacacac ccgccctgtg tgtgtcccct cacgcaagtg ccagggctgg
     1441 gccccttcca aatgtccctc caacacagat ccgcaagagt aaaggaaata agagcagtca
     1501 caacagagtg aaaaatctta agtaccaatg ggaagcaggg aattcctggg gtaaagtatc
     1561 acttttctgg ggctgggcta ggcataggtc tctttgcttt ctggtggtgg cctgtttgaa
     1621 agtaaaaacc tgcttggtgt gtaggttccg tatctccctg gagaagcacc agcaattctc
     1681 tttcttttac tgttatagaa tagcctgagg tcccctcgtc ccatccagct accaccacgg
     1741 ccaccactgc agccgggggc tggccttctc ctacttaggg aagaaaaagc aagtgttcac
     1801 tgctccttgc tgcattgatc caggagataa ttgtttcatt catcctgacc aagactgagc
     1861 cagcttagca actgctgggg agacaaatct cagaaccttg tcccagccag tgaggatgac
     1921 agtgacaccc agagggagta gaatacgcag aactaccagg tggcaaagta cttgtcatag
     1981 actcctttgc taatgctatg caaaaaattc tttagagatt ataacaaatt tttcaaatca
     2041 ttccttagat accttgaaag gcaggaaggg aagcgtatat acttaagaat acacaggata
     2101 ttttgggggg cagagaataa aacgttagtt aatccctttg tctgtcaatc acagtctcag
     2161 ttctcttgct ttcacattgt acttaaacct cctgctgtgc ctcgcatcct atgcttaata
     2221 aaagaacatg cttgaatatc a
//
