LOCUS       NM_001291997            2176 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens WW domain containing oxidoreductase (WWOX), transcript
            variant 4, mRNA.
ACCESSION   NM_001291997
VERSION     NM_001291997.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2176)
  AUTHORS   Cheng,L., Chang,Y., Xia,Z., Liu,Y., Liu,X., Xiong,L., Liu,C.,
            Zhu,X., Wang,M. and Qiu,L.
  TITLE     Remote modulation of WWOX by an intronic variant associated with
            survival of Chinese gastric cancer patients
  JOURNAL   Int J Cancer 154 (2), 307-319 (2024)
   PUBMED   37615513
  REMARK    GeneRIF: Remote modulation of WWOX by an intronic variant
            associated with survival of Chinese gastric cancer patients.
REFERENCE   2  (bases 1 to 2176)
  AUTHORS   Shin,M.J., Kim,H.S., Lee,P., Yang,N.G., Kim,J.Y., Eun,Y.S., Lee,W.,
            Kim,D., Lee,Y., Jung,K.E., Hong,D., Shin,J.M., Lee,S.H., Lee,S.Y.,
            Kim,C.D. and Kim,J.E.
  TITLE     Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin
            Inflammation in Psoriasis
  JOURNAL   Int J Mol Sci 25 (1), 167 (2023)
   PUBMED   38203337
  REMARK    GeneRIF: Mechanistic Investigation of WWOX Function in
            NF-kB-Induced Skin Inflammation in Psoriasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2176)
  AUTHORS   Dong,X.S., Wen,X.J., Zhang,S., Wang,D.G., Xiong,Y. and Li,Z.M.
  TITLE     Identification of compound heterozygous deletion of the WWOX gene
            in WOREE syndrome
  JOURNAL   BMC Med Genomics 16 (1), 291 (2023)
   PUBMED   37974179
  REMARK    GeneRIF: Identification of compound heterozygous deletion of the
            WWOX gene in WOREE syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2176)
  AUTHORS   Cheng,H.C., Huang,P.H., Lai,F.J., Jan,M.S., Chen,Y.L., Chen,S.Y.,
            Chen,W.L., Hsu,C.K., Huang,W. and Hsu,L.J.
  TITLE     Loss of fragile WWOX gene leads to senescence escape and genome
            instability
  JOURNAL   Cell Mol Life Sci 80 (11), 338 (2023)
   PUBMED   37897534
  REMARK    GeneRIF: Loss of fragile WWOX gene leads to senescence escape and
            genome instability.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2176)
  AUTHORS   Lin,C.Y., Wang,C.L., Wang,S.S., Yang,C.K., Li,J.R., Chen,C.S.,
            Hung,S.C., Chiu,K.Y., Cheng,C.L., Ou,Y.C. and Yang,S.F.
  TITLE     WWOX Polymorphisms as Predictors of the Biochemical Recurrence of
            Localized Prostate Cancer after Radical Prostatectomy
  JOURNAL   Int J Med Sci 20 (7), 969-975 (2023)
   PUBMED   37324196
  REMARK    GeneRIF: WWOX Polymorphisms as Predictors of the Biochemical
            Recurrence of Localized Prostate Cancer after Radical
            Prostatectomy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2176)
  AUTHORS   Bednarek,A.K., Keck-Waggoner,C.L., Daniel,R.L., Laflin,K.J.,
            Bergsagel,P.L., Kiguchi,K., Brenner,A.J. and Aldaz,C.M.
  TITLE     WWOX, the FRA16D gene, behaves as a suppressor of tumor growth
  JOURNAL   Cancer Res 61 (22), 8068-8073 (2001)
   PUBMED   11719429
  REMARK    GeneRIF: WWOX, the FRA16D gene, behaves as a suppressor of tumor
            growth.
REFERENCE   7  (bases 1 to 2176)
  AUTHORS   Paige,A.J., Taylor,K.J., Taylor,C., Hillier,S.G., Farrington,S.,
            Scott,D., Porteous,D.J., Smyth,J.F., Gabra,H. and Watson,J.E.
  TITLE     WWOX: a candidate tumor suppressor gene involved in multiple tumor
            types
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11417-11422 (2001)
   PUBMED   11572989
REFERENCE   8  (bases 1 to 2176)
  AUTHORS   Chang,N.S., Pratt,N., Heath,J., Schultz,L., Sleve,D., Carey,G.B.
            and Zevotek,N.
  TITLE     Hyaluronidase induction of a WW domain-containing oxidoreductase
            that enhances tumor necrosis factor cytotoxicity
  JOURNAL   J Biol Chem 276 (5), 3361-3370 (2001)
   PUBMED   11058590
REFERENCE   9  (bases 1 to 2176)
  AUTHORS   Ried,K., Finnis,M., Hobson,L., Mangelsdorf,M., Dayan,S.,
            Nancarrow,J.K., Woollatt,E., Kremmidiotis,G., Gardner,A.,
            Venter,D., Baker,E. and Richards,R.I.
  TITLE     Common chromosomal fragile site FRA16D sequence: identification of
            the FOR gene spanning FRA16D and homozygous deletions and
            translocation breakpoints in cancer cells
  JOURNAL   Hum Mol Genet 9 (11), 1651-1663 (2000)
   PUBMED   10861292
REFERENCE   10 (bases 1 to 2176)
  AUTHORS   Bednarek,A.K., Laflin,K.J., Daniel,R.L., Liao,Q., Hawkins,K.A. and
            Aldaz,C.M.
  TITLE     WWOX, a novel WW domain-containing protein mapping to human
            chromosome 16q23.3-24.1, a region frequently affected in breast
            cancer
  JOURNAL   Cancer Res 60 (8), 2140-2145 (2000)
   PUBMED   10786676
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF211943.1.
            
            On May 31, 2019 this sequence version replaced NM_001291997.1.
            
            Summary: This gene encodes a member of the short-chain
            dehydrogenases/reductases (SDR) protein family. This gene spans the
            FRA16D common chromosomal fragile site and appears to function as a
            tumor suppressor gene. Expression of the encoded protein is able to
            induce apoptosis, while defects in this gene are associated with
            multiple types of cancer. Disruption of this gene is also
            associated with autosomal recessive spinocerebellar ataxia 12.
            Disruption of a similar gene in mouse results in impaired
            steroidogenesis, additionally suggesting a metabolic function for
            the protein. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (4) differs in its 5' UTR and uses
            a downstream start codon, compared to variant 1. The encoded
            isoform (4) has a shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.11175.1,
                                           SRR1803611.114470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AF211943.1         1-232
            233-2176            AF211943.1         298-2241
FEATURES             Location/Qualifiers
     source          1..2176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1-q23.2"
     gene            1..2176
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /note="WW domain containing oxidoreductase"
                     /db_xref="GeneID:51741"
                     /db_xref="HGNC:HGNC:12799"
                     /db_xref="MIM:605131"
     exon            1..232
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..290
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            291..469
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1305
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /EC_number="1.1.1.-"
                     /note="isoform 4 is encoded by transcript variant 4; WW
                     domain-containing protein WWOX; fragile site FRA16D
                     oxidoreductase; short chain dehydrogenase/reductase family
                     41C member 1"
                     /codon_start=1
                     /product="WW domain-containing oxidoreductase isoform 4"
                     /protein_id="NP_001278926.1"
                     /db_xref="GeneID:51741"
                     /db_xref="HGNC:HGNC:12799"
                     /db_xref="MIM:605131"
                     /translation="MEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRN
                     MARASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFA
                     LPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLG
                     KLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNI
                     HRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQ
                     SEETARTLWALSERLIQERLGSQSG"
     exon            470..576
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..665
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..851
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1116
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..2176
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2152..2157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /note="hexamer: AATAAA"
     polyA_site      2176
                     /gene="WWOX"
                     /gene_synonym="D16S432E; DEE28; EIEE28; FOR; FRA16D;
                     HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcgca ggcgtgagcg gtcgggcccc gacgcgcgcg ggtctcgttt ggagcgggag
       61 tgagttcctg agcgagtgga cccggcagcg ggcgataggg gggccaggtg cctccacagt
      121 cagccatggc agcgctgcgc tacgcggggc tggacgacac ggacagtgag gacgagctgc
      181 ctccgggctg ggaggagaga accaccaagg acggctgggt ttactacgcc aaatttgcca
      241 tacggatggg aacaagaaac tgatgagaac ggacaagtgt tttttgttga ccatataaat
      301 aaaagaacca cctacttgga cccaagactg gcgtttactg tggatgataa tccgaccaag
      361 ccaaccaccc ggcaaagata cgacggcagc accactgcca tggaaattct ccagggccgg
      421 gatttcactg gcaaagtggt tgtggtcact ggagctaatt caggaatagg gttcgaaacc
      481 gccaagtctt ttgccctcca tggtgcacat gtgatcttgg cctgcaggaa catggcaagg
      541 gcgagtgaag cagtgtcacg cattttagaa gaatggcata aagccaaggt agaagcaatg
      601 accctggacc tcgctctgct ccgtagcgtg cagcattttg ctgaagcatt caaggccaag
      661 aatgtgcctc ttcatgtgct tgtgtgcaac gcagcaactt ttgctctacc ctggagtctc
      721 accaaagatg gcctggagac cacctttcaa gtgaatcatc tggggcactt ctaccttgtc
      781 cagctcctcc aggatgtttt gtgccgctca gctcctgccc gtgtcattgt ggtctcctca
      841 gagtcccatc gatttacaga tattaacgac tccttgggaa aactggactt cagtcgcctc
      901 tctccaacaa aaaacgacta ttgggcgatg ctggcttata acaggtccaa gctctgcaac
      961 atcctcttct ccaacgagct gcaccgtcgc ctctccccac gcggggtcac gtcgaacgca
     1021 gtgcatcctg gaaatatgat gtactccaac attcatcgca gctggtgggt gtacacactg
     1081 ctgtttacct tggcgaggcc tttcaccaag tccatgcaac agggagctgc caccaccgtg
     1141 tactgtgctg ctgtcccaga actggagggt ctgggaggga tgtacttcaa caactgctgc
     1201 cgctgcatgc cctcaccaga agctcagagc gaagagacgg cccggaccct gtgggcgctc
     1261 agcgagaggc tgatccaaga acggcttggc agccagtccg gctaagtgga gctcagagcg
     1321 gatgggcaca cacacccgcc ctgtgtgtgt cccctcacgc aagtgccagg gctgggcccc
     1381 ttccaaatgt ccctccaaca cagatccgca agagtaaagg aaataagagc agtcacaaca
     1441 gagtgaaaaa tcttaagtac caatgggaag cagggaattc ctggggtaaa gtatcacttt
     1501 tctggggctg ggctaggcat aggtctcttt gctttctggt ggtggcctgt ttgaaagtaa
     1561 aaacctgctt ggtgtgtagg ttccgtatct ccctggagaa gcaccagcaa ttctctttct
     1621 tttactgtta tagaatagcc tgaggtcccc tcgtcccatc cagctaccac cacggccacc
     1681 actgcagccg ggggctggcc ttctcctact tagggaagaa aaagcaagtg ttcactgctc
     1741 cttgctgcat tgatccagga gataattgtt tcattcatcc tgaccaagac tgagccagct
     1801 tagcaactgc tggggagaca aatctcagaa ccttgtccca gccagtgagg atgacagtga
     1861 cacccagagg gagtagaata cgcagaacta ccaggtggca aagtacttgt catagactcc
     1921 tttgctaatg ctatgcaaaa aattctttag agattataac aaatttttca aatcattcct
     1981 tagatacctt gaaaggcagg aagggaagcg tatatactta agaatacaca ggatattttg
     2041 gggggcagag aataaaacgt tagttaatcc ctttgtctgt caatcacagt ctcagttctc
     2101 ttgctttcac attgtactta aacctcctgc tgtgcctcgc atcctatgct taataaaaga
     2161 acatgcttga atatca
//
