LOCUS       NM_015691               6952 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens WWC family member 3 (WWC3), mRNA.
ACCESSION   NM_015691 NM_018458 XM_005274559
VERSION     NM_015691.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6952)
  AUTHORS   Qi,S., Zhu,Y., Liu,X., Li,P., Wang,Y., Zeng,Y., Yu,A., Wang,Y.,
            Sha,Z., Zhong,Z., Zhu,R., Yuan,H., Ye,D., Huang,S., Ling,C., Xu,Y.,
            Zhou,D., Zhang,L. and Yu,F.X.
  TITLE     WWC proteins mediate LATS1/2 activation by Hippo kinases and imply
            a tumor suppression strategy
  JOURNAL   Mol Cell 82 (10), 1850-1864 (2022)
   PUBMED   35429439
REFERENCE   2  (bases 1 to 6952)
  AUTHORS   Han,Q., Rong,X., Lin,X., Zhang,X., Fan,C., Zhao,H. and Wang,E.
  TITLE     WBP2 negatively regulates the Hippo pathway by competitively
            binding to WWC3 with LATS1 to promote non-small cell lung cancer
            progression
  JOURNAL   Cell Death Dis 12 (4), 384 (2021)
   PUBMED   33837178
  REMARK    GeneRIF: WBP2 negatively regulates the Hippo pathway by
            competitively binding to WWC3 with LATS1 to promote non-small cell
            lung cancer progression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6952)
  AUTHORS   Wang,Y., Jiang,M., Yao,Y. and Cai,Z.
  TITLE     WWC3 Inhibits Glioma Cell Proliferation Through Suppressing the
            Wnt/beta-Catenin Signaling Pathway
  JOURNAL   DNA Cell Biol 37 (1), 31-37 (2018)
   PUBMED   29115863
  REMARK    GeneRIF: WWC3 interacted with T cell factor 4 (TCF4).
REFERENCE   4  (bases 1 to 6952)
  AUTHORS   Wennmann,D.O., Schmitz,J., Wehr,M.C., Krahn,M.P., Koschmal,N.,
            Gromnitza,S., Schulze,U., Weide,T., Chekuri,A., Skryabin,B.V.,
            Gerke,V., Pavenstadt,H., Duning,K. and Kremerskothen,J.
  TITLE     Evolutionary and molecular facts link the WWC protein family to
            Hippo signaling
  JOURNAL   Mol Biol Evol 31 (7), 1710-1723 (2014)
   PUBMED   24682284
REFERENCE   5  (bases 1 to 6952)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002365.1, KC987947.1 and AC121345.12.
            
            On Sep 1, 2021 this sequence version replaced NM_015691.4.
            
            Summary: This gene encodes a member of the WWC family of proteins,
            which also includes the WWC1 (KIBRA) gene product and the WWC2 gene
            product. The protein encoded by this gene includes a C2 domain,
            which is known to mediate homodimerization in the related WWC1 gene
            product. [provided by RefSeq, Sep 2011].
            
            Sequence Note: The reference genome sequence does not support the
            complete ORF due to a single base deletion (rs754059274) versus the
            other genomes. The missing base is included in this RefSeq to
            represent the complete coding sequence.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KC987947.1, SRR14038197.1602654.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               AC002365.1         158627-158951
            326-396             KC987947.1         1-71
            397-400             AC002365.1         159023-159026
            401-3979            KC987947.1         76-3654
            3980-6952           AC121345.12        58405-61377
FEATURES             Location/Qualifiers
     source          1..6952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..6952
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /note="WWC family member 3"
                     /db_xref="GeneID:55841"
                     /db_xref="HGNC:HGNC:29237"
                     /db_xref="MIM:301089"
     exon            1..606
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..3979
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /codon_start=1
                     /product="protein WWC3"
                     /protein_id="NP_056506.3"
                     /db_xref="CCDS:CCDS14136.1"
                     /db_xref="GeneID:55841"
                     /db_xref="HGNC:HGNC:29237"
                     /db_xref="MIM:301089"
                     /translation="MPWLSGGRRRRRGQPREAPREPPPSAQPQREPPPPAPPAAVPTP
                     PAPSAPPPRARESAELPLPAGWEEARDYDGRVFYIDHNTRQTSWIDPRDRITKPLTFA
                     DCVGDELPLGWETVYDKQIGVYYMDHINKLTQIEDPREQWRREQERMLKEYLIVAQEA
                     LNAKKEIYQIKQQRFELAQEEYQQLHKMCEDDSRSYASSFSGYSTNTKYDPHQIKAEI
                     ASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQAIMSELR
                     TIKKAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHVGVPGDAGVPQQFCD
                     AGSQTDIIGEFVFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLDNESWPSTAEAD
                     RDRLQLIKEKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGATER
                     ILLQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSLASSR
                     GSLSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSGFHKQRR
                     SLDTPQSLASLSSRSSLSSLSPPSSPLDTPFLPASRDSPLAQLADSCEGPGLGALDRL
                     RAHASAMGDEDLPGMAALQPHGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKRLER
                     RARRISACLSDYSLASDSGVFEPLTKRNEDAEEPAYGDTASNGDPQIHVGLLRDSGSE
                     CLLVHVLQLKNPAGLAVKEDCKVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFR
                     IPVHSSALTLKSLQLYVCSVTPQLQEELLGIAQINLADYDSLSEMQLRWHSVQVFTSS
                     EPSRTREAGCAGESSARDPAHTISISGKTDAVTVLLARTTAQLQAVERELAEERAKLE
                     YTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEPCCMGIDSILGHP
                     FAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGSPFVRSGTIV
                     RSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQSCRSSLAELMA
                     RTSLDLELDLQASRTRQRQLNEELCALRELRQRLEDAQLRGQTDLPPWVLRDERLRGL
                     LREAERQTRQTKLDYRHEQAAEKMLKKASKEIYQLRGQSHKEPIQVQTFREKIAFFTR
                     PRINIPPLPADDV"
     exon            607..716
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            717..920
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            921..997
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1077
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1207
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1357
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1431
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1674
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1764
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..2330
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2451
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2526
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2613
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2806
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2980
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3132
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3298
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3463
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            3464..3556
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3784
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3912
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..6952
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6930..6935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /note="hexamer: ATTAAA"
     polyA_site      6952
                     /gene="WWC3"
                     /gene_synonym="BM042"
                     /note="major polyA site"
ORIGIN      
        1 cgggccgcgc cgaggaacga agatggccgg gcgcgccgcg ggaacggagg ggcggccggc
       61 agcggcggcg gcggcggcgg cggctcccgg gctgtgactt cgcgcgcggc ggccacccgg
      121 gctacctgaa cggagtgggc ggcgcgggca gcggcttgct agggcgggcg ggcggacgcc
      181 ggtgcacggg cgccgggcgg aggatgcgcc aggagcggcg ggcggctccc cgcggccgcc
      241 cccgcgcccc gggcgccggg ccttagtgct ggcggaggag gcggcgcgcg cggggcggcc
      301 gggcggcggc ggggcccgcg ccgtcatgcc ttggctgagc ggcggccggc ggcgacggcg
      361 gggacagccg cgcgaggccc cgcgggagcc gccgccttct gcgcagcccc agcgggaacc
      421 gccgccgccg gcgccccccg ccgcggtccc cacgccccca gctccttccg cgccgccgcc
      481 gcgggcccgg gagagcgccg agctgccgct gcccgccggc tgggaggagg cgcgagacta
      541 cgacggtcgc gtcttttaca ttgaccacaa cacgcgccag acgtcgtgga tcgacccccg
      601 cgaccggata acaaagccat tgacctttgc cgattgtgtt ggggacgaac ttcctttagg
      661 atgggaaacc gtatatgata aacaaattgg agtttattac atggaccaca taaataaact
      721 tacccagatt gaggatccaa gagaacagtg gaggcgagag caagagcgca tgttgaagga
      781 atatttaatt gtagctcagg aggctctcaa tgccaagaaa gaaatctacc agattaagca
      841 gcagcggttc gagctggccc aggaggaata ccagcagctg cacaaaatgt gtgaggatga
      901 cagccgctcg tacgccagct cattctctgg atattcaaca aatacaaagt atgacccaca
      961 ccaaattaaa gcagaaatag caagtcgtcg ggataggctt tccagattaa aacgagagct
     1021 gacccagatg aagcaggaac tgcagtacaa agaaaagggg gtggagaccc tgcaagagat
     1081 tgatcggaag atgtcaagta ctcacaccag ctacaaactg gatgaggcgc aggctatcat
     1141 gagtgagctc cggaccatca agaaggccat ttgcacaggc gagaaggaga ggcgggacct
     1201 gatgcatagc ctggccaagc tgaccgatag cttcaagaac agctgctccg ttaccgactc
     1261 tctagtggac ttccctcacc atgtaggcgt gcctggcgat gctggtgtac cccagcagtt
     1321 ctgcgatgcc ggctcccaga ctgatatcat cggggagttt gtctttgatg ataaaacaag
     1381 acttgtagac cgagtcagac ttaattggca atatgaagaa gccagaaaga gagtcgccaa
     1441 catccagcag cagctggccc ggcttgacaa tgagtcctgg ccaagcacgg ccgaggctga
     1501 cagggaccgg ctgcagctca tcaaggagaa ggaggccctg ctgcaggagc ttcagctcat
     1561 cattgcacag cgccgctctg cgggagatgt ggcccggctg gaggaggagc gggagcgcct
     1621 agaggaggag ctgcggcgtg cacgggccac ctccgcacag ggcgccacgg agaggattct
     1681 gcttcaggaa aaaaggaatt gtctacttat gcagctggaa gaagccaccc gcttaacatc
     1741 ctacctccag tcccagttaa aaagcctgtg tgccagcacc ctgacggtgt cctcggggag
     1801 cagccgcggg tccctagcct ccagccgtgg gtctctggcc tccagccggg gctccctgag
     1861 ctcggtcagc ttcacggaca tctacggcct cccgcagtac gagaagcccg acgctgaggg
     1921 cagccagctt ctacgcttcg acctcattcc cttcgactct ctggggcgag atgctccctt
     1981 ttcagagccc ccaggcccct cgggcttcca caagcagagg cggtccctgg acacgcccca
     2041 gtccctggca tcgctgtcct cccgctcctc gctgtcctcg ctgtcgcccc caagctcgcc
     2101 cctggacacg cccttcctcc ctgcctcacg ggactcgccg ctggcgcagc tggcggacag
     2161 ctgtgagggg ccaggcctgg gcgccctaga cagactgcgg gcacacgcct cggctatggg
     2221 ggacgaagac ttaccaggca tggcggccct tcagccacac ggggtccccg gggatgggga
     2281 agggccgcac gagcgaggac ccccaccagc cagcgctccc gtgggtggaa cagtgactct
     2341 tcgagaagac agtgccaaga ggttggagag gagggcacgc cgcatctccg catgtctgtc
     2401 ggattattcg ctagccagcg acagtggggt gtttgaacct ctaaccaaaa ggaacgaaga
     2461 tgccgaggag cctgcctacg gagacacggc cagtaacgga gatccccaga tccacgtggg
     2521 actcctgcgc gacagtggca gcgagtgtct cctcgtgcac gtgctgcagc tgaagaaccc
     2581 ggcggggctg gcggtgaagg aagactgcaa agtccacatc cgagtctatt tgcccccact
     2641 ggactcgggc acgcccaaca cttactgctc caaggctctg gagttccaag tgccgctggt
     2701 gtttaacgaa gtgttcagaa tccccgtgca ttccagcgcg ttgacactga agtcacttca
     2761 gttatacgtg tgttcagtga ctccgcagct gcaggaagaa ctgctgggca ttgctcagat
     2821 taacctggct gactatgaca gtttgagtga gatgcagctg cgctggcatt ccgtgcaggt
     2881 gttcaccagc tctgaaccat caaggacgcg ggaggctggg tgtgcaggag agagctccgc
     2941 ccgggaccct gcacacacca tctccatctc cggcaagacg gatgcggtga cggtgctcct
     3001 ggccagaacc acggcacagc tgcaggcggt ggagagggaa ctggccgagg agcgggccaa
     3061 gctggagtac acggaggagg aggtcctgga gatggagcgc aaggaggagc aggccgaggc
     3121 catatccgag cggagttggc aagcggactc ggtggatagc ggctgtagca actgcaccca
     3181 gaccagccct ccgtacccag agccctgttg catgggtatc gactccatcc tgggccaccc
     3241 atttgctgct caggcagggc cttacagccc cgagaaattt cagccctcgc ctcttaaggt
     3301 tgataaggaa accaacacgg aagatctctt tctggaagaa gcagccagcc tcgtgaagga
     3361 gcggcccagc cgccgggccc gagggtcgcc ttttgttcgg agtggcacga ttgtccgttc
     3421 ccagacattc tcgcctggag cacgaagcca gtatgtttgc agactttatc gtagtgacag
     3481 cgacagttca acgctgcccc ggaagtcccc ctttgtccga aatactttgg aaagacgaac
     3541 ccttcgctat aagcagtcat gcaggtcttc cctggctgag ctcatggccc gcacctccct
     3601 ggacttggag ctggatctcc aggcgtcgag aacacggcag aggcagctga atgaggagct
     3661 ctgcgccctc cgtgagctgc ggcagcggtt ggaggacgcc cagctccgtg gccagactga
     3721 cctcccaccc tgggtgcttc gggacgagcg gctccgtggc ctgctgcggg aggccgagcg
     3781 gcagacaaga cagaccaaac ttgactaccg tcatgagcag gcggctgaga agatgctgaa
     3841 gaaggcctcc aaggagatct accagctgcg tgggcagagc cacaaagagc ccatccaagt
     3901 gcagaccttt agggagaaga tagcattctt cacaaggcca aggatcaaca tacctcctct
     3961 cccagccgac gacgtctgat ggagtgcatt gtgcacatga agtatttatc cacctgtttt
     4021 attttcatga agttcttaga ctagctgaat ttgtctttaa aatatttgtg caaagctatt
     4081 aatatacaca ttttgtaaaa aaaaaaaaaa aacacgtata tctatacata tatattttat
     4141 aatagtgacg gcaacagggc ttggtttttc cttgttgtga aatcgacatc tctgaagaca
     4201 ggttatttta taaaagatca actatcatgt taagaatgta cagtttttat gctgttttat
     4261 ttgacttaaa ggctggaaga cagaaacgaa gtgagttcag gcaaattcac tgtattgtaa
     4321 tttatttata gtactttttt ttccttgaag gaaaatactg actttaagat gtattttaag
     4381 actgaaattt tgttctttag tacttttcat gcagtagaac ggaacttggg gctggtttgg
     4441 tttttgacac ctgaaatgcg aacgctatgt gctaaatttg tcaccgtatc atatgtgcat
     4501 ttaccatgta tattgtacac attcactccc ttgatgtcat gttaaaatgt cccctgcagt
     4561 ggttcaatcg tgactcggaa gcatgtgtgt gttgcagagg tcagtctctg gcgtgggccg
     4621 cacgccaacc gctcatttct gtgttgcctt tggaagcatc tttctgtgct cagcgtgagt
     4681 ctgaagcagg cgccagggcc tctggtgtac ggggcttcag cctgcttgct tgtggtggct
     4741 gtctgtgggg cttcagcctg actgtccgtg gtggctgtcc atgctgcccg cctcccccca
     4801 ccccgccctg tccgactgta acagaccagg agggtggcgg aggaactcct gccacgccac
     4861 tgtgtcatga aggaaagtga aagggaacga ggaagtagga atgcccacgc tcgttgactc
     4921 cgtgggtgaa tacagcagtt aggacataca caccatcacc tttgaaagtg cttgtttggg
     4981 ggagggaagg acatacgggt aactagaact acccagcgag tcgtccagag gagaggatca
     5041 ggtttgagtc aggaggctcc ctgtactgga gtcgtcccac tattcctcaa gaaatcttag
     5101 aaccagcttg tgaggaaaaa cattttttaa tgtaataaaa atatgccatt attctttgaa
     5161 atgccaaatg atataaatat tttgcctaat acatatttat tgtagatgaa atgcactctt
     5221 ctcgatgagg cctcgatttg aatcaatggg gtgggccaca ggaaatgtca gaggaaccag
     5281 aactcagaac tcttcctcct ggacctttct tcccttccct tggaggtatc cctttgaatc
     5341 aggcctctct cttctcatca gtctgtagct tccccccttg tataacctgc tttccttttt
     5401 acatttatta aaagtggatt ttgtaaaagc atttcattga cacgcgacct atcacagaca
     5461 atggaattcg tcagtggtgg taagactgaa atcctgatgc ttttcacact tcttgtctct
     5521 tgctatgtat ttctgcctct agccttgcca tgttttgcct tttttttttc tttttggcca
     5581 attccttttt atatgtgccc acaacagagg tggggagaca cggagcaccc tgggtccttc
     5641 ccagcgctgc tgggcaggcc ccgtctccag gccccagctg ttgaaacttt gaagggcaac
     5701 aaacaaccat ccacactgcc ggaccctagg ctgttcaggg aggcagctca tttccacccc
     5761 ggccccagga cacccagcct gtgccccaca aggatctctc taaatgggag ggattgaggc
     5821 tacttttctg ccaagcccta ttaagtagta atgtggggaa acccactgtg tcagtgcagg
     5881 aagccctaga caaatgtttt caaataaatt tcactgccca gcctgcacag atttccattt
     5941 gaagtacttc ccatccaccc tgacacccaa aggggttttt ttgttttgtt ttgtttttga
     6001 gacagggtct tgctttgttg cccaggctgg agtgcagtga cgtggtcata gctcactgca
     6061 gcctcaacct cctgggctca agtgaccctc ctgcctcagc ctcccaaagt tctgagatga
     6121 taggcatgag ccattgtgcc tagcctattt tgattttttt cttagagtca aggtcttgct
     6181 ctgttgccca ggctgatctt ggacttgcga gccaccatgc ctggctgggt tttttaaaaa
     6241 tagaatctca ctgatagcct gcaagaaaca gatgcagtgc ctgcttccgt atcagtccaa
     6301 ggagccctcg tgtttgccac ctttaccttt gaacctcccc ctgcctccct gcctgtgtcc
     6361 gcttttgcag ctcaatgcag ccatgacaag gaaagaaaag acaaaggaag gccagagagc
     6421 cgcgcagttc tctgcaggtg cagatgcagg cagtggaggt ggcctgagca ggcagaagga
     6481 caccaagcgc cctatgttgc ttgtcattca tgacgtggtc ttggagcttc tgactagttc
     6541 agactgccac gccaacccca gaaaataccc cacatgccag aaaagtgaag tcctaggtgt
     6601 ttccatctat gtttcaatct gtccatctac caggcctcgc gataaaaaca aaacaaaaaa
     6661 acgctgccag gttttagaag cagttctggt ctcaaaacca tcaggatcct gccaccaggg
     6721 ttcttttgaa atagtaccac atgtaaaagg gaatttggct ttcacttcat ctaatcactg
     6781 aattgtcagg ctttgattga taattgtaga aataagtagc cttctgttgt gggaataagt
     6841 tataatcagt attcatctct ttgttttttg tcactctttt ctctctaatt gtgtcatttg
     6901 tactgtttga aaaatatttc ttctataaaa ttaaactaac ctgccttaag aa
//
