LOCUS       NM_024949               8862 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens WW and C2 domain containing 2 (WWC2), transcript
            variant 2, mRNA.
ACCESSION   NM_024949
VERSION     NM_024949.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8862)
  AUTHORS   Hoffken,V., Di Persio,S., Laurentino,S., Wyrwoll,M.J., Terwort,N.,
            Hermann,A., Ropke,A., Oud,M.S., Wistuba,J., Kliesch,S.,
            Pavenstadt,H.J., Tuttelmann,F., Neuhaus,N. and Kremerskothen,J.
  TITLE     WWC2 expression in the testis: Implications for spermatogenesis and
            male fertility
  JOURNAL   FASEB J 37 (5), e22912 (2023)
   PUBMED   37086090
  REMARK    GeneRIF: WWC2 expression in the testis: Implications for
            spermatogenesis and male fertility.
REFERENCE   2  (bases 1 to 8862)
  AUTHORS   Qi,S., Zhu,Y., Liu,X., Li,P., Wang,Y., Zeng,Y., Yu,A., Wang,Y.,
            Sha,Z., Zhong,Z., Zhu,R., Yuan,H., Ye,D., Huang,S., Ling,C., Xu,Y.,
            Zhou,D., Zhang,L. and Yu,F.X.
  TITLE     WWC proteins mediate LATS1/2 activation by Hippo kinases and imply
            a tumor suppression strategy
  JOURNAL   Mol Cell 82 (10), 1850-1864 (2022)
   PUBMED   35429439
REFERENCE   3  (bases 1 to 8862)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 8862)
  AUTHORS   Wang,G., Zhou,Y., Chen,W., Yang,Y., Ye,J., Ou,H. and Wu,H.
  TITLE     miR-21-5p promotes lung adenocarcinoma cell proliferation,
            migration and invasion via targeting WWC2
  JOURNAL   Cancer Biomark 28 (4), 549-559 (2020)
   PUBMED   32623387
  REMARK    GeneRIF: miR-21-5p promotes lung adenocarcinoma cell proliferation,
            migration and invasion via targeting WWC2.
REFERENCE   5  (bases 1 to 8862)
  AUTHORS   Zhang,Y., Yan,S., Chen,J., Gan,C., Chen,D., Li,Y., Wen,J.,
            Kremerskothen,J., Chen,S., Zhang,J. and Cao,Y.
  TITLE     WWC2 is an independent prognostic factor and prevents invasion via
            Hippo signalling in hepatocellular carcinoma
  JOURNAL   J Cell Mol Med 21 (12), 3718-3729 (2017)
   PUBMED   28815883
  REMARK    GeneRIF: WWC2 functions as a tumor suppressor by negatively
            regulating the Hippo signaling pathway and may serve as a
            prognostic marker in hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 8862)
  AUTHORS   Stauffer,S., Chen,X., Zhang,L., Chen,Y. and Dong,J.
  TITLE     KIBRA promotes prostate cancer cell proliferation and motility
  JOURNAL   FEBS J 283 (10), 1800-1811 (2016)
   PUBMED   27220053
REFERENCE   7  (bases 1 to 8862)
  AUTHORS   Wennmann,D.O., Schmitz,J., Wehr,M.C., Krahn,M.P., Koschmal,N.,
            Gromnitza,S., Schulze,U., Weide,T., Chekuri,A., Skryabin,B.V.,
            Gerke,V., Pavenstadt,H., Duning,K. and Kremerskothen,J.
  TITLE     Evolutionary and molecular facts link the WWC protein family to
            Hippo signaling
  JOURNAL   Mol Biol Evol 31 (7), 1710-1723 (2014)
   PUBMED   24682284
REFERENCE   8  (bases 1 to 8862)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019193.7, DN999977.1,
            BM046889.1, AK126057.1, BC107683.1, AK074260.1, AL832424.1,
            BC053873.1, AK091401.1 and AC093844.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024949.5.
            
            Summary: This gene encodes a member of the
            WW-and-C2-domain-containing family of proteins. Members of this
            family have two N-terminal WW domains that mediate binding to
            target proteins harboring L/PPxY motifs, an internal C2 domain for
            membrane association, and C-terminal alpha protein kinase C binding
            sites and class III PDZ domain-interaction motifs. Proteins of this
            family are able to form homo- and heterodimers and to modulate
            hippo pathway signaling. [provided by RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.250573.1,
                                           SRR7346977.3016658.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403733.8/ ENSP00000384222.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC019193.7         120164-120216
            54-618              DN999977.1         27-591
            619-764             BM046889.1         2-147
            765-1456            AK126057.1         377-1068
            1457-2341           BC107683.1         1-885
            2342-4126           AK074260.1         1-1785
            4127-4731           AL832424.1         699-1303
            4732-5269           BC053873.1         3109-3646
            5270-6580           AL832424.1         1842-3152
            6581-7250           AK091401.1         303-972
            7251-7294           AL832424.1         3824-3867
            7295-7295           AC093844.3         111518-111518
            7296-8862           AL832424.1         3869-5435
FEATURES             Location/Qualifiers
     source          1..8862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..8862
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /note="WW and C2 domain containing 2"
                     /db_xref="GeneID:80014"
                     /db_xref="HGNC:HGNC:24148"
                     /db_xref="MIM:620110"
     exon            1..366
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..3814
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /note="isoform 2 is encoded by transcript variant 2; WW,
                     C2 and coiled-coil domain containing 2; BH3-only member B
                     protein"
                     /codon_start=1
                     /product="protein WWC2 isoform 2"
                     /protein_id="NP_079225.5"
                     /db_xref="CCDS:CCDS34109.2"
                     /db_xref="GeneID:80014"
                     /db_xref="HGNC:HGNC:24148"
                     /db_xref="MIM:620110"
                     /translation="MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDR
                     LTKPLSFADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKD
                     YLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYD
                     PDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEA
                     KAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLC
                     LSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAW
                     PGALDIEKEKLMLINEKEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTP
                     SRALAERLRLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGSSLGSLASSR
                     GSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLLQEKSGYIPSGPITTIHEN
                     EVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLSSRSSLSSLSPPGSPLVLEG
                     TFPMSSSHDASLHQFTADFEDCELSSHFADISLIENQILLDSDSGGASQSLSEDKDLN
                     ECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESVAGDSGVYEAFVKQPS
                     EMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRV
                     AVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVDLCSVSKHRREE
                     CLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQPLVDSIDLDA
                     VSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLREASDEIVAEKEAEV
                     KLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTLVDKETNTDEAA
                     NDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSSTLAKK
                     SLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQSRLNDELQ
                     ALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLM
                     RQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV"
     exon            367..476
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            477..680
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            681..757
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            758..837
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            838..967
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1114
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1188
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1431
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1521
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..2144
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2274
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2355
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2442
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2635
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2797
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2919
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3118
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3283
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3376
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3619
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3747
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..8862
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6368..6373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /note="hexamer: AATAAA"
     polyA_site      6389
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /note="major polyA site"
     regulatory      6505..6510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /note="hexamer: AATACA"
     polyA_site      6523
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /note="major polyA site"
     regulatory      6596..6601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /note="hexamer: AACAAA"
     polyA_site      6624
                     /gene="WWC2"
                     /gene_synonym="BOMB"
     regulatory      6819..6824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /note="hexamer: AATGAA"
     polyA_site      6835
                     /gene="WWC2"
                     /gene_synonym="BOMB"
     regulatory      8841..8846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="WWC2"
                     /gene_synonym="BOMB"
                     /note="hexamer: AATAAA"
     polyA_site      8862
                     /gene="WWC2"
                     /gene_synonym="BOMB"
ORIGIN      
        1 gggttcgctc gccggctccg acgcagacat ggtggactga tccgcagcgg ggccgcgaac
       61 agcgtttcct gaggcacctc ccgcgcgtgg ttccgccgcg ccccgcgccc tgcgcccctc
      121 agcccctcgc cggcgcccgc gtcgcgggtt ggcagcctag cccggcagcc gcgttcccgc
      181 cgcgtcccgc gcccggtacc tatggaggcg ccgctcgccg gcgaggccgc cgaccatgcc
      241 taggagggcc gggagcggtc agctgccgct gccccggggc tgggaggagg ccagggacta
      301 cgacggcaag gtcttctaca ttgaccacaa caccaggagg accagctgga tcgacccccg
      361 ggacaggtta acgaagccct tgtcatttgc tgattgtgtt ggggatgagc tgccgtgggg
      421 atgggaagca gggtttgacc ctcagattgg tgtctactac atcgatcaca tcaacaaaac
      481 cacgcagata gaagatccaa gaaaacaatg gaggggggaa caggagaaga tgctcaagga
      541 ctacctctct gtggcacagg atgccctccg gacacagaag gaactgtacc atgtgaagga
      601 gcagaggctg gcgctggccc tggatgaata cgtgcgatta aatgatgcct ataaggaaaa
      661 gtcaagttct cacacaagct tattctcagg atcttcatcc agtactaaat atgatcccga
      721 tattttaaaa gctgagatct ccactacaag attaagggtt aaaaagctaa agagagagct
      781 ctcacagatg aagcaggaac tgctctataa agaacaaggc tttgaaacat tgcagcaaat
      841 tgataaaaaa atgtctggag gccagagcgg gtatgaactc agtgaagcca aagccattct
      901 aacagaacta aaatctatca gaaaggcaat tagctcagga gaaaaagaaa aacaagatct
      961 gatgcagagt cttgctaagc tgcaggagcg gtttcatttg gatcagaaca ttggcagatc
     1021 tgagccagat ttgagatgta gtcctgtgaa ctctcattta tgtctctcca gacagaccct
     1081 tgatgctggg tcacaaacaa gcatttccgg agatattgga gtaagaagta gatcaaattt
     1141 agctgaaaag gtcaggctaa gcctacagta tgaagaagcc aaaagaagta tggccaactt
     1201 aaaaattgaa ctgtcaaaat tggacagtga ggcctggcct ggggcactgg atattgagaa
     1261 ggaaaaactg atgctgatta atgaaaaaga agaacttttg aaagagcttc agttcgtcac
     1321 cccacagaaa cgtacccaag atgaattaga acgcctagaa gctgaaaggc agcggctgga
     1381 agaagagttg ctgtctgtga ggggaacacc aagcagagct ctggccgaga gattgagatt
     1441 ggaagagaga agaaaagagc tgctacagaa acttgaagaa actactaaat taactactta
     1501 tttgcattca caacttaaaa gcctctctgc cagcaccctg tccatgtcat ctgggagcag
     1561 cctgggttcc ctggcatcga gtcggggctc tctgaacacc tccagcagag ggtcactcaa
     1621 ctccctcagt tccaccgaac tctattacag cagtcaaagt gatcagatag atgtggatta
     1681 tcagtataaa ctggacttcc ttctgcaaga gaaaagcggt tacattcctt ctggacccat
     1741 caccaccatc catgaaaacg aggtggtcaa gtcccctagc cagcctggcc agagtggact
     1801 ctgtggagtg gcagctgcag caacaggcca cactcctcca ctggctgagg ccccgaagtc
     1861 tgtggcctcc ctgtcctcga ggtcctccct ttcctccttg tctcctccag gctctccctt
     1921 ggttttggaa ggcacgtttc ccatgtcttc ttctcatgat gcctctctcc atcagttcac
     1981 tgctgacttt gaagactgtg agttgagtag ccattttgca gatatcagcc tcatcgaaaa
     2041 tcagattttg ctggattctg attcaggagg agcctcccag tctctttcag aggataaaga
     2101 ccttaatgaa tgtgctaggg agccattata tgaaggaact gcagatgtgg aaaaatcatt
     2161 accaaaaaga agagtgatcc acttgcttgg ggagaaaacc acttgtgtgt cggctgctgt
     2221 gtctgatgag tctgtggctg gagacagtgg ggtctatgaa gctttcgtga aacaacctag
     2281 tgaaatggaa gatgtcacat acagtgaaga ggatgtagcc attgtagaga ccgcccaggt
     2341 tcagatagga ctcagataca atgcaaaaag ttcaagtttc atggtgatta tagcacagct
     2401 ccgaaacctt catgccttct tgatacctca tacttcaaaa gtatatttta gggttgccgt
     2461 tcttccttcc tcaactgatg tcagctgtct gtttcgcaca aaagttcatc cgcccacaga
     2521 atccatttta ttcaatgatg tgttcagagt cgccatttcc caaacagcct tacaacagaa
     2581 gacactgagg gtagaccttt gctctgtcag taaacaccga agggaagaat gcctggctgg
     2641 aactcagatc agcctggcag atttaccatt ttccagtgag gttttcactc tatggtataa
     2701 cttgcttcct tccaagcaaa tgccttgcaa aaagaatgaa gaaaatgagg actctgtatt
     2761 tcaaccaaac cagccgttag tagattctat agacttggat gcagtgtcag ccttacttgc
     2821 aagaacatca gctgagttgt tagctgtgga acaagaatta gcacaagaag aagaagaaga
     2881 atcaggacaa gaagagccaa ggggcccaga tggagactgg ctaacaatgc taagagaggc
     2941 ctctgatgaa attgtggctg aaaaagaggc tgaagttaaa ttgccagagg acagtagctg
     3001 tacagaagat ttaagttcat gcactagtgt gcctgagatg aatgaagacg ggaacaggaa
     3061 agaaagcaac tgtgccaaag acctcagaag tcagccacct actagaatac caacactggt
     3121 tgacaaagag acaaacactg atgaagccgc taatgacaat atggcagttc gccccaaaga
     3181 gcgcagcagc ctgagctcta gacagcatcc gtttgtgagg agcagtgtga tagtgcgctc
     3241 acagaccttt tctccaggag agcggaacca gtacatctgc aggttaaatc ggagtgacag
     3301 tgacagttca accctggcta aaaaatcact gtttgtgaga aactccaccg aacgccgcag
     3361 tttgagggtc aaaaggacgg tttgccagtc agtccttaga agaacaacac aggaatgccc
     3421 agtgcggaca tctctagact tagaactgga ccttcaggca tctctgaccc ggcagagccg
     3481 cctcaatgat gagctgcagg cgctgaggga cttgcggcag aagctggagg aactgaaagc
     3541 tcagggagag actgaccttc caccaggcgt gctggaggat gagaggttcc agaggcttct
     3601 gaagcaagct gagaagcagg ctgaacagtc caaagaagag cagaagcaag gtctgaatgc
     3661 agagaagttg atgaggcaag tctccaagga cgtgtgtcgg ctccgggagc agagccagaa
     3721 ggtgcctcgg caggtgcagt ccttcaggga gaagattgcc tacttcacca gagcaaagat
     3781 aagcatccca tccctgccag ctgatgatgt gtgattacat gacttaagaa attatttttt
     3841 catctgttca ctttcttagg gagggtaaaa gactgaagat ttgtgttttt gttttggtgt
     3901 ttggtttttt ttggtaacgt aactgtcaac tcttgaagaa cttttatttc acatcagatt
     3961 ttcaacacat taatttgtaa agtaccttga gtgtaatttt tatatgctta aaaaagaaaa
     4021 aatcatataa gaaagatggg ataacctggt acacaaatgt tgcccagtat gtgcgcattg
     4081 ccagtggact tcattttgta aaaatggaat agaggcagta ccccacatgt gtactgttga
     4141 gccggctgtt gagaaacaac ttggttcagc cggtggtttt gcttctcctt tgtgttcctg
     4201 tgagtaggct gtgccgatgg cagcagcgcc acgtggtatc tgtgcgctgg cgaggagagg
     4261 agcgctttcc atttggaggc agtgtgagca cacgctggag tgcagcgttc caaagtccgc
     4321 ccgaaatgga tgctgcgtcc acggccatca cctgtgcggg aacacctggt ttccttaaga
     4381 caatttcctt tttgtccttt tatatttttc taaagaaaac taagatataa actaccaagt
     4441 gctcttaaga ataaaaataa gaataagaat acaaaggagc actactcttg gctacacgaa
     4501 agatcttggg attcatgaca ctgagggcag ggagaagaaa gaacaccagc cacgcagaga
     4561 tacaaataag ctcatcaaat gagcagctgg tttgtctcac tcagcctgaa tttgcattaa
     4621 gtgttcaaaa gtgagtttct ggcttgcact agtgttttgc cctaaatcta aggatggtgc
     4681 ctagtggtgg ccctgtgttc tgaggacaga gagagctgga ggggtggagg gaaatgcatc
     4741 ggcactcatt tggtgtaacc aagaagaggg ggaaagatgt cttgatagaa tcaaagttgc
     4801 caaaaacaaa gaagagttta tcaagcagat ttctaacatt tagtagaaac tacttcatag
     4861 ctctcatttt tagggggttc tatctataat ttatggtaaa tagttgggag gcaaagggaa
     4921 gaatgtgtgt ggggggatta ttaatttgaa gtataagcta aattgtttat taaaaagcct
     4981 attttggatg aacaagttta gagagataaa ctgactaatg tgtcctccag tttagaattt
     5041 caccttaccc gacccaggca cttcttaaaa acacagatcc tcagtgcagc tctgccagca
     5101 tcaaggcttt taaaatatgt agtatttagg ccatttaaac catacttatt actcaataac
     5161 ccaagaaaca attttgggtt agccatctaa tatagcaaat aaaatagatt ttttaaagaa
     5221 atccaaaatt gtcttaaagg aatggacccc ttgaagaaaa aaaaaaaaag ttttgttcct
     5281 cagttagaat gctcactagc tcactagcaa gaatttttat tttcttgaaa gcaattatat
     5341 atattttgga aagttcatgt tattggaatt gaagttcaaa ttaagcaact tctgagccta
     5401 gaactttaat tactttttcc taaatgtccc aacacttaca tacaaatttc tttgaagaca
     5461 taactggaca tggcagacac tgctttgaac aaaaaccagc ctagtgaatt gactgagtac
     5521 agtcctttaa ggctgcccag ttcattctat tagatgacta aggaaaacta gaaaaagaat
     5581 acagttcacc cttgtcaagg tcaaatgtga aagacagaag tttatttaat gtagaggtaa
     5641 atgaaggtga gctgttttca gcatcttagt ttgaccatga aaatgtctat agaattatgt
     5701 gtagttgttc cgtacgattt tattttcttc atttatttat ttacagtctt atttatgttc
     5761 tgtttaatat atagtttgat tctggccatt ttaaatattt gacacagaag agactatatt
     5821 ggaatattta cagctttata agtctttcat cagattagct gttgactttt tgtaatacaa
     5881 aaagtttcag acaagtatta aagaataaaa tctgtctcag gctggtagtt agcagttgtg
     5941 accaagatgc ttttggttgt tgtatttcac aaaatttcct catttctaac atgagagatg
     6001 aacttatttt aatataatcc tttttctaca ctttaaaagt cagcaatagt gttatgtatt
     6061 tataggcagc ttttaataat cttgtcatat ttgtactaac ccaaatgatt cacagtgaca
     6121 aaacatttta ataacttgat cacaaaacca tatggacaaa tatgaatttt aatattataa
     6181 atactatttt taaaaggtag aatttattcg cacagggtaa aaagaatgta atatttagtt
     6241 ctcaagtttg aattatcagt atattattac aattttgtat atcagaatct taagtgttac
     6301 aggtacaaaa agaatattgc tagccaaatg aacaaagttt agctaaatct ctgtagcatg
     6361 caaatcaaat aaattaaaat tttttgctat tgctttatct atattgtctt aaatatcaaa
     6421 agctcaggac tgaacttaat atttaatcag gttaaattct gaacatgttt ctgttttaat
     6481 ttgtcttgtt tgtaaacgta tgcaaataca tcacatagat taactggttt ctgcactttc
     6541 catgtgtttg tgggtggaaa aaaattcagt ggtttttttt aaaaaaaaaa gcaaaaacaa
     6601 agctacatat tgcctaatac tctatttcag tgtcgtttat tgttcagttt atttccctga
     6661 ttggcacaaa cacaagagtt tccttgaacc atgtaccaag caaatacaaa atatttcatg
     6721 aagaaatccc caggctggca gtttgtgatg aatagttctt gttggaacta tatgtattgc
     6781 tgataaaaaa ggacgaagta ttttcattga gcaaataaaa tgaagggctc cagaatatgt
     6841 gctctgtggt cgctgcgcct gggctggcag tgtgctccac agagaggcag ccgtcccagg
     6901 aggttatcta cccacacacc ccagtcctgc cctgccgtgc cccccacagg ctgctcagtg
     6961 cctgggaagc cagaaacgct gcccgtgaaa tacagaacac aggatgcaga agcacgtttg
     7021 tgtggcagag tctacttgaa tcatccaaaa cccaagatcg ccctcctgcc tctgacagta
     7081 tagaaggcgt gactgaatgt ggctgccttt tgaaaaaggt tccatagaga cactgaggtc
     7141 tctgattcag aaggagatga tgtgtctaca cctttcacct ctgaagcttc taaagagcta
     7201 gtaattattt tatataataa gacgtcatgc attttaaata aatatgcaac aagacctcag
     7261 gcttattata ctaggttatc ttaaacacct gaaataagta aatgatttgc caaatgattc
     7321 cgctccatat gaataatacc ttcaaagata catagagatt aatgttttat ttaccacttc
     7381 tgtgcaatcg ctattttaaa attgagaaaa ctcatccaca gtaatgggtg tcattactat
     7441 tcagtcttga ttgattttgg tctcagacta gaagataaaa atggtttacc agtcttggaa
     7501 agaaactata gtttaatagc cacaggaaaa gatgcatttt caaaaatcaa aagcacagtg
     7561 agatgactag agcgggacat cctaccaaat ccagtgttga gcaagcgtct cctgaacagc
     7621 agacgcttgt cctttctggc ttagtgtttc aggttggtgt ttctcgtctc cagttcttga
     7681 tgatgatctt gtgtttgtgc cactgcgtag tggcccgaag ctaggggagc gtggctggag
     7741 caggctgcac agtggagcag acaccctcct agcagaagag aaagtccagc aaaccagccc
     7801 agaaacaggg cctccccaaa ctcccacctg gggacaaagt ctgggacgtt ctcatcccag
     7861 aactcctgaa ccgtcttgtg ggcaacccaa gagacgggaa ccagggctgt gactcccgag
     7921 gcccaggaca gaattcctcc caggatcagc agtcgcctct tgagatctct ctgactctct
     7981 ccaattctca aacagtccag gccaaaccca gagaccagca ggcccagaaa tcccagccca
     8041 tttgacagaa acattaagat cctggagacc ctgagttcag caggcaaagc caggaaggag
     8101 tcaaagtcct tgcattgcat ccccacttcc tcttggatga cacaggtttg ccagagtccc
     8161 atggtccagt tttccatttc atttaagtcc aggttgaggt tcttccagtg tggcaggtag
     8221 tttgtaagac aggataaaac ccatcccagc aaagataatg aaactccagc tagttgagct
     8281 acagttctaa atactaaagc cattataatg tcctgagagc tttagccaaa ctaactcctg
     8341 cccttcggtt gctgtgaaaa gaagtgtgac acttgtgtta taacttatga aactcagaaa
     8401 tatttcttca ttgtgtatat aggaggattc ttgccagagt tgctattgtt tgattccatg
     8461 ttgaatgggt ttcacaaaag gatagggaaa taatgccgcc aaccagtaat gccaaggtgt
     8521 ggccaagatt gtgtttgtgt cctgtgggct ggatttgaca gaaagcagtt tgtcactgaa
     8581 atataattaa gtgataatct cctttcattg tcaaggttaa aatggctttc atgttattcc
     8641 caacctttct aacaaagaat taagtctaaa tgcaaaatgt ttaactgatg gttttggttc
     8701 aactcctcct gctttgtgtt tcactaactg cacctgtcag attttcatct cttatagttc
     8761 tcacatttca aatgtgcatg ttatggtaat actgagtgtt attttttaaa aataggttta
     8821 agaaaagtat ttcttaacca aataaatcaa tcttatcaga aa
//
