LOCUS       XM_047417019           10304 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens WW and C2 domain containing 1 (WWC1),
            transcript variant X13, mRNA.
ACCESSION   XM_047417019
VERSION     XM_047417019.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..10304
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="WW and C2 domain containing 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 37
                     ESTs, 371 long SRA reads, and 94% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     2 samples with support for all annotated introns"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
     CDS             3743..7018
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /codon_start=1
                     /product="protein KIBRA isoform X13"
                     /protein_id="XP_047272975.1"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
                     /translation="MLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHK
                     LGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLK
                     KIDKKMSDAQGSYKLDEAQAVLRETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRG
                     SHSDLWSSSSSLESSSFPLPKQYLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEEAK
                     RRLSCQCGQATPSNSELTHYQLPQASSKTARHLYLDSHFLFSLKRTTLNLGSVPSCRN
                     ACLRWIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEV
                     EQLEMARKRLEKDLQAARDTQSKALTERLKLNSKRNQLVRELEEATRQVATLHSQLKS
                     LSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEF
                     LLLEGATGFRPSGCITTIHEDEVAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLS
                     SPSPPCSPLMADPLLAGDAFLNSLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGK
                     QLGQAVNTAQGCGLKVACVSAAVSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAV
                     GATRIQIALKYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRT
                     RPLDASDTLVFNEVFWVSMSYPALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRS
                     GERSTRWYNLLSYKYLKKQSRELKPVGVMAPASGPASTVSWDQDAVSALLEQTAVELE
                     KRQEGRSSTQTLEDSWRYEETSENEAVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPA
                     LKVDKETNTETPAPSPTVVRPKDRRVGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRL
                     NRSDSDSSTLSKKPPFVRNSLERRSVRMKRPSPPPQPSSVKSLRSERLIRTSLDLELD
                     LQATRTWHSQLTQEISVLKELKEQLEQAKSHGEKELPQWLREDERFRLLLRMLEKRQM
                     DRAEHKGELQTDKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSA
                     DDV"
ORIGIN      
        1 gttagagggg gtggtcaaga ccccaggatt ccgtgggaga ccactggaga gagggcactc
       61 ggcgcagagg aaggcaacct gaggtgtgct ttttgacagg tgccttggaa gctgctgaga
      121 acagcacagg ggcagccagg gggccctgga acccgagggt ggggaggaag tgaagaagcg
      181 ggggagggca gatgagggag actggttatc caggaatctg gcagcaactt ggaagctgtt
      241 aggatggaga tggaggtgag aggcctcccg gaaagccttg cccctcgcct ctttctcctc
      301 tctttcttcc ctgatcgggg aagggggcgg cgaggctcct cagccctgca ccagcgggac
      361 ctgaccttgg tgggtaccag gccgctgtag gttgagataa tgtgcagagg cagatggagc
      421 ctgagatagc tcggtgtggc tcttacctct ccagactttc tcctggttgt ttggcatttc
      481 tttgctcaca tgctgcacac acacacatac attcaccctc tccatgtatg tcctagagtc
      541 cccggaccac gatgttgttg acacggtctg tgggcagagt gtcttgggga atgcggactt
      601 taaaccttgt ctgtgacctt gggggtcagg tccctgtaaa gcaaccaagg tgaatttctt
      661 ggactcttca tcttgtgtgg tgggggtgga ggtgtcccag aagtgtatgt agcaagatgt
      721 gggtcaaaaa aagaatataa gcggaaagaa aatgagagtt gagattctcg gtagtttctg
      781 ggagcactta ctttcattca ttcattcatt cgttcattca gcgcttcctg gatgcctcct
      841 ctacactcag caccatgctg aatgtctcat gaatgtaatc tggaaggtaa atatttagtg
      901 ctagagagca tctcttaggc aagctgcttc aacctctgag cctcagtttc cctgtttgtc
      961 agatggggga gcccaccatt tccctgaatt taaaaagttt gcttggaagg gaatattggg
     1021 atgcttaaaa cttggaaggg acgtacatca gcgcccaact cccatttgaa acataagaga
     1081 aaatttgaag cccagaggtg tgatttgctc aagtattttg atttttctgc cattctgcgt
     1141 accagttctt caccagctct gaagttctaa cctgcaaact tgtcaccctg acacactgct
     1201 tccccaccct tactcgggtc agttgccagc tctgctactg tgttggtgaa cttggcagca
     1261 ccttttctct tgtccttttc tcagaacaga cacaagttca aacatatgtg acctgcccca
     1321 atttaggtcc ctgtagttta cggaggcctg tgtgctgtta gcaggtggac gtcctgttgg
     1381 agggaaagga ccgcccctgc caacactgat aatcatgcat ctggggactt ctaatacagc
     1441 aataggaggc ccctctcaac agtaattctt tacccttgga aaagggtaag taagtagctt
     1501 ctatgaagaa ctgattggct ggagcacaat ctcccaaatt ttagtgttac atggaccacc
     1561 tccatgattt ttttttgcta tatccacctg tgctattgct tacttactcc ttgactttag
     1621 atcaactcac tttaaaaata tgtgtaccat tttcacaaat gggaaactag ttatatctat
     1681 tgtcatacag gggaaacaaa aaagataggc aaacaaaaaa aacaaaaaac cagggttagt
     1741 atattttagc taggtactgt ggccagccta aggccacagc acctcacctg cccagccttt
     1801 gtttttaagc agattggcaa gccatggaga ggcggcagaa acatagtggc acttaggtga
     1861 gcagctcacc ttcttcatct tgtgtcattg gtttttttgt ttgcttttgg tttttttgtt
     1921 tatttgtttt tgttttttgg agacagagtc tcgctctgtc gcccaggctg gagtccagtg
     1981 gtgcgatctt ggctcactgc aagtctgcct cctgggttca agcgattctc ctgcctcaac
     2041 ctcccgagta gctgggacta caggtgcacg ccaccacatc cagccaattt tttgtatttt
     2101 agtagagatg gggtttcact gtgttgccca ggctagtctt gaactcctga gctcaggcaa
     2161 tccgcccacc tcagcctccc aaagtgctag gattacaggc gtgagccacc acgcttggcc
     2221 ttgggtcact ggtttataaa cttcatctct gtacctcctt gtcatcccac ctggactggg
     2281 gtggtattgg gcccctgaac ttggggtcct gagggggtct catgtcaact ctgggggtca
     2341 ctattgtggt ccagctttgt atgttttgga aaagtgctaa ttggaggata gccacttgtg
     2401 gttttctgga atttccctcc ggcatacccc atttttgcct tttagttctg tctgtgtggc
     2461 cttgggcaaa tcacttgacc tctctgaggt ttgagtgctt gagaagtggg ttggttagat
     2521 ggtcttcaag ggcctgccag ctcttaaata ttatttcaaa cccttctgcc gctcttacct
     2581 ctccagactc catgagagga gaagggggaa cagggatggg ctatgagaaa aaggaagaag
     2641 aaatttaaca aagctgaaaa gagccaaact tattccgggg ggtggtgggt tggggagaaa
     2701 aaattctgcc aaggtagtta tatccctgca attaattaat gctgtgagac aaaaaattgc
     2761 actaaaaatt tctactccgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtttattt
     2821 gccttggatt tttccttacc tgaatcatgg agatgcccac ccattcccct gaatttaaaa
     2881 gaagtaagtc aaatggtcct tcagtcagaa aagtgatttc ttagccacca aggacaaaat
     2941 agcgtctctg gttaccaacc ctaaagaatg tcttggcaca ttcctccctc tggggctgag
     3001 ctgttttgtg tgctggccgg ccaggagctg ctgggggtag ggaatccagt tttcagcttc
     3061 ccctttcacc agggggttgg aagagcagcc aagcagccag ccttgccaac tctctcccct
     3121 tctcacccag gggaagactg ggaggccgaa attcctgagg atggttgtcc caacaaccgg
     3181 agagggtcca gtgggcagct tgggtcctgc ccactgggcc aaaggctcca gcagcaccac
     3241 aggcttttcc tgagtcaagg ccagcctggg aaggtgacag gcccttcggg aatcaggtgc
     3301 tgtggatcag gtctgaacag caccttggag ccgtgctcct tttgcggagt aactctgggt
     3361 gcttttgtga gctctagcga aggggccagc gtcctgtgta tttcacttcg tggtatgcaa
     3421 aacaaatgca ccgattgttc tcggaggaag aatagatctt tggggctggc cctcccagag
     3481 aaggttcctg cagcctgatt ccttcttgtt gtgcgatttg tattcagacc ttctcatagg
     3541 aaccacctgg gaattctggg cagtttctgg gtctgtatgg tacaccaaac cgctcacctt
     3601 tgctgactgc attagtgatg agttgccgct aggatgggaa gaggcatatg acccacaggt
     3661 tggagattac ttcatagacc acaacaccaa aaccactcag attgaggatc ctcgagtaca
     3721 atggcggcgg gagcaggaac atatgctgaa ggattacctg gtggtggccc aggaggctct
     3781 gagtgcacaa aaggagatct accaggtgaa gcagcagcgc ctggagcttg cacagcagga
     3841 gtaccagcaa ctgcatgccg tctgggagca taagctgggc tcccaggtca gcttggtctc
     3901 tggttcatca tccagctcca agtatgaccc tgagatcctg aaagctgaaa ttgccactgc
     3961 aaaatcccgg gtcaacaagc tgaagagaga gatggttcac ctccagcacg agctgcagtt
     4021 caaagagcgt ggctttcaga ccctgaagaa aatcgataag aaaatgtctg atgctcaggg
     4081 cagctacaaa ctggatgaag ctcaggctgt cttgagagaa acaaaagcca tcaaaaaggc
     4141 tattacctgt ggggaaaagg aaaagcaaga tctcattaag agccttgcca tgttgaagga
     4201 cggcttccgc actgacaggg ggtctcactc agacctgtgg tccagcagca gctctctgga
     4261 gagttcgagt ttcccgctac cgaaacagta cctggatgtg agctcccaga cagacatctc
     4321 gggaagcttc ggcatcaaca gcaacaatca gttggcagag aaggtcagat tgcgccttcg
     4381 atatgaagag gctaagagaa gactttcctg tcaatgtggc caggcaactc ccagcaattc
     4441 ggagcttaca cactaccagc tcccccaggc gtccagcaaa acagcaagac atctgtattt
     4501 ggacagccac ttcttgttct ctctgaagag gaccactctg aaccttggat ctgttccatc
     4561 ctgcaggaat gcctgtctta gatggatcgc caacctgaag atccagctgg ccaagcttga
     4621 cagtgaggcc tggcctgggg tgctggactc agagagggac cggctgatcc ttatcaacga
     4681 gaaggaggag ctgctgaagg agatgcgctt catcagcccc cgcaagtgga cccaggggga
     4741 ggtggagcag ctggagatgg cccggaagcg gctggaaaag gacctgcagg cagcccggga
     4801 cacccagagc aaggcgctga cggagaggtt aaagttaaac agtaagagga accagcttgt
     4861 gagagaactg gaggaagcca cccggcaggt ggcaactctg cactcccagc tgaaaagtct
     4921 ctcaagcagc atgcagtccc tgtcctcagg cagcagcccc ggatccctca cgtccagccg
     4981 gggctccctg gttgcatcca gcctggactc ctccacttca gccagcttca ctgacctcta
     5041 ctatgacccc tttgagcagc tggactcaga gctgcagagc aaggtggagt tcctgctcct
     5101 ggagggggcc accggcttcc ggccctcagg ctgcatcacc accatccacg aggatgaggt
     5161 ggccaagacc cagaaggcag agggaggtgg ccgcctgcag gctctgcgtt ccctgtctgg
     5221 caccccaaag tccatgacct ccctatcccc acgttcctct ctctcctccc cctccccacc
     5281 ctgttcccct ctcatggctg accccctcct ggctggtgat gccttcctca actccttgga
     5341 gtttgaagac ccggagctga gtgccactct ttgtgaactg agccttggta acagcgccca
     5401 ggaaagatac cggctggagg aaccaggaac ggagggcaag cagctgggcc aagctgtgaa
     5461 tacggcccag gggtgtggcc tgaaagtggc ctgtgtctca gccgccgtat cggacgagtc
     5521 agtggctgga gacagtggtg tgtacgaggc ttccgtgcag agactgggtg cttcagaagc
     5581 tgctgcattt gacagtgacg aatcggaagc agtgggtgcg acccgaattc agattgccct
     5641 gaagtatgat gagaagaata agcaatttgc aatattaatc atccagctga gtaacctttc
     5701 tgctctgttg cagcaacaag accagaaagt gaatatccgc gtggctgtcc ttccttgctc
     5761 tgaaagcaca acctgcctgt tccggacccg gcctctggac gcctcagaca ctctagtgtt
     5821 caatgaggtg ttctgggtat ccatgtccta tccagccctt caccagaaga ccttaagagt
     5881 cgatgtctgt accaccgaca ggagccatct ggaagagtgc ctgggaggcg cccagatcag
     5941 cctggcggag gtctgccggt ctggggagag gtcgactcgc tggtacaacc ttctcagcta
     6001 caaatacttg aagaaacaga gcagggagct caagccagtg ggagtcatgg cccctgcctc
     6061 agggcctgcc agcacggtga gctgggacca ggacgctgtg tctgctctgt tggaacagac
     6121 agcagtggag ctggagaaga ggcaggaggg caggagcagc acacagacac tggaagacag
     6181 ctggaggtat gaggagacca gtgagaatga ggcagtagcc gaggaagagg aggaggaggt
     6241 ggaggaggag gagggagaag aggatgtttt caccgagaaa gcctcacctg atatggatgg
     6301 gtacccagca ttaaaggtgg acaaagagac caacacggag accccggccc catcccccac
     6361 agtggtgcga cctaaggacc ggagagtggg caccccgtcc caggggccat ttcttcgagg
     6421 gagcaccatc atccgctcta agaccttctc cccaggaccc cagagccagt acgtgtgccg
     6481 gctgaatcgg agtgatagtg acagctccac tctgtccaaa aagccacctt ttgttcgaaa
     6541 ctccctggag cgacgcagcg tccggatgaa gcggccgtcc ccacccccac agccttcctc
     6601 ggtcaagtcg ctgcgctccg agcgtctgat ccgtacctcg ctggacctgg agttagacct
     6661 gcaggcgaca agaacctggc acagccaatt gacccaggag atctcggtgc tgaaggagct
     6721 caaggagcag ctggaacaag ccaagagcca cggggagaag gagctgccac agtggttgcg
     6781 tgaggacgag cgtttccgcc tgctgctgag gatgctggag aagcggcaga tggaccgagc
     6841 ggagcacaag ggtgagcttc agacagacaa gatgatgagg gcagctgcca aggatgtgca
     6901 caggctccga ggccagagct gtaaggaacc cccagaagtt cagtctttca gggagaagat
     6961 ggcatttttc acccggcctc ggatgaatat cccagctctc tctgcagatg acgtctaatc
     7021 gccagaaaag tatttccttt gttccactga ccaggctgtg aacattgact gtggctaaag
     7081 ttatttatgt ggtgttatat gaaggtactg agtcacaagt cctctagtgc tcttgttggt
     7141 ttgaagatga accgactttt tagtttgggt cctactgttg ttattaaaaa cagaacaaaa
     7201 acaaaacaca cacacacaca aaaacagaaa caaaaaaaac cagcattaaa ataataagat
     7261 tgtatagttt gtatatttag gagtgtattt ttgggaaaga aaatttaaat gaactaaagc
     7321 agtattgagt tgctgctctt cttaaaatcg tttagatttt ttttggtttg tacagctcca
     7381 ccttttagag gtcttactgc aataagaagt aatgcctggg ggacggtaat cctaatagga
     7441 cgtcccgcac ttgtcacagt acagctaatt tttcctagtt aacatatttt gtacaatatt
     7501 aaaaaaatgc acagaaacca ttggggggga ttcagaggtg catccacgga tcttcttgag
     7561 ctgtgacgtg tttttatgtg gctgcccaac gtggagcggg cagtgtgata ggctgggtgg
     7621 gctaagcagc ctagtctatg tgggtgacag gccacgctgg tctcagatgc ccagtgaagc
     7681 cactaacatg agtgagggga gggctgtggg gaactccatt cagttttatc tccatcaata
     7741 aagtggcctt tcaaaaagaa tcttcctctt gctctctttt tctttcctac ccctcacttc
     7801 atctgtttcc ctgatttttg actctcccct ttccagtcat ttctttccca cccatccgca
     7861 gtcctggaaa catttatttt ttcttttgcc cactgttttc atttgctcat taaattaaaa
     7921 tgactgctcg gctcattggg aatccacatc cccaagttag actggggata tgctctctgt
     7981 actgtctcct tctatggaat tccaccccac ccagagagag atgacttcac agtttgttca
     8041 tatgagcatc atcccatgtc gtccccaacc caggggctgg taggtgctac agcttgtgct
     8101 tcatgctgct cctgtggccc ctattcctac ccagctcaga gctttgcagg gtctactgca
     8161 gacaatcaga agtcagtttc taacaaatag caacagccac aaatctcttc ctccttcctc
     8221 tctgacatta ccctgtgcaa cttttctcaa agtctgttgc accactcagc aaagcaagtt
     8281 gcaccagcta tatcagaatc acctggggca gcctattaaa aatgcagact gttgagacca
     8341 tcctggctaa cacggtgaaa ccctgtctct actaaaaata caaaaaatta gccggccgtg
     8401 gtggcgggca gctactcggg aggctgaggc aggagaatga cctgaacctg ggaggcagag
     8461 cttgcagtga gctgagattg tgccactgca ctccagcctg ggtgacagag caagactccg
     8521 tctcaaaaaa aaaaaaaaaa gaaaaatgca gactggctgg cgcggtggct catgcttgta
     8581 atcccagcac tttgggaggc tgaggcgggc agatcaactg agatcggggg ttcgagacca
     8641 gcctgatcaa catggagaaa cctggtctct actaaaaata cataattagc tgggcgtagt
     8701 ggcgcatacc tgtaatccca gctacttggg tggccaaggc ttgaacccag gaggcggagg
     8761 ttgcggtgag ccgagatggc gccattgact ccagcctggg caacaagagc gtaactccat
     8821 ctcaaaaaaa taataataat aaaaataaaa tgcagactgt caggtcctct ctagacccac
     8881 tgaactatcc cgcccaccct gggacggtcc ccagtgccag tgttttaccc atgttccctc
     8941 tgtaagtctt atgcacaccg caatttgaga gccccactgg tataaagtga gtgaaaccca
     9001 ggcagagaca ggcaaaatgg tgaggcccgc atcctattgg tgagtcacac agggaacgct
     9061 gaaattcatg gccttctcca ggctactggg aacccatggg cggtgatgga gggagtggtg
     9121 ccaccttcac ttgctgctga ggctcttccc cctctcccca gcatactcct tacctggctg
     9181 tctctcctca tgtataagga acctatagtg gtgtagaatc tactcttctt ccccctgtgg
     9241 cttccaggcc cccctgtata gctgctatcc agcccgattt ctcaccactg gcccagggct
     9301 tcctcctgcc ccgtggcttc acgtctctga acacatcaat ctctgatgtt ctctctcctt
     9361 ccattgaatt ccaccagaca cattcagggt ttacttcgta atgtcttcat atgagtatca
     9421 atcaacacct tccccaactc aattgtacta ggttgtagag cacaaggatg gtctcgtgct
     9481 gctctgtggc acctgtgcct acactcctct gagctttgag gaggctgctc tctttgctga
     9541 ccccatgatc ttttctgccc ttctgttaag ggcattggcc acagcaacgg ggcaaatgcc
     9601 ccaagctggc tgtaagtgac ccatcccttt ggctcccatg attagaccaa ggagaggcat
     9661 ggggtccagc tgagccattc agaaccattc cttagcattt tccactcaaa ggttagagat
     9721 gagattttct cttcccaagg ctacctctgg ccatggttcc agcttcatgg gggcaatggg
     9781 attaggaaaa tgaggtcaac ctgcaaagga aagcagatgc aagagatgga gacagaatgg
     9841 gggtgtcctg gggatcttgg agcctgaatt cattggcaca aaaggcagca gcatcctcac
     9901 tgtatctgca gtccatttgg actcaataaa aactttgaaa gtcacatgtg ttatggaatt
     9961 ccttctcagt gacacattca tctgtgctca gttgtcccag caagggtcag cccctcatac
    10021 ccctgcagca tccgctgcta tgaagcagag ctgtaaacgc cctccctgtg tataggaaaa
    10081 gctacatgga gcaaatcctc ctgcctgaag aagtgcatct cagcatcact tcagctgtcg
    10141 gggcatttgt ggggagaacc agaccacctc tgcggaaggc agcagaccct cttccagcca
    10201 tggatggagt tgaattctct ataaacggtt caccagcaaa ccaccaatac attccattgt
    10261 ttgcctagag agaaatttaa aaataaataa atgttcactt ataa
//
