LOCUS       XM_047417018            7148 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens WW and C2 domain containing 1 (WWC1),
            transcript variant X11, mRNA.
ACCESSION   XM_047417018
VERSION     XM_047417018.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..7148
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="WW and C2 domain containing 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 41
                     ESTs, 400 long SRA reads, and 94% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     53 samples with support for all annotated introns"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
     CDS             509..3862
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /codon_start=1
                     /product="protein KIBRA isoform X11"
                     /protein_id="XP_047272974.1"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
                     /translation="MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKP
                     LTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVV
                     AQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEIL
                     KAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVL
                     RETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQ
                     YLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVL
                     DSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARDTQSKAL
                     TERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLV
                     ASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIHEDEVAK
                     TQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSPLMADPLLAGDAFLNSLE
                     FEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLGQAVNTAQGCGLKVACVSAAVSD
                     ESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILIIQL
                     SNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYPALH
                     QKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRELKP
                     VGVMAPASGPASTVSWDQDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENE
                     AVAEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRR
                     VGTPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRS
                     VRMKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLEQAKSH
                     GEKELPQWLREDERFRLLLRMLEKRMDRAEHKGELQTDKMMRAAAKDVHRLRGQSCKE
                     PPEVQSFREKMAFFTRPRMNIPALSADDV"
ORIGIN      
        1 gtttccgggg cagcgcggtt acctgcaccg cccgagccgc acctggcgga ggcagaagtc
       61 acaaacccgg cgagctcaga gcggtggagc ggagaggagg gacggcaccc ggctgcaggg
      121 aggagggagg cggcagcggc agcggcggcg tggagggcgc agcgcgccgc gcggcggagg
      181 agggcagacg gcggcggcgg cggcgctcgg ctcgctctgc ccggccggct gggcgcgcac
      241 ccgggctcgc accgcgccgc tgcggacgca catggcagcg tgagaggccg gcggcgggag
      301 gagcgggcgg cgccgggtcg gggctgcagg gccgcatgga cagcggcgcc accccggccg
      361 gcccctacta gggcccccca tctgcgggcg ccaccccccg gatcatggtg cctcggcggc
      421 cgcccgggct aagagcggcc ggctggagcc gctgagcccc cgctgcggcc gggagctgca
      481 tgggggagcg ccggcagcgc ttgggaagat gccccggccg gagctgcccc tgccggaggg
      541 ctgggaggag gcgcgcgact tcgacggcaa ggtctactac atagaccaca cgaaccgcac
      601 caccagctgg atcgacccgc gggacaggta caccaaaccg ctcacctttg ctgactgcat
      661 tagtgatgag ttgccgctag gatgggaaga ggcatatgac ccacaggttg gagattactt
      721 catagaccac aacaccaaaa ccactcagat tgaggatcct cgagtacaat ggcggcggga
      781 gcaggaacat atgctgaagg attacctggt ggtggcccag gaggctctga gtgcacaaaa
      841 ggagatctac caggtgaagc agcagcgcct ggagcttgca cagcaggagt accagcaact
      901 gcatgccgtc tgggagcata agctgggctc ccaggtcagc ttggtctctg gttcatcatc
      961 cagctccaag tatgaccctg agatcctgaa agctgaaatt gccactgcaa aatcccgggt
     1021 caacaagctg aagagagaga tggttcacct ccagcacgag ctgcagttca aagagcgtgg
     1081 ctttcagacc ctgaagaaaa tcgataagaa aatgtctgat gctcagggca gctacaaact
     1141 ggatgaagct caggctgtct tgagagaaac aaaagccatc aaaaaggcta ttacctgtgg
     1201 ggaaaaggaa aagcaagatc tcattaagag ccttgccatg ttgaaggacg gcttccgcac
     1261 tgacaggggg tctcactcag acctgtggtc cagcagcagc tctctggaga gttcgagttt
     1321 cccgctaccg aaacagtacc tggatgtgag ctcccagaca gacatctcgg gaagcttcgg
     1381 catcaacagc aacaatcagt tggcagagaa ggtcagattg cgccttcgat atgaagaggc
     1441 taagagaagg atcgccaacc tgaagatcca gctggccaag cttgacagtg aggcctggcc
     1501 tggggtgctg gactcagaga gggaccggct gatccttatc aacgagaagg aggagctgct
     1561 gaaggagatg cgcttcatca gcccccgcaa gtggacccag ggggaggtgg agcagctgga
     1621 gatggcccgg aagcggctgg aaaaggacct gcaggcagcc cgggacaccc agagcaaggc
     1681 gctgacggag aggttaaagt taaacagtaa gaggaaccag cttgtgagag aactggagga
     1741 agccacccgg caggtggcaa ctctgcactc ccagctgaaa agtctctcaa gcagcatgca
     1801 gtccctgtcc tcaggcagca gccccggatc cctcacgtcc agccggggct ccctggttgc
     1861 atccagcctg gactcctcca cttcagccag cttcactgac ctctactatg acccctttga
     1921 gcagctggac tcagagctgc agagcaaggt ggagttcctg ctcctggagg gggccaccgg
     1981 cttccggccc tcaggctgca tcaccaccat ccacgaggat gaggtggcca agacccagaa
     2041 ggcagaggga ggtggccgcc tgcaggctct gcgttccctg tctggcaccc caaagtccat
     2101 gacctcccta tccccacgtt cctctctctc ctccccctcc ccaccctgtt cccctctcat
     2161 ggctgacccc ctcctggctg gtgatgcctt cctcaactcc ttggagtttg aagacccgga
     2221 gctgagtgcc actctttgtg aactgagcct tggtaacagc gcccaggaaa gataccggct
     2281 ggaggaacca ggaacggagg gcaagcagct gggccaagct gtgaatacgg cccaggggtg
     2341 tggcctgaaa gtggcctgtg tctcagccgc cgtatcggac gagtcagtgg ctggagacag
     2401 tggtgtgtac gaggcttccg tgcagagact gggtgcttca gaagctgctg catttgacag
     2461 tgacgaatcg gaagcagtgg gtgcgacccg aattcagatt gccctgaagt atgatgagaa
     2521 gaataagcaa tttgcaatat taatcatcca gctgagtaac ctttctgctc tgttgcagca
     2581 acaagaccag aaagtgaata tccgcgtggc tgtccttcct tgctctgaaa gcacaacctg
     2641 cctgttccgg acccggcctc tggacgcctc agacactcta gtgttcaatg aggtgttctg
     2701 ggtatccatg tcctatccag cccttcacca gaagacctta agagtcgatg tctgtaccac
     2761 cgacaggagc catctggaag agtgcctggg aggcgcccag atcagcctgg cggaggtctg
     2821 ccggtctggg gagaggtcga ctcgctggta caaccttctc agctacaaat acttgaagaa
     2881 acagagcagg gagctcaagc cagtgggagt catggcccct gcctcagggc ctgccagcac
     2941 ggtgagctgg gaccaggacg ctgtgtctgc tctgttggaa cagacagcag tggagctgga
     3001 gaagaggcag gagggcagga gcagcacaca gacactggaa gacagctgga ggtatgagga
     3061 gaccagtgag aatgaggcag tagccgagga agaggaggag gaggtggagg aggaggaggg
     3121 agaagaggat gttttcaccg agaaagcctc acctgatatg gatgggtacc cagcattaaa
     3181 ggtggacaaa gagaccaaca cggagacccc ggccccatcc cccacagtgg tgcgacctaa
     3241 ggaccggaga gtgggcaccc cgtcccaggg gccatttctt cgagggagca ccatcatccg
     3301 ctctaagacc ttctccccag gaccccagag ccagtacgtg tgccggctga atcggagtga
     3361 tagtgacagc tccactctgt ccaaaaagcc accttttgtt cgaaactccc tggagcgacg
     3421 cagcgtccgg atgaagcggc cttcctcggt caagtcgctg cgctccgagc gtctgatccg
     3481 tacctcgctg gacctggagt tagacctgca ggcgacaaga acctggcaca gccaattgac
     3541 ccaggagatc tcggtgctga aggagctcaa ggagcagctg gaacaagcca agagccacgg
     3601 ggagaaggag ctgccacagt ggttgcgtga ggacgagcgt ttccgcctgc tgctgaggat
     3661 gctggagaag cggatggacc gagcggagca caagggtgag cttcagacag acaagatgat
     3721 gagggcagct gccaaggatg tgcacaggct ccgaggccag agctgtaagg aacccccaga
     3781 agttcagtct ttcagggaga agatggcatt tttcacccgg cctcggatga atatcccagc
     3841 tctctctgca gatgacgtct aatcgccaga aaagtatttc ctttgttcca ctgaccaggc
     3901 tgtgaacatt gactgtggct aaagttattt atgtggtgtt atatgaaggt actgagtcac
     3961 aagtcctcta gtgctcttgt tggtttgaag atgaaccgac tttttagttt gggtcctact
     4021 gttgttatta aaaacagaac aaaaacaaaa cacacacaca cacaaaaaca gaaacaaaaa
     4081 aaaccagcat taaaataata agattgtata gtttgtatat ttaggagtgt atttttggga
     4141 aagaaaattt aaatgaacta aagcagtatt gagttgctgc tcttcttaaa atcgtttaga
     4201 ttttttttgg tttgtacagc tccacctttt agaggtctta ctgcaataag aagtaatgcc
     4261 tgggggacgg taatcctaat aggacgtccc gcacttgtca cagtacagct aatttttcct
     4321 agttaacata ttttgtacaa tattaaaaaa atgcacagaa accattgggg gggattcaga
     4381 ggtgcatcca cggatcttct tgagctgtga cgtgttttta tgtggctgcc caacgtggag
     4441 cgggcagtgt gataggctgg gtgggctaag cagcctagtc tatgtgggtg acaggccacg
     4501 ctggtctcag atgcccagtg aagccactaa catgagtgag gggagggctg tggggaactc
     4561 cattcagttt tatctccatc aataaagtgg cctttcaaaa agaatcttcc tcttgctctc
     4621 tttttctttc ctacccctca cttcatctgt ttccctgatt tttgactctc ccctttccag
     4681 tcatttcttt cccacccatc cgcagtcctg gaaacattta ttttttcttt tgcccactgt
     4741 tttcatttgc tcattaaatt aaaatgactg ctcggctcat tgggaatcca catccccaag
     4801 ttagactggg gatatgctct ctgtactgtc tccttctatg gaattccacc ccacccagag
     4861 agagatgact tcacagtttg ttcatatgag catcatccca tgtcgtcccc aacccagggg
     4921 ctggtaggtg ctacagcttg tgcttcatgc tgctcctgtg gcccctattc ctacccagct
     4981 cagagctttg cagggtctac tgcagacaat cagaagtcag tttctaacaa atagcaacag
     5041 ccacaaatct cttcctcctt cctctctgac attaccctgt gcaacttttc tcaaagtctg
     5101 ttgcaccact cagcaaagca agttgcacca gctatatcag aatcacctgg ggcagcctat
     5161 taaaaatgca gactgttgag accatcctgg ctaacacggt gaaaccctgt ctctactaaa
     5221 aatacaaaaa attagccggc cgtggtggcg ggcagctact cgggaggctg aggcaggaga
     5281 atgacctgaa cctgggaggc agagcttgca gtgagctgag attgtgccac tgcactccag
     5341 cctgggtgac agagcaagac tccgtctcaa aaaaaaaaaa aaaagaaaaa tgcagactgg
     5401 ctggcgcggt ggctcatgct tgtaatccca gcactttggg aggctgaggc gggcagatca
     5461 actgagatcg ggggttcgag accagcctga tcaacatgga gaaacctggt ctctactaaa
     5521 aatacataat tagctgggcg tagtggcgca tacctgtaat cccagctact tgggtggcca
     5581 aggcttgaac ccaggaggcg gaggttgcgg tgagccgaga tggcgccatt gactccagcc
     5641 tgggcaacaa gagcgtaact ccatctcaaa aaaataataa taataaaaat aaaatgcaga
     5701 ctgtcaggtc ctctctagac ccactgaact atcccgccca ccctgggacg gtccccagtg
     5761 ccagtgtttt acccatgttc cctctgtaag tcttatgcac accgcaattt gagagcccca
     5821 ctggtataaa gtgagtgaaa cccaggcaga gacaggcaaa atggtgaggc ccgcatccta
     5881 ttggtgagtc acacagggaa cgctgaaatt catggccttc tccaggctac tgggaaccca
     5941 tgggcggtga tggagggagt ggtgccacct tcacttgctg ctgaggctct tccccctctc
     6001 cccagcatac tccttacctg gctgtctctc ctcatgtata aggaacctat agtggtgtag
     6061 aatctactct tcttccccct gtggcttcca ggcccccctg tatagctgct atccagcccg
     6121 atttctcacc actggcccag ggcttcctcc tgccccgtgg cttcacgtct ctgaacacat
     6181 caatctctga tgttctctct ccttccattg aattccacca gacacattca gggtttactt
     6241 cgtaatgtct tcatatgagt atcaatcaac accttcccca actcaattgt actaggttgt
     6301 agagcacaag gatggtctcg tgctgctctg tggcacctgt gcctacactc ctctgagctt
     6361 tgaggaggct gctctctttg ctgaccccat gatcttttct gcccttctgt taagggcatt
     6421 ggccacagca acggggcaaa tgccccaagc tggctgtaag tgacccatcc ctttggctcc
     6481 catgattaga ccaaggagag gcatggggtc cagctgagcc attcagaacc attccttagc
     6541 attttccact caaaggttag agatgagatt ttctcttccc aaggctacct ctggccatgg
     6601 ttccagcttc atgggggcaa tgggattagg aaaatgaggt caacctgcaa aggaaagcag
     6661 atgcaagaga tggagacaga atgggggtgt cctggggatc ttggagcctg aattcattgg
     6721 cacaaaaggc agcagcatcc tcactgtatc tgcagtccat ttggactcaa taaaaacttt
     6781 gaaagtcaca tgtgttatgg aattccttct cagtgacaca ttcatctgtg ctcagttgtc
     6841 ccagcaaggg tcagcccctc atacccctgc agcatccgct gctatgaagc agagctgtaa
     6901 acgccctccc tgtgtatagg aaaagctaca tggagcaaat cctcctgcct gaagaagtgc
     6961 atctcagcat cacttcagct gtcggggcat ttgtggggag aaccagacca cctctgcgga
     7021 aggcagcaga ccctcttcca gccatggatg gagttgaatt ctctataaac ggttcaccag
     7081 caaaccacca atacattcca ttgtttgcct agagagaaat ttaaaaataa ataaatgttc
     7141 acttataa
//
