LOCUS       XM_017009276            7316 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens WW and C2 domain containing 1 (WWC1),
            transcript variant X8, mRNA.
ACCESSION   XM_017009276
VERSION     XM_017009276.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017009276.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7316
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..7316
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /note="WW and C2 domain containing 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 39
                     ESTs, 430 long SRA reads, 1 Protein, and 94% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 17 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
     CDS             509..4030
                     /gene="WWC1"
                     /gene_synonym="HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168"
                     /codon_start=1
                     /product="protein KIBRA isoform X8"
                     /protein_id="XP_016864765.1"
                     /db_xref="GeneID:23286"
                     /db_xref="HGNC:HGNC:29435"
                     /db_xref="MIM:610533"
                     /translation="MPRPELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDPRDRYTKP
                     LTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVV
                     AQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEIL
                     KAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDKKMSDAQGSYKLDEAQAVL
                     RETKAIKKAITCGEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQ
                     YLDVSSQTDISGSFGINSNNQLAEKVRLRLRYEEAKRRLSCQCGQATPSNSELTHYQL
                     PQASSKTARHLYLDSHFLFSLKRTTLNLGSVPSCRNACLRWIANLKIQLAKLDSEAWP
                     GVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARDTQS
                     KALTERLKLNSKRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRG
                     SLVASSLDSSTSASFTDLYYDPFEQLDSELQSKVEFLLLEGATGFRPSGCITTIHEDE
                     VAKTQKAEGGGRLQALRSLSGTPKSMTSLSPRSSLSSPSPPCSPLMADPLLAGDAFLN
                     SLEFEDPELSATLCELSLGNSAQERYRLEEPGTEGKQLGQAVNTAQGCGLKVACVSAA
                     VSDESVAGDSGVYEASVQRLGASEAAAFDSDESEAVGATRIQIALKYDEKNKQFAILI
                     IQLSNLSALLQQQDQKVNIRVAVLPCSESTTCLFRTRPLDASDTLVFNEVFWVSMSYP
                     ALHQKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQSRE
                     LKPVGVMAPASGPASTDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENEAV
                     AEEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRRVG
                     TPSQGPFLRGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVR
                     MKRPSSVKSLRSERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEQLEQAKSHGE
                     KELPQWLREDERFRLLLRMLEKRMDRAEHKGELQTDKMMRAAAKDVHRLRGQSCKEPP
                     EVQSFREKMAFFTRPRMNIPALSADDV"
ORIGIN      
        1 gtttccgggg cagcgcggtt acctgcaccg cccgagccgc acctggcgga ggcagaagtc
       61 acaaacccgg cgagctcaga gcggtggagc ggagaggagg gacggcaccc ggctgcaggg
      121 aggagggagg cggcagcggc agcggcggcg tggagggcgc agcgcgccgc gcggcggagg
      181 agggcagacg gcggcggcgg cggcgctcgg ctcgctctgc ccggccggct gggcgcgcac
      241 ccgggctcgc accgcgccgc tgcggacgca catggcagcg tgagaggccg gcggcgggag
      301 gagcgggcgg cgccgggtcg gggctgcagg gccgcatgga cagcggcgcc accccggccg
      361 gcccctacta gggcccccca tctgcgggcg ccaccccccg gatcatggtg cctcggcggc
      421 cgcccgggct aagagcggcc ggctggagcc gctgagcccc cgctgcggcc gggagctgca
      481 tgggggagcg ccggcagcgc ttgggaagat gccccggccg gagctgcccc tgccggaggg
      541 ctgggaggag gcgcgcgact tcgacggcaa ggtctactac atagaccaca cgaaccgcac
      601 caccagctgg atcgacccgc gggacaggta caccaaaccg ctcacctttg ctgactgcat
      661 tagtgatgag ttgccgctag gatgggaaga ggcatatgac ccacaggttg gagattactt
      721 catagaccac aacaccaaaa ccactcagat tgaggatcct cgagtacaat ggcggcggga
      781 gcaggaacat atgctgaagg attacctggt ggtggcccag gaggctctga gtgcacaaaa
      841 ggagatctac caggtgaagc agcagcgcct ggagcttgca cagcaggagt accagcaact
      901 gcatgccgtc tgggagcata agctgggctc ccaggtcagc ttggtctctg gttcatcatc
      961 cagctccaag tatgaccctg agatcctgaa agctgaaatt gccactgcaa aatcccgggt
     1021 caacaagctg aagagagaga tggttcacct ccagcacgag ctgcagttca aagagcgtgg
     1081 ctttcagacc ctgaagaaaa tcgataagaa aatgtctgat gctcagggca gctacaaact
     1141 ggatgaagct caggctgtct tgagagaaac aaaagccatc aaaaaggcta ttacctgtgg
     1201 ggaaaaggaa aagcaagatc tcattaagag ccttgccatg ttgaaggacg gcttccgcac
     1261 tgacaggggg tctcactcag acctgtggtc cagcagcagc tctctggaga gttcgagttt
     1321 cccgctaccg aaacagtacc tggatgtgag ctcccagaca gacatctcgg gaagcttcgg
     1381 catcaacagc aacaatcagt tggcagagaa ggtcagattg cgccttcgat atgaagaggc
     1441 taagagaaga ctttcctgtc aatgtggcca ggcaactccc agcaattcgg agcttacaca
     1501 ctaccagctc ccccaggcgt ccagcaaaac agcaagacat ctgtatttgg acagccactt
     1561 cttgttctct ctgaagagga ccactctgaa ccttggatct gttccatcct gcaggaatgc
     1621 ctgtcttaga tggatcgcca acctgaagat ccagctggcc aagcttgaca gtgaggcctg
     1681 gcctggggtg ctggactcag agagggaccg gctgatcctt atcaacgaga aggaggagct
     1741 gctgaaggag atgcgcttca tcagcccccg caagtggacc cagggggagg tggagcagct
     1801 ggagatggcc cggaagcggc tggaaaagga cctgcaggca gcccgggaca cccagagcaa
     1861 ggcgctgacg gagaggttaa agttaaacag taagaggaac cagcttgtga gagaactgga
     1921 ggaagccacc cggcaggtgg caactctgca ctcccagctg aaaagtctct caagcagcat
     1981 gcagtccctg tcctcaggca gcagccccgg atccctcacg tccagccggg gctccctggt
     2041 tgcatccagc ctggactcct ccacttcagc cagcttcact gacctctact atgacccctt
     2101 tgagcagctg gactcagagc tgcagagcaa ggtggagttc ctgctcctgg agggggccac
     2161 cggcttccgg ccctcaggct gcatcaccac catccacgag gatgaggtgg ccaagaccca
     2221 gaaggcagag ggaggtggcc gcctgcaggc tctgcgttcc ctgtctggca ccccaaagtc
     2281 catgacctcc ctatccccac gttcctctct ctcctccccc tccccaccct gttcccctct
     2341 catggctgac cccctcctgg ctggtgatgc cttcctcaac tccttggagt ttgaagaccc
     2401 ggagctgagt gccactcttt gtgaactgag ccttggtaac agcgcccagg aaagataccg
     2461 gctggaggaa ccaggaacgg agggcaagca gctgggccaa gctgtgaata cggcccaggg
     2521 gtgtggcctg aaagtggcct gtgtctcagc cgccgtatcg gacgagtcag tggctggaga
     2581 cagtggtgtg tacgaggctt ccgtgcagag actgggtgct tcagaagctg ctgcatttga
     2641 cagtgacgaa tcggaagcag tgggtgcgac ccgaattcag attgccctga agtatgatga
     2701 gaagaataag caatttgcaa tattaatcat ccagctgagt aacctttctg ctctgttgca
     2761 gcaacaagac cagaaagtga atatccgcgt ggctgtcctt ccttgctctg aaagcacaac
     2821 ctgcctgttc cggacccggc ctctggacgc ctcagacact ctagtgttca atgaggtgtt
     2881 ctgggtatcc atgtcctatc cagcccttca ccagaagacc ttaagagtcg atgtctgtac
     2941 caccgacagg agccatctgg aagagtgcct gggaggcgcc cagatcagcc tggcggaggt
     3001 ctgccggtct ggggagaggt cgactcgctg gtacaacctt ctcagctaca aatacttgaa
     3061 gaaacagagc agggagctca agccagtggg agtcatggcc cctgcctcag ggcctgccag
     3121 cacggacgct gtgtctgctc tgttggaaca gacagcagtg gagctggaga agaggcagga
     3181 gggcaggagc agcacacaga cactggaaga cagctggagg tatgaggaga ccagtgagaa
     3241 tgaggcagta gccgaggaag aggaggagga ggtggaggag gaggagggag aagaggatgt
     3301 tttcaccgag aaagcctcac ctgatatgga tgggtaccca gcattaaagg tggacaaaga
     3361 gaccaacacg gagaccccgg ccccatcccc cacagtggtg cgacctaagg accggagagt
     3421 gggcaccccg tcccaggggc catttcttcg agggagcacc atcatccgct ctaagacctt
     3481 ctccccagga ccccagagcc agtacgtgtg ccggctgaat cggagtgata gtgacagctc
     3541 cactctgtcc aaaaagccac cttttgttcg aaactccctg gagcgacgca gcgtccggat
     3601 gaagcggcct tcctcggtca agtcgctgcg ctccgagcgt ctgatccgta cctcgctgga
     3661 cctggagtta gacctgcagg cgacaagaac ctggcacagc caattgaccc aggagatctc
     3721 ggtgctgaag gagctcaagg agcagctgga acaagccaag agccacgggg agaaggagct
     3781 gccacagtgg ttgcgtgagg acgagcgttt ccgcctgctg ctgaggatgc tggagaagcg
     3841 gatggaccga gcggagcaca agggtgagct tcagacagac aagatgatga gggcagctgc
     3901 caaggatgtg cacaggctcc gaggccagag ctgtaaggaa cccccagaag ttcagtcttt
     3961 cagggagaag atggcatttt tcacccggcc tcggatgaat atcccagctc tctctgcaga
     4021 tgacgtctaa tcgccagaaa agtatttcct ttgttccact gaccaggctg tgaacattga
     4081 ctgtggctaa agttatttat gtggtgttat atgaaggtac tgagtcacaa gtcctctagt
     4141 gctcttgttg gtttgaagat gaaccgactt tttagtttgg gtcctactgt tgttattaaa
     4201 aacagaacaa aaacaaaaca cacacacaca caaaaacaga aacaaaaaaa accagcatta
     4261 aaataataag attgtatagt ttgtatattt aggagtgtat ttttgggaaa gaaaatttaa
     4321 atgaactaaa gcagtattga gttgctgctc ttcttaaaat cgtttagatt ttttttggtt
     4381 tgtacagctc caccttttag aggtcttact gcaataagaa gtaatgcctg ggggacggta
     4441 atcctaatag gacgtcccgc acttgtcaca gtacagctaa tttttcctag ttaacatatt
     4501 ttgtacaata ttaaaaaaat gcacagaaac cattgggggg gattcagagg tgcatccacg
     4561 gatcttcttg agctgtgacg tgtttttatg tggctgccca acgtggagcg ggcagtgtga
     4621 taggctgggt gggctaagca gcctagtcta tgtgggtgac aggccacgct ggtctcagat
     4681 gcccagtgaa gccactaaca tgagtgaggg gagggctgtg gggaactcca ttcagtttta
     4741 tctccatcaa taaagtggcc tttcaaaaag aatcttcctc ttgctctctt tttctttcct
     4801 acccctcact tcatctgttt ccctgatttt tgactctccc ctttccagtc atttctttcc
     4861 cacccatccg cagtcctgga aacatttatt ttttcttttg cccactgttt tcatttgctc
     4921 attaaattaa aatgactgct cggctcattg ggaatccaca tccccaagtt agactgggga
     4981 tatgctctct gtactgtctc cttctatgga attccacccc acccagagag agatgacttc
     5041 acagtttgtt catatgagca tcatcccatg tcgtccccaa cccaggggct ggtaggtgct
     5101 acagcttgtg cttcatgctg ctcctgtggc ccctattcct acccagctca gagctttgca
     5161 gggtctactg cagacaatca gaagtcagtt tctaacaaat agcaacagcc acaaatctct
     5221 tcctccttcc tctctgacat taccctgtgc aacttttctc aaagtctgtt gcaccactca
     5281 gcaaagcaag ttgcaccagc tatatcagaa tcacctgggg cagcctatta aaaatgcaga
     5341 ctgttgagac catcctggct aacacggtga aaccctgtct ctactaaaaa tacaaaaaat
     5401 tagccggccg tggtggcggg cagctactcg ggaggctgag gcaggagaat gacctgaacc
     5461 tgggaggcag agcttgcagt gagctgagat tgtgccactg cactccagcc tgggtgacag
     5521 agcaagactc cgtctcaaaa aaaaaaaaaa aagaaaaatg cagactggct ggcgcggtgg
     5581 ctcatgcttg taatcccagc actttgggag gctgaggcgg gcagatcaac tgagatcggg
     5641 ggttcgagac cagcctgatc aacatggaga aacctggtct ctactaaaaa tacataatta
     5701 gctgggcgta gtggcgcata cctgtaatcc cagctacttg ggtggccaag gcttgaaccc
     5761 aggaggcgga ggttgcggtg agccgagatg gcgccattga ctccagcctg ggcaacaaga
     5821 gcgtaactcc atctcaaaaa aataataata ataaaaataa aatgcagact gtcaggtcct
     5881 ctctagaccc actgaactat cccgcccacc ctgggacggt ccccagtgcc agtgttttac
     5941 ccatgttccc tctgtaagtc ttatgcacac cgcaatttga gagccccact ggtataaagt
     6001 gagtgaaacc caggcagaga caggcaaaat ggtgaggccc gcatcctatt ggtgagtcac
     6061 acagggaacg ctgaaattca tggccttctc caggctactg ggaacccatg ggcggtgatg
     6121 gagggagtgg tgccaccttc acttgctgct gaggctcttc cccctctccc cagcatactc
     6181 cttacctggc tgtctctcct catgtataag gaacctatag tggtgtagaa tctactcttc
     6241 ttccccctgt ggcttccagg cccccctgta tagctgctat ccagcccgat ttctcaccac
     6301 tggcccaggg cttcctcctg ccccgtggct tcacgtctct gaacacatca atctctgatg
     6361 ttctctctcc ttccattgaa ttccaccaga cacattcagg gtttacttcg taatgtcttc
     6421 atatgagtat caatcaacac cttccccaac tcaattgtac taggttgtag agcacaagga
     6481 tggtctcgtg ctgctctgtg gcacctgtgc ctacactcct ctgagctttg aggaggctgc
     6541 tctctttgct gaccccatga tcttttctgc ccttctgtta agggcattgg ccacagcaac
     6601 ggggcaaatg ccccaagctg gctgtaagtg acccatccct ttggctccca tgattagacc
     6661 aaggagaggc atggggtcca gctgagccat tcagaaccat tccttagcat tttccactca
     6721 aaggttagag atgagatttt ctcttcccaa ggctacctct ggccatggtt ccagcttcat
     6781 gggggcaatg ggattaggaa aatgaggtca acctgcaaag gaaagcagat gcaagagatg
     6841 gagacagaat gggggtgtcc tggggatctt ggagcctgaa ttcattggca caaaaggcag
     6901 cagcatcctc actgtatctg cagtccattt ggactcaata aaaactttga aagtcacatg
     6961 tgttatggaa ttccttctca gtgacacatt catctgtgct cagttgtccc agcaagggtc
     7021 agcccctcat acccctgcag catccgctgc tatgaagcag agctgtaaac gccctccctg
     7081 tgtataggaa aagctacatg gagcaaatcc tcctgcctga agaagtgcat ctcagcatca
     7141 cttcagctgt cggggcattt gtggggagaa ccagaccacc tctgcggaag gcagcagacc
     7201 ctcttccagc catggatgga gttgaattct ctataaacgg ttcaccagca aaccaccaat
     7261 acattccatt gtttgcctag agagaaattt aaaaataaat aaatgttcac ttataa
//
